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6 results on '"Vitalba Gallitelli"'

1. CFTR modulators and pregnancy: A Case Report

Author

Vitalba Gallitelli, Rita Franco, Daniela Visconti, Carmela Paciullo, Ludovica Puri, and Marco De Santis

Abstract

Cystic fibrosis is the most common genetic disease characterized by the dysfunction of the CFTR protein and induces hydration and ionic transfers in the epithelium anomalies. This case report discusses about a pregnant woman, suffering from cystic fibrosis, who undertook the triple combination of CFTR modulators.

Published
2022

3. Anatomical distribution of sentinel lymph nodes in patients with endometrial cancer: a multicenter study

Author

Stefano Restaino, Alessandro Buda, Andrea Puppo, Vito Andrea Capozzi, Giulio Sozzi, Jvan Casarin, Vitalba Gallitelli, Ferdinando Murgia, Giuseppe Vizzielli, Alessandro Baroni, Giacomo Corrado, Tina Pasciuto, Debora Ferrari, Antonia Novelli, Roberto Berretta, Francesco Legge, Enrico Vizza, Vito Chiantera, Fabio Ghezzi, Fabio Landoni, Giovanni Scambia, Francesco Fanfani, Restaino, Stefano, Buda, Alessandro, Puppo, Andrea, Capozzi, Vito Andrea, Sozzi, Giulio, Casarin, Jvan, Gallitelli, Vitalba, Murgia, Ferdinando, Vizzielli, Giuseppe, Baroni, Alessandro, Corrado, Giacomo, Pasciuto, Tina, Ferrari, Debora, Novelli, Antonia, Berretta, Roberto, Legge, Francesco, Vizza, Enrico, Chiantera, Vito, Ghezzi, Fabio, Landoni, Fabio, Scambia, Giovanni, Fanfani, Francesco, Restaino, S, Buda, A, Puppo, A, Capozzi, V, Sozzi, G, Casarin, J, Gallitelli, V, Murgia, F, Vizzielli, G, Baroni, A, Corrado, G, Pasciuto, T, Ferrari, D, Novelli, A, Berretta, R, Legge, F, Vizza, E, Chiantera, V, Ghezzi, F, Landoni, F, Scambia, G, and Fanfani, F

Subjects
Sentinel Lymph Node Biopsy, Obstetrics and Gynecology, Hysterectomy, Endometrial Neoplasms, laparoscopes, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Oncology, laparoscope, Humans, Lymph Node Excision, endometrial neoplasm, Female, Lymph Nodes, Sentinel Lymph Node, Neoplasm Staging, Retrospective Studies
Abstract

ObjectiveSentinel lymph node (SLN) mapping represents the standard approach in uterine confined endometrial cancer patients. The aim of this study was to evaluate the anatomical distribution of SLNs and the most frequent locations of nodal metastasis.MethodsThis was an observational retrospective multicenter study involving eight high volume gynecologic cancer centers in Italy. We reviewed 1576 patients with a histologically confirmed diagnosis of endometrial cancer from September 2015 to June 2020. All patients underwent total hysterectomy with salpingo-ophorectomy and SLN mapping.ResultsA total of 3105 SLNs were mapped and removed, 2809 (90.5%) of these were bilateral and 296 (9.5%) unilateral. The overall detection rate was 93.4% (77.9% bilateral and 15.5% unilateral). The majority of SLNs (80%) and positive SLNs (77.8%) were found at the external iliac and obturator level in both endometrioid and non-endometrioid endometrial cancer. Negative SLNs were more frequent in patients with endometrioid compared with non-endometrioid cancer (91.9% vs 86.1%, pConclusionThe most frequent sites of SLNs and metastases were located in the pelvic area below the iliac vessel bifurcation. Our findings showed that older age, a higher body mass index, and non-endometrioid histology had a negative impact on mapping.

Published
2022

6. The complex relationship between infertility and female genital tract cancer: A review.

Author

Alessandra, Familiari, Vitalba, Gallitelli, Antonella, Biscione, Giulia, Di Marco, Carmine, Conte, Marco, D'Indinosante, Rachel, Schwab, Giacomo, Corrado, Anna, Fagotti, Valerio, Gallotta, and Giovanni, Scambia

Subjects
*GENITALIA, *FEMALE infertility, *FERTILITY preservation, *GYNECOLOGIC cancer, *OVARIAN cancer, *CHILDBEARING age, *INFERTILITY
Abstract

Introduction: The link between female infertility and gynecological cancer has always been a debated and challenging topic. Although cervical cancer has the worst impact on female fertility, as it is usually diagnosed in patients of reproductive age, endometrial and ovarian cancer are also diagnosed and treated often in relatively younger patients in which fertility preservation is a relevant issue. The aim of this review is to highlight the correlation between therapy for female infertility and the developing cancer's risk and to describe the fertility sparing treatments in gynecological oncology. Material and methods: A systematic review of the literature through the main scientific search engines (PubMed and Google Scholar) was performed. We selected the most relevant articles based on the largest case series and the latest updates. All selected documents have been listed in the references. Results: Fifty-six relevant articles published between 1996 and 2019 were identified. Results from the available evidence report no significant increased risk of endometrial, cervical, and ovarian cancer in patients having infertility treatments. In young patients diagnosed with gynecological cancer, preservation of fertility is a personalized choice depending on several factors (type, stage, age and desire to conceive, safety of the treatment, and feasibility of fertility sparing surgery). For ovarian cancer FIGO stage IA G1, IA G2 (grade), and IC G1; for endometrial adenocarcinoma grade 1 with no lymphovascular space invasion (LVSI) or myometrial invasion and for early-stage cervical cancer (FIGO stage 2018: IA1-IB1), fertility sparing treatment is possible. The role of fertility sparing treatment with the increase of personalization of therapies therapy is always a theme of discussion and research. Conclusion: At present data regarding the risk of gynecological cancers after infertility treatments are reassuring. Careful evaluation of female fertility-sparing options in young women interested by ovarian, endometrial, or cervical tumors should be carried out involving a multidisciplinary team and ensuring safety and efficacy. [ABSTRACT FROM AUTHOR]

Published
2022
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