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2. Mechanical thrombectomy in patients with heart failure: the Italian registry of Endovascular Treatment in Acute Stroke

Author

Gentile, Luana, Pracucci, Giovanni, Saia, Valentina, Falcou, Anne, Biraschi, Francesco, Zini, Andrea, Simonetti, Luigi, Riva, Letizia, Bigliardi, Guido, Vallone, Stefano, Nencini, Patrizia, Limbucci, Nicola, Diomedi, Marina, Da Ros, Valerio, Longoni, Marco, Ruggiero, Maria, Tassinari, Tiziana, Allegretti, Luca, Cerrato, Paolo, Rubino, Elisa, Bergui, Mauro, Cavallo, Roberto, Naldi, Andrea, Comelli, Chiara, Cappellari, Manuel, Zivelonghi, Cecilia, Plebani, Mauro, De Vito, Alessandro, Merli, Nicola, Saletti, Andrea, Musolino, Rosa Fortunata, Ferraù, Ludovica, Vinci, Sergio Lucio, Sacco, Simona, Orlandi, Berardino, De Santis, Federica, Filauri, Pietro, Ruiz, Luigi, Sepe, Federica Nicoletta, Gallesio, Ivan, Petruzzellis, Marco, Chiumarulo, Luigi, Sangalli, Davide, Salmaggi, Andrea, Filizzolo, Marco, Moller, Jessica, Melis, Maurizio, Comelli, Simone, Magoni, Mauro, Gilberti, Nicola, Gasparotti, Roberto, Invernizzi, Paolo, Pavia, Marco, Pinto, Vincenza, Laspada, Salvatore, Marcheselli, Simona, Ajello, Daniele, Viaro, Federica, Baracchini, Claudio, Causin, Francesco, Giannini, Nicola, Caselli, Maria Chiara, Mancuso, Michelangelo, Cosottini, Mirco, Scoditti, Umberto, Menozzi, Roberto, Russo, Monia, Amistá, Pietro, Napoletano, Rosa, Romano, Daniele Giuseppe, Tassi, Rossana, Bracco, Sandra, Carimati, Federico, Versino, Maurizio, Giorgianni, Andrea, De Boni, Antonella, Fasano, Antonio, Barbarini, Leonardo, Paladini, Adriana, Franchini, Enrica, Dall’Ora, Elisa, Comai, Alessio, Giovanni, Frisullo, Pedicelli, Alessandro, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Mangiafico, Salvatore, and Toni, Danilo

Published
2023
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9. Ischemic stroke and reperfusion therapies in diabetic patients

Author

Currò, Carmelo Tiberio, Fiume, Giulia, Cotroneo, Masina, Russo, Giuseppina, Casella, Carmela, Dell’Aera, Cristina, Fazio, Maria Carolina, Grillo, Francesco, Laganà, Angelina, Trimarchi, Giuseppe, Toscano, Antonio, Vinci, Sergio Lucio, Musolino, Rosa Fortunata, and La Spina, Paolino

Published
2022
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11. Mechanical thrombectomy in acute ischemic stroke due to large vessel occlusion in the anterior circulation and low baseline National Institute of Health Stroke Scale score: a multicenter retrospective matched analysis

Author

Alexandre, Andrea Maria, Valente, Iacopo, Pedicelli, Alessandro, Pezzullo, Angelo Maria, Colò, Francesca, Scarcia, Luca, Romi, Andrea, Piano, Mariangela, Macera, Antonio, Gabrieli, Joseph Domenico, Cester, Giacomo, Caragliano, Antonio Armando, Vinci, Sergio Lucio, Ruggiero, Maria, Commodaro, Christian, Saletti, Andrea, Lazzarotti, Guido Andrea, Cosottini, Mirco, Da Ros, Valerio, Bellini, Luigi, Lozupone, Emilio, Paladini, Adriana, Brunetti, Valerio, Morosetti, Roberta, Frisullo, Giovanni, Calabresi, Paolo, Marca, Giacomo Della, and Broccolini, Aldobrando

Published
2022
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14. Variants of the circle of Willis in ischemic stroke patients

Author

De Caro, Jolanda, Ciacciarelli, Antonio, Tessitore, Agostino, Buonomo, Orazio, Calzoni, Andrea, Francalanza, Isabella, Dell’Aera, Cristina, Cosenza, Domenico, Currò, Carmelo Tiberio, Granata, Francesca, Vinci, Sergio Lucio, Trimarchi, Giuseppe, Toscano, Antonio, Musolino, Rosa Fortunata, and La Spina, Paolino

Published
2021
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16. T1 relaxation:Chemo-physical fundamentals of magnetic resonance imaging and clinical applications

Author

Gaeta, Michele, Galletta, Karol, Cavallaro, Marco, Mormina, Enricomaria, Cannizzaro, Maria Teresa, Lanzafame, Ludovica Rosa Maria, D’Angelo, Tommaso, Blandino, Alfredo, Vinci, Sergio Lucio, Granata, Francesca, Gaeta, Michele, Galletta, Karol, Cavallaro, Marco, Mormina, Enricomaria, Cannizzaro, Maria Teresa, Lanzafame, Ludovica Rosa Maria, D’Angelo, Tommaso, Blandino, Alfredo, Vinci, Sergio Lucio, and Granata, Francesca

Abstract

Abstract: A knowledge of the complex phenomena that regulate T1 signal on Magnetic Resonance Imaging is essential in clinical practice for a more effective characterization of pathological processes. The authors review the physical basis of T1 Relaxation Time and the fundamental aspects of physics and chemistry that can influence this parameter. The main substances (water, fat, macromolecules, methemoglobin, melanin, Gadolinium, calcium) that influence T1 and the different MRI acquisition techniques that can be applied to enhance their presence in diagnostic images are then evaluated. An extensive case illustration of the different phenomena and techniques in the areas of CNS, abdomino-pelvic, and osteoarticular pathology is also proposed. Critical relevance statement: T1 relaxation time is strongly influenced by numerous factors related to tissue characteristics and the presence in the context of the lesions of some specific substances. An examination of these phenomena with extensive MRI exemplification is reported. Key Points: The purpose of the paper is to illustrate the chemical-physical basis of T1 Relaxation Time. MRI methods in accordance with the various clinical indications are listed. Several examples of clinical application in abdominopelvic and CNS pathology are reported. Graphical Abstract: (Figure presented.)

Published
2024

17. Baseline clinical and neuroradiological predictors of outcome in patients with large ischemic core undergoing mechanical thrombectomy: a retrospective multicenter study

Author

Alexandre, Andrea, Monforte, Mauro, Brunetti, Valerio, Scarcia, Luca, Cirillo, Luigi, Zini, Andrea, Scala, Irene, Nardelli, Vincenzo, Arbia, Francesco, Arbia, Giuseppe, Frisullo, Giovanni, Kalsoum, Erwah, Camilli, Arianna, De Leoni, Davide, Francesca, Colò, Abruzzese, Serena, Piano, Mariangela, Rollo, Claudia, Macera, Antonio, Ruggiero, Maria, Lafe, Elvi, Gabrieli, Joseph Domenico, Cester, Giacomo, Limbucci, Nicola, Arba, Francesco, Ferretti, Simone, Da Ros, Valerio, Bellini, Luigi, Salsano, Giancarlo, Mavilio, Nicola, Russo, Riccardo, Bergui, Mauro, Caragliano, Antonio Armando, Vinci, Sergio Lucio, Romano, Daniele Giuseppe, Frauenfelder, Giulia, Semeraro, Vittorio, Porzia, Ganimede Maria, Lozupone, Emilio, Romi, Andrea, Cavallini, Anna, Milonia, Luca, Muto, Massimo, Candelaresi, Paolo, Calabresi, Paolo, Pedicelli, Alessandro, Broccolini, Aldobrando, Arbia, Giuseppe (ORCID:0000-0001-5173-3931), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), Broccolini, Aldobrando (ORCID:0000-0001-8295-9271), Alexandre, Andrea, Monforte, Mauro, Brunetti, Valerio, Scarcia, Luca, Cirillo, Luigi, Zini, Andrea, Scala, Irene, Nardelli, Vincenzo, Arbia, Francesco, Arbia, Giuseppe, Frisullo, Giovanni, Kalsoum, Erwah, Camilli, Arianna, De Leoni, Davide, Francesca, Colò, Abruzzese, Serena, Piano, Mariangela, Rollo, Claudia, Macera, Antonio, Ruggiero, Maria, Lafe, Elvi, Gabrieli, Joseph Domenico, Cester, Giacomo, Limbucci, Nicola, Arba, Francesco, Ferretti, Simone, Da Ros, Valerio, Bellini, Luigi, Salsano, Giancarlo, Mavilio, Nicola, Russo, Riccardo, Bergui, Mauro, Caragliano, Antonio Armando, Vinci, Sergio Lucio, Romano, Daniele Giuseppe, Frauenfelder, Giulia, Semeraro, Vittorio, Porzia, Ganimede Maria, Lozupone, Emilio, Romi, Andrea, Cavallini, Anna, Milonia, Luca, Muto, Massimo, Candelaresi, Paolo, Calabresi, Paolo, Pedicelli, Alessandro, Broccolini, Aldobrando, Arbia, Giuseppe (ORCID:0000-0001-5173-3931), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Pedicelli, Alessandro (ORCID:0000-0002-2558-8838), and Broccolini, Aldobrando (ORCID:0000-0001-8295-9271)

Abstract

Background: Recent randomized trials have shown the benefit of mechanical thrombectomy (MT) also in patients with an established large ischemic core. Aim: The purpose of this study was to define baseline predictors of clinical outcome in patients with large vessel occlusion (LVO) in the anterior circulation and an Alberta Stroke Program Early CT score (ASPECTS) ≤ 5, undergoing MT. Material and methods: The databases of 16 comprehensive stroke centers were retrospectively screened for patients with LVO and ASPECTS ≤ 5 that received MT. Baseline clinical and neuroradiological features, including the differential contribution of all ASPECTS regions to the composite score, were collected. Primary clinical outcome measure was a 90-day modified Rankin Scale (mRS) score of 0-2. Statistical analysis used a logistic regression model and random forest algorithm. Results: 408 patients were available for analysis. In multivariate model, among baseline features, lower age (OR 0.962, 95% CI 0.943-0.982) and lower National Institute of Health Stroke Scale (NIHSS) score (OR 0.911, 95% CI 0.862-0.963) were associated with the mRS score 0-2. Involvement of the M2 (OR 0.398, 95% CI 0.206-0.770) or M4 (OR 0.496, 95% CI 0.260-0.945) ASPECTS regions was associated with an unfavorable outcome. Random forest analysis confirmed that age and baseline NIHSS score are the most important variables influencing clinical outcome, whereas involvement of cortical regions M5, M4, M2 and M1 can have a negative impact. Conclusion: Our retrospective analysis shows that, along with age and baseline clinical impairment, presence of early ischemic changes involving cortical areas has a role in clinical outcome in patients with large ischemic core undergoing MT.

Published
2024

19. Baseline clinical and neuroradiological predictors of outcome in patients with large ischemic core undergoing mechanical thrombectomy: a retrospective multicenter study

Author

Alexandre, Andrea, primary, Monforte, Mauro, additional, Brunetti, Valerio, additional, Scarcia, Luca, additional, Cirillo, Luigi, additional, Zini, Andrea, additional, Scala, Irene, additional, Nardelli, Vincenzo, additional, Arbia, Francesco, additional, Arbia, Giuseppe, additional, Frisullo, Giovanni, additional, Kalsoum, Erwah, additional, Camilli, Arianna, additional, De Leoni, Davide, additional, Francesca, Colò, additional, Abruzzese, Serena, additional, Piano, Mariangela, additional, Rollo, Claudia, additional, Macera, Antonio, additional, Ruggiero, Maria, additional, Lafe, Elvis, additional, Gabrieli, Joseph Domenico, additional, Cester, Giacomo, additional, Limbucci, Nicola, additional, Arba, Francesco, additional, Ferretti, Simone, additional, Da Ros, Valerio, additional, Bellini, Luigi, additional, Salsano, Giancarlo, additional, Mavilio, Nicola, additional, Russo, Riccardo, additional, Bergui, Mauro, additional, Caragliano, Antonio Armando, additional, Vinci, Sergio Lucio, additional, Romano, Daniele Giuseppe, additional, Frauenfelder, Giulia, additional, Semeraro, Vittorio, additional, Porzia, Ganimede Maria, additional, Lozupone, Emilio, additional, Romi, Andrea, additional, Cavallini, Anna, additional, Milonia, Luca, additional, Muto, Massimo, additional, Candelaresi, Paolo, additional, Calabresi, Paolo, additional, Pedicelli, Alessandro, additional, and Broccolini, Aldobrando, additional

Published
2024
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20. Point-Of-Care low-field MRI in acute Stroke (POCS): protocol for a multicentric prospective open-label study evaluating diagnostic accuracy

Author

Foschi, Matteo, primary, Galante, Angelo, additional, Ornello, Raffaele, additional, Necozione, Stefano, additional, Marini, Carmine, additional, Muselli, Mario, additional, Achard, Paola Olimpia, additional, Fratocchi, Luciano, additional, Vinci, Sergio Lucio, additional, Cavallaro, Marco, additional, Silvestrini, Mauro, additional, Polonara, Gabriele, additional, Marcheselli, Simona, additional, Straffi, Laura, additional, Colasurdo, Marco, additional, Sorrentino, Luca, additional, Franconi, Enrico, additional, Alecci, Marcello, additional, Caulo, Massimo, additional, and Sacco, Simona, additional

Published
2024
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21. Direct thrombectomy for stroke in the presence of absolute exclusion criteria for thrombolysis

Author

Cappellari, Manuel, Pracucci, Giovanni, Forlivesi, Stefano, Saia, Valentina, Limbucci, Nicola, Nencini, Patrizia, Inzitari, Domenico, Da Ros, Valerio, Sallustio, Fabrizio, Vallone, Stefano, Bigliardi, Guido, Zini, Andrea, Vinci, Sergio Lucio, Dell’Aera, Cristina, Bracco, Sandra, Cioni, Samuele, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Azzini, Cristiano, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Castellan, Lucio, Finocchi, Cinzia, Menozzi, Roberto, Scoditti, Umberto, Causin, Francesco, Viaro, Federica, Puglielli, Edoardo, Casalena, Alfonsina, Ruggiero, Maria, Biguzzi, Sara, Castellano, Davide, Cavallo, Roberto, Lazzarotti, Guido Andrea, Orlandi, Giovanni, Sgreccia, Alessandro, Denaro, Maria Federica, Cavasin, Nicola, Critelli, Adriana, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Chiumarulo, Luigi, Petruzzelli, Marco, Pellegrino, Carlo, Carimati, Federico, Burdi, Nicola, Prontera, Maria Pia, Auteri, Wiliam, Petrone, Alfredo, Guidetti, Giulio, Nicolini, Ettore, Ganci, Giuseppe, Sugo, Annalisa, Filauri, Pietro, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Nuzzi, Nunzio Paolo, Corato, Manuel, Amistà, Pietro, Gentile, Mauro, Barbero, Stefano, Schirru, Federica, Craparo, Giuseppe, Mannino, Marina, Simonetti, Luigi, Mangiafico, Salvatore, and Toni, Danilo

Published
2020
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23. Modern Treatment of Brain Arteriovenous Malformations Using Preoperative Planning Based on Navigated Transcranial Magnetic Stimulation: A Revisitation of the Concept of Eloquence

Author

Germanò, Antonino, Raffa, Giovanni, Conti, Alfredo, Fiore, Patrizia, Cardali, Salvatore Massimiliano, Esposito, Felice, Scibilia, Antonino, Quattropani, Maria C., Vinci, Sergio Lucio, Marzano, Giuseppina, Pergolizzi, Stefano, Longo, Marcello, and Angileri, Filippo Flavio

Published
2019
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24. Foam Cells Analysis from Retrieved Stroke Clot for the Identification of Atherothrombotic Etiology.

Author

Giammello, Fabrizio, Ciacciarelli, Antonio, Cosenza, Domenico, Galletta, Santi, Barresi, Valeria, La Spina, Paolino, Fazio, Maria Carolina, De Caro, Jolanda, Cotroneo, Masina, Dell'Aera, Cristina, Grillo, Francesco, Ammendola, Serena, Tessitore, Agostino, Vinci, Sergio Lucio, Musolino, Rosa Fortunata, Casella, Carmela, and Toscano, Antonio

Subjects
FOAM cells, STROKE, ATHEROSCLEROTIC plaque, ETIOLOGY of diseases, HISTOPATHOLOGY
Abstract

Background: In atherothrombotic acute ischemic stroke (AIS), when the atheroma breaks down, the clot can incorporate foam cells (FCs). The identification of the correct etiology is paramount for secondary stroke prevention. This study aims to evaluate the presence of the FC in the arterial clot, and to determine whether patients with FCs and patients without FCs (NFCs) had different cerebrovascular risk factors, haemato-chemical parameters, and atherosclerotic disease incidence, in order to predict the etiological diagnosis. Methods: We collected 100 clots retrieved by mechanical thrombectomy from 495 consecutive AIS patients with large vessel occlusion. An expert pathologist evaluated the FC presence by histological examination stained with hematoxylin and eosin. Results: We observed FCs in 29/100 (29%) of retrieved clots and divided the patients into two groups, with/without FCs. The two groups had similar clinical and laboratory features, with a discrepancy between the FC presence in the clot and the clinical etiological diagnosis, even if not statistically significant. Conclusions: Our study showed the presence of FCs in approximately one-third of the retrieved clots, but the identification of the clot that presumably comes from the atheromatous plaque rupture tended to disagree with the clinical diagnosis. Future studies may reveal their potential to disclose clot origin or specific patient characteristics, guiding treatment options. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Predictors for hemorrhagic transformation and cerebral edema in stroke patients with first-pass complete recanalization

Author

Cappellari, Manuel, primary, Pracucci, Giovanni, additional, Saia, Valentina, additional, Sallustio, Fabrizio, additional, Casetta, Ilaria, additional, Fainardi, Enrico, additional, Capasso, Francesco, additional, Nencini, Patrizia, additional, Vallone, Stefano, additional, Bigliardi, Guido, additional, Saletti, Andrea, additional, De Vito, Alessandro, additional, Ruggiero, Maria, additional, Longoni, Marco, additional, Semeraro, Vittorio, additional, Boero, Giovanni, additional, Silvagni, Umberto, additional, Stancati, Furio, additional, Lafe, Elvis, additional, Mazzacane, Federico, additional, Bracco, Sandra, additional, Tassi, Rossana, additional, Comelli, Simone, additional, Melis, Maurizio, additional, Romano, Daniele, additional, Napoletano, Rosa, additional, Menozzi, Roberto, additional, Scoditti, Umberto, additional, Chiumarulo, Luigi, additional, Petruzzellis, Marco, additional, Vinci, Sergio Lucio, additional, Ferraù, Ludovica, additional, Taglialatela, Francesco, additional, Zini, Andrea, additional, Sanna, Antioco, additional, Tassinari, Tiziana, additional, Iacobucci, Marta, additional, Nicolini, Ettore, additional, Bergui, Mauro, additional, Cerrato, Paolo, additional, Giorgianni, Andrea, additional, Princiotta Cariddi, Lucia, additional, Amistà, Pietro, additional, Russo, Monia, additional, Gallesio, Ivan, additional, Sepe, Federica, additional, Comai, Alessio, additional, Franchini, Enrica, additional, Filauri, Pietro, additional, Orlandi, Berardino, additional, Besana, Michele, additional, Giossi, Alessia, additional, Lazzarotti, Guido Andrea, additional, Orlandi, Giovanni, additional, Castellano, Davide, additional, Naldi, Andrea, additional, Plebani, Mauro, additional, Zivelonghi, Cecilia, additional, Invernizzi, Paolo, additional, Mangiafico, Salvatore, additional, and Toni, Danilo, additional

Published
2023
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28. Mechanical thrombectomy in young patients with large vessel occlusion‐related ischemic stroke: Data from the Italian Registry of Endovascular Treatment in Acute Stroke.

Author

Nicolini, Ettore, Saia, Valentina, Lorenzano, Svetlana, Pracucci, Giovanni, Iacobucci, Marta, De Michele, Manuela, Vallone, Stefano, Bergui, Mauro, Diomedi, Marina, Nencini, Patrizia, Tassi, Rossana, Saletti, Andrea, Puglielli, Edoardo, Naldi, Andrea, Vinci, Sergio Lucio, Giannini, Nicola, Malfatto, Laura, Roberto, Menozzi, Romano, Daniele G., and Cappellari, Manuel

Subjects
STROKE, ENDOVASCULAR surgery, ISCHEMIC stroke, THROMBECTOMY, CEREBRAL infarction
Abstract

Background and purpose: The weight of outcome predictors in acute ischemic stroke (AIS) patients older than 60 years is not necessarily mirrored in the younger population, posing the question of whether outcome determinants specific for the latter might vary. Very few data are available on predictors of outcome in young AIS patients receiving endovascular treatment (EVT). Methods: We analyzed data for patients aged between 16 and 55 years from the Italian Registry of Endovascular Treatment in Acute Stroke. We divided our population into patients <45 years old and patients aged between 45 and 55 years. After testing the differences between groups in terms of 90‐day modified Rankin Scale (mRS) 0–2, mortality, and symptomatic intracranial hemorrhage, we looked for predictors of poor outcome (mRS 3–6), death, and symptomatic intracerebral hemorrhage in the two groups. Results: A total of 438 patients younger than 45 years and 817 aged 45–55 years were included; 284 (34.8%) patients aged 45–55 years and 112 (25.6%) patients younger than 45 years old showed poor 90‐day functional outcome (p = 0.001). Predictors of poor outcome in the older group were baseline National Institutes of Health Stroke Scale (NIHSS; p < 0.001), diabetes (p = 0.027), poor collateral status (p = 0.036), and groin puncture‐to‐recanalization time (p = 0.010), whereas Thrombolysis in Cerebral Infarction (TICI) 2b–3 had an inverse association (p < 0.001). Predictors of poor outcome in patients younger than 45 years were baseline NIHSS (p < 0.001) and groin puncture‐to‐recanalization time (p = 0.015), whereas an inverse association was found for baseline Alberta Stroke Program Early CT Score (p = 0.010) and TICI 2b–3 (p < 0.001). Conclusions: Approximately one third of young adults treated with EVT do not reach a good functional outcome. Fast and successful recanalization, rather than common risk factors, has a major role in determining clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Management of severe cerebral venous sinus thrombosis after post-vaccination breakthrough COVID-19 infection: a case report and review of the literature

Author

Giammello, Fabrizio, primary, Grillo, Francesco, additional, Tessitore, Agostino, additional, Gardin, Anna, additional, Iatì, Domenico, additional, Caragliano, Antonio Armando, additional, Velo, Mariano, additional, Buonomo, Orazio, additional, Ferraù, Ludovica, additional, Toscano, Antonio, additional, Spina, Paolino La, additional, and Vinci, Sergio Lucio, additional

Published
2023
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30. Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population

Author

Granata Francesca, Visalli Carmela, Mormina Enricomaria, Caragliano Antonio Armando, Coglitore Alessandra, Vinci Sergio Lucio, Longo Marcello, and Tessitore Agostino

Subjects
Pathology, medicine.medical_specialty, multiple congenital melanocytic nevi, Central nervous system, Neuroimaging, Melanosis, children, Phakomatosis, Spinal cord compression, medicine, Humans, Radiology, Nuclear Medicine and imaging, Child, Intracranial pressure, non-melanotic neoplasms, meningeal melanomatosis, phakomatosis, business.industry, Neurocutaneous Syndromes, Leptomeninges, medicine.disease, Magnetic Resonance Imaging, cutaneous neuro-melanosis, neurocutaneous melanosis, pediatric, Neurocutaneous melanosis, medicine.anatomical_structure, business
Abstract

Background: Neurocutaneous Melanosis (NCM) is a rare nonfamilial phakomatosis characterized by the presence of congenital melanocytic nevi and abnormal melanocyte infiltration of the leptomeninges. Objective & Methods: This paper shows the importance of early diagnosis and the most important imaging features of the disease on CT and MR scans. PubMed database was searched from January 1972 to September 2020. Papers including imaging findings of NCM, clinical, follow-up, and treatment features were collected, selecting only 89 studies. Discussion: NCM is a term used for the first time by van Bogaert in 1948. It refers to a condition caused by an error during morphogenesis and migration leading to leptomeningeal melanocytic accumulation. Although histological findings are the gold standard for diagnosis confirmation, neuroimaging and clinical features strongly support the suspect of NCM. Localization and extension of the lesions are predictive of neurological manifestations related to increased intracranial pressure, mass lesions, or spinal cord compression. CT demonstrates sites of increased density in the anterior temporal lobe, mainly the amygdala, thalami, cerebellum, and frontal lobes base. However, MRI is the best imaging method to diagnose central nervous system lesions, often appearing as T1-short signal areas of the cerebral parenchyma, indicative of central nervous system melanosis. MRI can also reveal associated intracranial and intraspinal abnormalities. Conclusion: Early imaging, when available, is helpful if NCM suspect is raised and may be of guidance in comparing later studies. NCM requires a multidisciplinary approach since it is a multisystem disease with a genetic component.

Published
2021
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31. Three-Dimensional Constructive Interference in Steady State (3D CISS) Imaging and Clinical Applications in Brain Pathology

Author

Cavallaro, Marco, primary, Coglitore, Alessandra, additional, Tessitore, Agostino, additional, Galletta, Karol, additional, Frosina, Luciano, additional, Cuffari, Antonino, additional, Ingrassia, Roberta, additional, Scarcella, Sarah Caroline, additional, Caponnetto, Michele, additional, Longo, Mirta, additional, Granata, Francesca, additional, Vinci, Sergio Lucio, additional, and Mormina, Enricomaria, additional

Published
2022
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34. Cisternostomy for malignant middle cerebral artery infarction: proposed pathophysiological mechanisms and preliminary results

Author

Cardali, Salvatore Massimiliano, primary, Caffo, Maria, additional, Caruso, Gerardo, additional, Scalia, Gianluca, additional, Gorgoglione, Nicola, additional, Conti, Alfredo, additional, Vinci, Sergio Lucio, additional, Barresi, Valeria, additional, Granata, Francesca, additional, Ricciardo, Giuseppe, additional, Garufi, Giada, additional, Raffa, Giovanni, additional, and Germanò, Antonino, additional

Published
2022
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35. Can a 3D Virtual Imaging Model Predict Eagle Syndrome?

Author

Nastro Siniscalchi, Enrico, primary, Mormina, Enricomaria, additional, Cicchiello, Samuele, additional, Granata, Francesca, additional, Vinci, Sergio Lucio, additional, Galletta, Karol, additional, Catalfamo, Luciano, additional, and De Ponte, Francesco Saverio, additional

Published
2022
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38. Mechanical thrombectomy in acute ischemic stroke due to large vessel occlusion in the anterior circulation and low baseline National Institute of Health Stroke Scale score: a multicenter retrospective matched analysis

Author

Alexandre, Andrea Maria, primary, Valente, Iacopo, additional, Pedicelli, Alessandro, additional, Pezzullo, Angelo Maria, additional, Colò, Francesca, additional, Scarcia, Luca, additional, Romi, Andrea, additional, Piano, Mariangela, additional, Macera, Antonio, additional, Gabrieli, Joseph Domenico, additional, Cester, Giacomo, additional, Caragliano, Antonio Armando, additional, Vinci, Sergio Lucio, additional, Ruggiero, Maria, additional, Commodaro, Christian, additional, Saletti, Andrea, additional, Lazzarotti, Guido Andrea, additional, Cosottini, Mirco, additional, Da Ros, Valerio, additional, Bellini, Luigi, additional, Lozupone, Emilio, additional, Paladini, Adriana, additional, Brunetti, Valerio, additional, Morosetti, Roberta, additional, Frisullo, Giovanni, additional, Calabresi, Paolo, additional, Marca, Giacomo Della, additional, and Broccolini, Aldobrando, additional

Published
2021
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40. Microvascular imaging ultrasound (MicroV) and power Doppler vascularization analysis in a pediatric population with early scrotal pain onset

Author

Visalli, Carmela, primary, Vinci, Sergio Lucio, additional, Mondello, Stefania, additional, Kobeissy, Firas, additional, Salamone, Ignazio, additional, Coglitore, Alessandra, additional, Trimarchi, Renato, additional, Tessitore, Agostino, additional, Impellizzeri, Pietro, additional, and Mormina, Enricomaria, additional

Published
2021
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41. Comparison of aspiration versus combined technique as first-line approach in terminal internal carotid artery occlusion: a multicenter experience

Author

Diana, Francesco, primary, Vinci, Sergio Lucio, additional, Ruggiero, Maria, additional, Semeraro, Vittorio, additional, Bracco, Sandra, additional, Frauenfelder, Giulia, additional, Paolucci, Aldo, additional, Cirillo, Luigi, additional, Pesce, Alessandro, additional, Tessitore, Agostino, additional, Commodaro, Christian, additional, Ganimede, Maria Porzia, additional, Zanoni, Matteo, additional, Saponiero, Renato, additional, Zini, Andrea, additional, Velo, Mariano, additional, Modello, Beatrice, additional, Burdi, Nicola, additional, Cioni, Samuele, additional, Simonetti, Luigi, additional, and Romano, Daniele Giuseppe, additional

Published
2021
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43. Comparison of aspiration versus combined technique as first- line approach in terminal internal carotid artery occlusion: a multicenter experience.

Author

Diana, Francesco, Vinci, Sergio Lucio, Ruggiero, Maria, Semeraro, Vittorio, Bracco, Sandra, Frauenfelder, Giulia, Paolucci, Aldo, Cirillo, Luigi, Pesce, Alessandro, Tessitore, Agostino, Commodaro, Christian, Ganimede, Maria Porzia, Zanoni, Matteo, Saponiero, Renato, Zini, Andrea, Velo, Mariano, Modello, Beatrice, Burdi, Nicola, Cioni, Samuele, and Simonetti, Luigi

Subjects
ARTERIAL occlusions, STATISTICS, CAROTID artery diseases, ONE-way analysis of variance, RETROSPECTIVE studies, CHI-squared test, THROMBECTOMY, DESCRIPTIVE statistics, DATA analysis, LONGITUDINAL method
Abstract

Background There is no consensus on the most effective endovascular technique to use in patients with acute ischemic stroke due to terminal internal carotid artery (ICA) occlusion. The aim of this study was to compare safety and efficacy of the aspiration technique (AT) and combined technique (CT) as first-line approach in terminal ICA occlusions. Methods We performed a retrospective analysis of prospectively collected databases from seven Italian stroke centers. Patients were divided into two subgroups according to the first-line approach: AT group or CT group. We followed the STROBE guidelines for cohort studies. We used Chi-square test, one-way and multivariate ANOVA analysis, together with contrast analysis and post hoc tests, logistic regression and Pearson's bivariate correlation for the statistical analyses. Results Between January 2018 and August 2020, 353 patients were treated for a terminal ICA occlusion, with either AT or CT. CT was associated with a higher Thrombolysis in Cerebral Infarction (TICI) 2B-3 after the first pass (51.0% vs 26.9%) and at the end of the procedure (84% vs 73.3%) and with an improved clinical outcome at discharge (modified Rankin Scale (mRs) 0-2 of 47.8% vs 34.0%) and at 3 months' follow-up (mRs 0-2 of 56.5% vs 38.9%) compared with AT. Conclusion Thrombectomy of terminal ICA occlusions obtained using CT as first-line approach demonstrated better technical and functional outcomes in comparison with AT. [ABSTRACT FROM AUTHOR]

Published
2022
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46. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

48. Acute Stroke Treatment in Patients with Basilar Artery Occlusion: A Single-Center Observational Study

Author

Francalanza, Isabella, primary, Ciacciarelli, Antonio, additional, Caragliano, Antonio Armando, additional, Casella, Carmela, additional, Cotroneo, Masina, additional, Dell’Aera, Cristina, additional, Fazio, Maria Carolina, additional, Grillo, Francesco, additional, Pitrone, Antonio, additional, Vinci, Sergio Lucio, additional, Trimarchi, Giuseppe, additional, Musolino, Rosa Fortunata, additional, and La Spina, Paolino, additional

Published
2019
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49. Multimodal Surgical Treatment of High-Grade Gliomas in the Motor Area: The Impact of the Combination of Navigated Transcranial Magnetic Stimulation and Fluorescein-Guided Resection

Author

Raffa, Giovanni, primary, Scibilia, Antonino, additional, Conti, Alfredo, additional, Cardali, Salvatore Massimiliano, additional, Rizzo, Vincenzo, additional, Terranova, Carmen, additional, Quattropani, Maria Catena, additional, Marzano, Giuseppina, additional, Ricciardo, Giuseppe, additional, Vinci, Sergio Lucio, additional, and Germanò, Antonino, additional

Published
2019
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