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The herbs used in the study have potent anti-nephrotic activity and individually play a crucial role as follows; Angelica officinalis responsible for urinary retention, Boerhavia diffusa act as excellent diuretic, Carica papaya act as immunomodulator and recover kidney tissues, Cassia Fistula protects deoxyribose from damage, Cichorium intybus has good immunomodulatory action and modulate kidney function, Ficus hispida inhibits insulinase activity of liver and kidney, Fumaria indica play a crucial role in reduction of granuloma mass, Crataeva nurvala support kidney from microbial infection and act as urinary retention, Solidago virgaurea stimulates the kidneys with excellent support of kidney health and Vitex negundo is an excellent tonic for nephrotic disorder with good diuretic properties. At present, the polyherbal drugs available in the market are using in very high dose for the treatment of nephritis and observed that it extremely producing workload on the normal function of the kidney. The available Allopathic medicines are used in multiple dosage form for just symptomatic relief that produces side effect and leads to damage filtering units on prolonged exposure. The main purpose of the present study is to prepare a novel polyherbal dispersible tablet using plant's root extract which was scientifically proven and/or folklore medicine and possessing a prominent pharmacological potency for the treatment of glomerulonephritis. This preparation may diminish the economic burden and treatment cost which was not afforded by poor people. [ABSTRACT FROM AUTHOR]