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3. First insights for targeted therapies in odontogenic myxoma

Author

Pereira, Núbia Braga, Bastos, Victor Coutinho, de Souza, Juliana Cristina, Diniz, Marina Gonçalves, Vitório, Jéssica Gardone, Kitten, Gregory Thomas, de Oliveira Andrade, Luciana, de Avelar, Gleide Fernandes, Castro, Wagner Henriques, Bernardes, Vanessa Fátima, Dias, Adriana Abalen Martins, Gomez, Ricardo Santiago, and Gomes, Carolina Cavalieri

Published
2020
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4. The altered metabolic pathways of diffuse large B-cell lymphoma not otherwise specified

Author

Rodrigues-Fernandes, Carla Isabelly, primary, Martins-Chaves, Roberta Rayra, additional, Vitório, Jéssica Gardone, additional, Duarte-Andrade, Filipe Fideles, additional, Pereira, Thaís dos Santos Fontes, additional, Soares, Ciro Dantas, additional, Moreira, Victor Rezende, additional, Lebron, Yuri Abner Rocha, additional, Santos, Lucilaine Valéria de Souza, additional, Lange, Liséte Celina, additional, Canuto, Gisele André Baptista, additional, Gomes, Carolina Cavaliéri, additional, de Macedo, Adriana Nori, additional, Pontes, Hélder Antônio Rebelo, additional, Burbano, Rommel Mario Rodríguez, additional, Martins, Manoela Domingues, additional, Pires, Fábio Ramôa, additional, Mesquita, Ricardo Alves, additional, Gomez, Ricardo Santiago, additional, Santos-Silva, Alan Roger, additional, Lopes, Márcio Ajudarte, additional, Vargas, Pablo Agustin, additional, and Fonseca, Felipe Paiva, additional

Published
2023
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5. Metabolic landscape of oral squamous cell carcinoma

Author

Vitório, Jéssica Gardone, Duarte-Andrade, Filipe Fideles, dos Santos Fontes Pereira, Thaís, Fonseca, Felipe Paiva, Amorim, Larissa Stefhanne Damasceno, Martins-Chaves, Roberta Rayra, Gomes, Carolina Cavaliéri, Canuto, Gisele André Baptista, and Gomez, Ricardo Santiago

Published
2020
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9. Integrated proteomics, phosphoproteomics and metabolomics analyses reveal similarities among giant cell granulomas of the jaws with different genetic mutations

Author

Vitório, Jéssica Gardone, primary, Duarte‐Andrade, Filipe Fideles, additional, Pereira, Thais dos Santos Fontes, additional, Melo‐Braga, Marcella Nunes, additional, Canuto, Gisele André Baptista, additional, Macedo, Adriana Nori de, additional, Lebron, Yuri Abner Rocha, additional, Moreira, Victor Rezende, additional, Felicori, Liza Figueiredo, additional, Lange, Liséte Celina, additional, Santos, Lucilaine Valéria de Souza, additional, Larsen, Martin R., additional, Gomes, Carolina Cavalieri, additional, and Gomez, Ricardo Santiago, additional

Published
2022
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10. Chronic alcohol administration alters metabolomic profile of murine bone marrow.

Author

Pontes Pereira, Tássia Tatiane, Duarte-Andrade, Filipe Fideles, Vitório, Jéssica Gardone, Santo Pereira, Taiane do Espírito, Martins, Flavia Rayssa Braga, Marques Souza, Jéssica Amanda, Malacco, Nathália Luisa, Melo, Eliza Mathias, Costa Picossi, Carolina Raíssa, Pinto, Ernani, Gomez, Ricardo Santiago, Teixeira, Mauro Martins, de Macedo, Adriana Nori, Baptista Canuto, Gisele André, and Soriani, Frederico Marianetti

Subjects
BONE marrow, METABOLOMICS, BONE marrow cells, ALCOHOL drinking, CELL physiology
Abstract

Introduction: People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response. Methods: We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography-coupled mass spectrometry (GC-MS). Results: We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanol- treated animals: uracil, succinate, proline, nicotinamide, and tyrosine. Discussion: Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento‐ossifying fibroma pathogenesis

Author

Duarte‐Andrade, Filipe Fideles, primary, Pereira, Thais dos Santos Fontes, additional, Vitório, Jéssica Gardone, additional, Diniz, Marina Gonçalves, additional, Amorim, Larissa Stefhanne Damasceno, additional, Nawrocki, Arkadiusz, additional, Felicori, Liza Figueiredo, additional, De Marco, Luiz, additional, Gomes, Carolina Cavaliéri, additional, Larsen, Martin R., additional, Melo‐Braga, Marcella Nunes, additional, and Gomez, Ricardo Santiago, additional

Published
2022
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12. Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study.

Author

Leite‐Lima, Flávia, Bastos, Victor Coutinho, Vitório, Jéssica Gardone, Duarte‐Andrade, Filipe Fideles, Pereira, Thaís dos Santos Fontes, Martins‐Chaves, Roberta Rayra, Cruz, Aline Fernanda, de Lacerda, Júlio César Tanos, Lebron, Yuri Abner Rocha, Moreira, Victor Rezende, Santos, Lucilaine Valéria de Souza, Lange, Liséte Celina, de Macedo, Adriana Nori, Diniz, Marina Gonçalves, Gomes, Carolina Cavaliéri, de Castro, Wagner Henriques, Canuto, Gisele André Baptista, and Gomez, Ricardo Santiago

Subjects
PILOT projects, HIGH performance liquid chromatography, METABOLOMICS, FORMALDEHYDE, METABOLISM, MASS spectrometry, DESCRIPTIVE statistics, ODONTOGENIC cysts, ORAL mucosa
Abstract

Objective: We aimed to assess which metabolic pathways would be implicated in the phenotypic changes of the epithelial lining of odontogenic keratocyst after marsupialization, comparing pre‐ and post‐marsupialized lesions with adjacent oral mucosa. Materials and Methods: Eighteen formalin‐fixed and paraffin‐embedded tissues from six subjects were divided into three paired groups: odontogenic keratocyst pre‐ (n = 6) and post‐marsupialization (n = 6), and adjacent oral mucosa (n = 6). The metabolic pathways found in these groups were obtained by high‐performance liquid chromatography‐mass spectrometry‐based untargeted metabolomics performed. Results: Through putative metabolite annotation followed by pathway enrichment and predictive analysis with automated algorithms (Mummichog and Gene Set Enrichment Analysis), we found differences in many cellular processes that may be involved in inflammation, oxidative stress response, keratinocyte‐basal membrane attachment, differentiation, and proliferation functions, all relevant to odontogenic keratocyst pathobiology and the phenotype acquired after marsupialization. Conclusion: Our study was able to identify several metabolic pathways potentially involved in the metaplastic changes induced by marsupialization of odontogenic keratocysts. An improved comprehension of this process could pave the way for the development of targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study

Author

Bastos, Victor Coutinho, primary, Vitório, Jéssica Gardone, additional, Martins-Chaves, Roberta Rayra, additional, Leite-Lima, Flávia, additional, Lebron, Yuri Abner Rocha, additional, Moreira, Victor Rezende, additional, Duarte-Andrade, Filipe Fideles, additional, Pereira, Thaís dos Santos Fontes, additional, Santos, Lucilaine Valéria de Souza, additional, Lange, Liséte Celina, additional, Macedo, Adriana Nori de, additional, Canuto, Gisele André Baptista, additional, Gomes, Carolina Cavaliéri, additional, and Gomez, Ricardo Santiago, additional

Published
2021
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14. Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study

Author

Leite‐Lima, Flávia, primary, Bastos, Victor Coutinho, additional, Vitório, Jéssica Gardone, additional, Duarte‐Andrade, Filipe Fideles, additional, Pereira, Thaís dos Santos Fontes, additional, Martins‐Chaves, Roberta Rayra, additional, Cruz, Aline Fernanda, additional, de Lacerda, Júlio César Tanos, additional, Lebron, Yuri Abner Rocha, additional, Moreira, Victor Rezende, additional, Santos, Lucilaine Valéria de Souza, additional, Lange, Liséte Celina, additional, de Macedo, Adriana Nori, additional, Diniz, Marina Gonçalves, additional, Gomes, Carolina Cavaliéri, additional, de Castro, Wagner Henriques, additional, Canuto, Gisele André Baptista, additional, and Gomez, Ricardo Santiago, additional

Published
2021
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17. First insights for targeted therapies in odontogenic myxoma

Author

Pereira, Núbia Braga, primary, Bastos, Victor Coutinho, additional, de Souza, Juliana Cristina, additional, Diniz, Marina Gonçalves, additional, Vitório, Jéssica Gardone, additional, Kitten, Gregory Thomas, additional, de Oliveira Andrade, Luciana, additional, de Avelar, Gleide Fernandes, additional, Castro, Wagner Henriques, additional, Bernardes, Vanessa Fátima, additional, Dias, Adriana Abalen Martins, additional, Gomez, Ricardo Santiago, additional, and Gomes, Carolina Cavalieri, additional

Published
2019
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18. Oral pyogenic granulomas show MAPK/ERK signaling pathway activation, which occurs independently of BRAF , KRAS , HRAS , NRAS, GNA11, and GNA14 mutations

Author

Pereira, Thaís dos Santos Fontes, primary, Amorim, Larissa Stefhanne Damasceno, additional, Pereira, Núbia Braga, additional, Vitório, Jéssica Gardone, additional, Duarte‐Andrade, Filipe Fideles, additional, Guimarães, Letícia Martins, additional, Diniz, Marina Gonçalves, additional, Gomes, Carolina Cavaliéri, additional, and Gomez, Ricardo Santiago, additional

Published
2019
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19. Reticular and erosive oral lichen planus have a distinct metabolomic profile: A preliminary study using gas chromatography‐mass spectrometry

Author

Cruz, Aline Fernanda, primary, Vitório, Jéssica Gardone, additional, Duarte‐Andrade, Filipe Fideles, additional, Diniz, Marina Gonçalves, additional, Canuto, Gisele André Baptista, additional, Toledo, Juliano Simões, additional, Fonseca, Felipe Paiva, additional, Fernandes, Ana Paula, additional, André, Leiliane Coelho, additional, Gomes, Carolina Cavaliéri, additional, and Gomez, Ricardo Santiago, additional

Published
2019
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20. The importance of BRAF‐V600E mutation to ameloblastoma metabolism

Author

Duarte‐Andrade, Filipe Fideles, primary, Silva, André Myller Barbosa, additional, Vitório, Jéssica Gardone, additional, Canuto, Gisele André Baptista, additional, Costa, Sara Ferreira Santos, additional, Diniz, Marina Gonçalves, additional, Fernandes, Ana Paula, additional, Toledo, Juliano Simões, additional, André, Leiliane Coelho, additional, Gomes, Carolina Cavaliéri, additional, Gomez, Ricardo Santiago, additional, and Fonseca, Felipe Paiva, additional

Published
2019
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21. Evaluation of three recombinant proteins for the development of ELISA and immunochromatographic tests for visceral leishmaniasis serodiagnosis

Author

Santos, Anna Raquel Ribeiro dos, primary, Serufo, Ângela Vieira, additional, Figueiredo, Maria Marta, additional, Godoi, Lara Carvalho, additional, Vitório, Jéssica Gardone, additional, Marcelino, Andreza Pain, additional, Avelar, Daniel Moreira de, additional, Rodrigues, Fernandes Tenório Gomes, additional, Machado-Coelho, George Luiz Lins, additional, Medeiros, Fernanda Alvarenga Cardoso, additional, Jerônimo, Selma Maria Bezerra, additional, Oliveira, Edward José de, additional, Nascimento, Frederico Crepaldi, additional, Teixeira, Santuza Maria Ribeiro, additional, Gazzinelli, Ricardo Tostes, additional, Nagem, Ronaldo Alves Pinto, additional, and Fernandes, Ana Paula, additional

Published
2019
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22. Deregulation of desmosomal proteins and extracellular matrix proteases in odontogenic keratocyst.

Author

Diniz, Marina Gonçalves, Duarte‐Andrade, Filipe Fideles, Stussi, Fernanda, Vitório, Jéssica Gardone, Fonseca, Felipe Paiva, Ramos Domingues, Romênia, Paes Leme, Adriana F., Gomes, Carolina Cavaliéri, and Gomez, Ricardo Santiago

Subjects
CELL differentiation, LIQUID chromatography, MATRIX metalloproteinases, MOLECULAR biology, PROTEOMICS, CELL communication, GENE expression, CELLULAR signal transduction, GLYCOPROTEINS, MASS spectrometry, ODONTOGENIC cysts, EXTRACELLULAR space, CELL junctions, ORAL mucosa, PEPTIDES
Abstract

Objective: Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. Materials and Methods: We compared the proteomic profiles of five OKC and matched normal oral mucosa by using liquid chromatography–tandem mass spectrometry (LC‐MS/MS). Then, we performed enrichment analysis and a literature search for the immunoexpression of the proteomics targets. Results: We identified 1,150 proteins and 72 differently expressed proteins (log2 fold change ≥ 1.5; p <.05). Twenty‐seven peptides were exclusively detected in the OKC samples. We found 35 enriched pathways related to cell differentiation and tissue architecture, including keratinocyte differentiation, keratinization, desmosome, and extracellular matrix (ECM) organization and degradation. The immunoexpression information of 11 out of 50 proteins identified in the enriched pathways was obtained. We found the downregulation of four desmosomal proteins (JUP, PKP1, PKP3, and PPL) and upregulation of ECM proteases (MMP‐2, MMP‐9, and cathepsins). Conclusions: Proteomic analysis strengthened the notion that OKC cells have a similar proteomic profile to oral keratinocytes. Contextual investigation of the differentially expressed proteins revealed the deregulation of desmosome proteins and ECM degradation as important alterations in OKC pathobiology. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Leishmania (Sauroleishmania) tarentolae versus pathogenic species: comparative evaluation of protease activity, glycoconjugates, resistance to complement and metabolome composition.

Author

Andrade FFD, Vitório JG, Canuto GAB, Nunes FFC, Rodrigues IA, Almeida APMM, Nascimento FC, Costa AO, Vieira TDS, Silva ACC, André LC, Gontijo CMF, Junqueira C, Toledo JS, Fernandes AP, and Soares RP

Subjects
Animals, Glycosphingolipids metabolism, Complement System Proteins, Glycoconjugates, Leishmania enzymology, Metabolome, Peptide Hydrolases metabolism
Abstract

Background: Leishmania tarentolae is a non-pathogenic species found in lizards representing an important model for Leishmania biology. However, several aspects of this Sauroleishmania remain unknown to explain its low level of virulence., Objectives: We reported several aspects of L. tarentolae biology including glycoconjugates, proteolytic activities and metabolome composition in comparison to pathogenic species (Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum and Leishmania major)., Methods: Parasites were cultured for extraction and purification of lipophosphoglycan (LPG), immunofluorescence probing with anti-gp63 and resistance against complement. Parasite extracts were also tested for proteases activity and metabolome composition., Findings: Leishmania tarentolae does not express LPG on its surface. It expresses gp63 at lower levels compared to pathogenic species and, is highly sensitive to complement-mediated lysis. This species also lacks intracellular/extracellular activities of proteolytic enzymes. It has metabolic differences with pathogenic species, exhibiting a lower abundance of metabolites including ABC transporters, biosynthesis of unsaturated fatty acids and steroids, TCA cycle, glycine/serine/threonine metabolism, glyoxylate/dicarboxylate metabolism and pentose-phosphate pathways., Main Conclusions: The non-pathogenic phenotype of L. tarentolae is associated with alterations in several biochemical and molecular features. This reinforces the need of comparative studies between pathogenic and non-pathogenic species to elucidate the molecular mechanisms of virulence during host-parasite interactions.

Published
2024
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