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42. Die alpha-adrenerge Wirkung des Thymoxamins auf die Gefäße des Ziliarkörpers

Author

Virno M, Pellegrino N, Pecori-Giraldi J, and A. Planner-Terzaghi

Subjects
medicine.medical_specialty, Lagomorpha, biology, medicine.diagnostic_test, Chemistry, Pharmacology, biology.organism_classification, Ophthalmology, Blood pressure, Endocrinology, Ciliary body, medicine.anatomical_structure, Epinephrine, Internal medicine, Blood-Aqueous Barrier, medicine, Catecholamine, Paracentesis, Continuous recording, medicine.drug
Abstract

The effects of epinephrine on the permeability of the blood-aqueous barrier, stimulated by paracentesis of the anterior chamber, were studied in rabbits following alpha-adrenergic blocking by means of topical or systemic thymoxamine. The alpha-adrenergic block was tested by continuous recording of the systemic arterial blood pressure. The reversal of the vascular effects of epinephrine after administration of thymoxamine was demonstrated at the bloodaqueous barrier. The miotic property of thymoxamine is believed to have had no influence on our results.

Published
1983
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46. Propylenglycol. A new osmotic agent for ophthalmic uses

Author

Virno M, Pecori-Giraldi J, and Bietti Gb

Subjects
Blood Glucose, Male, Intraocular pressure, Dose, Eye Diseases, Nausea, Glaucoma, Administration, Oral, Cornea, Diabetes Complications, Ointments, Osmotic Pressure, Physiology (medical), Diabetes mellitus, Osmotherapy, Medicine, Edema, Humans, Intraocular Pressure, business.industry, medicine.disease, eye diseases, Sensory Systems, Ophthalmology, medicine.anatomical_structure, Propylene Glycols, Anesthesia, Bullous keratopathy, Female, sense organs, medicine.symptom, business
Abstract

Oral propylenglycol is able to lower intraocular pressure through an osmotic mechanism of action both in eyes suffering from different forms of glaucoma and in normal eyes. The dosage employed to obtain an effective reduction in intraocular pressure is 1.5 g./Kg of body weight. Duration of the tension-lowering effect is about 5 hours in most cases treated. The drop in pressure varied with the height of the pressure at the time therapy began - the higher the initial pressure, the greater the fall. The response varied with the strength of the dosages employed. Oral propylenglycol has proven particularly useful in longterm treatment of glaucomatous patients with diabetes, as it does not alter significantly blood sugar levels. The drug was fairly well tolerated and side-effects, such as headache, nausea, diarrhea and thirst were never reported. Only some patients complained of slight dizziness. The topical application of an ointment composed of propylenglycol has proven effective in clearing the cornea in 8 patients suffering from corneal edema of various origin, sometimes accompanied by bullous keratopathy.

Published
1973

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