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20,615 results on '"Virologie"'

2. The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P

Author

Virologie, Celbiologie, IOV CCB, Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Cellbiology, Luteijn, Rutger D, van Terwisga, Sypke R, Ver Eecke, Jill E, Onia, Liberty, Zaver, Shivam A, Woodward, Joshua J, Wubbolts, Richard W, Raulet, David H, van Kuppeveld, Frank J M, Virologie, Celbiologie, IOV CCB, Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Cellbiology, Luteijn, Rutger D, van Terwisga, Sypke R, Ver Eecke, Jill E, Onia, Liberty, Zaver, Shivam A, Woodward, Joshua J, Wubbolts, Richard W, Raulet, David H, and van Kuppeveld, Frank J M

Published
2024

3. Modulation of nucleotide metabolism by picornaviruses

Author

Virologie, Afd Chemical Biology and Drug Discovery, Veterinaire biochemie, Equine Musculoskeletal Biology, CS_Locomotion, Faculteit Diergeneeskunde, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Metabolomics, Nouwen, Lonneke V, Breeuwsma, Martijn, Zaal, Esther A, van de Lest, Chris H A, Buitendijk, Inge, Zwaagstra, Marleen, Balić, Pascal, Filippov, Dmitri V, Berkers, Celia R, van Kuppeveld, Frank J M, Virologie, Afd Chemical Biology and Drug Discovery, Veterinaire biochemie, Equine Musculoskeletal Biology, CS_Locomotion, Faculteit Diergeneeskunde, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Metabolomics, Nouwen, Lonneke V, Breeuwsma, Martijn, Zaal, Esther A, van de Lest, Chris H A, Buitendijk, Inge, Zwaagstra, Marleen, Balić, Pascal, Filippov, Dmitri V, Berkers, Celia R, and van Kuppeveld, Frank J M

Published
2024

4. Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Author

Virologie, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Kaiser, Franziska K, Hernandez, Mariana Gonzalez, Krüger, Nadine, Englund, Ellinor, Du, Wenjuan, Mykytyn, Anna Z, Raadsen, Mathijs P, Lamers, Mart M, Rodrigues Ianiski, Francine, Shamorkina, Tatiana M, Snijder, Joost, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Schreiner, Tom, Gruber-Dujardin, Eva, Bleyer, Martina, Batura, Olga, Erffmeier, Lena, Hinkel, Rabea, Rocha, Cheila, Mirolo, Monica, Drabek, Dubravka, Bosch, Berend-Jan, Emalfarb, Mark, Valbuena, Noelia, Tchelet, Ronen, Baumgärtner, Wolfgang, Saloheimo, Markku, Pöhlmann, Stefan, Grosveld, Frank, Haagmans, Bart L, Osterhaus, Albert D M E, Virologie, Afd Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Kaiser, Franziska K, Hernandez, Mariana Gonzalez, Krüger, Nadine, Englund, Ellinor, Du, Wenjuan, Mykytyn, Anna Z, Raadsen, Mathijs P, Lamers, Mart M, Rodrigues Ianiski, Francine, Shamorkina, Tatiana M, Snijder, Joost, Armando, Federico, Beythien, Georg, Ciurkiewicz, Malgorzata, Schreiner, Tom, Gruber-Dujardin, Eva, Bleyer, Martina, Batura, Olga, Erffmeier, Lena, Hinkel, Rabea, Rocha, Cheila, Mirolo, Monica, Drabek, Dubravka, Bosch, Berend-Jan, Emalfarb, Mark, Valbuena, Noelia, Tchelet, Ronen, Baumgärtner, Wolfgang, Saloheimo, Markku, Pöhlmann, Stefan, Grosveld, Frank, Haagmans, Bart L, and Osterhaus, Albert D M E

Published
2024

5. Low gH/gL (Sub)Species-Specific Antibody Levels Indicate Elephants at Risk of Fatal Elephant Endotheliotropic Herpesvirus Hemorrhagic Disease

Author

Immunologie, Virologie, Infectious Diseases and Immunology - Immunology, Infectious Diseases and Immunology - Virology, Hoornweg, Tabitha E., Schaftenaar, Willem, Rutten, Victor PMG, Haan, Cornelis de, Immunologie, Virologie, Infectious Diseases and Immunology - Immunology, Infectious Diseases and Immunology - Virology, Hoornweg, Tabitha E., Schaftenaar, Willem, Rutten, Victor PMG, and Haan, Cornelis de

Published
2024

6. Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge in mice

Author

Virologie, Sub Structural Biochemistry, Infectious Diseases and Immunology - Virology, Pascha, Mirte N., Ballegeer, Marlies, Roelofs, Marc C., Meuris, Leander, Albulescu, Irina C., Kuppeveld, Frank J. M. van, Hurdiss, Daniel L., Bosch, Berend-Jan, Zeev-Ben-Mordehai, Tzviya, Saelens, Xavier, Haan, Cornelis A. M. de, Virologie, Sub Structural Biochemistry, Infectious Diseases and Immunology - Virology, Pascha, Mirte N., Ballegeer, Marlies, Roelofs, Marc C., Meuris, Leander, Albulescu, Irina C., Kuppeveld, Frank J. M. van, Hurdiss, Daniel L., Bosch, Berend-Jan, Zeev-Ben-Mordehai, Tzviya, Saelens, Xavier, and Haan, Cornelis A. M. de

Published
2024

7. Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a Myosin Vb Splice Variant and Rab10

Author

Virologie, Infectious Diseases and Immunology - Virology, Lapierre, Lynne, Roland, Joseph T., Manning, Elizabeth H., Caldwell, Catherine, Glenn, Honor L., Vidalain, Pierre-Olivier, Tangy, Frederic, Hogue, Brenda G., Haan, Cornelis de, Goldenring, James R., Virologie, Infectious Diseases and Immunology - Virology, Lapierre, Lynne, Roland, Joseph T., Manning, Elizabeth H., Caldwell, Catherine, Glenn, Honor L., Vidalain, Pierre-Olivier, Tangy, Frederic, Hogue, Brenda G., Haan, Cornelis de, and Goldenring, James R.

Published
2024

8. Role of the pol gene enhancer in HIV-1 transcription and replication in myeloid infected cells

Author

Journées Francophones de Virologie 2024 (XXVI: 10-12 avril 2024: Bruxelles, Belgium), Marray, Tristan, Hernalsteens, Olivier, Verdikt, Roxane, Vanhulle, Caroline, Dutilleul, Antoine, Nestola, Lorena, Stiernon, Lara, Cristinelli, Sara SC, Verhasselt, Bruno, Galons, Hervé, Ciuffi, Angela, Sáez-Cirión, Asier, Rohr, Olivier, Van Lint, Carine, Journées Francophones de Virologie 2024 (XXVI: 10-12 avril 2024: Bruxelles, Belgium), Marray, Tristan, Hernalsteens, Olivier, Verdikt, Roxane, Vanhulle, Caroline, Dutilleul, Antoine, Nestola, Lorena, Stiernon, Lara, Cristinelli, Sara SC, Verhasselt, Bruno, Galons, Hervé, Ciuffi, Angela, Sáez-Cirión, Asier, Rohr, Olivier, and Van Lint, Carine

Abstract

info:eu-repo/semantics/published

Published
2024

9. Role of the cellular transcription factor Yin-Yang 1 (YY1) in the cis-regulatory region (IRR) of the Human Immunodeficiency Virus type 1 (HIV-1)

Author

XXVIes Journées Francophones de Virologie (2024-04-10 au 2024-04-12: Bruxelles, Campus Solbosch), Dutilleul, Antoine, Stiernon, Lara, Marray, Tristan, Claveria Rodriguez, Valentin, Hernalsteens, Olivier, Nestola, Lorena, Vanhulle, Caroline, Van Lint, Carine, XXVIes Journées Francophones de Virologie (2024-04-10 au 2024-04-12: Bruxelles, Campus Solbosch), Dutilleul, Antoine, Stiernon, Lara, Marray, Tristan, Claveria Rodriguez, Valentin, Hernalsteens, Olivier, Nestola, Lorena, Vanhulle, Caroline, and Van Lint, Carine

Abstract

info:eu-repo/semantics/nonPublished

Published
2024

10. Identification of a new role for the E3-ubiquitin ligase activity of UHRF1 promoting HIV-1 transcriptional silencing

Author

Journées Francophones de Virologie (10 au 12 avril 2024: Université Libre de Bruxelles, Bruxelles, Belgique), Bendoumou, Maryam, Ait-Ammar, Amina, Nestola, Lorena, Van Lint, Carine, Journées Francophones de Virologie (10 au 12 avril 2024: Université Libre de Bruxelles, Bruxelles, Belgique), Bendoumou, Maryam, Ait-Ammar, Amina, Nestola, Lorena, and Van Lint, Carine

Abstract

info:eu-repo/semantics/published

Published
2024

11. Répression de la transactivation induite par Tax du promoteur du Virus T-lymphotrope humain de type 1 (HTLV-1) via le facteur cellulaire UHRF1

Author

Journées Francophones de Virologie (10-12 avril 2024: Bruxelles, Belgique), Greguor, Loris LG, Plant, Estelle, Peeters, Karim KP, Vreux, Laure, Martinelli, Valérie, Bendoumou, Maryam, Galais, Mathilde, Nestola, Lorena, Vanhulle, Caroline, Pique, Claudine, Cheret, Antoine, Van Lint, Carine, Journées Francophones de Virologie (10-12 avril 2024: Bruxelles, Belgique), Greguor, Loris LG, Plant, Estelle, Peeters, Karim KP, Vreux, Laure, Martinelli, Valérie, Bendoumou, Maryam, Galais, Mathilde, Nestola, Lorena, Vanhulle, Caroline, Pique, Claudine, Cheret, Antoine, and Van Lint, Carine

Abstract

Le virus T-lymphotrope humain de type 1 (HTLV-1) est un rétrovirus responsable d’uncancer agressif appelé leucémie à cellules T de l'adulte, pour lequel il n'existe actuellementaucun traitement efficace. La transcription sens à partir de la Longue Répétition Terminale 5'(LTR5’) est généralement réprimée ou exprimée de manière intermittente in vivo, permettantau virus d'échapper au système immunitaire et d'induire le développement tumoral. La protéinevirale Tax joue un rôle important dans la régulation transcriptionnelle du HTLV-1 entransactivant le promoteur LTR5’. Nous avons précédemment démontré le rôle du facteurcellulaire UHRF1 dans la répression épigénétique du promoteur LTR5’ viral en conditionsbasales. Ici, nous avons étudié le rôle d’UHRF1 dans la transactivation induite par Tax duLTR5’ viral.Nos résultats ont montré qu’UHRF1 réprime la transactivation du promoteur du HTLV-1par Tax dans des conditions de transfection transitoire. De plus, nous avons mis en évidencela colocalisation et l’interaction entre UHRF1 et Tax via les domaines SRA et RING d’UHRF1.Dans des conditions de surexpression, nous avons observé une diminution de l’expressionprotéique de Tax. Cependant, nous observons le même effet au niveau des transcrits de Tax,suggérant un rôle d’UHRF1 sur le promoteur CMV du plasmide d’expression de Tax. Nousavons donc réalisé des expériences similaires avec des plasmides d’expression contenantd’autres gènes en aval du promoteur CMV. Nous avons observé des effets variables d’unplasmide à l’autre, suggérant un rôle d’UHRF1 au niveau des transcrits et non pas dupromoteur CMV.En conclusion, cette étude démontre un effet répresseur d'UHRF1 sur la transactivationpar Tax du promoteur du HTLV-1. UHRF1 est donc capable de réprimer l’expression virale enconditions basale et de transactivation, suggérant UHRF1 comme une excellente ciblepotentielle pour le développement de nouvelles stratégies thérapeutiques contre l'infection parle HTLV-1 et contre l'ATL., info:eu-repo/semantics/published

Published
2024

12. Rôle du facteur cellulaire BCL11b dans la répression transcriptionnelle du Virus T-Lymphotrope humain de type 1 (HTLV-1)

Author

XXVI èmes Journées Francophones de Virologie (10 au 12-04-24: Bruxelles, Belgique), van Drielen, Sarah, Vreux, Laure, Plant, Estelle, Hernalsteens, Olivier, Peloponese, Jean Marie, Galais, Mathilde, Santangelo, Marion, Vanhulle, Caroline, Fauquenoy, Sylvain, Robette, Gwenaelle, Martinelli, Valérie, Bellefroid, Maxime, Nestola, Lorena, Tram, Julie, Rodari, Anthony, Ait-Ammar, Amina, Greguor, Loris, Pique, Claudine, Cheret, Antoine, Rohr, Olivier, Van Lint, Carine, Schwartz, Christian, XXVI èmes Journées Francophones de Virologie (10 au 12-04-24: Bruxelles, Belgique), van Drielen, Sarah, Vreux, Laure, Plant, Estelle, Hernalsteens, Olivier, Peloponese, Jean Marie, Galais, Mathilde, Santangelo, Marion, Vanhulle, Caroline, Fauquenoy, Sylvain, Robette, Gwenaelle, Martinelli, Valérie, Bellefroid, Maxime, Nestola, Lorena, Tram, Julie, Rodari, Anthony, Ait-Ammar, Amina, Greguor, Loris, Pique, Claudine, Cheret, Antoine, Rohr, Olivier, Van Lint, Carine, and Schwartz, Christian

Abstract

0, info:eu-repo/semantics/published

Published
2024

13. Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases

Author

Infectiebiologie, Infectious Diseases and Immunology - Infection Biology, Virologie, Infectious Diseases and Immunology - Virology, Defourny, Kyra A Y, Pei, Xinyi, van Kuppeveld, Frank J M, Nolte-T Hoen, Esther N M, Infectiebiologie, Infectious Diseases and Immunology - Infection Biology, Virologie, Infectious Diseases and Immunology - Virology, Defourny, Kyra A Y, Pei, Xinyi, van Kuppeveld, Frank J M, and Nolte-T Hoen, Esther N M

Published
2024

14. Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection

Author

Afd Biomol.Mass Spect. and Proteomics, Virologie, Pathobiologie, Faculteit Diergeneeskunde, Veterinaire biochemie, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Cancer, Cell Biology, Metabolism & Cancer - Metabolomics, Veth, Tim S, Nouwen, Lonneke V, Zwaagstra, Marleen, Lyoo, Heyrhyoung, Wierenga, Kathryn A, Westendorp, Bart, Altelaar, Maarten A F M, Berkers, Celia, van Kuppeveld, Frank J M, Heck, Albert J R, Afd Biomol.Mass Spect. and Proteomics, Virologie, Pathobiologie, Faculteit Diergeneeskunde, Veterinaire biochemie, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Infectious Diseases and Immunology - Virology, Cell Biology, Metabolism & Cancer - Cancer, Cell Biology, Metabolism & Cancer - Metabolomics, Veth, Tim S, Nouwen, Lonneke V, Zwaagstra, Marleen, Lyoo, Heyrhyoung, Wierenga, Kathryn A, Westendorp, Bart, Altelaar, Maarten A F M, Berkers, Celia, van Kuppeveld, Frank J M, and Heck, Albert J R

Published
2024

15. Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry

Author

Virologie, Infectious Diseases and Immunology - Virology, Yang, Yong-Le, Wang, Bin, Li, Wentao, Cai, Hou-Li, Qian, Qian-Yu, Qin, Yu, Shi, Fang-Shu, Bosch, Berend-Jan, Huang, Yao-Wei, Virologie, Infectious Diseases and Immunology - Virology, Yang, Yong-Le, Wang, Bin, Li, Wentao, Cai, Hou-Li, Qian, Qian-Yu, Qin, Yu, Shi, Fang-Shu, Bosch, Berend-Jan, and Huang, Yao-Wei

Published
2024

16. Drug repurposing screens identify Tubercidin as a potent antiviral agent against porcine nidovirus infections

Author

Virologie, Infectious Diseases and Immunology - Virology, Wang, Tianliang, Zheng, Guanmin, Chen, Zilu, Wang, Yue, Zhao, Chenxu, Li, Yaqin, Yuan, Yixin, Duan, Hong, Zhu, Hongsen, Yang, Xia, Li, Wentao, Du, Wenjuan, Li, Yongtao, Li, Dongliang, Virologie, Infectious Diseases and Immunology - Virology, Wang, Tianliang, Zheng, Guanmin, Chen, Zilu, Wang, Yue, Zhao, Chenxu, Li, Yaqin, Yuan, Yixin, Duan, Hong, Zhu, Hongsen, Yang, Xia, Li, Wentao, Du, Wenjuan, Li, Yongtao, and Li, Dongliang

Published
2024

18. Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain

Author

Rodon, Jordi, Mykytyn, Anna Z, Te, Nigeer, Okba, Nisreen M A, Lamers, Mart M, Pailler-García, Lola, Cantero, Guillermo, Albulescu, Irina, Bosch, Berend-Jan, Peiris, Malik, Bensaid, Albert, Vergara-Alert, Júlia, Haagmans, Bart L, Segalés, Joaquim, Virologie, Virologie, and Virology

Subjects
Microbiology (medical), Camelus, Herpesvirus 1, Epidemiology, Herpesvirus 1, Cercopithecine, Cercopithecine, New World, Dromedary camels, Virus Shedding, Infectious Diseases, SDG 3 - Good Health and Well-being, Camelids, Middle East Respiratory Syndrome Coronavirus, Animals, Humans, Coronavirus Infections, Camelids, New World, Respiratory syndrome coronavirus
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which might explain why they outcompete clade C strains in the Arabian Peninsula.

Published
2023

20. Depressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH)

Author

Salmon, D., Usubillaga, R., Sogni, P., Terris, B., Tremeaux, P., Katlama, C., Valantin, M.A., Stitou, H., Simon, A., Cacoub, P., Nafissa, S., Benhamou, Y., Charlotte, F., Fourati, Virologie: S., Poizot-Martin, I., Zaegel, O., Laroche, H., Tamalet, C., Pialoux, G., Chas, J., Callard, P., Bendjaballah, F., Amiel, C., Le Pendeven, C., Marchou, B., Alric, L., Barange, K., Metivier, S., Selves, J., Larroquette, F., Rosenthal, E., Infectiologie, Naqvi, A., Rio, V., Haudebourg, J., Saint-Paul, M.C., Monte, A. De, Giordanengo, V., Partouche, C., Bouchaud, O., Martin, A., Ziol, M., Baazia, Y., Iwaka-Bande, V., Gerber, A., Uzan, M., Bicart-See, A., Garipuy, D., Ferro-Collados, M.J., Virologie, Nicot, F., Gervais, A., Yazdanpanah, Y., Adle-Biassette, H., Alexandre, G., Peytavin, G., Lascoux-Combe, C., Molina, J.M., Bertheau, P., Chaix, M.L., Delaugerre, C., Maylin, S., Lacombe, K., Bottero, J., Krause, J., Girard, P.M., Wendum, D., Cervera, P., Adam, J., Viala, C., Vittecocq, D., Goujard, C., Quertainmont, Y., Teicher, E., Pallier, C., Lortholary, O., Duvivier, C., Rouzaud, C., Lourenco, J., Touam, F., Louisin, C., Avettand-Fenoel, V., Gardiennet, E., Mélard, A., Neau, D., Ochoa, A., Blanchard, E., Castet-Lafarie, S., Cazanave, C., Malvy, D., Dupon, M., Dutronc, H., Dauchy, F., Lacaze-Buzy, L., Desclaux, A., Bioulac-Sage, P., Trimoulet, P., Reigadas, S., Morlat, P., Lacoste, D., Bonnet, F., Bernard, N., Hessamfar, M., J, Paccalin, F., Martell, C., Pertusa, M.C., Vandenhende, M., Mercié, P., Pistone, T., Receveur, M.C., Méchain, M., Duffau, P., Rivoisy, C., Faure, I., Caldato, S., Bellecave, P., Tumiotto, C., Pellegrin, J.L., Viallard, J.F., Lazzaro, E., Greib, C., Zucman, D., Majerholc, C., Brollo, M., Farfour, E., Boué, F., Devoto, J. Polo, Kansau, I., Chambrin, V., Pignon, C., Berroukeche, L., Fior, R., Martinez, V., Abgrall, S., Favier, M., Deback, C., Lévy, Y., Dominguez, S., Lelièvre, J.D., Lascaux, A.S., Melica, G., Billaud, E., Raffi, F., Allavena, C., Reliquet, V., Boutoille, D., Biron, C., Lefebvre, M., Hall, N., Bouchez, S., Rodallec, A., Le Guen, L., Hemon, C., Miailhes, P., Peyramond, D., Chidiac, C., Ader, F., Biron, F., Boibieux, A., Cotte, L., Ferry, T., Perpoint, T., Koffi, J., Zoulim, F., Bailly, F., Lack, P., Maynard, M., Radenne, S., Amiri, M., Valour, F., Augustin-Normand, C., Scholtes, C., Le-Thi, T.T., Piroth, L., Chavanet, P., Duong Van Huyen, M., Buisson, M., Waldner-Combernoux, A., Mahy, S., Salmon Rousseau, A., Martins, C., Aumaître, H., Galim, S., Bani-Sadr, F., Lambert, D., Nguyen, Y., Berger, J.L., Hentzien, M., Brodard, V., Rey, D., Partisani, M., Batard, M.L., Cheneau, C., Priester, M., Bernard-Henry, C., de Mautort, E., Fischer, P., Gantner, P., Fafi-Kremer, S., Roustant, F., Platterier, P., Kmiec, I., Traore, L., Lepuil, S., Parlier, S., Sicart-Payssan, V., Bedel, E., Anriamiandrisoa, S., Pomes, C., Mole, M., Bolliot, C., Catalan, P., Mebarki, M., Adda-Lievin, A., Thilbaut, P., Ousidhoum, Y., Makhoukhi, F.Z., Braik, O., Bayoud, R., Gatey, C., Pietri, M.P., Le Baut, V., Ben Rayana, R., Bornarel, D., Chesnel, C., Beniken, D., Pauchard, M., Akel, S., Lions, C., Ivanova, A., Ritleg, A.-S., Debreux, C., Chalal, L., Zelie, J., Hue, H., Soria, A., Cavellec, M., Breau, S., Joulie, A., Fisher, P., Gohier, S., Croisier-Bertin, D., Ogoudjobi, S., Brochier, C., Thoirain-Galvan, V., Le Cam, M., Wittkop, L., Esterle, L., Izopet, J., Serfaty, L., Paradis, V., Spire, B., Carrieri, P., Zaegel-Faucher, O., Meyer, L., Boufassa, F., Autran, B., Roque, A.M., Solas, C., Fontaine, H., Costagliola, D., Petrov-Sanchez, V., Levier, A., P. Carrieri, Chalouni, M., Conte, V., Dequae-Merchadou, L., Desvallées, M., Gilbert, C., Gillet, S., Guillochon, Q., Khan, C., Knight, R., Marcellin, F., Michel, L., Mora, M., Protopopescu, C., Roux, P., Barré, T., Ramier, C., Sow, A., Di Beo, V., Bureau, M., Marcellin, Fabienne, Brégigeon-Ronot, Sylvie, Ramier, Clémence, Protopopescu, Camelia, Gilbert, Camille, Di Beo, Vincent, Duvivier, Claudine, Bureau-Stoltmann, Morgane, Rosenthal, Eric, Wittkop, Linda, Salmon-Céron, Dominique, Carrieri, Patrizia, Sogni, Philippe, and Barré, Tangui

Published
2023
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21. Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

Author

Okba, Nisreen M A, Widjaja, Ivy, van Dieren, Brenda, Aebischer, Andrea, van Amerongen, Geert, de Waal, Leon, Stittelaar, Koert J, Schipper, Debby, Martina, Byron, van den Brand, Judith M A, Beer, Martin, Bosch, Berend-Jan, Haagmans, Bart L, LS Virologie, VPDC pathologie, dPB I&I, dPB CR, Virologie, dI&I I&I-1, Virology, LS Virologie, VPDC pathologie, dPB I&I, dPB CR, Virologie, and dI&I I&I-1

Subjects
0301 basic medicine, Epidemiology, viruses, Antibody Affinity, medicine.disease_cause, Antibodies, Viral, Virus Replication, Immunogenicity, Vaccine, Middle East Respiratory Syndrome Coronavirus/immunology, Drug Discovery, Antibodies, Viral/immunology, Viral/immunology, Antigen Presentation, Chemistry, Immunogenicity, General Medicine, Articles, Antibodies, Neutralizing/immunology, Spike Glycoprotein, Vaccination, Infectious Diseases, Spike Glycoprotein, Coronavirus, Spike Glycoprotein, Coronavirus/biosynthesis, Middle East Respiratory Syndrome Coronavirus, Female, Rabbits, Coronavirus Infections, Research Article, Protein Binding, spytag-spycatcher, Middle East respiratory syndrome coronavirus, 030106 microbiology, Antigen presentation, Immunology, Genetic Vectors, rabbit, Enzyme-Linked Immunosorbent Assay, Microbiology, Antibodies, Coronavirus Infections/immunology, 03 medical and health sciences, Immune system, Protein Domains, MERS-coronavirus, Neutralization Tests, Virology, medicine, Animals, Humans, Avidity, lumazine synthase, Binding Sites, SARS-CoV-2, Viral Vaccines, spike, biochemical phenomena, metabolism, and nutrition, Antibodies, Neutralizing, Neutralizing/immunology, Heptad repeat, 030104 developmental biology, HEK293 Cells, Viral Vaccines/immunology, Viral replication, i301, Antibody Formation, Parasitology, Coronavirus/biosynthesis, Vaccine
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2, and receptor binding domain (RBD) ─ and tested their immunogenicity and protective capacity in rabbits. Using a “plug-and-display” SpyTag/SpyCatcher system, we coupled RBD to lumazine synthase (LS) particles producing multimeric RBD-presenting particles (RBD-LS). RBD-LS vaccination induced antibody responses of high magnitude and quality (avidity, MERS-CoV neutralizing capacity, and mucosal immunity) with cross-clade neutralization. The antibody responses were associated with blocking viral replication and upper and lower respiratory tract protection against MERS-CoV infection in rabbits. This arrayed multivalent presentation of the viral RBD using the antigen-SpyTag/LS-SpyCatcher is a promising MERS-CoV vaccine candidate and this platform may be applied for the rapid development of vaccines against other emerging viruses such as SARS-CoV-2.

Published
2020

22. A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Author

Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, Li, Wentao, Okba, Nisreen M A, Albulescu, Irina, Widjaja, Ivy, van Dieren, Brenda, Fernandez-Delgado, Raul, Sola, Isabel, Hurdiss, Daniel L, Daramola, Olalekan, Grosveld, Frank, van Kuppeveld, Frank J M, Haagmans, Bart L, Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan, Virologie, dI&I I&I-1, LS Virologie, Cell biology, Virology, Virologie, dI&I I&I-1, and LS Virologie

Subjects
0301 basic medicine, Chemistry(all), Protein Conformation, viruses, General Physics and Astronomy, Antibodies, Viral, medicine.disease_cause, Biochemistry, Epitopes, Mice, 0302 clinical medicine, Protein structure, skin and connective tissue diseases, Coronavirus, chemistry.chemical_classification, Multidisciplinary, virus diseases, Spike Glycoprotein, Coronavirus, Monoclonal, Antibody, Coronavirus Infections, Camelus, medicine.drug_class, Science, Protein subunit, Cross Reactions, Biology, Physics and Astronomy(all), Antibodies, Monoclonal, Humanized, Monoclonal antibody, Article, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, Animals, Humans, SARS-CoV-2, Biochemistry, Genetics and Molecular Biology(all), General Chemistry, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Antibodies, Neutralizing, Virology, respiratory tract diseases, Protein Subunits, 030104 developmental biology, chemistry, Viral infection, biology.protein, Glycoprotein, 030217 neurology & neurosurgery, Genetics and Molecular Biology(all)
Abstract

The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines. Structural studies show exposed sites on the spike trimer that might be targeted by antibodies with cross-species specificity. Here we isolated two human monoclonal antibodies from immunized humanized mice that display a remarkable cross-reactivity against distinct spike proteins of betacoronaviruses including SARS-CoV, SARS-CoV-2, MERS-CoV and the endemic human coronavirus HCoV-OC43. Both cross-reactive antibodies target the stem helix in the spike S2 fusion subunit which, in the prefusion conformation of trimeric spike, forms a surface exposed membrane-proximal helical bundle. Both antibodies block MERS-CoV infection in cells and provide protection to mice from lethal MERS-CoV challenge in prophylactic and/or therapeutic models. Our work highlights an immunogenic and vulnerable site on the betacoronavirus spike protein enabling elicitation of antibodies with unusual binding breadth., Here, the authors report the isolation and characterization of two human monoclonal antibodies (mAbs) from immunized mice with trimeric spike ectodomains of three human betacoronaviruses HCoV-OC43, SARS-CoV and MERSCoV, and show that while exhibiting cross-reactivity, the mAbs only neutralize MERS-CoV but not SARS-CoV nor SARS-CoV-2, likely due to the subtle epitope differences in the spike S2 fusion subunit.

Published
2021

23. Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

Author

Sikkema, Reina S, Tobias, Tijs, Oreshkova, Nadia, de Bruin, Erwin, Okba, Nisreen, Chandler, Felicity, Hulst, Marcel M, Rodon, Jordi, Houben, Manon, van Maanen, Kees, Bultman, Hans, Meester, Marina, Gerhards, Nora M, Bouwknegt, Martijn, Urlings, Bert, Haagmans, Bart, Kluytmans, Jan, Geurtsvan Kessel, Corine H, van der Poel, Wim H M, Koopmans, Marion P G, Stegeman, Arjan, FAH GZ varken, dFAH AVR, dFAH I&I, LS Virologie, FAH veterinaire epidemiologie, Producció Animal, Sanitat Animal, FAH GZ varken, dFAH AVR, dFAH I&I, LS Virologie, FAH veterinaire epidemiologie, and Virology

Subjects
Letter, Bioinformatica & Diermodellen, Coronaviruses, Epidemiology, Swine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Infectious and parasitic diseases, RC109-216, Biology, medicine.disease_cause, Microbiology, SDG 3 - Good Health and Well-being, Virology, antibody, Bio-informatics & Animal models, Drug Discovery, Replication (statistics), medicine, Animals, Public Health Surveillance, Epidemiology, Bio-informatics & Animal models, One Health, Animal species, Netherlands, Retrospective Studies, Coronavirus, Epidemiologie, Swine Diseases, Transmission (medicine), SARS-CoV-2, fungi, COVID-19, food and beverages, Environmental Exposure, General Medicine, QR1-502, Virology & Molecular Biology, Virologie & Moleculaire Biologie, Infectious Diseases, Epidemiologie, Bioinformatica & Diermodellen, Parasitology
Abstract

In order to assess the risk of SARS-CoV-2 infection, transmission and reservoir development in swine, we combined results of an experimental and two observational studies. First, intranasal and intratracheal challenge of eight pigs did not result in infection, based on clinical signs and PCR on swab and lung tissue samples. Two serum samples returned a low positive result in virus neutralization, in line with findings in other infection experiments in pigs. Next, a retrospective observational study was performed in the Netherlands in the spring of 2020. Serum samples (N =417) obtained at slaughter from 17 farms located in a region with a high human case incidence in the first wave of the pandemic. Samples were tested with protein micro array, plaque reduction neutralization test and receptor-binding-domain ELISA. None of the serum samples was positive in all three assays, although six samples from one farm returned a low positive result in PRNT (titers 40-80). Therefore we conclude that serological evidence for large scale transmission was not observed. Finally, an outbreak of respiratory disease in pigs on one farm, coinciding with recent exposure to SARS-CoV-2 infected animal caretakers, was investigated. Tonsil swabs and paired serum samples were tested. No evidence for infection with SARS-CoV-2 was found. In conclusion, Although in both the experimental and the observational study few samples returned low antibody titer results in PRNT infection with SARS-CoV-2 was not confirmed. It was concluded that sporadic infections in the field cannot be excluded, but large-scale SARS-CoV-2 transmission among pigs is unlikely. info:eu-repo/semantics/publishedVersion

Published
2022

24. Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants

Author

Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z, Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J M, Hurdiss, Daniel L, Haagmans, Bart L, Grosveld, Frank, Bosch, Berend-Jan, Virologie, Cell biology, Virology, and Virologie

Subjects
SARS-CoV-2, Immunology, Coronavirus/genetics, antibody-mediated neutralization, heavy-chain-only antibody, Antibodies, Monoclonal, COVID-19, neutralization escape, Spike Glycoprotein, Antibodies, Spike Glycoprotein, Coronavirus/genetics, avidity, SARS-CoV-2/genetics, Cricetinae, Monoclonal, Immunology and Allergy, Animals, Humans, Immunoglobulin Heavy Chains/genetics
Abstract

Emerging SARS-CoV-2 variants have accrued mutations within the spike protein rendering most therapeutic monoclonal antibodies against COVID-19 ineffective. Hence there is an unmet need for broad-spectrum mAb treatments for COVID-19 that are more resistant to antigenically drifted SARS-CoV-2 variants. Here we describe the design of a biparatopic heavy-chain-only antibody consisting of six antigen binding sites recognizing two distinct epitopes in the spike protein NTD and RBD. The hexavalent antibody showed potent neutralizing activity against SARS-CoV-2 and variants of concern, including the Omicron sub-lineages BA.1, BA.2, BA.4 and BA.5, whereas the parental components had lost Omicron neutralization potency. We demonstrate that the tethered design mitigates the substantial decrease in spike trimer affinity seen for escape mutations for the hexamer components. The hexavalent antibody protected against SARS-CoV-2 infection in a hamster model. This work provides a framework for designing therapeutic antibodies to overcome antibody neutralization escape of emerging SARS-CoV-2 variants.

Published
2023

25. The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy

Author

van der Grein, Susanne G, Defourny, Kyra A Y, Rabouw, Huib H, Goerdayal, Soenita S, van Herwijnen, Martijn J C, Wubbolts, Richard W, Altelaar, Maarten, van Kuppeveld, Frank J M, Nolte-'t Hoen, Esther N M, Virologie, Celbiologie, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research, IOV CCB, Virologie, Celbiologie, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Centre for Biomolecular Research, and IOV CCB

Subjects
Lysis, Picornavirus, viruses, Viral Proteins/metabolism, Mutant, General Physics and Astronomy, Antiviral Agents, General Biochemistry, Genetics and Molecular Biology, Virus, Flow cytometry, Virion/metabolism, Extracellular Vesicles, Viral Proteins, medicine, Autophagy, Encephalomyocarditis virus, Multidisciplinary, medicine.diagnostic_test, biology, Chemistry, Antiviral Agents/metabolism, Virion, Wild type, Extracellular Vesicles/metabolism, General Chemistry, Encephalomyocarditis virus/metabolism, biology.organism_classification, Virus Release, Cell biology
Abstract

Naked viruses can escape host cells before the induction of lysis via release in extracellular vesicles (EVs). These nanosized EVs cloak the secreted virus particles in a host-derived membrane, which alters virus-host interactions that affect infection efficiency and antiviral immunity. Currently, little is known about the viral and host factors regulating this form of virus release. Here, we assessed the role of the encephalomyocarditis virus (EMCV) Leader protein, a ‘viral security protein’ that subverts the host antiviral response. EV release upon infection with wildtype virus or a Leader-deficient mutant was characterized at the single particle level using high-resolution flow cytometry. Inactivation of the Leader abolished EV induction during infection and strongly reduced EV-enclosed virus release. We demonstrate that the Leader promotes the release of virions within EVs by stimulating a secretory arm of autophagy. This newly discovered role of the EMCV Leader adds to the variety of mechanisms via which this protein affects virus-host interactions. Moreover, these data provide first evidence for a crucial role of a non-structural viral protein in the non-lytic release of picornaviruses via packaging in EVs.

Published
2022

26. The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy

Author

Virologie, dB&C I&I, Celbiologie, LS Virologie, Afd Biomol.Mass Spect. and Proteomics, IOV CCB, dI&I I&I-1, van der Grein, Susanne G, Defourny, Kyra A Y, Rabouw, Huib H, Goerdayal, Soenita S, van Herwijnen, Martijn J C, Wubbolts, Richard W, Altelaar, Maarten, van Kuppeveld, Frank J M, Nolte-'t Hoen, Esther N M, Virologie, dB&C I&I, Celbiologie, LS Virologie, Afd Biomol.Mass Spect. and Proteomics, IOV CCB, dI&I I&I-1, van der Grein, Susanne G, Defourny, Kyra A Y, Rabouw, Huib H, Goerdayal, Soenita S, van Herwijnen, Martijn J C, Wubbolts, Richard W, Altelaar, Maarten, van Kuppeveld, Frank J M, and Nolte-'t Hoen, Esther N M

Published
2022

27. An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats

Author

Langereis, Martijn A, Albulescu, Irina C, Stammen-Vogelzangs, Judith, Lambregts, Morindy, Stachura, Ken, Miller, Suzan, Bosco-Lauth, Angela M, Hartwig, Airn E, Porter, Stephanie M, Allen, Michelle, Mogler, Mark, van Kuppeveld, Frank J M, Bosch, Berend-Jan, Vermeij, Paul, de Groof, Ad, Bowen, Richard A, Davis, Randy, Xu, Zach, Tarpey, Ian, LS Virologie, Virologie, dI&I I&I-1, LS Virologie, Virologie, and dI&I I&I-1

Subjects
Immunogen, viruses, Immunology, Alphavirus, medicine.disease_cause, Virus, Article, Antigen, RNA vaccines, medicine, Pharmacology (medical), Neutralizing antibody, RC254-282, Pharmacology, CATS, biology, SARS-CoV-2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, biology.organism_classification, Virology, Vaccination, Infectious Diseases, Venezuelan equine encephalitis virus, biology.protein, Immunologic diseases. Allergy
Abstract

Early in the SARS-CoV-2 pandemic concerns were raised regarding infection of new animal hosts and the effect on viral epidemiology. Infection of other animals could be detrimental by causing clinical disease, allowing further mutations, and bares the risk for the establishment of a non-human reservoir. Cats were the first reported animals susceptible to natural and experimental infection with SARS-CoV-2. Given the concerns these findings raised, and the close contact between humans and cats, we aimed to develop a vaccine candidate that could reduce SARS-CoV-2 infection and in addition to prevent spread among cats. Here we report that a Replicon Particle (RP) vaccine based on Venezuelan equine encephalitis virus, known to be safe and efficacious in a variety of animal species, could induce neutralizing antibody responses in guinea pigs and cats. The design of the SARS-CoV-2 spike immunogen was critical in developing a strong neutralizing antibody response. Vaccination of cats was able to induce high neutralizing antibody responses, effective also against the SARS-CoV-2 B.1.1.7 variant. Interestingly, in contrast to control animals, the infectious virus could not be detected in oropharyngeal or nasal swabs of vaccinated cats after SARS-CoV-2 challenge. Correspondingly, the challenged control cats spread the virus to in-contact cats whereas the vaccinated cats did not transmit the virus. The results show that the RP vaccine induces protective immunity preventing SARS-CoV-2 infection and transmission. These data suggest that this RP vaccine could be a multi-species vaccine useful to prevent infection and spread to and between animals should that approach be required.

Published
2021

29. Receptor Density-Dependent Motility of Influenza Virus Particles on Surface Gradients

Author

LS Virologie, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Hamming, P H Erik, Overeem, Nico J, Diestelhorst, Kevin, Fiers, Tren, Tieke, Malte, Vos, Gaël M, Boons, Geert-Jan P H, van der Vries, Erhard, Block, Stephan, Huskens, Jurriaan, LS Virologie, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Hamming, P H Erik, Overeem, Nico J, Diestelhorst, Kevin, Fiers, Tren, Tieke, Malte, Vos, Gaël M, Boons, Geert-Jan P H, van der Vries, Erhard, Block, Stephan, and Huskens, Jurriaan

Published
2023

30. Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain

Author

Virologie, Rodon, Jordi, Mykytyn, Anna Z, Te, Nigeer, Okba, Nisreen M A, Lamers, Mart M, Pailler-García, Lola, Cantero, Guillermo, Albulescu, Irina, Bosch, Berend-Jan, Peiris, Malik, Bensaid, Albert, Vergara-Alert, Júlia, Haagmans, Bart L, Segalés, Joaquim, Virologie, Rodon, Jordi, Mykytyn, Anna Z, Te, Nigeer, Okba, Nisreen M A, Lamers, Mart M, Pailler-García, Lola, Cantero, Guillermo, Albulescu, Irina, Bosch, Berend-Jan, Peiris, Malik, Bensaid, Albert, Vergara-Alert, Júlia, Haagmans, Bart L, and Segalés, Joaquim

Published
2023

32. Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants

Author

Virologie, Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z, Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J M, Hurdiss, Daniel L, Haagmans, Bart L, Grosveld, Frank, Bosch, Berend-Jan, Virologie, Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z, Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J M, Hurdiss, Daniel L, Haagmans, Bart L, Grosveld, Frank, and Bosch, Berend-Jan

Published
2023

33. Identification of Z-Tyr-Ala-CHN 2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2.

Author

Virologie, Doijen, Jordi, Temmerman, Koen, Van den Eynde, Christel, Diels, Annick, Van den Broeck, Nick, Van Gool, Michiel, Heo, Inha, Jaensch, Steffen, Zwaagstra, Marleen, Diosa Toro, Mayra, Chiu, Winston, De Jonghe, Steven, Leyssen, Pieter, Bojkova, Denisa, Ciesek, Sandra, Cinatl, Jindrich, Verschueren, Lore, Buyck, Christophe, Van Kuppeveld, Frank, Neyts, Johan, Van Loock, Marnix, Van Damme, Ellen, Virologie, Doijen, Jordi, Temmerman, Koen, Van den Eynde, Christel, Diels, Annick, Van den Broeck, Nick, Van Gool, Michiel, Heo, Inha, Jaensch, Steffen, Zwaagstra, Marleen, Diosa Toro, Mayra, Chiu, Winston, De Jonghe, Steven, Leyssen, Pieter, Bojkova, Denisa, Ciesek, Sandra, Cinatl, Jindrich, Verschueren, Lore, Buyck, Christophe, Van Kuppeveld, Frank, Neyts, Johan, Van Loock, Marnix, and Van Damme, Ellen

Published
2023

34. Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands

Author

Virologie, Sikkema, Reina S, Bruin, Erwin de, Ramakers, Christian, Bentvelsen, Robbert, Li, Wentao, Bosch, Berend-Jan, Westerhuis, Brenda, Haagmans, Bart, Koopmans, Marion P G, Fraaij, Pieter L A, Virologie, Sikkema, Reina S, Bruin, Erwin de, Ramakers, Christian, Bentvelsen, Robbert, Li, Wentao, Bosch, Berend-Jan, Westerhuis, Brenda, Haagmans, Bart, Koopmans, Marion P G, and Fraaij, Pieter L A

Published
2023

35. Failure to experimentally infect 10 days-old piglets with a cell culture-propagated infectious stock of a classical genotype 1a porcine epidemic diarrhea virus

Author

Virologie, Infectious Diseases and Immunology - Virology, Gerber, Priscilla F, Cao, Dianjun, Xiao, Chao-Ting, Chen, Qi, Lager, Kelly, Bosch, Berend Jan, Meng, Xiang-Jin, Halbur, Patrick G, Opriessnig, Tanja, Virologie, Infectious Diseases and Immunology - Virology, Gerber, Priscilla F, Cao, Dianjun, Xiao, Chao-Ting, Chen, Qi, Lager, Kelly, Bosch, Berend Jan, Meng, Xiang-Jin, Halbur, Patrick G, and Opriessnig, Tanja

Published
2023

36. Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats

Author

Virologie, Infectious Diseases and Immunology - Virology, Hartmann, Katrin, Egberink, Herman, Möstl, Karin, Addie, Diane D, Belák, Sándor, Boucraut-Baralon, Corine, Frymus, Tadeusz, Lloret, Albert, Hofmann-Lehmann, Regina, Marsilio, Fulvio, Pennisi, Maria Grazia, Tasker, Séverine, Thiry, Etienne, Truyen, Uwe, Hosie, Margaret J, Virologie, Infectious Diseases and Immunology - Virology, Hartmann, Katrin, Egberink, Herman, Möstl, Karin, Addie, Diane D, Belák, Sándor, Boucraut-Baralon, Corine, Frymus, Tadeusz, Lloret, Albert, Hofmann-Lehmann, Regina, Marsilio, Fulvio, Pennisi, Maria Grazia, Tasker, Séverine, Thiry, Etienne, Truyen, Uwe, and Hosie, Margaret J

Published
2023

37. Feline Infectious Peritonitis: European Advisory Board on Cat Diseases Guidelines

Author

Virologie, Infectious Diseases and Immunology - Virology, Tasker, Séverine, Addie, Diane D, Egberink, Herman, Hofmann-Lehmann, Regina, Hosie, Margaret J, Truyen, Uwe, Belák, Sándor, Boucraut-Baralon, Corine, Frymus, Tadeusz, Lloret, Albert, Marsilio, Fulvio, Pennisi, Maria Grazia, Thiry, Etienne, Möstl, Karin, Hartmann, Katrin, Virologie, Infectious Diseases and Immunology - Virology, Tasker, Séverine, Addie, Diane D, Egberink, Herman, Hofmann-Lehmann, Regina, Hosie, Margaret J, Truyen, Uwe, Belák, Sándor, Boucraut-Baralon, Corine, Frymus, Tadeusz, Lloret, Albert, Marsilio, Fulvio, Pennisi, Maria Grazia, Thiry, Etienne, Möstl, Karin, and Hartmann, Katrin

Published
2023

38. Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats

Author

Virologie, Infectious Diseases and Immunology - Virology, Pennisi, Maria Grazia, Belák, Sándor, Tasker, Séverine, Addie, Diane D, Boucraut-Baralon, Corine, Egberink, Herman, Frymus, Tadeusz, Hartmann, Katrin, Hofmann-Lehmann, Regina, Lloret, Albert, Marsilio, Fulvio, Thiry, Etienne, Truyen, Uwe, Möstl, Karin, Hosie, Margaret J, Virologie, Infectious Diseases and Immunology - Virology, Pennisi, Maria Grazia, Belák, Sándor, Tasker, Séverine, Addie, Diane D, Boucraut-Baralon, Corine, Egberink, Herman, Frymus, Tadeusz, Hartmann, Katrin, Hofmann-Lehmann, Regina, Lloret, Albert, Marsilio, Fulvio, Thiry, Etienne, Truyen, Uwe, Möstl, Karin, and Hosie, Margaret J

Published
2023

39. Sialoglycan binding triggers spike opening in a human coronavirus

Author

Sub Biomol.Mass Spectrometry & Proteom., Virologie, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Infectious Diseases and Immunology - Virology, Pronker, Matti F, Creutznacher, Robert, Drulyte, Ieva, Hulswit, Ruben J G, Li, Zeshi, van Kuppeveld, Frank J M, Snijder, Joost, Lang, Yifei, Bosch, Berend-Jan, Boons, Geert-Jan, Frank, Martin, de Groot, Raoul J, Hurdiss, Daniel L, Sub Biomol.Mass Spectrometry & Proteom., Virologie, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Infectious Diseases and Immunology - Virology, Pronker, Matti F, Creutznacher, Robert, Drulyte, Ieva, Hulswit, Ruben J G, Li, Zeshi, van Kuppeveld, Frank J M, Snijder, Joost, Lang, Yifei, Bosch, Berend-Jan, Boons, Geert-Jan, Frank, Martin, de Groot, Raoul J, and Hurdiss, Daniel L

Published
2023

40. Difference in respiratory syncytial virus-specific Fc-mediated antibody effector functions between children and adults

Author

Virologie, Immunologie, Infectious Diseases and Immunology - Immunology, Infectious Diseases and Immunology - Virology, Lakerveld, Anke J, Gelderloos, Anne T, Schepp, Rutger M, de Haan, Cornelis A M, van Binnendijk, Robert S, Rots, Nynke Y, van Beek, Josine, van Els, Cécile A C M, van Kasteren, Puck B, Virologie, Immunologie, Infectious Diseases and Immunology - Immunology, Infectious Diseases and Immunology - Virology, Lakerveld, Anke J, Gelderloos, Anne T, Schepp, Rutger M, de Haan, Cornelis A M, van Binnendijk, Robert S, Rots, Nynke Y, van Beek, Josine, van Els, Cécile A C M, and van Kasteren, Puck B

Published
2023

41. Antiviral responses are shaped by heterogeneity in viral replication dynamics

Author

Virologie, Infectious Diseases and Immunology - Virology, Bruurs, Lucas J M, Müller, Micha, Schipper, Jelle G, Rabouw, Huib H, Boersma, Sanne, van Kuppeveld, Frank J M, Tanenbaum, Marvin E, Virologie, Infectious Diseases and Immunology - Virology, Bruurs, Lucas J M, Müller, Micha, Schipper, Jelle G, Rabouw, Huib H, Boersma, Sanne, van Kuppeveld, Frank J M, and Tanenbaum, Marvin E

Published
2023

43. Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIb

Author

Virologie, Infectious Diseases and Immunology - Virology, Laajala, Mira, Zwaagstra, Marleen, Martikainen, Mari, Nekoua, Magloire Pandoua, Benkahla, Mehdi, Sane, Famara, Gervais, Emily, Campagnola, Grace, Honkimaa, Anni, Sioofy-Khojine, Amir-Babak, Hyöty, Heikki, Ojha, Ravi, Bailliot, Marie, Balistreri, Giuseppe, Peersen, Olve, Hober, Didier, Van Kuppeveld, Frank, Marjomäki, Varpu, Virologie, Infectious Diseases and Immunology - Virology, Laajala, Mira, Zwaagstra, Marleen, Martikainen, Mari, Nekoua, Magloire Pandoua, Benkahla, Mehdi, Sane, Famara, Gervais, Emily, Campagnola, Grace, Honkimaa, Anni, Sioofy-Khojine, Amir-Babak, Hyöty, Heikki, Ojha, Ravi, Bailliot, Marie, Balistreri, Giuseppe, Peersen, Olve, Hober, Didier, Van Kuppeveld, Frank, and Marjomäki, Varpu

Published
2023

44. Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis

Author

Virologie, Infectious Diseases and Immunology - Virology, Liu, Minglong, Morewood, Richard, Yoshisada, Ryoji, Pascha, Mirte N, Hopstaken, Antonius J P, Tarcoveanu, Eliza, Poole, David A, de Haan, Cornelis A M, Nitsche, Christoph, Jongkees, Seino A K, Virologie, Infectious Diseases and Immunology - Virology, Liu, Minglong, Morewood, Richard, Yoshisada, Ryoji, Pascha, Mirte N, Hopstaken, Antonius J P, Tarcoveanu, Eliza, Poole, David A, de Haan, Cornelis A M, Nitsche, Christoph, and Jongkees, Seino A K

Published
2023

45. H3N2 influenza A virus gradually adapts to human-type receptor binding and entry specificity after the start of the 1968 pandemic

Author

Virologie, Infectious Diseases and Immunology - Virology, Liu, Mengying, Bakker, A Sophie, Narimatsu, Yoshiki, van Kuppeveld, Frank J M, Clausen, Henrik, de Haan, Cornelis A M, de Vries, Erik, Virologie, Infectious Diseases and Immunology - Virology, Liu, Mengying, Bakker, A Sophie, Narimatsu, Yoshiki, van Kuppeveld, Frank J M, Clausen, Henrik, de Haan, Cornelis A M, and de Vries, Erik

Published
2023

46. Identification of Evolutionary Trajectories Shared across Human Betacoronaviruses

Author

Virologie, Infectious Diseases and Immunology - Virology, Escalera-Zamudio, Marina, Kosakovsky Pond, Sergei L, Martínez de la Viña, Natalia, Gutiérrez, Bernardo, Inward, Rhys P D, Thézé, Julien, van Dorp, Lucy, Castelán-Sánchez, Hugo G, Bowden, Thomas A, Pybus, Oliver G, Hulswit, Ruben J G, Virologie, Infectious Diseases and Immunology - Virology, Escalera-Zamudio, Marina, Kosakovsky Pond, Sergei L, Martínez de la Viña, Natalia, Gutiérrez, Bernardo, Inward, Rhys P D, Thézé, Julien, van Dorp, Lucy, Castelán-Sánchez, Hugo G, Bowden, Thomas A, Pybus, Oliver G, and Hulswit, Ruben J G

Published
2023

47. Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020–2022

Author

Klinische infectiologie en microb. lab., Virologie, FAH Evidence based Veterinary Medicine, Infectious Diseases and Immunology - KLIF, Infectious Diseases and Immunology - Virology, Duijvestijn, Mirjam B. H. M., Schuurman, Nancy N. M. P., Vernooij, Johannes C. M., Leeuwen, Michelle A. J. M. van, Bosch, Berend-Jan, Brand, Judith M. A. van den, Wagenaar, Jaap A., Kuppeveld, Frank J. M. van, Egberink, Herman F., Verhagen, Josanne H., Klinische infectiologie en microb. lab., Virologie, FAH Evidence based Veterinary Medicine, Infectious Diseases and Immunology - KLIF, Infectious Diseases and Immunology - Virology, Duijvestijn, Mirjam B. H. M., Schuurman, Nancy N. M. P., Vernooij, Johannes C. M., Leeuwen, Michelle A. J. M. van, Bosch, Berend-Jan, Brand, Judith M. A. van den, Wagenaar, Jaap A., Kuppeveld, Frank J. M. van, Egberink, Herman F., and Verhagen, Josanne H.

Published
2023

48. Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies

Author

Virologie, Infectious Diseases and Immunology - Virology, Zitzmann, Carolin, Dächert, Christopher, Schmid, Bianca, van der Schaar, Hilde, van Hemert, Martijn, Perelson, Alan S, van Kuppeveld, Frank J M, Bartenschlager, Ralf, Binder, Marco, Kaderali, Lars, Virologie, Infectious Diseases and Immunology - Virology, Zitzmann, Carolin, Dächert, Christopher, Schmid, Bianca, van der Schaar, Hilde, van Hemert, Martijn, Perelson, Alan S, van Kuppeveld, Frank J M, Bartenschlager, Ralf, Binder, Marco, and Kaderali, Lars

Published
2023

49. Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1

Author

Virologie, Infectious Diseases and Immunology - Virology, Gonzalez-Hernandez, Mariana, Kaiser, Franziska Karola, Steffen, Imke, Ciurkiewicz, Malgorzata, van Amerongen, Geert, Tchelet, Ronen, Emalfarb, Mark, Saloheimo, Markku, Wiebe, Marilyn G, Vitikainen, Marika, Albulescu, Irina C, Bosch, Berend-Jan, Baumgärtner, Wolfgang, Haagmans, Bart L, Osterhaus, Albert D M E, Virologie, Infectious Diseases and Immunology - Virology, Gonzalez-Hernandez, Mariana, Kaiser, Franziska Karola, Steffen, Imke, Ciurkiewicz, Malgorzata, van Amerongen, Geert, Tchelet, Ronen, Emalfarb, Mark, Saloheimo, Markku, Wiebe, Marilyn G, Vitikainen, Marika, Albulescu, Irina C, Bosch, Berend-Jan, Baumgärtner, Wolfgang, Haagmans, Bart L, and Osterhaus, Albert D M E

Published
2023

50. Kinetic analysis of paramyxovirus-sialoglycan receptor interactions reveals virion motility

Author

Afd Chemical Biology and Drug Discovery, Virologie, Infectious Diseases and Immunology - Virology, Wu, Xuesheng, Goebbels, Maite, Chao, Lemeng, Wennekes, Tom, van Kuppeveld, Frank J M, de Vries, Erik, de Haan, Cornelis A M, Afd Chemical Biology and Drug Discovery, Virologie, Infectious Diseases and Immunology - Virology, Wu, Xuesheng, Goebbels, Maite, Chao, Lemeng, Wennekes, Tom, van Kuppeveld, Frank J M, de Vries, Erik, and de Haan, Cornelis A M

Published
2023

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