2,013 results on '"Visser W"'
Search Results
2. Treatment of Obesity with Thyroid hormones in Europe. Data from the THESIS* Collaboration
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Galofré, J. C., Díez, J. J., Attanasio, R., Nagy, E. V., Negro, R., Papini, E., Perros, P., Žarković, M., Akarsu, E., Alevizaki, M., Ayvaz, G., Bednarczuk, T., Beleslin, B. N., Berta, E., Bodor, M., Borissova, A. M., Boyanov, M., Buffet, C., Burlacu, M. C., Dobnig, H., Fadeyev, V., Field, B. C. T., Fliers, E., Führer, D., Hakala, T., Jiskra, J., Kopp, P., Krebs, M., Kršek, M., Kužma, M., Lantz, M., Lazúrová, I., Leenhardt, L., Luchytskiy, V., Puga, F. M., McGowan, A., Metso, S., Moran, C., Morgunova, T., Niculescu, D. A., Perić, B., Planck, T., Poiana, C., Robenshtok, E., Rosselet, P. O., Ruchala, M., Riis, K. R., Shepelkevich, A., Tronko, M., Unuane, D., Vardarli, I., Visser, W. E., Vryonidou, M., Younes, Y. R., and Hegedüs, L.
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- 2024
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3. Selenoprotein deficiency disorder predisposes to aortic aneurysm formation.
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Schoenmakers, Erik, Marelli, Federica, Jørgensen, Helle, Visser, W, Moran, Carla, Groeneweg, Stefan, Avalos, Carolina, Jurgens, Sean, Figg, Nichola, Finigan, Alison, Wali, Neha, Agostini, Maura, Wardle-Jones, Hannah, Lyons, Greta, Rusk, Rosemary, Gopalan, Deepa, Twiss, Philip, Visser, Jacob, Goddard, Martin, Nashef, Samer, Heijmen, Robin, Clift, Paul, Sinha, Sanjay, Pirruccello, James, Ellinor, Patrick, Busch-Nentwich, Elisabeth, Ramirez-Solis, Ramiro, Murphy, Michael, Persani, Luca, Bennett, Martin, and Chatterjee, Krishna
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Humans ,Male ,Mice ,Animals ,Zebrafish ,Selenocysteine ,Muscle ,Smooth ,Vascular ,Aortic Aneurysm ,Selenoproteins ,Myocytes ,Smooth Muscle - Abstract
Aortic aneurysms, which may dissect or rupture acutely and be lethal, can be a part of multisystem disorders that have a heritable basis. We report four patients with deficiency of selenocysteine-containing proteins due to selenocysteine Insertion Sequence Binding Protein 2 (SECISBP2) mutations who show early-onset, progressive, aneurysmal dilatation of the ascending aorta due to cystic medial necrosis. Zebrafish and male mice with global or vascular smooth muscle cell (VSMC)-targeted disruption of Secisbp2 respectively show similar aortopathy. Aortas from patients and animal models exhibit raised cellular reactive oxygen species, oxidative DNA damage and VSMC apoptosis. Antioxidant exposure or chelation of iron prevents oxidative damage in patients cells and aortopathy in the zebrafish model. Our observations suggest a key role for oxidative stress and cell death, including via ferroptosis, in mediating aortic degeneration.
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- 2023
4. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
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Sterenborg, Rosalie B. T. M., Steinbrenner, Inga, Li, Yong, Bujnis, Melissa N., Naito, Tatsuhiko, Marouli, Eirini, Galesloot, Tessel E., Babajide, Oladapo, Andreasen, Laura, Astrup, Arne, Åsvold, Bjørn Olav, Bandinelli, Stefania, Beekman, Marian, Beilby, John P., Bork-Jensen, Jette, Boutin, Thibaud, Brody, Jennifer A., Brown, Suzanne J., Brumpton, Ben, Campbell, Purdey J., Cappola, Anne R., Ceresini, Graziano, Chaker, Layal, Chasman, Daniel I., Concas, Maria Pina, Coutinho de Almeida, Rodrigo, Cross, Simone M., Cucca, Francesco, Deary, Ian J., Kjaergaard, Alisa Devedzic, Echouffo Tcheugui, Justin B., Ellervik, Christina, Eriksson, Johan G., Ferrucci, Luigi, Freudenberg, Jan, Fuchsberger, Christian, Gieger, Christian, Giulianini, Franco, Gögele, Martin, Graham, Sarah E., Grarup, Niels, Gunjača, Ivana, Hansen, Torben, Harding, Barbara N., Harris, Sarah E., Haunsø, Stig, Hayward, Caroline, Hui, Jennie, Ittermann, Till, Jukema, J. Wouter, Kajantie, Eero, Kanters, Jørgen K., Kårhus, Line L., Kiemeney, Lambertus A. L. M., Kloppenburg, Margreet, Kühnel, Brigitte, Lahti, Jari, Langenberg, Claudia, Lapauw, Bruno, Leese, Graham, Li, Shuo, Liewald, David C. M., Linneberg, Allan, Lominchar, Jesus V. T., Luan, Jian’an, Martin, Nicholas G., Matana, Antonela, Meima, Marcel E., Meitinger, Thomas, Meulenbelt, Ingrid, Mitchell, Braxton D., Møllehave, Line T., Mora, Samia, Naitza, Silvia, Nauck, Matthias, Netea-Maier, Romana T., Noordam, Raymond, Nursyifa, Casia, Okada, Yukinori, Onano, Stefano, Papadopoulou, Areti, Palmer, Colin N. A., Pattaro, Cristian, Pedersen, Oluf, Peters, Annette, Pietzner, Maik, Polašek, Ozren, Pramstaller, Peter P., Psaty, Bruce M., Punda, Ante, Ray, Debashree, Redmond, Paul, Richards, J. Brent, Ridker, Paul M., Russ, Tom C., Ryan, Kathleen A., Olesen, Morten Salling, Schultheiss, Ulla T., Selvin, Elizabeth, Siddiqui, Moneeza K., Sidore, Carlo, Slagboom, P. Eline, Sørensen, Thorkild I. A., Soto-Pedre, Enrique, Spector, Tim D., Spedicati, Beatrice, Srinivasan, Sundararajan, Starr, John M., Stott, David J., Tanaka, Toshiko, Torlak, Vesela, Trompet, Stella, Tuhkanen, Johanna, Uitterlinden, André G., van den Akker, Erik B., van den Eynde, Tibbert, van der Klauw, Melanie M., van Heemst, Diana, Verroken, Charlotte, Visser, W. Edward, Vojinovic, Dina, Völzke, Henry, Waldenberger, Melanie, Walsh, John P., Wareham, Nicholas J., Weiss, Stefan, Willer, Cristen J., Wilson, Scott G., Wolffenbuttel, Bruce H. R., Wouters, Hanneke J. C. M., Wright, Margaret J., Yang, Qiong, Zemunik, Tatijana, Zhou, Wei, Zhu, Gu, Zöllner, Sebastian, Smit, Johannes W. A., Peeters, Robin P., Köttgen, Anna, Teumer, Alexander, and Medici, Marco
- Published
- 2024
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5. EBD in de praktijk: diëtistisch zorgproces
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Runia, S., Visser, W. K., Witteman, L., Tiebie, J. E. C., Heerkens, Y. F., Former-Boon, M., editor, van Duinen, J.J., editor, and Schuurman, R.W.C., editor
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- 2024
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6. Comparison of two different TSH-receptor antibody assays: A clinical practice study
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van Balkum, Mathé, Schreurs, Marco W.J., Visser, W. Edward, Peeters, Robin P., and Dik, Willem A.
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- 2023
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7. Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients
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Francke, M. I., Visser, W. J., Severs, D., de Mik - van Egmond, A. M. E., Hesselink, D. A., and De Winter, B. C. M.
- Published
- 2022
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8. How to approach clinically discordant FT4 results when changing testing platforms: real-world evidence
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Giovanella, Luca, Duntas, Leonidas, D’Aurizio, Federica, Kurka, Hedwig, Ammer, Tatjana, Rank, Christopher M., Visser, W. Edward, and van den Berg, Sjoerd A. A.
- Published
- 2022
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9. 3,3′,5-tri-iodothyroacetic acid (TRIAC) transporters
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Chen, Zhongli, primary, Yildiz, Sena, additional, Markova, Boyka, additional, de Rooij, Linda J, additional, Leeuwenburgh, Selmar, additional, Hamers, Timo, additional, Peeters, Robin P, additional, Heuer, Heike, additional, Meima, Marcel E, additional, and Visser, W. Edward, additional
- Published
- 2024
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10. Resistance to Thyroid Hormone Beta Due to THRB Mutation in a Patient Misdiagnosed With TSH-Secreting Pituitary Adenoma.
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Wenjun Liao, Waisayanand, Nipawan, Fanhchaksai, Kanda, Visser, W. Edward, Meima, Marcel E., and Wejaphikul, Karn
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THYROID hormone receptors ,MAGNETIC resonance imaging ,PITUITARY tumors ,STEROID receptors ,GENETIC testing - Abstract
Elevated concentrations of T3 and T4 concomitant with nonsuppressed TSH are found in both TSH-producing tumors and resistance to thyroid hormone beta (RTHß), posing a diagnostic challenge. We demonstrate here a 54-year-old female who presented with palpitations, goiter, and elevated free T4 with nonsuppressed TSH concentrations (TSH 2.2 mIU/L [normal range, NR 0.27-4.2 mIU/L] and FT4 59.08 pmol/L [NR 12.0-22.0 pmol/L]). Because magnetic resonance imaging revealed a pituitary microadenoma (4 mm), she was diagnosed with TSH-secreting pituitary adenoma and underwent transsphenoidal surgery. Pathological reports showed no tumor cells. Subsequent genetic testing revealed a pathogenic variant in the THRB gene resulting in a His435Arg amino acid substitution in the T3 receptor isoform beta 1 (TRß1), suggestive of RTHß. In vitro and ex vivo studies revealed that the His435Arg mutated TRß1 (TRß1-H435R) completely abolishes the T3-induced transcriptional activation, nuclear receptor corepressor 1 release, steroid receptor coactivator 1 recruitment, and T3-induced thyroid hormone target gene expression, confirming the pathogenicity of this variant. The identification of a pituitary microadenoma in a patient with RTHß led to a misdiagnosis of a TSH-producing tumor and unnecessary surgery. Genetic testing proved pivotal for an accurate diagnosis, suggesting earlier consideration in similar clinical scenarios. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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11. 3,3′,5-Triiodothyroacetic Acid Transporters.
- Author
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Chen, Zhongli, Yildiz, Sena, Markova, Boyka, de Rooij, Linda J., Leeuwenburgh, Selmar, Hamers, Timo, Peeters, Robin P., Heuer, Heike, Meima, Marcel E., and Visser, W. Edward
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FLUORESCENCE in situ hybridization ,MONOCARBOXYLATE transporters ,MEMBRANE transport proteins ,SMALL molecules ,CHOROID plexus ,ORGANIC anion transporters - Abstract
Introduction: Thyroid hormone transporters are essential for thyroid hormones to enter target cells. Monocarboxylate transporter (MCT) 8 is a key transporter and is expressed at the blood–brain barrier (BBB), in neural cells and many other tissues. Patients with MCT8 deficiency have severe neurodevelopmental delays because of cerebral hypothyroidism and chronic sequelae of peripheral thyrotoxicosis. The T3 analog 3,3′,5-triiodothyroacetic acid (TRIAC) rescued neurodevelopmental features in animal models mimicking MCT8 deficiency and improved key metabolic features in patients with MCT8 deficiency. However, the identity of the transporter(s) that facilitate TRIAC transport are unknown. Here, we screened candidate transporters that are expressed at the human BBB and/or brain–cerebrospinal fluid barrier and known thyroid hormone transporters for TRIAC transport. Materials and Methods: Plasma membrane expression was determined by cell surface biotinylation assays. Intracellular accumulation of 1 nM TRIAC was assessed in COS-1 cells expressing candidate transporters in Dulbecco's phosphate-buffered saline (DPBS)/0.1% glucose or Dulbecco's modified Eagle's medium (DMEM) with or without 0.1% bovine serum albumin (BSA). Expression of Slc22a8 was determined by fluorescent in situ hybridization in brain sections from wild-type and Mct8/Oatp1c1 knockout mice at postnatal days 12, 21, and 120. Results: In total, 59 plasma membrane transporters were selected for screening of TRIAC accumulation (n = 40 based on expression at the human BBB and/or brain–cerebrospinal fluid barrier and having small organic molecules as substrates; n = 19 known thyroid hormone transporters). Screening of the selected transporter panel showed that 18 transporters facilitated significant intracellular accumulation of TRIAC in DPBS/0.1% glucose or DMEM in the absence of BSA. In the presence of BSA, substantial transport was noted for SLCO1B1 and SLC22A8 (in DPBS/0.1% glucose and DMEM) and SLC10A1, SLC22A6, and SLC22A24 (in DMEM). The zebrafish and mouse orthologs of these transporters similarly facilitated intracellular accumulation of TRIAC. Highest Slc22a8 mRNA expression was detected in mouse brain capillary endothelial cells and choroid plexus epithelial cells at early postnatal time points, but was reduced at P120. Conclusions: Human SLC10A1, SLCO1B1, SLC22A6, SLC22A8, and SLC22A24 as well as their mouse and zebrafish orthologs are efficient TRIAC transporters. These findings contribute to the understanding of TRIAC treatment in patients with MCT8 deficiency and animal models thereof. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Towards Personalized TSH Reference Ranges: A Genetic and Population-Based Approach in Three Independent Cohorts.
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Kuś, Aleksander, Sterenborg, Rosalie B.T.M., Haug, Eirin B., Galesloot, Tessel E., Visser, W. Edward, Smit, Johannes W.A., Bednarczuk, Tomasz, Peeters, Robin P., Åsvold, Bjørn O., Teumer, Alexander, and Medici, Marco
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GENETIC profile ,SINGLE nucleotide polymorphisms ,GENETIC variation ,THYROTROPIN ,HYPERTHYROIDISM ,THYROID diseases - Abstract
Background: Serum thyroid-stimulating hormone (TSH) measurement is the diagnostic cornerstone for primary thyroid dysfunction. There is high inter-individual but limited intra-individual variation in TSH concentrations, largely due to genetic factors. The currently used wide population-based reference intervals may lead to inappropriate management decisions. Methods: A polygenic score (PGS) including 59 genetic variants was used to calculate genetically determined TSH reference ranges in a thyroid disease-free cohort (n = 6,834). Its effect on reclassification of diagnoses was investigated when compared to using population-based reference ranges. Next, results were validated in a second independent population-based thyroid disease-free cohort (n = 3,800). Potential clinical implications were assessed in a third independent population-based cohort including individuals without thyroid disease (n = 26,321) as well as individuals on levothyroxine (LT4) treatment (n = 1,132). Results: PGS was a much stronger predictor of individual TSH concentrations than FT4 (total variance in TSH concentrations explained 9.2–11.1% vs. 2.4–2.7%, respectively) or any other nongenetic factor (total variance in TSH concentrations explained 0.2–1.8%). Genetically determined TSH reference ranges differed significantly between PGS quartiles in all cohorts, while the differences in FT4 concentrations were absent or only minor. Up to 24.7–30.1% of individuals, previously classified as having subclinical hypo- and hyperthyroidism when using population-based TSH reference ranges, were reclassified as euthyroid when genetically determined TSH reference ranges were applied. Individuals in the higher PGS quartiles had a higher probability of being prescribed LT4 treatment compared to individuals from the lower PGS quartiles (3.3% in Q1 vs. 5.2% in Q4, P
for trend =1.7 × 10−8 ). Conclusions: Individual genetic profiles have the potential to personalize TSH reference ranges, with large effects on reclassification of diagnosis and LT4 prescriptions. As the currently used PGS can only predict approximately 10% of inter-individual variation in TSH concentrations, it should be further improved when more genetic variants determining TSH concentrations are identified in future studies. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Identification of iodotyrosines as novel substrates for the thyroid hormone transporter MCT8
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Groeneweg, Stefan, primary, Zevenbergen, Chantal, additional, Lima de Souza, Elaine C., additional, van Geest, Ferdy S., additional, Kloeckener-Gruissem, Barbara, additional, Laczko, Endre, additional, Camargo, Simone M.R., additional, Meima, Marcel E, additional, Peeters, Robin P, additional, and Visser, W. Edward, additional
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- 2024
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14. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
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Osinga, Joris A.J., primary, Liu, Yindi, additional, Männistö, Tuija, additional, Vafeiadi, Marina, additional, Tao, Fang-Biao, additional, Vaidya, Bijay, additional, Vrijkotte, Tanja G.M., additional, Mosso, Lorena, additional, Bassols, Judit, additional, López-Bermejo, Abel, additional, Boucai, Laura, additional, Aminorroaya, Ashraf, additional, Feldt-Rasmussen, Ulla, additional, Hisada, Aya, additional, Yoshinaga, Jun, additional, Broeren, Maarten A.C., additional, Itoh, Sachiko, additional, Kishi, Reiko, additional, Ashoor, Ghalia, additional, Chen, Liangmiao, additional, Veltri, Flora, additional, Lu, Xuemian, additional, Taylor, Peter N., additional, Brown, Suzanne J., additional, Chatzi, Leda, additional, Popova, Polina V., additional, Grineva, Elena N., additional, Ghafoor, Farkhanda, additional, Pirzada, Amna, additional, Kianpour, Maryam, additional, Oken, Emily, additional, Suvanto, Eila, additional, Hattersley, Andrew, additional, Rebagliato, Marisa, additional, Riaño-Galán, Isolina, additional, Irizar, Amaia, additional, Vrijheid, Martine, additional, Delgado-Saborit, Juana Maria, additional, Fernández-Somoano, Ana, additional, Santa-Marina, Loreto, additional, Boelaert, Kristien, additional, Brenta, Gabriela, additional, Dhillon-Smith, Rima, additional, Dosiou, Chrysoula, additional, Eaton, Jennifer L., additional, Guan, Haixia, additional, Lee, Sun Y., additional, Maraka, Spyridoula, additional, Morris-Wiseman, Lilah F., additional, Nguyen, Caroline T., additional, Shan, Zhongyan, additional, Guxens, Mònica, additional, Pop, Victor J.M., additional, Walsh, John P., additional, Nicolaides, Kypros H., additional, D'Alton, Mary E., additional, Visser, W. Edward, additional, Carty, David M., additional, Delles, Christian, additional, Nelson, Scott M., additional, Alexander, Erik K., additional, Chaker, Layal, additional, Palomaki, Glenn E., additional, Peeters, Robin P., additional, Bliddal, Sofie, additional, Huang, Kun, additional, Poppe, Kris G., additional, Pearce, Elizabeth N., additional, Derakhshan, Arash, additional, and Korevaar, Tim I.M., additional
- Published
- 2024
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15. Patients’ persistent symptoms, clinician demographics and geo-economic factors are associated with choice of therapy for hypothyroidism by European thyroid specialists: The “THESIS”* collaboration (*Treatment of Hypothyroidism in Europe by Specialists, an International Survey)
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Attanasio, Roberto, primary, Žarković, Miloš, additional, Papini, Enrico, additional, Nagy, Endre V., additional, Negro, Roberto, additional, Perros, Petros, additional, Akarsu, Ersin, additional, Alevizaki, Maria, additional, Ayvaz, Göksun, additional, Bednarczuk, Tomasz, additional, Beleslin, Biljana, additional, Berta, Eszter, additional, Bodor, Miklos, additional, Borissova, Anna Maria, additional, Boyanov, Mihail, additional, Buffet, Camille, additional, Burlacu, Maria-Cristina, additional, Ciric, Jasmina, additional, Díez, Juan J, additional, Dobnig, Harald, additional, Fadeyev, Valentin V, additional, Field, Benjamin CT, additional, Fliers, Eric, additional, Führer, Dagmar, additional, Galofré, Juan Carlos, additional, Hakala, Tommi, additional, Jiskra, Jan, additional, Kopp, Peter A., additional, Krebs, Michael, additional, Kršek, Michal, additional, Kuzma, Martin, additional, Lantz, Mikael, additional, Lazúrová, Ivica, additional, Leenhardt, Laurence, additional, Luchytskiy, Vitaliy, additional, Marques Puga, Francisca, additional, McGowan, Anne, additional, Metso, Saara, additional, Moran, Carla, additional, Morgunova, Tatyana, additional, Niculescu, Dan Alexandru, additional, Perić, Božidar, additional, Planck, Tereza, additional, Poiana, Catalina, additional, Robenshtok, Eyal, additional, Rosselet, Patrick Olivier, additional, Ruchala, Marek, additional, Ryom Riis, Kamilla, additional, Shepelkevich, Alla, additional, Tronko, Mykola D., additional, Unuane, David, additional, Vardarli, Irfan, additional, Visser, W. Edward, additional, Vryonidou, Andromachi, additional, Younes, Younes Ramazan, additional, and Hegedus, Laszlo, additional
- Published
- 2024
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16. Clinical and Histopathological Risk Factors for Radioactive Iodine Refractory Follicular and Oncocytic Thyroid Carcinoma
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Stegenga, Merel T, primary, van Velsen, Evert F S, additional, Oudijk, Lindsey, additional, Verburg, Frederik A, additional, van Ginhoven, Tessa M, additional, Peeters, Robin P, additional, Medici, Marco, additional, Visser, W Edward, additional, and van Kemenade, Folkert J, additional
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- 2024
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17. Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development
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Krieger, Teresa G., Moran, Carla M., Frangini, Alberto, Visser, W. Edward, Schoenmakers, Erik, Muntoni, Francesco, Clark, Chris A., Gadian, David, Chong, Wui K., Kuczynski, Adam, Dattani, Mehul, Lyons, Greta, Efthymiadou, Alexandra, Varga-Khadem, Faraneh, Simons, Benjamin D., Chatterjee, Krishna, and Livesey, Frederick J.
- Published
- 2019
18. Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
- Author
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Sterenborg, Rosalie B.T.M., Steinbrenner, Inga, Li, Yong, Bujnis, Melissa N., Naito, Tatsuhiko, Marouli, Eirini, Galesloot, Tessel E., Babajide, Oladapo, Andreasen, Laura, Astrup, Arne, Åsvold, Bjørn Olav, Bandinelli, Stefania, Beekman, Marian, Beilby, John P., Bork-Jensen, Jette, Boutin, Thibaud, Brody, Jennifer A., Brown, Suzanne J., Brumpton, Ben, Campbell, Purdey J., Cappola, Anne R., Ceresini, Graziano, Chaker, Layal, Chasman, Daniel I., Concas, Maria Pina, Coutinho de Almeida, Rodrigo, Cross, Simone M., Cucca, Francesco, Deary, Ian J., Kjaergaard, Alisa Devedzic, Echouffo Tcheugui, Justin B., Ellervik, Christina, Eriksson, Johan G., Ferrucci, Luigi, Freudenberg, Jan, Fuchsberger, Christian, Gieger, Christian, Giulianini, Franco, Gögele, Martin, Graham, Sarah E., Grarup, Niels, Gunjača, Ivana, Hansen, Torben, Harding, Barbara N., Harris, Sarah E., Haunsø, Stig, Hayward, Caroline, Hui, Jennie, Ittermann, Till, Jukema, J. Wouter, Kajantie, Eero, Kanters, Jørgen K., Kårhus, Line L., Kiemeney, Lambertus A.L.M., Kloppenburg, Margreet, Kühnel, Brigitte, Lahti, Jari, Langenberg, Claudia, Lapauw, Bruno, Leese, Graham, Li, Shuo, Liewald, David C.M., Linneberg, Allan, Lominchar, Jesus V.T., Luan, Jian’an, Martin, Nicholas G., Matana, Antonela, Meima, Marcel E., Meitinger, Thomas, Meulenbelt, Ingrid, Mitchell, Braxton D., Møllehave, Line T., Mora, Samia, Naitza, Silvia, Nauck, Matthias, Netea-Maier, Romana T., Noordam, Raymond, Nursyifa, Casia, Okada, Yukinori, Onano, Stefano, Papadopoulou, Areti, Palmer, Colin N.A., Pattaro, Cristian, Pedersen, Oluf, Peters, Annette, Pietzner, Maik, Polašek, Ozren, Pramstaller, Peter P., Psaty, Bruce M., Punda, Ante, Ray, Debashree, Redmond, Paul, Richards, J. Brent, Ridker, Paul M., Russ, Tom C., Ryan, Kathleen A., Olesen, Morten Salling, Schultheiss, Ulla T., Selvin, Elizabeth, Siddiqui, Moneeza K., Sidore, Carlo, Slagboom, P. Eline, Sørensen, Thorkild I.A., Soto-Pedre, Enrique, Spector, Tim D., Spedicati, Beatrice, Srinivasan, Sundararajan, Starr, John M., Stott, David J., Tanaka, Toshiko, Torlak, Vesela, Trompet, Stella, Tuhkanen, Johanna, Uitterlinden, André G., van den Akker, Erik B., van den Eynde, Tibbert, van der Klauw, Melanie M., van Heemst, Diana, Verroken, Charlotte, Visser, W. Edward, Vojinovic, Dina, Völzke, Henry, Waldenberger, Melanie, Walsh, John P., Wareham, Nicholas J., Weiss, Stefan, Willer, Cristen J., Wilson, Scott G., Wolffenbuttel, Bruce H.R., Wouters, Hanneke J.C.M., Wright, Margaret J., Yang, Qiong, Zemunik, Tatijana, Zhou, Wei, Zhu, Gu, Zöllner, Sebastian, Smit, Johannes W.A., Peeters, Robin P., Köttgen, Anna, Teumer, Alexander, Medici, Marco, Sterenborg, Rosalie B.T.M., Steinbrenner, Inga, Li, Yong, Bujnis, Melissa N., Naito, Tatsuhiko, Marouli, Eirini, Galesloot, Tessel E., Babajide, Oladapo, Andreasen, Laura, Astrup, Arne, Åsvold, Bjørn Olav, Bandinelli, Stefania, Beekman, Marian, Beilby, John P., Bork-Jensen, Jette, Boutin, Thibaud, Brody, Jennifer A., Brown, Suzanne J., Brumpton, Ben, Campbell, Purdey J., Cappola, Anne R., Ceresini, Graziano, Chaker, Layal, Chasman, Daniel I., Concas, Maria Pina, Coutinho de Almeida, Rodrigo, Cross, Simone M., Cucca, Francesco, Deary, Ian J., Kjaergaard, Alisa Devedzic, Echouffo Tcheugui, Justin B., Ellervik, Christina, Eriksson, Johan G., Ferrucci, Luigi, Freudenberg, Jan, Fuchsberger, Christian, Gieger, Christian, Giulianini, Franco, Gögele, Martin, Graham, Sarah E., Grarup, Niels, Gunjača, Ivana, Hansen, Torben, Harding, Barbara N., Harris, Sarah E., Haunsø, Stig, Hayward, Caroline, Hui, Jennie, Ittermann, Till, Jukema, J. Wouter, Kajantie, Eero, Kanters, Jørgen K., Kårhus, Line L., Kiemeney, Lambertus A.L.M., Kloppenburg, Margreet, Kühnel, Brigitte, Lahti, Jari, Langenberg, Claudia, Lapauw, Bruno, Leese, Graham, Li, Shuo, Liewald, David C.M., Linneberg, Allan, Lominchar, Jesus V.T., Luan, Jian’an, Martin, Nicholas G., Matana, Antonela, Meima, Marcel E., Meitinger, Thomas, Meulenbelt, Ingrid, Mitchell, Braxton D., Møllehave, Line T., Mora, Samia, Naitza, Silvia, Nauck, Matthias, Netea-Maier, Romana T., Noordam, Raymond, Nursyifa, Casia, Okada, Yukinori, Onano, Stefano, Papadopoulou, Areti, Palmer, Colin N.A., Pattaro, Cristian, Pedersen, Oluf, Peters, Annette, Pietzner, Maik, Polašek, Ozren, Pramstaller, Peter P., Psaty, Bruce M., Punda, Ante, Ray, Debashree, Redmond, Paul, Richards, J. Brent, Ridker, Paul M., Russ, Tom C., Ryan, Kathleen A., Olesen, Morten Salling, Schultheiss, Ulla T., Selvin, Elizabeth, Siddiqui, Moneeza K., Sidore, Carlo, Slagboom, P. Eline, Sørensen, Thorkild I.A., Soto-Pedre, Enrique, Spector, Tim D., Spedicati, Beatrice, Srinivasan, Sundararajan, Starr, John M., Stott, David J., Tanaka, Toshiko, Torlak, Vesela, Trompet, Stella, Tuhkanen, Johanna, Uitterlinden, André G., van den Akker, Erik B., van den Eynde, Tibbert, van der Klauw, Melanie M., van Heemst, Diana, Verroken, Charlotte, Visser, W. Edward, Vojinovic, Dina, Völzke, Henry, Waldenberger, Melanie, Walsh, John P., Wareham, Nicholas J., Weiss, Stefan, Willer, Cristen J., Wilson, Scott G., Wolffenbuttel, Bruce H.R., Wouters, Hanneke J.C.M., Wright, Margaret J., Yang, Qiong, Zemunik, Tatijana, Zhou, Wei, Zhu, Gu, Zöllner, Sebastian, Smit, Johannes W.A., Peeters, Robin P., Köttgen, Anna, Teumer, Alexander, and Medici, Marco
- Abstract
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.
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- 2024
19. Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia-Related Complications:A Meta-Analysis
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van Dijk, Sam P.J., van Driel, M. H. Elise, van Kinschot, Caroline M.J., Engel, Maarten F.M., Franssen, Gaston J.H., van Noord, Charlotte, Visser, W. Edward, Verhoef, Cornelis, Peeters, Robin P., van Ginhoven, Tessa M., van Dijk, Sam P.J., van Driel, M. H. Elise, van Kinschot, Caroline M.J., Engel, Maarten F.M., Franssen, Gaston J.H., van Noord, Charlotte, Visser, W. Edward, Verhoef, Cornelis, Peeters, Robin P., and van Ginhoven, Tessa M.
- Abstract
Objective: The aim of this Meta-analysis is to evaluate the impact of different treatment strategies for early postoperative hypoparathyroidism on hypocalcemia-related complications and long-term hypoparathyroidism. Data Sources: Embase.com, MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and the top 100 references of Google Scholar were searched to September 20, 2022. Review Methods: Articles reporting on adult patients who underwent total thyroidectomy which specified a treatment strategy for postthyroidectomy hypoparathyroidism were included. Random effect models were applied to obtain pooled proportions and 95% confidence intervals. Primary outcome was the occurrence of major hypocalcemia-related complications. Secondary outcome was long-term hypoparathyroidism. Results: Sixty-six studies comprising 67 treatment protocols and 51,096 patients were included in this Meta-analysis. In 8 protocols (3806 patients), routine calcium and/or active vitamin D medication was given to all patients directly after thyroidectomy. In 49 protocols (44,012 patients), calcium and/or active vitamin D medication was only given to patients with biochemically proven postthyroidectomy hypoparathyroidism. In 10 protocols (3278 patients), calcium and/or active vitamin D supplementation was only initiated in case of clinical symptoms of hypocalcemia. No patient had a major complication due to postoperative hypocalcemia. The pooled proportion of long-term hypoparathyroidism was 2.4% (95% confidence interval, 1.9-3.0). There was no significant difference in the incidence of long-term hypoparathyroidism between the 3 supplementation groups. Conclusions: All treatment strategies for postoperative hypocalcemia prevent major complications of hypocalcemia. The early postoperative treatment protocol for postthyroidectomy hypoparathyroidism does not seem to influence recovery of parathyroid function in the long term.
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- 2024
20. Regional Collaboration and Trends in Clinical Management of Thyroid Cancer
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van Dijk, Sam P.J., Coerts, Hannelore I., Lončar, Ivona, van Kinschot, Caroline M.J., von Meyenfeldt, Erik M., Edward Visser, W., van Noord, Charlotte, Zengerink, Hans F., ten Broek, Marc R.J., Verhoef, Cornelis, Peeters, Robin P., van Ginhoven, Tessa M., van Dijk, Sam P.J., Coerts, Hannelore I., Lončar, Ivona, van Kinschot, Caroline M.J., von Meyenfeldt, Erik M., Edward Visser, W., van Noord, Charlotte, Zengerink, Hans F., ten Broek, Marc R.J., Verhoef, Cornelis, Peeters, Robin P., and van Ginhoven, Tessa M.
- Abstract
Objective: This study examines the trends in the management of thyroid cancer and clinical outcomes in the Southwestern region of The Netherlands from 2010 to 2021, where a regional collaborative network has been implemented in January 2016. Study Design: Retrospective cohort study. Setting: This study encompasses all patients diagnosed with thyroid cancer of any subtype between January 2010 and June 2021 in 10 collaborating hospitals in the Southwestern region of The Netherlands. Methods: The primary outcome of this study was the occurrence of postoperative complications. Secondary outcomes were trends in surgical management, centralization, and waiting times of patients with thyroid cancer. Results: This study included 1186 patients with thyroid cancer. Median follow-up was 58 [interquartile range: 24-95] months. Surgery was performed in 1027 (86.6%) patients. No differences in postoperative complications, such as long-term hypoparathyroidism, permanent recurrent nerve paresis, or reoperation due to bleeding were seen over time. The percentage of patients with low-risk papillary thyroid carcinoma referred to the academic hospital decreased from 85% (n = 120/142) in 2010 to 2013 to 70% (n = 120/171) in 2014 to 2017 and 62% (n = 100/162) in 2018 to 2021 (P <.01). The percentage of patients undergoing a hemithyroidectomy alone was 9% (n = 28/323) in 2010 to 2013 and increased to 20% (n = 63/317; P <.01) in 2018 to 2021. Conclusion: The establishment of a regional oncological network coincided with a de-escalation of thyroid cancer treatment and centralization of complex patients and interventions. However, no differences in postoperative complications over time were observed. Determining the impact of regional oncological networks on quality of care is challenging in the absence of uniform quality indicators.
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- 2024
21. Risk Factors for Thyroid Dysfunction in Pregnancy:An Individual Participant Data Meta-Analysis
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Osinga, Joris A. J., Liu, Yindi, Männistö, Tuija, Vafeiadi, Marina, Tao, Fang-Biao, Vaidya, Bijay, Vrijkotte, Tanja G. M., Mosso, Lorena, Bassols, Judit, López-Bermejo, Abel, Boucai, Laura, Aminorroaya, Ashraf, Feldt-Rasmussen, Ulla, Hisada, Aya, Yoshinaga, Jun, Broeren, Maarten A. C., Itoh, Sachiko, Kishi, Reiko, Ashoor, Ghalia, Chen, Liangmiao, Veltri, Flora, Lu, Xuemian, Taylor, Peter N., Brown, Suzanne J., Chatzi, Leda, Popova, Polina V., Grineva, Elena N., Ghafoor, Farkhanda, Pirzada, Amna, Kianpour, Maryam, Oken, Emily, Suvanto, Eila, Hattersley, Andrew, Rebagliato, Marisa, Riaño-Galán, Isolina, Irizar, Amaia, Vrijheid, Martine, Delgado-Saborit, Juana Maria, Fernández-Somoano, Ana, Santa-Marina, Loreto, Boelaert, Kristien, Brenta, Gabriela, Dhillon-Smith, Rima, Dosiou, Chrysoula, Eaton, Jennifer L., Guan, Haixia, Lee, Sun Y., Maraka, Spyridoula, Morris-Wiseman, Lilah F., Nguyen, Caroline T., Shan, Zhongyan, Guxens, Mònica, Pop, Victor J. M., Walsh, John P., Nicolaides, Kypros H., D'Alton, Mary E., Visser, W. Edward, Carty, David M., Delles, Christian, Nelson, Scott M., Alexander, Erik K., Chaker, Layal, Palomaki, Glenn E., Peeters, Robin P., Bliddal, Sofie, Huang, Kun, Poppe, Kris G., Pearce, Elizabeth N., Derakhshan, Arash, Korevaar, Tim I. M., Osinga, Joris A. J., Liu, Yindi, Männistö, Tuija, Vafeiadi, Marina, Tao, Fang-Biao, Vaidya, Bijay, Vrijkotte, Tanja G. M., Mosso, Lorena, Bassols, Judit, López-Bermejo, Abel, Boucai, Laura, Aminorroaya, Ashraf, Feldt-Rasmussen, Ulla, Hisada, Aya, Yoshinaga, Jun, Broeren, Maarten A. C., Itoh, Sachiko, Kishi, Reiko, Ashoor, Ghalia, Chen, Liangmiao, Veltri, Flora, Lu, Xuemian, Taylor, Peter N., Brown, Suzanne J., Chatzi, Leda, Popova, Polina V., Grineva, Elena N., Ghafoor, Farkhanda, Pirzada, Amna, Kianpour, Maryam, Oken, Emily, Suvanto, Eila, Hattersley, Andrew, Rebagliato, Marisa, Riaño-Galán, Isolina, Irizar, Amaia, Vrijheid, Martine, Delgado-Saborit, Juana Maria, Fernández-Somoano, Ana, Santa-Marina, Loreto, Boelaert, Kristien, Brenta, Gabriela, Dhillon-Smith, Rima, Dosiou, Chrysoula, Eaton, Jennifer L., Guan, Haixia, Lee, Sun Y., Maraka, Spyridoula, Morris-Wiseman, Lilah F., Nguyen, Caroline T., Shan, Zhongyan, Guxens, Mònica, Pop, Victor J. M., Walsh, John P., Nicolaides, Kypros H., D'Alton, Mary E., Visser, W. Edward, Carty, David M., Delles, Christian, Nelson, Scott M., Alexander, Erik K., Chaker, Layal, Palomaki, Glenn E., Peeters, Robin P., Bliddal, Sofie, Huang, Kun, Poppe, Kris G., Pearce, Elizabeth N., Derakhshan, Arash, and Korevaar, Tim I. M.
- Abstract
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity). Exclusion criteria were pre-existing thyroid disease and use of thyroid interfering medication. We analyzed individual participant data using mixed-effects regression models. Primary outcomes were overt and subclinical hypothyroidism and a treatment indication (defined as overt hypothyroidism, subclinical hypothyroidism with thyrotropin >10 mU/L, or subclinical hypothyroidism with TPOAb positivity). Results: The study population comprised 65,559 participants in 25 cohorts. The screening rate in cohorts using risk factors currently recommended (age >30 years, parity ≥2, BMI ≥40) was 58%, with a detection rate for overt and subclinical hypothyroidism of 59%. The absolute risk for overt or subclinical hypothyroidism varied <2% over the full range of age and BMI and for any parity. Receiver operating characteristic curves, fitted using maternal age, BMI, smoking status, parity, and gestational age at blood sampling as explanatory variables, yielded areas under the curve ranging from 0.58 to 0.63 for the primary outcomes. TPOAbs/TgAbs positivity was associated with overt hypothyroidism (approximate risk for antibody negativity 0.1%, isolated TgAb positivity 2.4%, isolated TPOAb positivity 3.8%, combined antibody positivity 7.0%; p < 0.001), subclinical hypothyroidism (r, Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity). Exclusion criteria were pre-existing thyroid disease and use of thyroid interfering medication. We analyzed individual participant data using mixed-effects regression models. Primary outcomes were overt and subclinical hypothyroidism and a treatment indication (defined as overt hypothyroidism, subclinical hypothyroidism with thyrotropin >10 mU/L, or subclinical hypothyroidism with TPOAb positivity). Results: The study population comprised 65,559 participants in 25 cohorts. The screening rate in cohorts using risk factors currently recommended (age >30 years, parity ≥2, BMI ≥40) was 58%, with a detection rate for overt and subclinical hypothyroidism of 59%. The absolute risk for overt or subclinical hypothyroidism varied <2% over the full range of age and BMI and for any parity. Receiver operating characteristic curves, fitted using maternal age, BMI, smoking status, parity, and gestational age at blood sampling as explanatory variables, yielded areas under the curve ranging from 0.58 to 0.63 for the primary outcomes. TPOAbs/TgAbs positivity was associated with overt hypothyroidism (approximate risk for antibody negativity 0.1%, isolated TgAb positivity 2.4%, isolated TPOAb positivity 3.8%, combined antibody positivity 7.0%; p < 0.001), subclinical hypothyroidism (risk f
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- 2024
22. Clinical and Histopathological Risk Factors for Radioactive Iodine Refractory Follicular and Oncocytic Thyroid Carcinoma
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Stegenga, Merel T, van Velsen, Evert F S, Oudijk, Lindsey, Verburg, Frederik A, van Ginhoven, Tessa M, Peeters, Robin P, Medici, Marco, Visser, W Edward, van Kemenade, Folkert J, Stegenga, Merel T, van Velsen, Evert F S, Oudijk, Lindsey, Verburg, Frederik A, van Ginhoven, Tessa M, Peeters, Robin P, Medici, Marco, Visser, W Edward, and van Kemenade, Folkert J
- Abstract
CONTEXTS:Risk factors for radioactive iodine (RAI)-refractory disease in follicular (FTC) and oncocytic thyroid carcinoma (OTC) are unknown. Therefore, the aim of this study is to identify clinical and histopathological risk factors for RAI-refractory disease in FTC and OTC patients, facilitated by an extensive histopathological revision.METHODS: All adult FTC and OTC patients treated at Erasmus MC (the Netherlands) between 2000 and 2016 were retrospectively included. 2015 ATA Guidelines were used to define RAI-refractory disease. An extensive histopathological revision was performed applying the 2022 WHO Classification using Palga: Dutch Pathology Databank. Logistic regression was used to identify risk factors for RAI-refractory disease, stratified for histological subtype.RESULTS: Ninety FTC and 52 OTC patients were included, of which 14 FTC (15.6%) and 22 OTC (42.3%) developed RAI-refractory disease over a follow-up time of 8.5 years. RAI-refractory disease occurred in OTC after fewer cycles than in FTC (2.0 [IQR: 1.0-2.0] vs 2.5 [IQR: 2.0-3.75]), and it substantially decreased the 10-year disease specific survival, especially in OTC (46.4%; FTC 85.7%). In FTC, risk factors were higher age at diagnosis, pT3/pT4-stage, N1-stage, widely invasive tumors and extra-thyroidal extension. N1-stage and M1-stage were the strongest risk factors in OTC, rather than histopathological characteristics of the primary tumor.CONCLUSION: To our knowledge, this is the first study that correlates clinical and histopathological risk factors with RAI-refractory disease in FTC and OTC, facilitated by a histopathological revision. In FTC, risk factors for RAI-refractory disease were foremost histopathological characteristics of the primary tumor, whereas in OTC presentation with lymph node and distant metastasis was associated with RAI-refractory disease. Our data can help clinical decision making, particular
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- 2024
23. Diagnosis and Therapy in MCT8 Deficiency:Ongoing Challenges
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Freund, Matthijs E.T., van der Most, Floor, Visser, W. Edward, Freund, Matthijs E.T., van der Most, Floor, and Visser, W. Edward
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- 2024
24. Monocarboxylate transporter 8 deficiency: update on clinical characteristics and treatment
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van Geest, Ferdy S., Groeneweg, Stefan, and Visser, W. Edward
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- 2021
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25. Predictors of treatment response in lymphogenic metastasized papillary thyroid cancer: a histopathological study.
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Kinschot, Caroline M J van, Oudijk, Lindsey, Noord, Charlotte van, Korevaar, Tim I M, Nederveen, Francien H van, Peeters, Robin P, Kemenade, Folkert J van, and Visser, W Edward
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THYROID cancer ,LYMPHATIC metastasis ,HISTOPATHOLOGY ,LYMPH nodes - Abstract
Background Lymph node metastases in papillary thyroid cancer (PTC) increase the risk for persistent and recurrent disease. Data on the predictive value of histopathological features of lymph node metastases, however, are inconsistent. The aim of this study was to evaluate the prognostic significance of known and new histopathological features of lymph node metastases in a well-defined cohort of PTC patients with clinically evident lymph node metastases. Methods A total of 1042 lymph node metastases, derived from 129 PTC patients, were reexamined according to a predefined protocol and evaluated for diameter, extranodal extension, cystic changes, necrosis, calcifications, and the proportion of the lymph node taken up by tumor cells. Predictors for a failure to achieve a complete biochemical and structural response to treatment were determined. Results The presence of more than 5 lymph node metastases was the only independent predictor for a failure to achieve a complete response to treatment (odds ratio [OR] 3.39 [95% CI, 1.57-7.33], P <.05). Diameter nor any of the other evaluated lymph node features were significantly associated with the response to treatment. Conclusions Detailed reexamination of lymph nodes revealed that only the presence of more than 5 lymph node metastases was an independent predictor of failure to achieve a complete response to treatment. No predictive value was found for other histopathological features, including the diameter of the lymph node metastases. These findings have the potential to improve risk stratification in patients with PTC and clinically evident lymph node metastases. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Meetinstrumenten voor de diëtetiek : April 2019
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Heerkens, Y. F., Visser, W. K., Tiebie, J., Runia, S., Former, Majorie, editor, van Asseldonk, Gerdie, editor, Drenth, Jacqueline, editor, and Schuurman, Caroelien, editor
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- 2019
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27. Methodisch handelen : April 2019
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Runia, S., Visser, W. K., Tiebie, J., Heerkens, Y. F., Former, Majorie, editor, van Asseldonk, Gerdie, editor, Drenth, Jacqueline, editor, and Schuurman, Caroelien, editor
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- 2019
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28. Eenduidig taalgebruik bij het diagnostisch en therapeutisch handelen van de diëtist : April 2019
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Visser, W. K., Runia, S., Tiebie, J., Heerkens, Y. F., Former, Majorie, editor, van Asseldonk, Gerdie, editor, Drenth, Jacqueline, editor, and Schuurman, Caroelien, editor
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- 2019
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29. Methodisch handelen en kritisch redeneren
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Runia, S., Visser, W. K., Tiebie, J. E. C., Heerkens, Y. F., Former-Boon, M., editor, and van Duinen, J.J., editor
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- 2019
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30. Disorders of Thyroid Hormone Transporters and Receptors
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Visser, W. Edward, Luster, Markus, editor, Duntas, Leonidas H., editor, and Wartofsky, Leonard, editor
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- 2019
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31. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study
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Groeneweg, Stefan, van Geest, Ferdy S, Abacı, Ayhan, Alcantud, Alberto, Ambegaonkar, Gautam P, Armour, Christine M, Bakhtiani, Priyanka, Barca, Diana, Bertini, Enrico S, van Beynum, Ingrid M, Brunetti-Pierri, Nicola, Bugiani, Marianna, Cappa, Marco, Cappuccio, Gerarda, Castellotti, Barbara, Castiglioni, Claudia, Chatterjee, Krishna, de Coo, Irenaeus F M, Coutant, Régis, Craiu, Dana, Crock, Patricia, DeGoede, Christian, Demir, Korcan, Dica, Alice, Dimitri, Paul, Dolcetta-Capuzzo, Anna, Dremmen, Marjolein H G, Dubey, Rachana, Enderli, Anina, Fairchild, Jan, Gallichan, Jonathan, George, Belinda, Gevers, Evelien F, Hackenberg, Annette, Halász, Zita, Heinrich, Bianka, Huynh, Tony, Kłosowska, Anna, van der Knaap, Marjo S, van der Knoop, Marieke M, Konrad, Daniel, Koolen, David A, Krude, Heiko, Lawson-Yuen, Amy, Lebl, Jan, Linder-Lucht, Michaela, Lorea, Cláudia F, Lourenço, Charles M, Lunsing, Roelineke J, Lyons, Greta, Malikova, Jana, Mancilla, Edna E, McGowan, Anne, Mericq, Veronica, Lora, Felipe M, Moran, Carla, Müller, Katalin E, Oliver-Petit, Isabelle, Paone, Laura, Paul, Praveen G, Polak, Michel, Porta, Francesco, Poswar, Fabiano O, Reinauer, Christina, Rozenkova, Klara, Menevse, Tuba S, Simm, Peter, Simon, Anna, Singh, Yogen, Spada, Marco, van der Spek, Jet, Stals, Milou A M, Stoupa, Athanasia, Subramanian, Gopinath M, Tonduti, Davide, Turan, Serap, den Uil, Corstiaan A, Vanderniet, Joel, van der Walt, Adri, Wémeau, Jean-Louis, Wierzba, Jolante, de Wit, Marie-Claire Y, Wolf, Nicole I, Wurm, Michael, Zibordi, Federica, Zung, Amnon, Zwaveling-Soonawala, Nitash, and Visser, W Edward
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- 2020
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32. Interpretation of thyroid function tests during pregnancy
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Visser, W. Edward and Peeters, Robin P.
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- 2020
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33. Biosynthesis, Transport, Metabolism, and Actions of Thyroid Hormones
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Visser, W. Edward, additional
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- 2021
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34. Can the contra indication for cardiac implantable electronic devices in bioelectronic impedance analysis be removed?
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Zweers, H., primary, Noom, E., additional, Visser, W., additional, Jans, I., additional, Willems, L., additional, Verhoeven, M., additional, and Theuns, D., additional
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- 2023
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35. Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis
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van Dijk, Sam P. J., primary, van Driel, M. H. Elise, additional, van Kinschot, Caroline M. J., additional, Engel, Maarten F. M., additional, Franssen, Gaston J. H., additional, van Noord, Charlotte, additional, Visser, W. Edward, additional, Verhoef, Cornelis, additional, Peeters, Robin P., additional, and van Ginhoven, Tessa M., additional
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- 2023
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36. Characteristics of specialists treating hypothyroid patients: the “THESIS” collaborative
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Žarković, Miloš, primary, Attanasio, Roberto, additional, Nagy, Endre V., additional, Negro, Roberto, additional, Papini, Enrico, additional, Perros, Petros, additional, Cohen, Chagit Adler, additional, Akarsu, Ersin, additional, Alevizaki, Maria, additional, Ayvaz, Göksun, additional, Bednarczuk, Tomasz, additional, Berta, Eszter, additional, Bodor, Miklos, additional, Borissova, Anna Maria, additional, Boyanov, Mihail, additional, Buffet, Camille, additional, Burlacu, Maria-Cristina, additional, Ćirić, Jasmina, additional, Díez, Juan J., additional, Dobnig, Harald, additional, Fadeyev, Valentin, additional, Field, Benjamin C. T., additional, Fliers, Eric, additional, Frølich, Jacob Stampe, additional, Führer, Dagmar, additional, Galofré, Juan Carlos, additional, Hakala, Tommi, additional, Jiskra, Jan, additional, Kopp, Peter, additional, Krebs, Michael, additional, Kršek, Michal, additional, Kužma, Martin, additional, Lantz, Mikael, additional, Lazúrová, Ivica, additional, Leenhardt, Laurence, additional, Luchytskiy, Vitaliy, additional, McGowan, Anne, additional, Melo, Miguel, additional, Metso, Saara, additional, Moran, Carla, additional, Morgunova, Tatyana, additional, Mykola, Tronko, additional, Beleslin, Biljana Nedeljković, additional, Niculescu, Dan Alexandru, additional, Perić, Božidar, additional, Planck, Tereza, additional, Poiana, Catalina, additional, Puga, Francisca Marques, additional, Robenshtok, Eyal, additional, Rosselet, Patrick, additional, Ruchala, Marek, additional, Riis, Kamilla Ryom, additional, Shepelkevich, Alla, additional, Unuane, David, additional, Vardarli, Irfan, additional, Visser, W. Edward, additional, Vrionidou, Andromachi, additional, Younes, Younes R., additional, Yurenya, Elena, additional, and Hegedüs, Laszlo, additional
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- 2023
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37. Defining Gestational Thyroid Dysfunction Through Modified Nonpregnancy Reference Intervals: An Individual Participant Meta-analysis
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Osinga, Joris A J, Nelson, Scott M, Walsh, John P, Ashoor, Ghalia, Palomaki, Glenn E, López-Bermejo, Abel, Bassols, Judit, Aminorroaya, Ashraf, Broeren, Maarten A C, Chen, Liangmiao, Lu, Xuemian, Brown, Suzanne J, Veltri, Flora, Huang, Kun, Männistö, Tuija, Vafeiadi, Marina, Taylor, Peter N, Tao, Fang-Biao, Chatzi, Lida, Kianpour, Maryam, Suvanto, Eila, Grineva, Elena N, Nicolaides, Kypros H, D'Alton, Mary E, Poppe, Kris G, Alexander, Erik, Feldt-Rasmussen, Ulla, Bliddal, Sofie, Popova, Polina V, Chaker, Layal, Visser, W Edward, Peeters, Robin P, Derakhshan, Arash, Vrijkotte, Tanja G M, Pop, Victor J M, and Korevaar, Tim I M
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- 2024
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38. A Blueprint for Performance-Driven Operations Management
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Visser, W. F.
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- 2020
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39. Oer it gearfallen fan ‘neame’ mei ‘nimme’
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Visser, W., Visser, W., Visser, W., and Visser, W.
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The Frisian system of strong verbs seems to be in a constant state of flux. This article highlights a particular instance of this, viz. the paradigm of the weak verb neame „call, name‟, which is converging more and more with that of the strong verb nimme „take‟. There are more cases in which Dutch has two verbs, a weak and a strong one, whereas Frisian only has one strong verb (with both meanings). This convergence is proposed to derive from phonological changes. It results in one and the same paradigm of the present tense for both verbs, paving the way for a complete conver-gence. Interestingly, the strong verbs are the „winner‟ here, in spite of the fact that weak verbs are assumed to be the unmarked, productive verb class  
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- 2023
40. Novel mutations in SLC16A2 associated with a less severe phenotype of MCT8 deficiency
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Masnada, Silvia, Groenweg, Stefan, Saletti, Veronica, Chiapparini, Luisa, Castellotti, Barbara, Salsano, Ettore, Visser, W. Edward, and Tonduti, Davide
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- 2019
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41. Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial
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Groeneweg, Stefan, Peeters, Robin P, Moran, Carla, Stoupa, Athanasia, Auriol, Françoise, Tonduti, Davide, Dica, Alice, Paone, Laura, Rozenkova, Klara, Malikova, Jana, van der Walt, Adri, de Coo, Irenaeus F M, McGowan, Anne, Lyons, Greta, Aarsen, Femke K, Barca, Diana, van Beynum, Ingrid M, van der Knoop, Marieke M, Jansen, Jurgen, Manshande, Martien, Lunsing, Roelineke J, Nowak, Stan, den Uil, Corstiaan A, Zillikens, M Carola, Visser, Frank E, Vrijmoeth, Paul, de Wit, Marie Claire Y, Wolf, Nicole I, Zandstra, Angelique, Ambegaonkar, Gautam, Singh, Yogen, de Rijke, Yolanda B, Medici, Marco, Bertini, Enrico S, Depoorter, Sylvia, Lebl, Jan, Cappa, Marco, De Meirleir, Linda, Krude, Heiko, Craiu, Dana, Zibordi, Federica, Oliver Petit, Isabelle, Polak, Michel, Chatterjee, Krishna, Visser, Theo J, and Visser, W Edward
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- 2019
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42. Dynamic flow stress of shock loaded low carbon steel
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Visser, W. and Ghonem, H.
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- 2019
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43. Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
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Medici, Marco, Porcu, Eleonora, Pistis, Giorgio, Teumer, Alexander, Brown, Suzanne J, Jensen, Richard A, Rawal, Rajesh, Roef, Greet L, Plantinga, Theo S, Vermeulen, Sita H, Lahti, Jari, Simmonds, Matthew J, Husemoen, Lise Lotte N, Freathy, Rachel M, Shields, Beverley M, Pietzner, Diana, Nagy, Rebecca, Broer, Linda, Chaker, Layal, Korevaar, Tim IM, Plia, Maria Grazia, Sala, Cinzia, Völker, Uwe, Richards, J Brent, Sweep, Fred C, Gieger, Christian, Corre, Tanguy, Kajantie, Eero, Thuesen, Betina, Taes, Youri E, Visser, W Edward, Hattersley, Andrew T, Kratzsch, Jürgen, Hamilton, Alexander, Li, Wei, Homuth, Georg, Lobina, Monia, Mariotti, Stefano, Soranzo, Nicole, Cocca, Massimiliano, Nauck, Matthias, Spielhagen, Christin, Ross, Alec, Arnold, Alice, van de Bunt, Martijn, Liyanarachchi, Sandya, Heier, Margit, Grabe, Hans Jörgen, Masciullo, Corrado, Galesloot, Tessel E, Lim, Ee M, Reischl, Eva, Leedman, Peter J, Lai, Sandra, Delitala, Alessandro, Bremner, Alexandra P, Philips, David IW, Beilby, John P, Mulas, Antonella, Vocale, Matteo, Abecasis, Goncalo, Forsen, Tom, James, Alan, Widen, Elisabeth, Hui, Jennie, Prokisch, Holger, Rietzschel, Ernst E, Palotie, Aarno, Feddema, Peter, Fletcher, Stephen J, Schramm, Katharina, Rotter, Jerome I, Kluttig, Alexander, Radke, Dörte, Traglia, Michela, Surdulescu, Gabriela L, He, Huiling, Franklyn, Jayne A, Tiller, Daniel, Vaidya, Bijay, de Meyer, Tim, Jørgensen, Torben, Eriksson, Johan G, O'Leary, Peter C, Wichmann, Eric, Hermus, Ad R, Psaty, Bruce M, Ittermann, Till, Hofman, Albert, Bosi, Emanuele, Schlessinger, David, Wallaschofski, Henri, Pirastu, Nicola, Aulchenko, Yurii S, de la Chapelle, Albert, Netea-Maier, Romana T, Gough, Stephen CL, Schwabedissen, Henriette Meyer zu, Frayling, Timothy M, and Kaufman, Jean-Marc
- Subjects
Biological Sciences ,Genetics ,Prevention ,Clinical Research ,Autoimmune Disease ,2.1 Biological and endogenous factors ,Aetiology ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Metabolic and endocrine ,Autoantibodies ,Genetic Loci ,Genome-Wide Association Study ,Graves Disease ,Hashimoto Disease ,Humans ,Iodide Peroxidase ,Risk Factors ,Thyroiditis ,Autoimmune ,Thyrotropin ,Developmental Biology - Abstract
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P
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- 2014
44. Management of Postthyroidectomy Hypoparathyroidism and Its Effect on Hypocalcemia‐Related Complications: A Meta‐Analysis.
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van Dijk, Sam P. J., van Driel, M. H. Elise, van Kinschot, Caroline M. J., Engel, Maarten F. M., Franssen, Gaston J. H., van Noord, Charlotte, Visser, W. Edward, Verhoef, Cornelis, Peeters, Robin P., and van Ginhoven, Tessa M.
- Abstract
Objective: The aim of this Meta‐analysis is to evaluate the impact of different treatment strategies for early postoperative hypoparathyroidism on hypocalcemia‐related complications and long‐term hypoparathyroidism. Data Sources: Embase.com, MEDLINE, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and the top 100 references of Google Scholar were searched to September 20, 2022. Review Methods: Articles reporting on adult patients who underwent total thyroidectomy which specified a treatment strategy for postthyroidectomy hypoparathyroidism were included. Random effect models were applied to obtain pooled proportions and 95% confidence intervals. Primary outcome was the occurrence of major hypocalcemia‐related complications. Secondary outcome was long‐term hypoparathyroidism. Results: Sixty‐six studies comprising 67 treatment protocols and 51,096 patients were included in this Meta‐analysis. In 8 protocols (3806 patients), routine calcium and/or active vitamin D medication was given to all patients directly after thyroidectomy. In 49 protocols (44,012 patients), calcium and/or active vitamin D medication was only given to patients with biochemically proven postthyroidectomy hypoparathyroidism. In 10 protocols (3278 patients), calcium and/or active vitamin D supplementation was only initiated in case of clinical symptoms of hypocalcemia. No patient had a major complication due to postoperative hypocalcemia. The pooled proportion of long‐term hypoparathyroidism was 2.4% (95% confidence interval, 1.9‐3.0). There was no significant difference in the incidence of long‐term hypoparathyroidism between the 3 supplementation groups. Conclusions: All treatment strategies for postoperative hypocalcemia prevent major complications of hypocalcemia. The early postoperative treatment protocol for postthyroidectomy hypoparathyroidism does not seem to influence recovery of parathyroid function in the long term. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Decreased hepatic thyroid hormone signaling in systemic and liver-specific, but not brain-specific accelerated aging due to DNA repair deficiency in mice
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Barnhoorn, Sander, primary, Meima, Marcel E., additional, Peeters, Robin P., additional, Darras, Veerle M., additional, Leeuwenburgh, Selmar, additional, Hoeijmakers, Jan H.j., additional, Vermeij, Wilbert P., additional, and Visser, W. Edward, additional
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- 2023
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46. A symptom-based algorithm for calcium management after thyroid surgery: a prospective multi-center study
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van Kinschot, Caroline M.j., primary, Loncar, Ivona, additional, van Ginhoven, Tessa M., additional, Visser, W. Edward, additional, Peeters, Robin P., additional, and van Noord, Charlotte, additional
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- 2023
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47. Increased cardiovascular morbidity and mortality in patients with resistance to thyroid hormone
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Refetoff, Samuel, primary, Persani, Luca, additional, and Visser, W Edward, additional
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- 2023
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48. Regional Collaboration and Trends in Clinical Management of Thyroid Cancer
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van Dijk, Sam P.J., primary, Coerts, Hannelore I., additional, Lončar, Ivona, additional, van Kinschot, Caroline M.J., additional, von Meyenfeldt, Erik M., additional, Edward Visser, W., additional, van Noord, Charlotte, additional, Zengerink, Hans F., additional, ten Broek, Marc R.J., additional, Verhoef, Cornelis, additional, Peeters, Robin P., additional, and van Ginhoven, Tessa M., additional
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- 2023
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49. Author Reply to Peer Reviews of Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency
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Chen, Zhongli, primary, Leeuwenburgh, Selmar, additional, Zijderveld, Wouter F., additional, Broekhuizen, Michelle, additional, Tan, Lunbo, additional, Neuman, Rugina I., additional, Jongejan, Rutchanna M.S., additional, de Rijke, Yolanda B., additional, Reiss, Irwin K.M., additional, Danser, A.H. Jan, additional, Peeters, Robin P., additional, Meima, Marcel E., additional, and Visser, W. Edward, additional
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- 2023
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50. Regional collaboration and trends in clinical management of thyroid cancer
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Coerts, Hannelore, van Dijk, Sam, Lončar, Ivona, van Kinschot, Caroline, von Meyenfeldt, Erik, Visser, W. Edward, van Noord, Charlotte, Zengerink, Hans, Broek, Marc ten, Verhoef, Cornelis, Peeters, Robin, and van Ginhoven, Tessa
- Published
- 2024
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