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26. sj-docx-1-anp-10.1177_00048674231173342 – Supplemental material for Predictors of the 6-year outcome of obsessive-compulsive disorder: Findings from the Netherlands Obsessive-Compulsive Disorder Association study

Author

Tibi, Lee, van Oppen, Patricia, van Balkom, Anton JLM, Eikelenboom, Merijn, Visser, Henny, and Anholt, Gideon E

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), Neuroscience
Abstract

Supplemental material, sj-docx-1-anp-10.1177_00048674231173342 for Predictors of the 6-year outcome of obsessive-compulsive disorder: Findings from the Netherlands Obsessive-Compulsive Disorder Association study by Lee Tibi, Patricia van Oppen, Anton JLM van Balkom, Merijn Eikelenboom, Henny Visser and Gideon E Anholt in Australian & New Zealand Journal of Psychiatry

Published
2023
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27. Neurobiology of psychotherapies in OCD: shared and distinct patterns of effect and prediction

Author

P.C. Van Oppen, Van Den Heuvel, Odile, Vriend, Chris, Broekhuizen, Aniek, Visser, Henny, A.J.L.M. Van Balkom, and Koenen, Emma

Subjects
Psychiatry, Medical Sciences, anxiety disorders, OCD, obsessive compulsive disorder, FOS: Clinical medicine, fMRI, Medicine and Health Sciences, Medical Specialties, Neurosciences, CBT, task-based fMRI, cognitive behavioral therapy
Abstract

Analysis plan for pre-post and prediction analysis of task-based fMRI during symptom provocation

Published
2023
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31. Relationship between insight and brain activation during symptom provocation in obsessive-compulsive disorder

Author

Broekhuizen, Aniek, Vriend, Chris, van den Heuvel, Odile, Visser, Henny, van Balkom, A.J.L.M., van Oppen, P.C., Wolf, Nadja, and Koenen, Emma

Subjects
Medical Sciences, anxiety disorders, insight, FOS: Clinical medicine, obsessive compulsive disorder, Neurosciences, Medicine and Health Sciences, functional MRI, Psychiatry and Psychology, clinical trial, psychiatry, MRI
Abstract

Relationship between insight and brain activation during symptom provocation in obsessive-compulsive disorder

Published
2022
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32. Therapeutic alliance as predictor of treatment outcome in psychotherapeutic treatment of obsessive compulsive disorder

Author

Wolf, Nadja, Visser, Henny, van Balkom, A.J.L.M., and van Oppen, P.C.

Subjects
OCD, Obsessive Compulsive Disorder, mental disorders, Medicine and Health Sciences, Psychiatry and Psychology, Therapeutic alliance, behavioral disciplines and activities
Abstract

The aim of this study is to replicate and extend previous research on the relationship between therapeutic alliance and treatment outcome in patients with OCD. The first objective is to determine to what extent overall therapeutic alliance measured by patients as well as by therapists contributes to treatment outcome in patients with OCD. The second objective is to explore the individual predictive value of the different components of therapeutic alliance on treatment outcome.

Published
2022
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35. Predictors of Intensive Treatment in Patients With Obsessive-Compulsive Disorder

Author

du Mortier, Johanna A.M., Remmerswaal, Karin C.P., Batelaan, Neeltje M., Visser, Henny A.D., Twisk, Jos W.R., van Oppen, Patricia, van Balkom, Anton J.L.M., Shavitt, R.G., Miguel, E.C., van den Heuvel, O., Lochner, C., Reddy, J.Y.C., Simpson, H.B., Psychiatry, APH - Mental Health, and Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention

Abstract

Background: Few studies have investigated which patients with obsessive-compulsive disorder (OCD) do not recover through regular cognitive behavior therapy or pharmacotherapy and subsequently end up in intensive treatment like day treatment or inpatient treatment. Knowing the predictors of intensive treatment in these patients is significant because it could prevent intensive treatment. This study has identified predictors of intensive treatment in patients with OCD. Methods: Using 6-year longitudinal data of the Netherlands Obsessive Compulsive Disorder Association (NOCDA), potential predictors of intensive treatment were assessed in patients with OCD (n = 419). Intensive treatment was assessed using the Treatment Inventory Costs in Patients with Psychiatric Disorders (TIC-P). Examined potential predictors were: sociodemographics, and clinical and psychosocial characteristics. Logistic Generalized Estimating Equations was used to estimate to what extent the various characteristics (at baseline, 2- and 4-year assessment) predicted intensive treatment in the following 2 years, averaged over the three assessment periods. Results: Being single, more severe comorbid depression, use of psychotropic medication, and a low quality of life predicted intensive treatment in the following 2 years. Conclusions: Therapists should be aware that patients with OCD who are single, who have more severe comorbid depression, who use psychotropic medication, and who have a low quality of life or a drop in quality of life are at risk for intensive treatment. Intensive treatment might be prevented by focusing regular treatment not only on OCD symptoms but also on comorbid depression and on quality of life. Intensive treatment might be improved by providing extra support in treatment or by adjusting treatment to impairments due to comorbid depressive symptoms or a low quality of life.

Published
2022

37. Development and psychometric evaluation of the Decision Tool Anxiety Disorders, OCD and PTSD (DTAOP): Facilitating the early detection of patients in need of highly specialized care

Author

van Krugten, Frédérique C. W., primary, Kaddouri, Meriam, additional, Goorden, Maartje, additional, van Balkom, Anton J. L. M., additional, Berretty, Ed W., additional, Cath, Daniëlle C., additional, Hendriks, Gert-Jan, additional, Matthijssen, Suzy J. M. A., additional, Visser, Henny A. D., additional, van Vliet, Irene M., additional, Brouwer, Werner B. F., additional, and Hakkaart-van Roijen, Leona, additional

Published
2021
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39. Development and psychometric evaluation of the Decision Tool Anxiety Disorders, OCD and PTSD (DTAOP):Facilitating the early detection of patients in need of highly specialized care

Author

van Krugten, Frédérique C.W., Kaddouri, Meriam, Goorden, Maartje, van Balkom, Anton J.L.M., Berretty, Ed W., Cath, Daniëlle C., Hendriks, Gert Jan, Matthijssen, Suzy J.M.A., Visser, Henny A.D., van Vliet, Irene M., Brouwer, Werner B.F., Hakkaart-Van Roijen, Leona, van Krugten, Frédérique C.W., Kaddouri, Meriam, Goorden, Maartje, van Balkom, Anton J.L.M., Berretty, Ed W., Cath, Daniëlle C., Hendriks, Gert Jan, Matthijssen, Suzy J.M.A., Visser, Henny A.D., van Vliet, Irene M., Brouwer, Werner B.F., and Hakkaart-Van Roijen, Leona

Abstract

Background Early identification of patients with an anxiety disorder, obsessive-compulsive disorder (OCD), or post-traumatic stress disorder (PTSD) in need of highly specialized care could facilitate the selection of the optimal initial treatment in these patients. This paper describes the development and psychometric evaluation of the Decision Tool Anxiety Disorders, OCD and PTSD (DTAOP), which aims to aid clinicians in the early identification of patients with an anxiety disorder, OCD, or PTSD in need of highly specialized mental healthcare. Methods A systematic literature review and a concept mapping procedure were carried out to inform the development of the DTAOP. To evaluate the psychometric properties of the DTAOP, a cross-sectional study in 454 patients with a DSM-IV-TR anxiety disorder was carried out. Feasibility was evaluated by the completion time and the content clarity of the DTAOP. Inter-rater reliability was assessed in a subsample of 87 patients. Spearman’s rank correlation coefficients between the DTAOP and EuroQol five-dimensional questionnaire (EQ-5D-5L) scores were computed to examine the convergent validity. Criterion validity was assessed against independent clinical judgments made by clinicians. Results The average time required to complete the eight-item DTAOP was 4.6 min and the total DTAOP was evaluated as clear in the majority (93%) of the evaluations. Krippendorff’s alpha estimates ranged from 0.427 to 0.839. Based on the qualitative feedback, item wording and instructions were improved. As hypothesized, the DTAOP correlated negatively with EQ-5D-5L scores. The area under the curve was 0.826 and the cut-off score of ≥4 optimized sensitivity (70%) and specificity (71%). Conclusions The DTAOP demonstrated excellent feasibility and good validity, but weak inter-rater reliability. Based on the qualitative feedback and reliability estimates, revisions and refinements of the wording and instructions w

Published
2021

44. Chronic obsessive–compulsive disorder: prognostic factors

Author

van Oudheusden, Lucas J. B., primary, Eikelenboom, Merijn, additional, van Megen, Harold J. G. M., additional, Visser, Henny A. D., additional, Schruers, Koen, additional, Hendriks, Gert-Jan, additional, van der Wee, Nic, additional, Hoogendoorn, Adriaan W., additional, van Oppen, Patricia, additional, and van Balkom, Anton J. L. M., additional

Published
2018
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45. New treatment models for compulsive disorders

Author

Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Abstract

Obsessive compulsive disorder (OCD) as well as related disorders such as body dysmorphic disorder, tic disorder, and trichotillomania are all common and often debilitating. Although treatments are available, more effective approaches to these problems are needed. Thus this review article presents what is currently known about OCD and related disorders and suggests that understanding OCD more broadly as a compulsive disorder may allow for more effective treatment options. Toward that goal, the review presents new models of psychopharmacology and psychotherapy, as well as new brain stimulation strategies. Treatment advances, grounded in the neuroscience, have promise in advancing treatment response for OCD as well as other disorders of compulsivity.

Published
2016

46. New treatment models for compulsive disorders

Author

Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, van Balkom, Anton J L M, Leerstoel Hout, Experimental psychopathology, Grant, Jon E, Fineberg, Naomi, van Ameringen, Michael, Cath, Danielle, Visser, Henny, Carmi, Lior, Pallanti, Stefano, Hollander, Eric, and van Balkom, Anton J L M

Published
2016

49. Inference-Based Cognitive Behavioral Therapy versus Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: A Multisite Randomized Controlled Non-Inferiority Trial.

Author

Wolf, Nadja, van Oppen, Patricia, Hoogendoorn, Adriaan W., van den Heuvel, Odile A., van Megen, Harold J.G.M., Broekhuizen, Aniek, Kampman, Mirjam, Cath, Daniëlle C., Schruers, Koen R.J., van Es, Saskia M., Opdam, Tamara, van Balkom, Anton J.L.M., and Visser, Henny A.D.

Subjects
*COGNITIVE therapy, *PSYCHIATRIC treatment, *OBSESSIVE-compulsive disorder, *MENTAL illness, *TREATMENT effectiveness
Abstract

Introduction: Although cognitive behavioral therapy (CBT) effectively treats obsessive-compulsive disorder (OCD), many patients refuse CBT or drop out prematurely, partly because of anxiety regarding exposure and response prevention (ERP) exercises. Inference-based cognitive behavioral therapy (I-CBT) focuses on correcting distorted inferential thinking patterns, enhancing reality-based reasoning, and addressing obsessional doubt by targeting underlying dysfunctional reasoning, without incorporating an ERP component. We hypothesized that I-CBT would be non-inferior to CBT. Additionally, we hypothesized that I-CBT would be more tolerable than CBT. Methods: 197 participants were randomly assigned to 20 sessions CBT or I-CBT and assessed at baseline, posttreatment, and 6 and 12 months’ follow-up. The primary outcome was OCD symptom severity measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS; non-inferiority margin: 2 points). The secondary outcome, treatment tolerability, was assessed using the Treatment Acceptability/Adherence Scale (TAAS). A linear mixed-effects model was used to assess the non-inferiority of the primary outcome and superiority of secondary outcomes. Results: Statistically significant within-group improvements in the primary and secondary outcomes were observed in both treatments. No statistically significant between-group differences in Y-BOCS were found at any assessment point, but the confidence intervals exceeded the non-inferiority threshold, making the results inconclusive. The estimated mean posttreatment TAAS score was significantly higher in the I-CBT group than in the CBT group. Conclusion: While both CBT and I-CBT are effective for OCD, whether I-CBT is non-inferior to CBT in terms of OCD symptom severity remains inconclusive. Nevertheless, I-CBT offers better tolerability and warrants consideration as an alternative treatment for OCD. [ABSTRACT FROM AUTHOR]

Published
2024
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