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Background: Parkinson’s disease and essential tremor are common diseases that cannot be cured. These diseases cause a major impact on the patients’ lifestyle, and as they are progressive over time, their symptoms tend to get worse as well as these individuals’ quality of life. Objective: To analyze how the duration of the disease impact quality of life and other aspects related to the disease. Methods: A systematic review was carried out, and a meta-analysis developed including original articles published after 2006 that assessed the quality of life of patients with diseases that presented tremor as a symptom. Results: The number of papers found totaled 7.114, out of those, 27 were included in the systematic review, and 15 of them were also included in the meta-analysis. The articles found analyzed sociodemographic, neuropsychiatric scales, and disease severity scales. In the meta-analysis we found that the time of disease impacts the score of PDQ-39 in numbers of dominants, the mini-mental score, and the UPDRS score. Conclusion: Longer time of disease since diagnostic results in a negative impact on the patients’ quality of life, cognition, emotional status, activities of daily living, motor examination, and therapy complication. more...

BACKGROUND: Proper fixation of the surgical mesh determines the success of a herniorrhaphy. Understanding the inflammatory response and the mechanical properties of the mesh helps to define whether a fixation method is superior. AIM: This study aimed to evaluate the healing of defects in the abdominal wall of rats, comparing the repair of macroporous polypropylene meshes fixed with surgical glue and polypropylene thread. METHODS: In 20 Wistar rats, a defect was produced in the abdominal wall, with the integrity of the parietal peritoneum. For correction, the meshes were fixed with surgical glue (2-octyl cyanoacrylate) (subgroup C1), or polypropylene suture (subgroup C2). The two subgroups of 10 animals were euthanized on the 90th postoperative day, and the fragments of the abdominal wall were submitted to macroscopic, histological, and tensiometric analysis. RESULTS: Macroscopic analysis did not show any abnormalities. Tensiometry on the 90th postoperative day in subgroup C1 showed mean rupture tension of 28.47N and in subgroup C2 32.06N (p=0.773). The inflammatory process score revealed that both groups are in the subacute phase (p=0.380). CONCLUSION: The fixation of a polypropylene macroporous mesh to repair an abdominal wall defect can be performed with surgical glue (2-octyl cyanoacrylate) or polypropylene suture, both methods being equally effective. RESUMO - RACIONAL: A adequada fixação da tela cirúrgica determina o sucesso de uma herniorrafia. Entender a resposta inflamatória e as propriedades mecânicas da tela contribui para definir se há superioridade de um método de fixação. OBJETIVO: Avaliar a cicatrização de defeitos em parede abdominal de ratos, comparando-se o reparo das telas de polipropileno macroporosas fixadas com cola cirúrgica e fio de polipropileno. MÉTODOS: Foi produzido defeito na parede abdominal de 20 ratos Wistar com integridade do peritônio parietal. Na correção, as telas foram fixadas com cola cirúrgica 2-octil cianoacrilato (C1) ou sutura (C2). Os dois subgrupos de 10 animais foram eutanasiados no 90º dia de pós-operatório e os fragmentos da parede abdominal foram submetidos a análise macroscópica, histológica e tensiométrica. RESULTADOS: A análise macroscópica não mostrou qualquer anormalidade. A tensiometria no 90º dia de pós-operatório no subgrupo C1 demonstrou tensão média de ruptura de 28,47N e no subgrupo C2 de 32,06N (p=0,773). O escore de processo inflamatório revelou que ambos os grupos se encontram na fase subaguda (p=0,380). CONCLUSÃO: A fixação de tela macroporosa de polipropileno para reparo de defeito em parede abdominal pode ser realizada com cola cirúrgica (2-octil cianoacrilato) ou sutura de polipropileno, sendo ambos os métodos igualmente eficazes. more...

O uso do selênio (Se) na alimentação humana e animal tem despertado a atenção dos pesquisadores devido ao seu duplo status como nutriente essencial e altamente tóxico (GIERUS, 2007). Diversos estudos apontam o papel do mineral na fertilidade masculina, contudo, não há evidências claras sobre a sua influência na fertilidade feminina. A partir disso, este trabalho objetivou analisar a relação entre o uso de selênio e a reprodução feminina, através de análises do ciclo estral, níveis de FSH e LH, e avaliação da taxa de fecundidade. Neste estudo, 36 ratas foram divididas em 3 grupos, e submetidas às técnicas de lavado vaginal e gavagem com selênio quelado, além de histerectomia total para contagem do número de fetos gerados. A análise dos resultados apontou que não houve influência significativa do selênio na fertilidade e fecundidade das ratas. more...

Introduction: Breast cancer is the most common malignant neoplasm in women, except for non-melanoma skin tumors, and the population pyramid demonstrates an aging trend in most countries; it is necessary to value the analysis of the therapies used in this population, but elderly, seeking the de-escalation of treatment, mainly reducing the use of chemotherapy drugs. In this context, the application of genetic signatures contributes to determine a less toxic treatment in these women with luminal biological profile tumors, where toxicity is less tolerated and with a higher risk of fatal outcomes by therapy. The MINDACT study evaluated this population using MammaPrint™, but patients over 70 years of age were poorly represented, corresponding only to 0.8% of the patients evaluated (56 of 6693 patients), and only 26 patients with high clinical risk. Objective: The aim of this study was to verify the possibility of de-escalation of systemic treatment with the use of MammaPrint™ genetic signature in elderly women by comparing the prevalence of data from the MINDACT study population with a cohort of Brazilian patients submitted to the examination (AGEMA-BRA). Methods: This is a cross-sectional study comparing the prevalence of low- and high-risk genomic patients in a population with luminal profile breast carcinoma with high clinical risk in MINDACT study populations with a Brazilian cohort older than 70 years, evaluated by the genetic signature MammaPrint™, between 2016 and 2020. This study describes the analysis of data with the estimation of simple and relative frequencies of variables in relation to low- and high-risk classification and study populations (AGEMABRA and MINDACT). Then, the chi-square test was used to verify the differences between the proportions. To measure the intensity of differences/associations, relative risks (RRs) and their 95% confidence intervals were calculated. The tests were considered significant when p more...