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11 results on '"Vire, Emmanuelle"'

1. Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Author

Jones, Emma, Hill, Elizabeth, Linehan, Jacqueline, Nazari, Tamsin, Caulder, Adam, Codner, Gemma F., Hutchison, Marie, Mackenzie, Matthew, Farmer, Michael, Coysh, Thomas, De Oliveira, Michael Wiggins, Al-Doujaily, Huda, Sandberg, Malin, Viré, Emmanuelle, Cunningham, Thomas J., Asante, Emmanuel A., Brandner, Sebastian, Collinge, John, and Mead, Simon

Published
2024
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3. Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Author

Jones, Emma, Hummerich, Holger, Viré, Emmanuelle, Uphill, James, Dimitriadis, Athanasios, Speedy, Helen, Campbell, Tracy, Norsworthy, Penny, Quinn, Liam, Whitfield, Jerome, Linehan, Jacqueline, Jaunmuktane, Zane, Brandner, Sebastian, Jat, Parmjit, Nihat, Akin, How Mok, Tze, Ahmed, Parvin, Collins, Steven, Stehmann, Christiane, Sarros, Shannon, Kovacs, Gabor G, Geschwind, Michael D, Golubjatnikov, Aili, Frontzek, Karl, Budka, Herbert, Aguzzi, Adriano, Karamujić-Čomić, Hata, van der Lee, Sven J, Ibrahim-Verbaas, Carla A, van Duijn, Cornelia M, Sikorska, Beata, Golanska, Ewa, Liberski, Pawel P, Calero, Miguel, Calero, Olga, Sanchez-Juan, Pascual, Salas, Antonio, Martinón-Torres, Federico, Bouaziz-Amar, Elodie, Haïk, Stéphane, Laplanche, Jean-Louis, Brandel, Jean-Phillipe, Amouyel, Phillipe, Lambert, Jean-Charles, Parchi, Piero, Bartoletti-Stella, Anna, Capellari, Sabina, Poleggi, Anna, Ladogana, Anna, Pocchiari, Maurizio, Aneli, Serena, Matullo, Giuseppe, Knight, Richard, Zafar, Saima, Zerr, Inga, Booth, Stephanie, Coulthart, Michael B, Jansen, Gerard H, Glisic, Katie, Blevins, Janis, Gambetti, Pierluigi, Safar, Jiri, Appleby, Brian, Collinge, John, and Mead, Simon

Published
2020
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4. DNA methylation analysis of archival lymphoreticular tissues in Creutzfeldt-Jakob disease and the prevalence of vCJD infection in the UK

Author

Mead, Simon H, primary, Guntoro, Fernando, additional, Vire, Emmanuelle, additional, Giordani, Chiara, additional, Darwent, Lee, additional, Hummerich, Holger, additional, Linehan, Jacqueline, additional, Sinka, Kathy, additional, Jaunmuktane, Zane, additional, Brandner, Sebastian, additional, and Collinge, John, additional

Published
2022
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7. The Polycomb group protein EZH2 directly controls DNA methylation

Author

Vire, Emmanuelle, Brenner, Carmen, Deplus, Rachel, Blanchon, Loic, Fraga, Mario, Didelot, Celine, Morey, Lluis, Van Eynde, Aleyde, Bernard, David, Vanderwinden, Jean-Marie, Bollen, Mathieu, Esteller, Manel, Di Croce, Luciano, de Launoit, Yvan, and Fuks, Francois

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Emmanuelle Viré [1]; Carmen Brenner [1]; Rachel Deplus [1]; Loïc Blanchon [1]; Mario Fraga [2]; Céline Didelot [1]; Lluis Morey [3]; Aleyde Van Eynde [4]; David Bernard [1]; Jean-Marie [...]

Published
2006
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8. Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

Author

Xu, Hong, Xian, Jian, Vire, Emmanuelle, McKinney, Steven, Wong, Jason, Wei, Vivien, Tong, Rebecca, Kouzarides, Tony, Caldas, Carlos, and Aparicio, Samuel

Subjects
BRCA2 Protein, Chromatin Immunoprecipitation, endocrine system diseases, Reverse Transcriptase Polymerase Chain Reaction, Genes, BRCA2, Real-Time Polymerase Chain Reaction, Response Elements, female genital diseases and pregnancy complications, Article, Up-Regulation, Gene Expression Regulation, Neoplastic, Gene Knockout Techniques, Mice, Cell Line, Tumor, Neoplasms, Animals, Humans, Interferons, skin and connective tissue diseases, neoplasms, Oligonucleotide Array Sequence Analysis
Abstract

BRCA2 mutations are significantly associated with early-onset breast cancer, and the tumour-suppressing function of BRCA2 has been attributed to its involvement in homologous recombination (HR)-mediated DNA repair. In order to identify additional functions of BRCA2, we generated BRCA2-knockout HCT116 human colorectal carcinoma cells. Using genome-wide microarray analyses, we have discovered a link between the loss of BRCA2 and the up-regulation of a subset of interferon (IFN)-related genes, including APOBEC3F and APOBEC3G. The over-expression of IFN-related genes was confirmed in different human BRCA2(-/-) and mouse Brca2(-/-) tumour cell lines, and was independent of senescence and apoptosis. In isogenic wild-type BRCA2 cells, we observed over-expression of IFN-related genes after treatment with DNA-damaging agents, and following ionizing radiation. Cells with endogenous DNA damage because of defective BRCA1 or RAD51 also exhibited over-expression of IFN-related genes. Transcriptional activity of the IFN-stimulated response element (ISRE) was increased in BRCA2 knockout cells, and the expression of BRCA2 greatly decreased IFNα-stimulated ISRE reporter activity, suggesting that BRCA2 directly represses the expression of IFN-related genes through the ISRE. Finally, the colony-forming capacity of BRCA2 knockout cells was significantly reduced in the presence of either IFNβ or IFNγ, suggesting that IFNs may have potential as therapeutic agents in cancer cells with BRCA2 mutations. The GEO Accession No. for microarray analysis is GSE54830.

Published
2014

10. Myc represses transcription through recruitment of DNA methyltransferase corepressor

Author

UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service de dentisterie pédiatrique et de soins bucco-dentaires pour personnes à besoins particuliers, Brenner, Carmen, Deplus, Rachel, Didelot, Céline, Loriot, Axelle, Vire, Emmanuelle, De Smet, Charles, Gutierrez, Arantxa, Danovi, Davide, Bernard, David, Boon, Thierry, Pelicci, Pier Giuseppe, Amati, Bruno, Kouzarides, Tony, de Launoit, Yvan, Di Croce, Luciano, Fuks, François, UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, UCL - (SLuc) Service de dentisterie pédiatrique et de soins bucco-dentaires pour personnes à besoins particuliers, Brenner, Carmen, Deplus, Rachel, Didelot, Céline, Loriot, Axelle, Vire, Emmanuelle, De Smet, Charles, Gutierrez, Arantxa, Danovi, Davide, Bernard, David, Boon, Thierry, Pelicci, Pier Giuseppe, Amati, Bruno, Kouzarides, Tony, de Launoit, Yvan, Di Croce, Luciano, and Fuks, François

Abstract

The Myc transcription factor is an essential mediator of cell growth and proliferation through its ability to both positively and negatively regulate transcription. The mechanisms by which Myc silences gene expression are not well understood. The current model is that Myc represses transcription through functional interference with transcriptional activators. Here we show that Myc binds the corepressor Dnmt3a and associates with DNA methyltransferase activity in vivo. In cells with reduced Dnmt3a levels, we observe specific reactivation of the Myc-repressed p21Cip1 gene, whereas the expression of Myc-activated E-boxes genes is unchanged. In addition, we find that Myc can target Dnmt3a selectively to the promoter of p21Cip1. Myc is known to be recruited to the p21Cip1 promoter by the DNA-binding factor Miz-1. Consistent with this, we observe that Myc and Dnmt3a form a ternary complex with Miz-1 and that this complex can corepress the p21Cip1 promoter. Finally, we show that DNA methylation is required for Myc-mediated repression of p21Cip1. Our data identify a new mechanism by which Myc can silence gene expression not only by passive functional interference but also by active recruitment of corepressor proteins. Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell.

Published
2005

11. The Polycomb group protein EZH2 directly controls DNA methylation

Author

Vire, Emmanuelle, Brenner, Carmen, Deplus, Rachel, Blanchon, Loic, Fraga, Mario, Didelot, Celine, Morey, Lluis, Van Eynde, Aleyde, Bernard, David, Vanderwinden, Jean-Marie, Bollen, Mathieu, Esteller, Manel, Croce, Luciano Di, de Launoit, Yvan, and Fuks, Francois

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Emmanuelle Viré; Carmen Brenner; Rachel Deplus; Loïc Blanchon; Mario Fraga; Céline Didelot; Lluis Morey; Aleyde Van Eynde; David Bernard; Jean-Marie Vanderwinden; Mathieu Bollen; Manel Esteller; Luciano Di Croce; Yvan [...]

Published
2007
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