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9 results on '"Vismara, Irma"'

2. Contributors

Author

Assunção-Silva, Rita C., primary, Benech, Carlo Alberto, additional, Bergui, Mauro, additional, Boccaccini, Leonardo, additional, Boido, Beatrice, additional, Boniolo, Giovanni, additional, Carpanese, Fernando, additional, Casalini, Tommaso, additional, Cioffi, Armando, additional, Di Liberto, Alessandra, additional, Ferraris, Marilena, additional, Ferrero, Bruno, additional, Gimona, Mario, additional, Gomes, Eduardo D., additional, González-Cantalapiedra, Antonio, additional, Imaninezhad, Mozhdeh, additional, Kubinová, Šárka, additional, Lima, Rui, additional, López-Peña, Mónica, additional, Masi, Maurizio, additional, Mauri, Emanuele, additional, Molinaro, Fano, additional, Morbidoni, Giulia, additional, Muñoz Guzón, Fernando María, additional, Naddeo, Francesco, additional, Papa, Simonetta, additional, Perale, Giuseppe, additional, Perez, Rosa, additional, Permuy, María, additional, Pertici, Gianni, additional, Reinert, Michael, additional, Rinaldis, Andrea De, additional, Rocha, Luís A., additional, Rossi, Filippo, additional, Russo, Raúl E., additional, Salgado, António J., additional, Sanchini, Virginia, additional, Sheth, Saahil, additional, Silva, N.A., additional, Tomatis, Alberto, additional, Veglianese, Pietro, additional, Vismara, Irma, additional, Zaca’, Domenico, additional, Zazzera, Pier Luigi La, additional, and Zustiak, Silviya Petrova, additional

Published
2020
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5. Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

Author

Vismara, Irma, primary, Papa, Simonetta, additional, Veneruso, Valeria, additional, Mauri, Emanuele, additional, Mariani, Alessandro, additional, De Paola, Massimiliano, additional, Affatato, Roberta, additional, Rossetti, Arianna, additional, Sponchioni, Mattia, additional, Moscatelli, Davide, additional, Sacchetti, Alessandro, additional, Rossi, Filippo, additional, Forloni, Gianluigi, additional, and Veglianese, Pietro, additional

Published
2019
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6. A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury

Author

Redaelli, Veronica, primary, Papa, Simonetta, additional, Marsella, Gerardo, additional, Grignaschi, Giuliano, additional, Bosi, Alice, additional, Ludwig, Nicola, additional, Luzi, Fabio, additional, Vismara, Irma, additional, Rimondo, Stefano, additional, Veglianese, Pietro, additional, Tepteva, Svetlana, additional, Mazzola, Silvia, additional, Zerbi, Pietro, additional, Porcu, Luca, additional, Roughan, John V., additional, Parati, Gianfranco, additional, and Calvillo, Laura, additional

Published
2019
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8. Double conjugated nanogels for selective intracellular drug delivery

Author

Mauri, Emanuele, primary, Veglianese, Pietro, additional, Papa, Simonetta, additional, Mariani, Alessandro, additional, De Paola, Massimiliano, additional, Rigamonti, Riccardo, additional, Chincarini, Giulia M. F., additional, Vismara, Irma, additional, Rimondo, Stefano, additional, Sacchetti, Alessandro, additional, and Rossi, Filippo, additional

Published
2017
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9. Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

Author

Vismara, Irma, Papa, Simonetta, Veneruso, Valeria, Mauri, Emanuele, Mariani, Alessandro, De Paola, Massimiliano, Affatato, Roberta, Rossetti, Arianna, Sponchioni, Mattia, Moscatelli, Davide, Sacchetti, Alessandro, Rossi, Filippo, Forloni, Gianluigi, and Veglianese, Pietro

Abstract

Astrogliosis has a very dynamic response during the progression of spinal cord injury, with beneficial or detrimental effects on recovery. It is therefore important to develop strategies to target activated astrocytes and their harmful molecular mechanisms so as to promote a protective environment to counteract the progression of the secondary injury. The challenge is to formulate an effective therapy with maximum protective effects, but reduced side effects. In this study, a functionalized nanogel-based nanovector was selectively internalized in activated mouse or human astrocytes. Rolipram, an anti-inflammatory drug, when administered by these nanovectors limited the inflammatory response in A1 astrocytes, reducing iNOS and Lcn2, which in turn reverses the toxic effect of proinflammatory astrocytes on motor neurons in vitro, showing advantages over conventionally administered anti-inflammatory therapy. When tested acutely in a spinal cord injury mouse model, it improved motor performance, but only in the early stage after injury, reducing the astrocytosis and preserving neuronal cells.

Published
2020
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