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2. Endothelial microRNAs in INOCA patients with diabetes mellitus

Author

Ferrone, Marco, Ciccarelli, Michele, Varzideh, Fahimeh, Kansakar, Urna, Guerra, Germano, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Fiordelisi, Antonella, Venga, Enzo, Esposito, Mafalda, Rainone, Antonio, Ricciardi, Roberto, Del Giudice, Carmine, Minicucci, Fabio, Tesorio, Tullio, Visco, Valeria, Iaccarino, Guido, Gambardella, Jessica, Santulli, Gaetano, and Mone, Pasquale

Published
2024
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3. Correction to: Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study

Author

Santulli, Gaetano, Visco, Valeria, Ciccarelli, Michele, Ferrante, Mario Nicola Vittorio, De Masi, Piero, Pansini, Antonella, Virtuoso, Nicola, Pirone, Armando, Guerra, Germano, Verri, Veronica, Macina, Gaetano, Taurino, Alessandro, Komici, Klara, and Mone, Pasquale

Published
2024
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7. Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function

Author

Falcão‐Pires, Inês, primary, Ferreira, Ana Filipa, additional, Trindade, Fábio, additional, Bertrand, Luc, additional, Ciccarelli, Michele, additional, Visco, Valeria, additional, Dawson, Dana, additional, Hamdani, Nazha, additional, Van Laake, Linda W., additional, Lezoualc'h, Frank, additional, Linke, Wolfgang A., additional, Lunde, Ida G, additional, Rainer, Peter P., additional, Abdellatif, Mahmoud, additional, Van der Velden, Jolanda, additional, Cosentino, Nicola, additional, Paldino, Alessia, additional, Pompilio, Giulio, additional, Zacchigna, Serena, additional, Heymans, Stephane, additional, Thum, Thomas, additional, and Tocchetti, Carlo Gabriele, additional

Published
2024
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8. Vitamin D: A Bridge between Kidney and Heart

Author

Secondulfo, Carmine, primary, Visco, Valeria, additional, Virtuoso, Nicola, additional, Fortunato, Martino, additional, Migliarino, Serena, additional, Rispoli, Antonella, additional, La Mura, Lucia, additional, Stellato, Adolfo, additional, Caliendo, Giuseppe, additional, Settembre, Emanuela, additional, Galluccio, Fabiana, additional, Hamzeh, Sarah, additional, and Bilancio, Giancarlo, additional

Published
2024
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9. Technological Developments, Exercise Training Programs, and Clinical Outcomes in Cardiac Telerehabilitation in the Last Ten Years: A Systematic Review.

Author

Garofano, Marina, Vecchione, Carmine, Calabrese, Mariaconsiglia, Rusciano, Maria Rosaria, Visco, Valeria, Granata, Giovanni, Carrizzo, Albino, Galasso, Gennaro, Bramanti, Placido, Corallo, Francesco, Izzo, Carmine, Ciccarelli, Michele, and Bramanti, Alessia

Subjects
CARDIOVASCULAR disease related mortality, HEALTH services accessibility, HUMAN services programs, DIFFUSION of innovations, COST effectiveness, EXERCISE therapy, HOSPITAL care, MEDICAL care, TELEREHABILITATION, TREATMENT effectiveness, POPULATION geography, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, TECHNOLOGY, ONLINE information services, CORONARY artery disease, CARDIAC rehabilitation
Abstract

Background: Cardiovascular diseases (CVDs) are associated with very high rates of re-hospitalization and mortality worldwide, so the complexity of these pathologies requires frequent access to hospital facilities. The guidelines also emphasize the importance of cardiac rehabilitation (CR) programs, which have demonstrated a favorable effect on outcomes, and cardiac telerehabilitation (CTR) could represent an innovative healthcare delivery model. The aim of our review is to study how technologies used in rehabilitation have changed over time and also to understand what types of rehabilitation programs have been used in telerehabilitation. Methods: We searched randomized controlled trials (RCTs) in three electronic databases, PubMed, Web of Science, and Scopus, from January 2015 to January 2024, using relevant keywords. Initially, 502 articles were found, and 79 duplicates were identified and eliminated with EndNote. Results: In total, 16 RCTs fulfilled the pre-defined criteria, which were analyzed in our systematic review. The results showed that after CTR, there was a significant improvement in main outcome measures, as well as in relation to technological advances. Conclusions: Moreover, compared to center-based rehabilitation, CTR can offer further advantages, with better cost-effectiveness, the breakdown of geographical barriers, and the improvement of access to treatment for the female population, which is traditionally more socially committed. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin.

Author

Santulli, Gaetano, Visco, Valeria, Varzideh, Fahimeh, Guerra, Germano, Kansakar, Urna, Gasperi, Maurizio, Marro, Anna, Wilson, Scott, Vittorio Ferrante, Mario Nicola, Pansini, Antonella, Pirone, Armando, Di Lorenzo, Francesco, Tartaglia, Domenico, Iaccarino, Guido, Macina, Gaetano, Agyapong, Esther Densu, Forzano, Imma, Jankauskas, Stanislovas S., Komici, Klara, and Ciccarelli, Michele

Abstract

BACKGROUND: Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals. METHODS: We screened elders with prefrail hypertension from March 2021 to January 2023. We assessed the correlation linking cognitive dysfunction (Montreal Cognitive Assessment score), insulin resistance (triglyceride-to-glucose index), and physical impairment (5-meter gait speed). Then, we measured the risk of developing frailty after a 1-year follow-up period, adjusting the outcome using multivariable Cox regression analysis. We also investigated the impact of administering 500 mg of metformin once daily to a subset of frail subjects for an additional 6 months. RESULTS: We assessed the relationship between the triglyceride-to-glucose index and the Montreal Cognitive Assessment score, observing a significant correlation (r, 0.880; P<0.0001). Similarly, we analyzed the association between the triglycerideto-glucose index and 5-meter gait speed, uncovering a significant link between insulin resistance and physical impairment (r, 0.809; P<0.0001). Prediabetes was found to significantly (P<0.0001) elevate the risk of frailty development compared with individuals without prediabetes by the end of the 1-year follow-up, a finding confirmed via multivariable analysis with Cox regression. Furthermore, among the subgroup of subjects who developed frailty, those who received metformin exhibited a significant decrease in frailty levels (P<0.0001). CONCLUSIONS: Insulin resistance and prediabetes play substantial roles in the development of cognitive and physical impairments, highlighting their importance in managing hypertension, even before the onset of frank diabetes. Metformin, a well-established drug for the treatment of diabetes, has shown favorable effects in mitigating frailty. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function

Author

Ciccarelli, Michele, primary, Pires, Inês Falcão, additional, Bauersachs, Johann, additional, Bertrand, Luc, additional, Beauloye, Christophe, additional, Dawson, Dana, additional, Hamdani, Nazha, additional, Hilfiker-Kleiner, Denise, additional, van Laake, Linda W, additional, Lezoualc’h, Frank, additional, Linke, Wolfgang A, additional, Lunde, Ida G, additional, Rainer, Peter P, additional, Rispoli, Antonella, additional, Visco, Valeria, additional, Carrizzo, Albino, additional, Ferro, Matteo Dal, additional, Stolfo, Davide, additional, van der Velden, Jolanda, additional, Zacchigna, Serena, additional, Heymans, Stephane, additional, Thum, Thomas, additional, and Tocchetti, Carlo Gabriele, additional

Published
2023
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13. Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview.

Author

Izzo, Carmine, Secondulfo, Carmine, Bilancio, Giancarlo, Visco, Valeria, Virtuoso, Nicola, Migliarino, Serena, Ciccarelli, Michele, Di Pietro, Paola, La Mura, Lucia, Damato, Antonio, Carrizzo, Albino, and Vecchione, Carmine

Subjects
RENAL osteodystrophy, ARTERIAL calcification, CALCIUM metabolism, PULSE wave analysis, VASCULAR smooth muscle
Abstract

Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting 697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million disability-adjusted life years (DALYs) and 1.2 million deaths in 2017. The mortality rate for CKD has increased by 41.5% between 1990 and 2017, positioning it as a significant cause of global mortality. CKD is associated with diverse health complications, impacting cardiovascular, neurological, nutritional, and endocrine aspects. One prominent complication is CKD–mineral and bone disorder (MBD), a complex condition involving dysregulation of bone turnover, mineralization, and strength, accompanied by soft tissue and vascular calcification. Alterations in mineral metabolism, including calcium, phosphate, parathyroid hormone (PTH), vitamin D, fibroblast growth factor-23 (FGF-23), and Klotho, play pivotal roles in CKD-MBD. These disturbances, observed early in CKD, contribute to the progression of bone disorders and renal osteodystrophy (ROD). Vascular calcification (VC) is a key component of CKD-MBD, accelerated by CKD. The pathophysiology involves complex processes in vascular smooth muscle cells and the formation of calciprotein particles (CPP). VC is closely linked to cardiovascular events and mortality, emphasizing its prognostic significance. Various serum markers and imaging techniques, including lateral plain X-ray, Kauppila Score, Adragao Score, and pulse wave velocity, aid in VC detection. Additionally, pQCT provides valuable information on arterial calcifications, offering an advantage over traditional scoring systems. CKD poses a substantial global health burden, and its complications, including CKD-MBD and VC, significantly contribute to morbidity and mortality. Understanding the intricate relationships between mineral metabolism, bone disorders, and vascular calcification is crucial for effective diagnosis and therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Interventions to Address Cardiovascular Risk in Obese Patients: Many Hands Make Light Work

Author

Visco, Valeria, primary, Izzo, Carmine, additional, Bonadies, Davide, additional, Di Feo, Federica, additional, Caliendo, Giuseppe, additional, Loria, Francesco, additional, Mancusi, Costantino, additional, Chivasso, Pierpaolo, additional, Di Pietro, Paola, additional, Virtuoso, Nicola, additional, Carrizzo, Albino, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2023
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15. Sacubitril/Valsartan vs. Standard Medical Therapy on Exercise Capacity in HFrEF Patients

Author

Campanile, Alfonso, primary, Visco, Valeria, additional, De Carlo, Stefania, additional, Ferruzzi, Germano Junior, additional, Mancusi, Costantino, additional, Izzo, Carmine, additional, Mongiello, Felice, additional, Di Pietro, Paola, additional, Virtuoso, Nicola, additional, Ravera, Amelia, additional, Bonadies, Domenico, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2023
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16. Artificial intelligence in cardiovascular prevention: new ways will open new doors

Author

Ciccarelli, Michele, primary, Giallauria, Francesco, additional, Carrizzo, Albino, additional, Visco, Valeria, additional, Silverio, Angelo, additional, Cesaro, Arturo, additional, Calabrò, Paolo, additional, De Luca, Nicola, additional, Mancusi, Costantino, additional, Masarone, Daniele, additional, Pacileo, Giuseppe, additional, Tourkmani, Nidal, additional, Vigorito, Carlo, additional, and Vecchione, Carmine, additional

Published
2023
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18. Artificial Intelligence in Hypertension Management: An Ace up Your Sleeve

Author

Visco, Valeria, primary, Izzo, Carmine, additional, Mancusi, Costantino, additional, Rispoli, Antonella, additional, Tedeschi, Michele, additional, Virtuoso, Nicola, additional, Giano, Angelo, additional, Gioia, Renato, additional, Melfi, Americo, additional, Serio, Bianca, additional, Rusciano, Maria Rosaria, additional, Di Pietro, Paola, additional, Bramanti, Alessia, additional, Galasso, Gennaro, additional, D’Angelo, Gianni, additional, Carrizzo, Albino, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2023
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20. 874 A NOT-SO-RARE COMPLICATION OF CONNECTIVE TISSUE DISEASE

Author

Bonadies, Davide, primary, Palumbo, Rossana, additional, Manna, Martina La, additional, Santopietro, Mario, additional, Sorvillo, Graziano, additional, Visco, Valeria, additional, Vigorito, Francesco, additional, Ciccarelli, Michele, additional, Galasso, Gennaro, additional, Vecchione, Carmine, additional, and Soriente, Lucia, additional

Published
2022
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21. 719 CIRCULATING SORTILIN LEVELS ARE INCREASED IN PATIENTS RECEIVING LONG-TERM WARFARIN AND ITS INHIBITION ATTENUATES WARFARIN-INDUCED VASCULAR CALCIFICATION

Author

Di Pietro, Paola, primary, Abate, Angela Carmelita, additional, Rusciano, Maria Rosaria, additional, Visco, Valeria, additional, Izzo, Carmine, additional, Iacoviello, Licia, additional, Toni, Anna Laura, additional, Ciccarelli, Michele, additional, Carrizzo, Albino, additional, and Vecchione, Carmine, additional

Published
2022
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24. Whole-Exome Sequencing Revealed New Candidate Genes for Human Dilated Cardiomyopathy

Author

D’Agostino, Ylenia, primary, Palumbo, Domenico, additional, Rusciano, Maria Rosaria, additional, Strianese, Oriana, additional, Amabile, Sonia, additional, Di Rosa, Domenico, additional, De Angelis, Elena, additional, Visco, Valeria, additional, Russo, Fabio, additional, Alexandrova, Elena, additional, Salvati, Annamaria, additional, Giurato, Giorgio, additional, Nassa, Giovanni, additional, Tarallo, Roberta, additional, Galasso, Gennaro, additional, Ciccarelli, Michele, additional, Weisz, Alessandro, additional, and Rizzo, Francesca, additional

Published
2022
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25. Cardiovascular Implications of microRNAs in Coronavirus Disease 2019

Author

Izzo, Carmine, primary, Visco, Valeria, additional, Gambardella, Jessica, additional, Ferruzzi, Germano Junior, additional, Rispoli, Antonella, additional, Rusciano, Maria Rosaria, additional, Toni, Anna Laura, additional, Virtuoso, Nicola, additional, Carrizzo, Albino, additional, Di Pietro, Paola, additional, Iaccarino, Guido, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2022
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27. Predictors of sacubitril/valsartan high dose tolerability in a real world population with HFrEF

Author

Visco, Valeria, primary, Radano, Ilaria, additional, Campanile, Alfonso, additional, Ravera, Amelia, additional, Silverio, Angelo, additional, Masarone, Daniele, additional, Pacileo, Giuseppe, additional, Correale, Michele, additional, Mazzeo, Pietro, additional, Dattilo, Giuseppe, additional, Giallauria, Francesco, additional, Cuomo, Alessandra, additional, Mercurio, Valentina, additional, Tocchetti, Carlo Gabriele, additional, Di Pietro, Paola, additional, Carrizzo, Albino, additional, Citro, Rodolfo, additional, Galasso, Gennaro, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2022
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28. A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm®) and Anthocyanins Exerts Beneficial Cardiovascular Effects

Author

Di Pietro, Paola, primary, Lizio, Rosario, additional, Izzo, Carmine, additional, Visco, Valeria, additional, Damato, Antonio, additional, Venturini, Eleonora, additional, De Lucia, Massimiliano, additional, Galasso, Gennaro, additional, Migliarino, Serena, additional, Rasile, Barbara, additional, Ciccarelli, Michele, additional, Vecchione, Carmine, additional, and Carrizzo, Albino, additional

Published
2022
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30. Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Author

Visco, Valeria, primary, Vitale, Carolina, additional, Rispoli, Antonella, additional, Izzo, Carmine, additional, Virtuoso, Nicola, additional, Ferruzzi, Germano Junior, additional, Santopietro, Mario, additional, Melfi, Americo, additional, Rusciano, Maria Rosaria, additional, Maglio, Angelantonio, additional, Di Pietro, Paola, additional, Carrizzo, Albino, additional, Galasso, Gennaro, additional, Vatrella, Alessandro, additional, Vecchione, Carmine, additional, and Ciccarelli, Michele, additional

Published
2022
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35. Accuracy of home blood pressure measurement: the ACCURAPRESS study – a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell'Ipertensione Arteriosa).

Author

Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Fucile, Ilaria, and Sorvillo, Gianmarco

Subjects
BLOOD pressure measurement, AMBULATORY blood pressure monitoring, BLOOD pressure, HYPERTENSION, ATHEROSCLEROTIC plaque
Abstract

Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. The survey included 30 different items on how to perform the HBPM. It was developed by the 'Young Investigators' group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Whole-Exome Sequencing Revealed New Candidate Genes for Human Dilated Cardiomyopathy.

Author

D'Agostino, Ylenia, Palumbo, Domenico, Rusciano, Maria Rosaria, Strianese, Oriana, Amabile, Sonia, Di Rosa, Domenico, De Angelis, Elena, Visco, Valeria, Russo, Fabio, Alexandrova, Elena, Salvati, Annamaria, Giurato, Giorgio, Nassa, Giovanni, Tarallo, Roberta, Galasso, Gennaro, Ciccarelli, Michele, Weisz, Alessandro, and Rizzo, Francesca

Subjects
DILATED cardiomyopathy, GENE ontology, RECESSIVE genes, ATP-binding cassette transporters, CONGENITAL heart disease, HUMAN genes, GENETIC variation, HEART failure
Abstract

Dilated cardiomyopathy (DCM) is a complex disease affecting young adults. It is a pathological condition impairing myocardium activity that leads to heart failure and, in the most severe cases, transplantation, which is currently the only possible therapy for the disease. DCM can be attributed to many genetic determinants interacting with environmental factors, resulting in a highly variable phenotype. Due to this complexity, the early identification of causative gene mutations is an important goal to provide a genetic diagnosis, implement pre-symptomatic interventions, and predict prognosis. The advent of next-generation sequencing (NGS) has opened a new path for mutation screening, and exome sequencing provides a promising approach for identifying causal variants in known genes and novel disease-associated candidates. We analyzed the whole-exome sequencing (WES) of 15 patients affected by DCM without overloading (hypertension, valvular, or congenital heart disease) or chronic ischemic conditions. We identified 70 pathogenic or likely pathogenic variants and 1240 variants of uncertain clinical significance. Gene ontology enrichment analysis was performed to assess the potential connections between affected genes and biological or molecular function, identifying genes directly related to extracellular matrix organization, transcellular movement through the solute carrier and ATP-binding cassette transporter, and vitamin B12 metabolism. We found variants in genes implicated to a different extent in cardiac function that may represent new players in the complex genetic scenario of DCM. [ABSTRACT FROM AUTHOR]

Published
2022
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37. A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm ®) and Anthocyanins Exerts Beneficial Cardiovascular Effects.

Author

Di Pietro, Paola, Lizio, Rosario, Izzo, Carmine, Visco, Valeria, Damato, Antonio, Venturini, Eleonora, De Lucia, Massimiliano, Galasso, Gennaro, Migliarino, Serena, Rasile, Barbara, Ciccarelli, Michele, Vecchione, Carmine, and Carrizzo, Albino

Subjects
OMEGA-3 fatty acids, LYSINE, ANTHOCYANINS, VASCULAR resistance, CEREBROVASCULAR disease, MESENTERIC artery, VASOACTIVE intestinal peptide
Abstract

Omega-3 fatty acids have been shown to exert several beneficial effects in the prevention of cardiovascular and cerebrovascular diseases. The objective of the present study was to analyze the effects of a novel high-load omega-3 lysine complex, AvailOm®, its related constituents and a novel mixture of AvailOm® with specific vasoactive anthocyanins on vascular function in mice resistance artery. Pressure myograph was used to perform vascular reactivity studies. Nitric oxide and oxidative stress were assessed by difluorofluorescein diacetate and dihydroethidium, respectively. Increasing doses of AvailOm® exerted a dose-response vasorelaxation via AMPK-eNOS-mediated signaling. Omega-3 Ethyl Ester was identified as the main bioactive derivative of AvailOm®, being capable of inducing vasorelaxant action to the same extent of entire product. The combination of AvailOm® with a mix of potent vasoactive anthocyanins (C3-glu + DP3-glu + Mal3-glu + Mal3-gal + PEO3-gal), strongly protected mesenteric arteries from vascular dysfunction and oxidative stress evoked by oxidized-LDL. These data demonstrate for the first time the direct effects of AvailOm® on resistance arteries. The evidence that the combination of specific vasoactive anthocyanins and AvailOm® further enhanced the vasculoprotective properties of these compounds, may offer new promising perspectives for preventing the onset of cardiovascular and cerebrovascular events. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Author

Visco, Valeria, primary, Pascale, Antonietta Valeria, additional, Virtuoso, Nicola, additional, Mongiello, Felice, additional, Cinque, Federico, additional, Gioia, Renato, additional, Finelli, Rosa, additional, Mazzeo, Pietro, additional, Manzi, Maria Virginia, additional, Morisco, Carmine, additional, Rozza, Francesco, additional, Izzo, Raffaele, additional, Cerasuolo, Federica, additional, Ciccarelli, Michele, additional, and Iaccarino, Guido, additional

Published
2020
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43. Larger blood pressure reduction by fixed-dose compared to free dose combination therapy of ace inhibitor and calcium antagonist in hypertensive patients

Author

Visco, Valeria, Finelli, Rosa, Pascale, Antonietta Valeria, Giannotti, Rocco, Fabbricatore, Davide, Ragosa, Nicola, Ciccarelli, Michele, and Iaccarino, Guido

Subjects
ACE Inhibitors, Blood pressure control, Hypertension, Combination therapy, Calcium antagonist
Abstract

The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily fixed (Fixed) over free doses in separate administrations combination therapy in hypertensives. In a population of 39 consecutive outpatient patients referred to the departmental Hypertension clinic of the University Hospital of Salerno Medical School with the first diagnosis of arterial hypertension, we tested the hypothesis that the Fixed achieve a better control of blood pressure than the Free combination. Patients were randomized to either strategy and after 3 months patients underwent a clinical assessment to evaluate the antihypertensive effect. The two groups, matched for anthropometric and clinical parameters, received Amlodipine (5-10 mg/daily) and Perindopril (5-10 mg/daily). Perindopril and Amlodipine doses did not significantly differ between the two groups. After 3 months BP control was improved in both groups and BP targets were similarly reached in both groups (SBP; Fixed: 61.54%; Free 69.23%; n.s. DPB; Fixed: 80.77%; Free 84.62%; n.s.). The reduction in systolic blood pressure was similar in both groups (Fixed:7.64±2.49%; Free: 7.81±4.00%, n.s.), while the reduction of diastolic blood pressure was greater in the Fixed group (Fixed: 14.22±2.03%; Free: 4.92±5.00%, p

Published
2017
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46. Abstract 16382: Length of Food Chain is Crucial in Determining the Impact of Mediterranean Diet on Metabolic Syndrome and Cardiovascular Risk

Author

Santulli, Gaetano, Pascale, Valeria, Finelli, Rosa, Visco, Valeria, Coscioni, Enrico, Giannotti, Rocco, Massari, Angelo, Ciccarelli, Michele, and Iaccarino, Guido

Abstract

Introduction:Substantial evidence has shown that Mediterranean diet can reduce the risk of metabolic syndrome (MS). However, the development of retail distribution has radically changed food supply worldwide. For instance, in the Mediterranean area, industrial retail favors shipments of groceries from regions that are intensive producers of mass food, generating the long supply chain (LSC) of food; on the other hand, short supply chains (SSCs) typically involve local self-producers promoting local markets. To our knowledge, the role of food retail and distribution in the determination of the risk of developing MS has not been studied hitherto.Hypothesis:We hypothesized that food chain length could affect the risk of developing metabolic alterations such as MS in a population accustomed to Mediterranean diet.Methods:We compared the SSC of food, in which aliments are mainly produced in loco, usually with traditional and low-technology methodologies, to the LSC of food. MS was defined using the latest ?Harmonized Criteria? to diagnose MS [CirculationVol.120 (16), Pg.1640]. The study was registered in the ClincalTrial.govdatabase (NCT03305276).Results:We recruited 407 subjects (average age: 56 years; 59% males), all adhering to Mediterranean diet, living in rural or urbanized areas of Southern Italy. The most important source of food in rural areas is represented by locally grown vegetables and meat of courtyard animals (SSC), whereas in metropolitan areas people mainly eat retail food (LSC). The actual dietary habits were confirmed through a validate questionnaire, designed to distinguish SSC and LSC viaa specific score. No significant differences were observed between SSC and LSC groups in terms of common demographic and metabolic parameters. Intriguingly, we found that being on Mediterranean diet with a SSC significantly (p=0.007) reduced the prevalence of MS compared with LSC, a result that was confirmed after correcting for confounding variables.Conclusions:Taken together, our findings show for the first time that the length of food supply chain is an independent predictor of the risk of MS in a population accustomed to Mediterranean diet, supporting the importance of local food environments in the determination of cardiovascular risk.

Published
2019
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47. Accuracy of home blood pressure measurement: the ACCURAPRESS study - a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell'Ipertensione Arteriosa)

Author

Costantino, Mancusi, Valeria, Bisogni, Alessandro, Maloberti, Maria Virginia, Manzi, Valeria, Visco, Marco, Biolcati, Valentina, Giani, Francesco, Spannella, Silvia, Monticone, Francesca, Saladini, Giulia, Rivasi, Giada, Turrin, Giacomo, Pucci, Martino, Pengo, Fabio, Bertacchini, Claudio, Ferri, Guido, Grassi, Maria Lorenza, Muiesan, Letizia, Ristori, Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Mancusi, C, Bisogni, V, Maloberti, A, Manzi, M, Visco, V, Biolcati, M, Giani, V, Spannella, F, Monticone, S, Saladini, F, Rivasi, G, Turrin, G, Pucci, G, Pengo, M, Bertacchini, F, Ferri, C, Grassi, G, and Muiesan, M

Subjects
home blood pressure monitoring, ambulatory blood pressure monitoring, accuracy, Hypertension, Humans, Reproducibility of Results, Blood Pressure, measurement, Blood Pressure Monitoring, Ambulatory
Abstract

Purpose: Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. Materials and methods: The survey included 30 different items on how to perform the HBPM. It was developed by the ‘Young Investigators’ group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. Results: A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Conclusions: Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients.

Published
2022

48. Predictors of sacubitril/valsartan high dose tolerability in a real world population with HFrEF

Author

Valeria Visco, Ilaria Radano, Alfonso Campanile, Amelia Ravera, Angelo Silverio, Daniele Masarone, Giuseppe Pacileo, Michele Correale, Pietro Mazzeo, Giuseppe Dattilo, Francesco Giallauria, Alessandra Cuomo, Valentina Mercurio, Carlo Gabriele Tocchetti, Paola Di Pietro, Albino Carrizzo, Rodolfo Citro, Gennaro Galasso, Carmine Vecchione, Michele Ciccarelli, Visco, Valeria, Radano, Ilaria, Campanile, Alfonso, Ravera, Amelia, Silverio, Angelo, Masarone, Daniele, Pacileo, Giuseppe, Correale, Michele, Mazzeo, Pietro, Dattilo, Giuseppe, Giallauria, Francesco, Cuomo, Alessandra, Mercurio, Valentina, Tocchetti, Carlo Gabriele, Di Pietro, Paola, Carrizzo, Albino, Citro, Rodolfo, Galasso, Gennaro, Vecchione, Carmine, and Ciccarelli, Michele

Subjects
Male, Heart Failure, Tetrazoles, Angiotensin-Converting Enzyme Inhibitors, Stroke Volume, Middle Aged, Angiotensin Receptor Antagonists, Ventricular Dysfunction, Left, Humans, Valsartan, Female, Cardiology and Cardiovascular Medicine, Retrospective Studies, Aged
Abstract

The angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan (Sac/Val) demonstrated to be superior to enalapril in reducing hospitalizations, cardiovascular and all-cause mortality in patients with ambulatory heart failure and reduced ejection fraction (HFrEF), in particular when it is maximally up-titrated. Unfortunately, the target dose is achieved in less than 50% of HFrEF patients, thus undermining the beneficial effects on the outcomes. In this study, we aimed to evaluate the role of Sac/Val and its titration dose on reverse cardiac remodelling and determine which echocardiographic index best predicts the up-titration success.From January 2020 to June 2021, we retrospectively identified 95 patients (65.6 [59.1-72.8] years; 15.8% females) with chronic HFrEF who were prescribed Sac/Val from the HF Clinics of 5 Italian University Hospitals and evaluated the tolerability of Sac/Val high dose (the ability of the patient to achieve and stably tolerate the maximum dose) as the primary endpoint in the cohort. We used a multivariable logistic regression analysis, with a stepwise backward selection method, to determine the independent predictors of Sac/Val maximum dose tolerability, using, as candidate predictors, only variables with a P-value0.1 in the univariate analyses. Candidate predictors identified for the multivariable backward logistic regression analysis were age, sex, body mass index (BMI), chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), dyslipidaemia, atrial fibrillation, systolic blood pressure (SBP), baseline tolerability of ACEi/ARBs maximum dose, left ventricle global longitudinal strain (LVgLS), LV ejection fraction (EF), tricuspid annulus plane systolic excursion (TAPSE), right ventricle (RV) fractional area change (FAC), RV global and free wall longitudinal strain (RVgLS and RV-FW-LS). After the multivariable analysis, only one categorical (ACEi/ARBs maximum dose at baseline) and three continuous (younger age, higher SBP, and higher TAPSE), resulted significantly associated with the study outcome variable with a strong discriminatory capacity (area under the curve 0.874, 95% confidence interval (CI) (0.794-0.954) to predict maximum Sac/Val dose tolerability.Our study is the first to analyse the potential role of echocardiography and, in particular, of RV dysfunction, measured by TAPSE, in predicting Sac/Val maximum dose tolerability. Therefore, patients with RV dysfunction (baseline TAPSE16 mm, in our cohort) might benefit from a different strategy to titrate Sac/Val, such as starting from the lowest dose and/or waiting for a more extended period of observation before attempting with the higher doses.

Published
2022

49. The metabolic role of grk2 in insulin resistance and associated conditions

Author

Federica Andrea Cerasuolo, Paolo Poggio, Antonella Fiordelisi, Guido Iaccarino, Valeria Visco, Michele Ciccarelli, Maria Rosaria Rusciano, Daniela Sorriento, Sorriento, Daniela, Rusciano, Maria Rosaria, Visco, Valeria, Fiordelisi, Antonella, Cerasuolo, Federica Andrea, Poggio, Paolo, Ciccarelli, Michele, and Iaccarino, Guido

Subjects
0301 basic medicine, G-Protein-Coupled Receptor Kinase 2, medicine.medical_treatment, Diabetes, GRK2, Heart failure, Hypertension, Insulin resistance, Animals, Diabetes Mellitus, Diabetes Mellitus, Type 2, Heart Failure, Humans, Inflammation, Insulin, Insulin-Secreting Cells, Mice, Muscle, Skeletal, Myocardium, Peptides, Phenotype, Phosphorylation, Risk, Signal Transduction, Insulin Resistance, Review, Type 2 diabetes, 030204 cardiovascular system & hematology, 0302 clinical medicine, lcsh:QH301-705.5, biology, General Medicine, Skeletal, Muscle, Type 2, medicine.medical_specialty, 03 medical and health sciences, Diabetes mellitus, Internal medicine, medicine, G protein-coupled receptor kinase, business.industry, Beta adrenergic receptor kinase, medicine.disease, Internal ribosome entry site, 030104 developmental biology, Endocrinology, lcsh:Biology (General), diabete, biology.protein, business, Dyslipidemia
Abstract

Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.

Published
2021

50. Serum Uric Acid and Left Ventricular Mass in Essential Hypertension

Author

Valeria Visco, Antonietta Valeria Pascale, Nicola Virtuoso, Felice Mongiello, Federico Cinque, Renato Gioia, Rosa Finelli, Pietro Mazzeo, Maria Virginia Manzi, Carmine Morisco, Francesco Rozza, Raffaele Izzo, Federica Cerasuolo, Michele Ciccarelli, Guido Iaccarino, Visco, Valeria, Pascale, Antonietta Valeria, Virtuoso, Nicola, Mongiello, Felice, Cinque, Federico, Gioia, Renato, Finelli, Rosa, Mazzeo, Pietro, Manzi, Maria Virginia, Morisco, Carmine, Rozza, Francesco, Izzo, Raffaele, Cerasuolo, Federica, Ciccarelli, Michele, and Iaccarino, Guido

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, hypertension, Population, Renal function, Cardiovascular Medicine, 030204 cardiovascular system & hematology, left ventricular mass, Essential hypertension, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, uric acid, Internal medicine, medicine, risk factors, 030212 general & internal medicine, Hyperuricemia, education, Original Research, education.field_of_study, business.industry, medicine.disease, Blood pressure, risk factor, chemistry, lcsh:RC666-701, left ventricular ma, Hypertension, Hypertrophy, Left ventricular mass, Risk factors, Uric acid, Cohort, Cardiology, hypertrophy, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract

Serum uric acid (sUA) has been associated with cardiovascular risk. Although the recent mechanistic hypothesis poses the basis for the association between sUA and left ventricular mass index (LVMi), the issue remains poorly investigated in a clinical setup. Through a retrospective analysis of the database of the departmental Hypertension Clinic of University Hospital of Salerno Medical School, we identified 177 essential hypertensives (age 60.3 ± 13.3 years; 85 men), free from uric acid-modulating medications and severe chronic kidney disease, and whose sUA values, anthropometric, clinical, and echocardiographic data were available. In the studied cohort, the average duration of hypertension was 8.4 ± 7.1 years. LVMi associated with classical determinants, such as age, blood pressure, and kidney function, although after multivariate correction, only age remained significant. Also, sUA correlated positively with LVMi, as well as body size, metabolism, and kidney function. In a multivariate analysis, sUA confirmed the independent association with LVMi. Also, levels of sUA >5.6 mg/dl are associated with larger cardiac size. We confirmed our data in a replicate analysis performed in a larger population (1,379 hypertensives) from an independent clinic. Our results demonstrate that sUA increases with LVMi, and a cutoff of 5.6 mg/dl predict larger LV sizes. Our data suggest that hyperuricemia might help to stratify the risk of larger cardiac size in hypertensives.

Published
2020

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