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The article deals with the conceptual design of a habitable module conceived for long-duration space exploration missions. The pressurized habitation module was specifically sized for a near-Earth asteroid mission, named ‘humAn Exploration mission to a Near Earth Asteroid’. This mission is conceived as an intermediate step before going to further destinations and aims at testing technologies necessary for reaching more challenging targets. In accordance to the mission objectives, the habitation module was devised as a reusable space infrastructure, suitable for different exploration scenarios with only minor changes in the architecture/design. This article describes the design process that, starting from the mission statement, was followed to define the objectives, the requirements and the architecture of the module in terms of system and subsystem configuration. In particular, the habitation module was designed to safely sustain the life of four astronauts, for a mission to a near-Earth asteroid lasting about 6 months. The main subsystems of the habitation module were sized in order to provide the astronauts with the needed resources, support the activities during all operational phases, including the extra-vehicular activities on the asteroid’s surface and protect them against the external environment, with particular attention to space radiation, one of the most critical aspects of this kind of mission. In this regard, appropriate analyses were carried out for selecting the best shielding strategy. For the execution of the extra-vehicular activities on the asteroid surface, a dedicated airlock and specific extra-vehicular activity support tools were included. This article reports a detailed description of the subsystems and their innovative aspects. Starting from the mission phases and the related scenarios, different modes of operations were identified. System budgets were evaluated for the envisaged operational modes. This article illustrates both the applied methodologies and the results, highlighting the major criticalities to be faced (long exposure to space radiations, extra-vehicular activity operations on the asteroid surface) and the key technologies (radiation shielding, inflatable technology, extra-vehicular activity support tools). [ABSTRACT FROM AUTHOR]