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1. $s$-wave scattering lengths for the $^7$Be+p system from an $\textit{R}$-matrix analysis

Author

Paneru, S. N., Brune, C. R., Giri, R., Livesay, R. J., Greife, U., Blackmon, J. C., Bardayan, D. W., Chipps, K. A., Davids, B., Connolly, D. S., Chae, K. Y., Champagne, A. E., Deibel, C., Jones, K. L., Johnson, M. S., Kozub, R. L., Ma, Z., Nesaraja, C. D., Pain, S. D., Sarazin, F., Shriner Jr., J. F., Stracener, D. W., Smith, M. S., Thomas, J. S., Visser, D. W., and Wrede, C.

Subjects
Nuclear Experiment, Astrophysics - Solar and Stellar Astrophysics, Nuclear Theory
Abstract

The astrophysical $S$-factor for the radiative proton capture reaction on $^7$Be ($S_{17}$) at low energies is affected by the $s$-wave scattering lengths. We report the measurement of elastic and inelastic scattering cross sections for the $^7$Be+p system in the center-of-mass energy range 0.474 - 2.740 MeV and center-of-mass angular range of 70$^\circ$- 150$^\circ$. A radioactive $^7$Be beam produced at Oak Ridge National Laboratory's (ORNL) Holifield Radioactive Ion Beam Facility was accelerated and bombarded a thin polypropylene (CH$_{2}$)$_\text n$ target. Scattered ions were detected in the segmented Silicon Detector Array. Using an $\textit{R}$-matrix analysis of ORNL and Louvain-la-Neuve cross section data, the $s$-wave scattering lengths for channel spins 1 and 2 were determined to be 17.34$^{+1.11}_{-1.33}$ and -3.18$^{+0.55}_{-0.50}$ fm, respectively. The uncertainty in the $s$-wave scattering lengths reported in this work is smaller by a factor of 5-8 compared to the previous measurement, which may reduce the overall uncertainty in $S_{17}$ at zero energy. The level structure of $^8$B is discussed based upon the results from this work. Evidence for the existence of 0$^+$ and 2$^+$ levels in $^8$B at 1.9 and 2.21 MeV, respectively, is observed.

Published
2019
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2. Central-line-associated bloodstream infection burden among Dutch neonatal intensive care units

Author

Jansen, S. J., Broer, S. D.L., Hemels, M. A.C., Visser, D. H., Antonius, T. A.J., Heijting, I. E., Bergman, K. A., Termote, J. U.M., Hütten, M. C., van der Sluijs, J. P.F., d'Haens, E. J., Kornelisse, R. F., Lopriore, E., Bekker, V., Jansen, S. J., Broer, S. D.L., Hemels, M. A.C., Visser, D. H., Antonius, T. A.J., Heijting, I. E., Bergman, K. A., Termote, J. U.M., Hütten, M. C., van der Sluijs, J. P.F., d'Haens, E. J., Kornelisse, R. F., Lopriore, E., and Bekker, V.

Abstract

Background: The establishment of an epidemiological overview provides valuable insights needed for the (future) dissemination of infection-prevention initiatives. Aim: To describe the nationwide epidemiology of central-line-associated bloodstream infections (CLABSI) among Dutch Neonatal Intensive Care Units (NICUs). Methods: Data from 2935 neonates born at <32 weeks' gestation and/or with a birth weight <1500 g admitted to all nine Dutch NICUs over a two-year surveillance period (2019–2020) were analysed. Variations in baseline characteristics, CLABSI incidence per 1000 central-line days, pathogen distribution and CLABSI care bundles were evaluated. Multi-variable logistic mixed-modelling was used to identify significant predictors for CLABSI. Results:A total of 1699 (58%) neonates received a central line, in which 160 CLABSI episodes were recorded. Coagulase-negative staphylococci were the most common infecting organisms of all CLABSI episodes (N=100, 63%). An almost six-fold difference in the CLABSI incidence between participating units was found (2.91–16.14 per 1000 line-days). Logistic mixed-modelling revealed longer central line dwell-time (adjusted odds ratio (aOR):1.08, P<0.001), umbilical lines (aOR:1.85, P=0.03) and single rooms (aOR:3.63, P=0.02) to be significant predictors of CLABSI. Variations in bundle elements included intravenous tubing care and antibiotic prophylaxis. Conclusions: CLABSI remains a common problem in preterm infants in The Netherlands, with substantial variation in incidence between centres. Being the largest collection of data on the burden of neonatal CLABSI in The Netherlands, this epidemiological overview provides a solid foundation for the development of a collaborative platform for continuous surveillance, ideally leading to refinement of national evidence-based guidelines. Future efforts should focus on ensuring availab

Published
2024

5. Crisis management competencies: A university stakeholder perspective.

Author

Pharaoh, Courtley D. and Visser, D. J.

Subjects
*CRISIS management, *SENIOR leadership teams, *INVESTMENT management, *OPEN-ended questions, *HIGHER education
Abstract

South African Universities faced an unforeseen crisis in the form of the #FeesMustFall (#FMF) movement. The Executive Management of the affected Universities was criticized for how the crisis was handled. Due to the significant cost (over R1 billion) to the higher education sector, not just in fiscal losses, but the loss of life, the investment into crisis management would be justified. Crisis management is a business action that includes planning and organising to prepare for and to respond to threats to business activities. Reviewing the literature identified a void regarding the crisis management competencies needed by the Executive Management as perceived by stakeholders. This exploratory study made use of a mixed methodology research design. A self-administered questionnaire incorporating open-ended questions was used to identify and explore the competencies perceived by the stakeholders as important during times of crisis. Simple descriptive statistics were used to identify the top management competencies needed in a time of crisis as perceived by the stakeholders. This was compared with the findings in the literature. The study identified 10 management competencies perceived by stakeholders of which eight competencies are consistent with crisis management competencies found in the literature. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Particle decay branching ratios for states of astrophysical importance in 19Ne

Author

Visser, D. W., Caggiano, J. A., Lewis, R., Handler, W. B., Parikh, A., and Parker, P. D.

Subjects
Nuclear Experiment
Abstract

We have measured proton and alpha-particle branching ratios of excited states in 19Ne formed using the 19F(3He,t) reaction at a beam energy of 25 MeV. These ratios have a large impact on the astrophysical reaction rates of 15O(alpha,gamma), 18F(p,gamma) and 18F(p,alpha), which are of interest in understanding energy generation in x-ray bursts and in interpreting anticipated gamma-ray observations of novae. We detect decay protons and alpha-particles using a silicon detector array in coincidence with tritons measured in the focal plane detector of our Enge split-pole spectrograph. The silicon array consists of five strip detectors of the type used in the Louvain-Edinburgh Detector Array, subtending angles from 130 degrees to 165 degrees with approximately 14% lab efficiency. The correlation angular distributions give additional confidence in some prior spin-parity assignments that were based on gamma branchings. We measure Gamma_p/Gamma=0.387+-0.016 for the 665 keV proton resonance, which agrees well with the direct measurement of Bardayan et al., Comment: 5 pages, 2 figures, 3 tables. Prepared using RevTex 4 and BibTex. Further minor revisions, incl. fig. 1 font size increase, 1 table removal, and minor changes to the text

Published
2003
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8. Order to disorder transition in the XY-like quantum magnet Cs2CoCl4 induced by noncommuting applied fields

Author

Kenzelmann, M., Coldea, R., Tennant, D. A., Visser, D., Hofmann, M., Smeibidl, P., and Tylczynski, Z.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We explore the effects of noncommuting applied fields on the ground-state ordering of the quasi-one-dimensional spin-1/2 XY-like antiferromagnet Cs2CoCl4 using single-crystal neutron diffraction. In zero field interchain couplings cause long-range order below T_N=217(5) mK with chains ordered antiferromagnetically along their length and moments confined to the (b,c) plane. Magnetic fields applied at an angle to the XY planes are found to initially stabilize the order by promoting a spin-flop phase with an increased perpendicular antiferromagnetic moment. In higher fields the antiferromagnetic order becomes unstable and a transition occurs to a phase with no long-range order in the (b,c) plane, proposed to be a spin liquid phase that arises when the quantum fluctuations induced by the noncommuting field become strong enough to overcome ordering tendencies. Magnetization measurements confirm that saturation occurs at much higher fields and that the proposed spin-liquid state exists in the region 2.10 < H_SL < 2.52 T || a. The observed phase diagram is discussed in terms of known results on XY-like chains in coexisting longitudinal and transverse fields., Comment: revtex, 14 figures, 2 tables, to appear in Phys. Rev. B

Published
2002
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16. Single-neutron excitations in neutron-rich N = 51 nuclei

Author

Thomas, J. S., Bardayan, D. W., Blackmon, J. C., Cizewski, J. A., Fitzgerald, R. P., Greife, U., Gross, C. J., Johnson, M. S., Jones, K. L., Kozub, R. L., Liang, J. F., Livesay, R. J., Ma, Z., Moazen, B. H., Nesaraja, C. D., Shapira, D., Smith, M. S., Visser, D. W., Gross, Carl J., editor, Nazarewicz, Witold, editor, and Rykaczewski, Krzysztof P., editor

Published
2005
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21. Review of Liriomyza huidobrensis (Blanchard, 1926) (Diptera: Agromyzidae) on potatoes in South Africa, with special reference to biological control using entomopathogens and parasitoids

Author

Mugala, T, Visser, D, Malan, AP, and Addison, P

Subjects
biocontrol agents, Diglyphus isaea, entomopathogenic fungi, potato leaf miner, entomopathogenic nematodes
Abstract

Potatoes are among the four most widely consumed vegetable crops worldwide. However, a potato crop can be infested by various pests like the devastating leaf miner, Liriomyza huidobrensis (Blanchard, 1926) (Diptera: Agromyzidae). This leaf miner has, since the early 2000s, become an important pest of potatoes in South Africa. It is highly invasive, causing up to 70% damage of solanaceous crops. Direct damage results from the adult female flies feeding on the leaf mesophyll during oviposition, and the larvae mining the leaves. Indirect damage is induced through pathogens entering through perforations that act as vectors of plant diseases. Biocontrol agents, such as entomopathogenic nematodes (EPNs), entomopathogenic fungi (EPF) and parasitoids, have shown potential for control of L. huidobrensis. This review investigates the biology and morphological identification of L. huidobrensis, its host range and the potential of associated biocontrol agents, like EPNs, EPF and parasitoids, as future control options.

Published
2022

22. Psychometrics of the observational scales of the Utrecht Scale for Evaluation of Rehabilitation (USER): Content and structural validity, internal consistency and reliability

Author

Jansen, M., Doornebosch, A.J., Waal, M.W.M. de, Wattel, E.M., Visser, D., Spek, B., and Smit, E.B.

Subjects
Clinimetrics, Geriatric rehabilitation, Post-acute care, Physical functioning, Cognitive functioning
Abstract

Introduction: : Establish content and structural validity, internal consistency, inter-rater reliability, and measurement error of the physical and cognitive scales of the Utrecht Scale for Evaluation clinical Rehabilitation (USER) in geriatric rehabilitation. Material and methods: : First, an expert consensus-meeting (N=7) was organised for content validity wherein scale content validity index (CVI) was measured. Second, in a sample of geriatric rehabilitation patient structural validity (N=616) was assessed by confirmatory factor analyses for exploring unidimensionality. Cut-off criteria were: Root Mean Square Error of Approximation (RMSEA) 0.95. Local independence (residual correlation0.30 and Hs-coefficient >0.50) were also calculated. Cronbach alphas were calculated for internal consistency. Alpha's > 0.7 was considered adequate. T hird, two nurses independently administered the USER to 37 patients. Intraclass-correlation coefficients (ICC) were calculated for inter-rater reliability (IRR), standard error of measurement (SEM) and Smallest Detectable Change (SDC). Results: : The CVI for physical functioning was moderate (0.73) and excellent for cognitive functioning (0.97). Structural validity physical scale was acceptable (CFI;0.95, TLI;0.93, RMSEA;0.07, ECV;0.78, OmegaH;0.87; Monotonicity;(Hi;0.52-0.75 and Hs;0.63)). Cognitive scale was good (CFI;0.98, TLI;0.96, RMSEA;0.05, ECV;0.66 and OmegaH;0.90. Monotonicity;(Hi;0.30 -0.70 and Hs;0.61)). Cronbach's alpha were high: physical scale;0.92 and cognitive scale;0.94. Reliability physical scale ICC;0.94, SEM;5 and SDC;14 and cognitive scale ICC;0.88, SEM;5 and SDC;13. Conclusion: : The observational scales of the USER have shown sufficient content and structural validity, internal consistency, and interrater reliability for measuring physical and cognitive function in geriatric rehabilitation. Trial registration: : N/A

Published
2021

28. Cardiac CT derived 3D reconstruction discriminates for complexity and hemodynamic effect of transcatheter mitral valve repair

Author

Meijerink, F, primary, Wolsink, I, additional, Holierook, M, additional, Chekanova, E V, additional, Planken, R N, additional, Van Randen, A, additional, De Winter, R J, additional, Beijk, M A M, additional, Koch, K T, additional, Robbers-Visser, D, additional, Boekholdt, S M, additional, Bouma, B J, additional, and Baan, J, additional

Published
2021
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30. Anomalous coronary artery from the pulmonary artery diagnosed in adulthood: a case series on variations of coronary anatomy and the diagnostic value of cardiac magnetic resonance imaging.

Author

Yazdi, Mehrdad Talebian, Robbers-Visser, D, Bilt, I A C van der, Boekholdt, S M, Koolbergen, D R, Planken, R N, and Groenink, M

Subjects
CARDIAC magnetic resonance imaging, PULMONARY artery, CORONARY arteries, MUCOCUTANEOUS lymph node syndrome, ANATOMICAL variation, PATIENT selection
Abstract

Background Anomalous coronary artery from the pulmonary artery is a rare congenital disorder with high mortality rates in infancy. Adult cases can present with life-threatening arrhythmias and sudden cardiac death. Case summary We report three cases of adults with anomalous pulmonary origin of each of the main coronary branches. The first patient with an anomalous left coronary artery from the pulmonary artery presented with an out-of-hospital cardiac arrest. The second patient with an anomalous circumflex artery from the pulmonary artery was evaluated for a bicuspid aortic valve and a suspected coronary fistula but was otherwise asymptomatic. The third patient with an anomalous right coronary artery from the pulmonary artery presented with anginal symptoms. In all cases, the diagnosis was made by cardiac computed tomography or coronary angiography. Cardiac magnetic resonance imaging was performed in all patients to guide clinical decision making on surgical or non-invasive management. All patients underwent surgical repair. In two patients, a dual coronary artery system was restored by aortic reimplantation of the anomalous coronary artery. In one patient, aortic reimplantation was unsuccessful due to poor vessel quality and the anomalous coronary artery was ligated. Clinical follow-up during 1.8–9.7 years did not show any cardiovascular complications and all patients are currently alive and asymptomatic. Discussion Anomalous coronary artery from the pulmonary artery can have various clinical presentations in adulthood. Cardiac magnetic resonance imaging is a useful modality to guide selection of patients who might have symptomatic or prognostic benefit from surgical repair. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Sustainable neonatal CLABSI surveillance: consensus towards new criteria in the Netherlands

Author

Heijting, I. E., Antonius, T. A. J., Tostmann, A., de Boode, W. P., Hogeveen, M., Hopman, J., Kornelisse, R. F., d’ Haens, E. J., Hemels, M. A. C., Termote, J. U. M., Bekker, V., Jansen, S. J., Visser, D. H., Sluijs-Bens, J. P. F. van der, Hutten, M. C., Bergman, K. A., Pediatrics, Neonatology, and Amsterdam Reproduction & Development (AR&D)

Subjects
Delphi Technique, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 0302 clinical medicine, Medical microbiology, Infection control, Pharmacology (medical), Blood culture, 030212 general & internal medicine, Netherlands, Central line-associated bloodstream infections (CLABSI), education.field_of_study, Catheter-related infections, Surveillance, medicine.diagnostic_test, Epidemiological monitoring, Hospital-acquired infections (HAI), Infectious Diseases, Neonatal intensive care unit (NICU), Epidemiological Monitoring, Microbiology (medical), medicine.medical_specialty, Catheterization, Central Venous, Consensus, Population, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], lcsh:Infectious and parasitic diseases, Sepsis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Cross infection, SDG 3 - Good Health and Well-being, 030225 pediatrics, medicine, Humans, lcsh:RC109-216, Neonatology, Quality improvement, education, Infection Control, business.industry, Research, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Public Health, Environmental and Occupational Health, Infant, Newborn, Fungal pathogen, medicine.disease, Newborn, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Emergency medicine, business
Abstract

Background Central line-associated bloodstream infections (CLABSI) are a main focus of infection prevention and control initiatives in neonatal care. Standardised surveillance of neonatal CLABSI enables intra- and interfacility comparisons which can contribute to quality improvement. To date, there is no national registration system for CLABSI in neonatal care in the Netherlands and several criteria are used for local monitoring of CLABSI incidence rates. To achieve standardised CLABSI surveillance we conducted a consensus procedure with regard to nationwide neonatal CLABSI surveillance criteria (SC). Methods A modified Delphi consensus procedure for the development of nationwide neonatal CLABSI SC was performed between January 2016 and January 2017 in the Netherlands. An expert panel was formed by members of the Working Group on Neonatal Infectious Diseases of the Section of Neonatology of the Dutch Paediatric Society. The consensus procedure consisted of three expert panel rounds. Results The expert panel achieved consensus on Dutch neonatal CLABSI SC. Neonatal CLABSI is defined as a bloodstream infection occurring more than 72 h after birth, associated with an indwelling central venous or arterial line and laboratory confirmed by one or more blood cultures. In addition, the blood culture finding should not be related to an infection at another site and one of the following criteria can be applied: 1. a bacterial or fungal pathogen is identified from one or more blood cultures; 2. the patient has clinical symptoms of sepsis and 2A) a common commensal is identified in two separate blood cultures or 2B) a common commensal is identified by one blood culture and C-reactive protein level is above 10 mg/L in the first 36 h following blood culture collection. Conclusions The newly developed Dutch neonatal CLABSI SC are concise, specified to the neonatal population and comply with a single blood culture policy in actual neonatal clinical practice. International agreement upon neonatal CLABSI SC is needed to identify best practices for infection prevention and control.

Published
2021

35. Sdu Commentaar Burgerlijk Procesrecht 2021

Author

Boer, M.H de, Hammerstein, A., Hermans, R.M., and Visser, D

Subjects
Business Law (Commercial Law), Onderneming en Algemeen Vermogensrecht
Abstract

Item does not contain fulltext 2568 p.

Published
2021

41. Patient information portal for congenital aortic and pulmonary valve disease: a stepped-wedge cluster randomised trial

Author

Etnel, J.R., Bons, L.R., Heer, F. de, Robbers-Visser, D., Beijnum, I.M. van, Straver, B., Jongbloed, M.R., Kiès, P., Slieker, M.G., Dijk, A.P.J. van, Kluin, J., Bertels, R.A., Utens, E., The, R., Galen, E. van, Mulder, B. J. M., Blom, N.A., Hazekamp, M.G., Roos-Hesselink, J.W., Helbing, W.A., Bogers, A., Takkenberg, J.J., Etnel, J.R., Bons, L.R., Heer, F. de, Robbers-Visser, D., Beijnum, I.M. van, Straver, B., Jongbloed, M.R., Kiès, P., Slieker, M.G., Dijk, A.P.J. van, Kluin, J., Bertels, R.A., Utens, E., The, R., Galen, E. van, Mulder, B. J. M., Blom, N.A., Hazekamp, M.G., Roos-Hesselink, J.W., Helbing, W.A., Bogers, A., and Takkenberg, J.J.

Abstract

Contains fulltext : 234054.pdf (Publisher’s version ) (Open Access), BACKGROUND: In response to an increased need for patient information in congenital heart disease, we previously developed an online, evidence-based information portal for patients with congenital aortic and pulmonary valve disease. To assess its effectiveness, a stepped-wedge cluster randomised trial was conducted. METHODS: Adult patients and caregivers of paediatric patients with congenital aortic and/or pulmonary valve disease and/or tetralogy of Fallot who visited the outpatient clinic at any of the four participating centres in the Netherlands between 1 March 2016-1 July 2017 were prospectively included. The intervention (information portal) was introduced in the outpatient clinic according to a stepped-wedge randomised design. One month after outpatient clinic visit, each participant completed a questionnaire on disease-specific knowledge, anxiety, depression, mental quality of life, involvement and opinion/attitude concerning patient information and involvement. RESULTS: 343 participants were included (221 control, 122 intervention). Cardiac diagnosis (p=0.873), educational level (p=0.153) and sex (p=0.603) were comparable between the two groups. All outcomes were comparable between groups in the intention-to-treat analyses. However, only 51.6% of subjects in the intervention group (n=63) reported actually visiting the portal. Among these subjects (as-treated), disease-specific knowledge (p=0.041) and mental health (p=0.039) were significantly better than in control subjects, while other baseline and outcome variables were comparable. CONCLUSION: Even after being invited by their cardiologists, only half of the participants actually visited the information portal. Only in those participants that actually visited the portal, knowledge of disease and mental health were significantly better. This underlines the importance of effective implementation of online evidence-based patient information portals in clinical practice.

Published
2021

42. Validation of the Dutch Version of the Breakthrough Pain Assessment Tool in Patients With Cancer

Author

Oldenmenger, W.H. (Wendy), Lucas, A. (Anne), van der Werff, G.F.H. (Gertruud F.H.), Webber, K. (Katherine), Visser, D. (Dick), Velden, A.W.G. (A. W G) van der, Rijt, C.C.D. (Carin) van der, Oldenmenger, W.H. (Wendy), Lucas, A. (Anne), van der Werff, G.F.H. (Gertruud F.H.), Webber, K. (Katherine), Visser, D. (Dick), Velden, A.W.G. (A. W G) van der, and Rijt, C.C.D. (Carin) van der

Abstract

Context: Essential for adequate management of breakthrough cancer pain is a combination of accurate (re-)assessment and a personalized treatment plan. The Breakthrough Pain Assessment Tool (BAT) has been proven to be a brief, multidimensional, reliable, and valid questionnaire for the assessment of breakthrough cancer pain. Objectives: The aim of this study was to examine the validity and reliability of the Dutch Language version of the BAT (BAT-DL) in patients with cancer. Methods: The BAT was forward-backward translated into the Dutch language. Thereafter, the psychometric properties of the BAT-DL were tested, that is factor structure, reliability (internal consistency and test-retest reliability), validity (content validity and construct validity), and the responsiveness to change. Results: The BAT-DL confirmed the two-factor structure in 170 patients with cancer: pain severity/impact factor and pain duration/medication efficacy factor. The Cronbach's alpha coefficient was 0.72, and the intraclass correlation for the test-retest reliability was 0.81. The BAT-DL showed to be able to differentiate between different group of patients and correlated significantly with the Brief Pain Inventory. In addition, the BAT-DL was capable to detect clinically important changes over time. Conclusion: The BAT-DL is a valid and reliable questionnaire to assess breakthrough pain in Dutch patients with cancer and is a relevant questionnaire for daily practice.

Published
2021
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43. E3 Opportunity Assessment: Developing the future energy workforce.

Author

Briggs, C, Rutovitz, J, Visser, D, Sharpe, S, Taylor, H, Jennings, K, Niklas, S, Annette, B, Ferraro, S, Mahmoudi, F, Sharp, D, Mortimer, G, Briggs, C, Rutovitz, J, Visser, D, Sharpe, S, Taylor, H, Jennings, K, Niklas, S, Annette, B, Ferraro, S, Mahmoudi, F, Sharp, D, and Mortimer, G

Published
2021

49. Multicentre reference values for cardiac magnetic resonance imaging derived ventricular size and function for children aged 0-18 years

Author

van der Ven, J P G, Sadighy, Z, Valsangiacomo Buechel, E R, Sarikouch, S, Robbers-Visser, D, Kellenberger, C J; https://orcid.org/0000-0001-9122-2431, Kaiser, T, Beerbaum, P, Boersma, E, Helbing, W A, van der Ven, J P G, Sadighy, Z, Valsangiacomo Buechel, E R, Sarikouch, S, Robbers-Visser, D, Kellenberger, C J; https://orcid.org/0000-0001-9122-2431, Kaiser, T, Beerbaum, P, Boersma, E, and Helbing, W A

Abstract

AIMS Cardiovascular magnetic resonance (CMR) imaging is an important tool in the assessment of paediatric cardiac disease. Reported reference values of ventricular volumes and masses in the paediatric population are based on small cohorts and several methodologic differences between studies exist. We sought to create steady-state free precession (SSFP) CMR reference values for biventricular volumes and mass by combining data of previously published studies and re-analysing these data in a standardized manner. METHODS AND RESULTS A total of 141 healthy children (68 boys) from three European centres underwent cine-SSFP CMR imaging. Cardiac structures were manually contoured for end-diastolic and end-systolic phases in the short-axis orientation according to current standardized CMR post-processing guidelines. Volumes and masses were derived from these contours. Age-related reference curves were constructed using the lambda mu sigma method. Median age was 12.7 years (range 0.6-18.5). We report biventricular volumes and masses, unindexed and indexed for body surface area, stratified by age groups. In general, boys had approximately 15% higher biventricular volumes and masses compared with girls. Only in children aged <6 years old no gender differences could be observed. Left ventricle ejection fraction was slightly higher in boys in this study population (median 67% vs. 65%, P = 0.016). Age-related reference curves showed non-linear relations between age and cardiac parameters. CONCLUSION We report volumetric SSFP CMR imaging reference values for children aged 0-18 years old in a relatively large multi-centre cohort. These references can be used in the follow-up of paediatric cardiac disease and for research purposes.

Published
2020

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