1. Novel left ventricular mechanical index in pulmonary arterial hypertension
- Author
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Kenzo Ichimura, Everton J. Santana, Tatiana Kuznetsova, Nicholas Cauwenberghs, František Sabovčik, Lindsey Chun, Nadia L. C. Francisco, Vitaly O. Kheyfets, Michael Salerno, Roham T. Zamanian, Edda Spiekerkoetter, and Francois Haddad
- Subjects
echocardiography ,pulmonary hypertension ,ventricular function ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Ventricular interdependence plays an important role in pulmonary arterial hypertension (PAH). It can decrease left ventricular (LV) longitudinal strain (LVLS) and lead to a leftward displacement (“transverse shortening”) of the interventricular septum (sTS). For this study, we hypothesized the ratio of LVLS/sTS would be a sensitive marker of systolic ventricular interactions in PAH. In a cross‐sectional cohort of patients with PAH (n = 57) and matched controls (n = 57), we quantified LVLS and septal TS in the amplitude and time domain. We then characterized LV phenotypes using upset plots, ventricular interactions using network analysis, and longitudinal analysis in a representative cohort of 45 patients. We also measured LV metrics in mice subjected to pulmonary arterial banding (PAB) using a 7 T magnetic resonance imaging at baseline, Week 1, and Week 7 post‐PAB (N = 9). Patients with PAH had significantly reduced absolute LVLS (15.4 ± 3.4 vs. 20.1 ± 2.3%, p
- Published
- 2023
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