5 results on '"Vineer, H.R."'
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2. Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database
- Author
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Vineer, H.R., Morgan, E.R., Hertzberg, H., Bartley, D.J., Bosco, A., Charlier, J., Chartier, C., Claerebout, E., De Waal, T., Hendrickx, G., Hinney, B., Hoglund, Johan, Jezek, J., Kasny, M., Keane, O.M., Martínez Valladares, María, Mateus, T.L., Mcintyre, J., Mickiewicz, M., Munoz, A.M., Phythian, C.J., Ploeger, H.W., Rataj, A.V., Skuce, P.J., Simin, S., Sotiraki, S., Spinu, M., Stuen, S., Thamsborg, S.M., Vadlejch, J., Varady, M., Von Samson-Himmelstjerna, G., Rinaldi, L., European Commission, Livestock Helminth Research Alliance, University of Liverpool, Veterinary Medicines Directorate (UK), Scottish Government's Rural and Environment Science and Analytical Services, Ministerio de Economía y Competitividad (España), Ministry of Education, Youth and Sports (Czech Republic), Department for Environment, Food and Rural Affairs (UK), Martínez Valladares, María, and Martínez Valladares, María [0000-0002-3723-1895]
- Subjects
Europe ,Database ,Maps ,Prevalence ,Liver fluke ,Ruminants ,Anthelmintic resistance ,Gastrointestinal nematodes - Abstract
16 páginas, 2 tablas, 6 figuras., Helminth infections are ubiquitous in grazing ruminant production systems, and are responsible for significant costs and production losses. Anthelmintic Resistance (AR) in parasites is now widespread throughout Europe, although there are still gaps in our knowledge in some regions and countries. AR is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, and increased greenhouse gas emissions through increased parasitism and farm inputs. A better understanding of the extent of AR in Europe is needed to develop and advocate more sustainable parasite control approaches. A database of European published and unpublished AR research on gastrointestinal nematodes (GIN) and liver fluke (Fasciola hepatica) was collated by members of the European COST Action “COMBAR” (Combatting Anthelmintic Resistance in Ruminants), and combined with data from a previous systematic review of AR in GIN. A total of 197 publications on AR in GIN were available for analysis, representing 535 studies in 22 countries and spanning the period 1980–2020. Reports of AR were present throughout the European continent and some reports indicated high within-country prevalence. Heuristic sample size-weighted estimates of European AR prevalence over the whole study period, stratified by anthelmintic class, varied between 0 and 48%. Estimated regional (country) prevalence was highly heterogeneous, ranging between 0% and 100% depending on livestock sector and anthelmintic class, and generally increased with increasing research effort in a country. In the few countries with adequate longitudinal data, there was a tendency towards increasing AR over time for all anthelmintic classes in GIN: aggregated results in sheep and goats since 2010 reveal an average prevalence of resistance to benzimidazoles (BZ) of 86%, macrocyclic lactones except moxidectin (ML) 52%, levamisole (LEV) 48%, and moxidectin (MOX) 21%. All major GIN genera survived treatment in various studies. In cattle, prevalence of AR varied between anthelmintic classes from 0–100% (BZ and ML), 0–17% (LEV) and 0–73% (MOX), and both Cooperia and Ostertagia survived treatment. Suspected AR in F. hepatica was reported in 21 studies spanning 6 countries. For GIN and particularly F. hepatica, there was a bias towards preferential sampling of individual farms with suspected AR, and research effort was biased towards Western Europe and particularly the United Kingdom. Ongoing capture of future results in the live database, efforts to avoid bias in farm recruitment, more accurate tests for AR, and stronger appreciation of the importance of AR among the agricultural industry and policy makers, will support more sophisticated analyses of factors contributing to AR and effective strategies to slow its spread., This review is based upon work from COST Action COMBAR CA16230, supported by COST (European Cooperation in Science and Technology) and from the Livestock Helminth Research Alliance (LiHRA). HRV and ERM are supported by UK Research and Innovation (UKRI) through BBSRC grant BB/ M003949/1; HRV is also supported by the University of Liverpool’s Institute of Infection and Global Health, and ERM by UKRI BBSRC project BB/R010250/1 and the UK Department of Food, Environment and Rural Affairs, Veterinary Medicines Directorate grant VM0543. DJB is supported by the Scottish Government’s Rural and Environmental Science and Analytical Services (RESAS) division. MMV was funded by the Spanish “Ramón y Cajal” Programme of the Ministry of Economy and Competitiveness (MMV, RYC2015-18368). MK and JV were supported by the Czech Republic Ministry of Education, Youth and Sports INTER-COST project (LTC19018). The authors would like to thank all COMBAR consortium members who contributed to the development of the database but who did not meet the ICMJE criteria for co-authorship. Thanks are also due to Carine Paraud (ANSES Niort) and Philippe Jacquiet (National Veterinary School, Toulouse) for providing unpublished data from sheep and goat surveys for France and to Vasile Cozma (University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania) for providing data from surveys for Romania.
- Published
- 2020
3. Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database
- Author
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European Commission, Livestock Helminth Research Alliance, University of Liverpool, Veterinary Medicines Directorate (UK), Scottish Government's Rural and Environment Science and Analytical Services, Ministerio de Economía y Competitividad (España), Ministry of Education, Youth and Sports (Czech Republic), Department for Environment, Food & Rural Affairs (UK), Martínez Valladares, María [0000-0002-3723-1895], Vineer, H.R., Morgan, E.R., Hertzberg, H., Bartley, D.J., Bosco, A., Charlier, J., Chartier, C., Claerebout, E., De Waal, T., Hendrickx, G., Hinney, B., Hoglund, Johan, Jezek, J., Kasny, M., Keane, O.M., Martínez Valladares, María, Mateus, T.L., Mcintyre, J., Mickiewicz, M., Munoz, A.M., Phythian, C.J., Ploeger, H.W., Rataj, A.V., Skuce, P.J., Simin, S., Sotiraki, S., Spinu, M., Stuen, S., Thamsborg, S.M., Vadlejch, J., Varady, M., Von Samson-Himmelstjerna, G., Rinaldi, L., European Commission, Livestock Helminth Research Alliance, University of Liverpool, Veterinary Medicines Directorate (UK), Scottish Government's Rural and Environment Science and Analytical Services, Ministerio de Economía y Competitividad (España), Ministry of Education, Youth and Sports (Czech Republic), Department for Environment, Food & Rural Affairs (UK), Martínez Valladares, María [0000-0002-3723-1895], Vineer, H.R., Morgan, E.R., Hertzberg, H., Bartley, D.J., Bosco, A., Charlier, J., Chartier, C., Claerebout, E., De Waal, T., Hendrickx, G., Hinney, B., Hoglund, Johan, Jezek, J., Kasny, M., Keane, O.M., Martínez Valladares, María, Mateus, T.L., Mcintyre, J., Mickiewicz, M., Munoz, A.M., Phythian, C.J., Ploeger, H.W., Rataj, A.V., Skuce, P.J., Simin, S., Sotiraki, S., Spinu, M., Stuen, S., Thamsborg, S.M., Vadlejch, J., Varady, M., Von Samson-Himmelstjerna, G., and Rinaldi, L.
- Abstract
Helminth infections are ubiquitous in grazing ruminant production systems, and are responsible for significant costs and production losses. Anthelmintic Resistance (AR) in parasites is now widespread throughout Europe, although there are still gaps in our knowledge in some regions and countries. AR is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, and increased greenhouse gas emissions through increased parasitism and farm inputs. A better understanding of the extent of AR in Europe is needed to develop and advocate more sustainable parasite control approaches. A database of European published and unpublished AR research on gastrointestinal nematodes (GIN) and liver fluke (Fasciola hepatica) was collated by members of the European COST Action “COMBAR” (Combatting Anthelmintic Resistance in Ruminants), and combined with data from a previous systematic review of AR in GIN. A total of 197 publications on AR in GIN were available for analysis, representing 535 studies in 22 countries and spanning the period 1980–2020. Reports of AR were present throughout the European continent and some reports indicated high within-country prevalence. Heuristic sample size-weighted estimates of European AR prevalence over the whole study period, stratified by anthelmintic class, varied between 0 and 48%. Estimated regional (country) prevalence was highly heterogeneous, ranging between 0% and 100% depending on livestock sector and anthelmintic class, and generally increased with increasing research effort in a country. In the few countries with adequate longitudinal data, there was a tendency towards increasing AR over time for all anthelmintic classes in GIN: aggregated results in sheep and goats since 2010 reveal an average prevalence of resistance to benzimidazoles (BZ) of 86%, macrocyclic lactones except moxidectin (ML) 52%, levamisole (LEV) 48%, and moxidectin (MOX) 21%. All maj
- Published
- 2020
4. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe
- Author
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European Cooperation in Science and Technology, Livestock Helminth Research Alliance, Biotechnology and Biological Sciences Research Council (UK), University of Liverpool, Ministerio de Economía y Competitividad (España), Martínez Valladares, María [0000-0002-3723-1895], Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Vineer, H.R., Hinney, B., von Samson-Himmelstjerna, G., Bâcescu, B., Mickiewicz, M., Mateus, T.L., Martínez Valladares, María, Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Hoglund, Johan, Morgan, E.R., Bartley, D.J., Claerebout, E., European Cooperation in Science and Technology, Livestock Helminth Research Alliance, Biotechnology and Biological Sciences Research Council (UK), University of Liverpool, Ministerio de Economía y Competitividad (España), Martínez Valladares, María [0000-0002-3723-1895], Charlier, J., Rinaldi, L., Musella, V., Ploeger, H.W., Chartier, C., Vineer, H.R., Hinney, B., von Samson-Himmelstjerna, G., Bâcescu, B., Mickiewicz, M., Mateus, T.L., Martínez Valladares, María, Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Hoglund, Johan, Morgan, E.R., Bartley, D.J., and Claerebout, E.
- Abstract
We report a European wide assessment of the economic burden of gastrointestinal nematodes, Fasciola hepatica (common liver fluke) and Dictyocaulus viviparus (bovine lungworm) infections to the ruminant livestock industry. The economic impact of these parasitic helminth infections was estimated by a deterministic spreadsheet model as a function of the proportion of the ruminant population exposed to grazing, the infection frequency and intensity, the effect of the infection on animal productivity and mortality and anthelmintic treatment costs. In addition, we estimated the costs of anthelmintic resistant nematode infections and collected information on public research budgets addressing helminth infections in ruminant livestock. The epidemiologic and economic input data were collected from international databases and via expert opinion of the Working Group members of the European Co-operation in Science and Technology (COST) action COMbatting Anthelmintic Resistance in ruminants (COMBAR). In order to reflect the effects of uncertainty in the input data, low and high cost estimates were obtained by varying uncertain input data arbitrarily in both directions by 20 %. The combined annual cost [low estimate-high estimate] of the three helminth infections in 18 participating countries was estimated at € 1.8 billion [€ 1.0–2.7 billion]. Eighty-one percent of this cost was due to lost production and 19 % was attributed to treatment costs. The cost of gastrointestinal nematode infections with resistance against macrocyclic lactones was estimated to be € 38 million [€ 11–87 million] annually. The annual estimated costs of helminth infections per sector were € 941 million [€ 488 – 1442 million] in dairy cattle, € 423 million [€ 205–663 million] in beef cattle, € 151million [€ 90–213 million] in dairy sheep, € 206 million [€ 132–248 million] in meat sheep and € 86 million [€ 67–107 million] in dairy goats. Important data gaps were present in all phases of the calculations which
- Published
- 2020
5. 100 Questions in Livestock Helminthology Research
- Author
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European Cooperation in Science and Technology, Ministerio de Economía y Competitividad (España), European Commission, Morgan, E.R., Aziz, N.A.A., Blanchard, A., Charlier, J., Charvet, C., Claerebout, E., Geldhof, Peter, Greer, A.W., Hertzberg, H., Hodgkinson, J., Hoglund, Johan, Hoste, Hervé, Kaplan, R.M., Martínez Valladares, María, Mitchell, S., Ploeger, H.W., Rinaldi, L., von Samson-Himmelstjerna, G., Sotiraki, Smaragda, Schnyder, M., Skuce, Philip, Bartley, D., Kenyon, F., Thamsborg, S.M., Vineer, H.R., de Waal, T., Williams, Andrew R., van Wyk, J.A., Vercruysse, J., European Cooperation in Science and Technology, Ministerio de Economía y Competitividad (España), European Commission, Morgan, E.R., Aziz, N.A.A., Blanchard, A., Charlier, J., Charvet, C., Claerebout, E., Geldhof, Peter, Greer, A.W., Hertzberg, H., Hodgkinson, J., Hoglund, Johan, Hoste, Hervé, Kaplan, R.M., Martínez Valladares, María, Mitchell, S., Ploeger, H.W., Rinaldi, L., von Samson-Himmelstjerna, G., Sotiraki, Smaragda, Schnyder, M., Skuce, Philip, Bartley, D., Kenyon, F., Thamsborg, S.M., Vineer, H.R., de Waal, T., Williams, Andrew R., van Wyk, J.A., and Vercruysse, J.
- Abstract
An elicitation exercise was conducted to collect and identify pressing questions concerning the study of helminths in livestock, to help guide research priorities. Questions were invited from the research community in an inclusive way. Of 385 questions submitted, 100 were chosen by online vote, with priority given to open questions in important areas that are specific enough to permit investigation within a focused project or programme of research. The final list of questions was divided into ten themes. We present the questions and set them briefly in the context of the current state of knowledge. Although subjective, the results provide a snapshot of current concerns and perceived priorities in the field of livestock helminthology, and we hope that they will stimulate ongoing or new research efforts.
- Published
- 2019
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