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38 results on '"Vitalina Gryshkova"'

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1. Testing the nonclinical Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm with an established anti‐seizure medication: Levetiracetam case study

2. Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

3. New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

4. Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

5. microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes

6. Applying the CiPA Approach to Evaluate Cardiac Proarrhythmia Risk of some Antimalarials Used Off‐label in the First Wave of COVID‐19

7. INSPIRE

8. Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

10. Applying CiPA paradigm for assessing proarrhythmia risk of Covid-19 current off-label used therapies

12. Fatty-Acid Binding Protein 4 (FABP4) as a Potential Preclinical Biomarker of Drug-Induced Kidney Injury

13. Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

14. New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

15. miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats

16. Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson’s disease

17. Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

19. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

20. An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

21. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers

22. Generation of Monoclonal Antibodies Against Tumor-Associated Antigen MX35/sodium-Dependent Phosphate Transporter NaPi2b

23. Effect of Anti-NaPi2b Monoclonal Antibody on Phosphate Transport in Renal Cancer Cell Line SK-RC-18

26. Creation of cellular models for the analysis of sodium-dependent phosphate transporter NaPi2b, a potential marker for ovarian cancer

27. Development of Monoclonal Antibodies Specific for the Human Sodium-dependent Phosphate Co-transporter NaPi2b

28. His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor

30. De-risking primary and secondary pharmacology mediated adverse effects as a path to increase likelihood of success in drug development

31. The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization

32. Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers

33. Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation

34. Identification of phosphate transporter NaPi2b as MX35 cancer antigen by modified SEREX approach

35. Calr Mutants Retroviral Mouse Models Lead to a Myeloproliferative Neoplasm Mimicking an Essential Thrombocythemia Progressing to a Myelofibrosis

36. The sodium-dependent phosphate transporter NaPi2b is a new target antigen in ovarian carcinoma and is recognized by the anti- cancer antibody MX35

37. Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515

38. Inhibition of sodium-dependent phosphate transporter NaPi2b function with MX35 antibody

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