746 results on '"Vinci, Maria"'
Search Results
2. Pediatric brain tumor patients display altered immune activation and reduced lymphopoiesis at the onset of disease
- Author
-
Rosichini, Marco, Del Baldo, Giada, De Luca, Carmen Dolores, Benini, Francesca, Genah, Shirley, Vinci, Maria, Cerimele, Alfredo, Coccetti, Marianna, Flamini, Sara, Carsetti, Rita, Cacchione, Antonella, Carai, Andrea, Mastronuzzi, Angela, Locatelli, Franco, and Velardi, Enrico
- Published
- 2024
- Full Text
- View/download PDF
3. Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies
- Author
-
Damiano, Giulia, Rinaldi, Raffaella, Raucci, Angela, Molinari, Chiara, Sforza, Annalisa, Pirola, Sergio, Paneni, Francesco, Genovese, Stefano, Pompilio, Giulio, and Vinci, Maria Cristina
- Published
- 2024
- Full Text
- View/download PDF
4. Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling
- Author
-
Pedace, Lucia, Pizzi, Simone, Abballe, Luana, Vinci, Maria, Antonacci, Celeste, Patrizi, Sara, Nardini, Claudia, Del Bufalo, Francesca, Rossi, Sabrina, Pericoli, Giulia, Gianno, Francesca, Besharat, Zein Mersini, Tiberi, Luca, Mastronuzzi, Angela, Ferretti, Elisabetta, Tartaglia, Marco, Locatelli, Franco, Ciolfi, Andrea, and Miele, Evelina
- Published
- 2024
- Full Text
- View/download PDF
5. Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients
- Author
-
Vinci, Maria Cristina, Costantino, Sarah, Damiano, Giulia, Rurali, Erica, Rinaldi, Raffaella, Vigorelli, Vera, Sforza, Annalisa, Carulli, Ermes, Pirola, Sergio, Mastroiacovo, Giorgio, Raucci, Angela, El-Osta, Assam, Paneni, Francesco, and Pompilio, Giulio
- Published
- 2024
- Full Text
- View/download PDF
6. GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
- Author
-
Liu, Ilon, Alencastro Veiga Cruzeiro, Gustavo, Bjerke, Lynn, Rogers, Rebecca F., Grabovska, Yura, Beck, Alexander, Mackay, Alan, Barron, Tara, Hack, Olivia A., Quezada, Michael A., Molinari, Valeria, Shaw, McKenzie L., Perez-Somarriba, Marta, Temelso, Sara, Raynaud, Florence, Ruddle, Ruth, Panditharatna, Eshini, Englinger, Bernhard, Mire, Hafsa M., Jiang, Li, Nascimento, Andrezza, LaBelle, Jenna, Haase, Rebecca, Rozowsky, Jacob, Neyazi, Sina, Baumgartner, Alicia-Christina, Castellani, Sophia, Hoffman, Samantha E., Cameron, Amy, Morrow, Murry, Nguyen, Quang-De, Pericoli, Giulia, Madlener, Sibylle, Mayr, Lisa, Dorfer, Christian, Geyeregger, Rene, Rota, Christopher, Ricken, Gerda, Ligon, Keith L., Alexandrescu, Sanda, Cartaxo, Rodrigo T., Lau, Benison, Uphadhyaya, Santhosh, Koschmann, Carl, Braun, Emelie, Danan-Gotthold, Miri, Hu, Lijuan, Siletti, Kimberly, Sundström, Erik, Hodge, Rebecca, Lein, Ed, Agnihotri, Sameer, Eisenstat, David D., Stapleton, Simon, King, Andrew, Bleil, Cristina, Mastronuzzi, Angela, Cole, Kristina A., Waanders, Angela J., Montero Carcaboso, Angel, Schüller, Ulrich, Hargrave, Darren, Vinci, Maria, Carceller, Fernando, Haberler, Christine, Slavc, Irene, Linnarsson, Sten, Gojo, Johannes, Monje, Michelle, Jones, Chris, and Filbin, Mariella G.
- Published
- 2024
- Full Text
- View/download PDF
7. Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
- Author
-
Pericoli, Giulia, Galardi, Angela, Paolini, Alessandro, Petrilli, Lucia Lisa, Pepe, Gerardo, Palma, Alessandro, Colletti, Marta, Ferretti, Roberta, Giorda, Ezio, Levi Mortera, Stefano, Burford, Anna, Carai, Andrea, Mastronuzzi, Angela, Mackay, Alan, Putignani, Lorenza, Jones, Chris, Pascucci, Luisa, Peinado, Hector, Helmer-Citterich, Manuela, de Billy, Emmanuel, Masotti, Andrea, Locatelli, Franco, Di Giannatale, Angela, and Vinci, Maria
- Published
- 2023
- Full Text
- View/download PDF
8. Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
- Author
-
Sun, Claire Xin, Daniel, Paul, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Sooraj, Dhanya, Carvalho, Diana, Storm, Phillip B., Baubet, Valerie, Sayles, Leanne C., Fernandez, Elisabet, Nguyen, Thy, Pörksen, Mia, Doan, Anh, Crombie, Duncan E., Panday, Monty, Zhukova, Nataliya, Dun, Matthew D., Ludlow, Louise E., Day, Bryan, Stringer, Brett W., Neeman, Naama, Rubens, Jeffrey A., Raabe, Eric H., Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I., Ekert, Paul G., Dumevska, Biljana, Ziegler, David S., Tsoli, Maria, Syed Sulaiman, Nur Farhana, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E. Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E., and Firestein, Ron
- Published
- 2023
- Full Text
- View/download PDF
9. Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment
- Author
-
Herdlevær, Ida, Petrilli, Lucia Lisa, Qosaj, Fatime, Vinci, Maria, Bressan, Dario, Gavasso, Sonia, Akslen, Lars A., editor, and Watnick, Randolph S., editor
- Published
- 2022
- Full Text
- View/download PDF
10. Quantification of spatial subclonal interactions enhancing the invasive phenotype of pediatric glioma
- Author
-
Tari, Haider, Kessler, Ketty, Trahearn, Nick, Werner, Benjamin, Vinci, Maria, Jones, Chris, and Sottoriva, Andrea
- Published
- 2022
- Full Text
- View/download PDF
11. Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections
- Author
-
Terreri, Sara, Piano Mortari, Eva, Vinci, Maria Rosaria, Russo, Cristina, Alteri, Claudia, Albano, Christian, Colavita, Francesca, Gramigna, Giulia, Agrati, Chiara, Linardos, Giulia, Coltella, Luana, Colagrossi, Luna, Deriu, Gloria, Ciofi Degli Atti, Marta, Rizzo, Caterina, Scarsella, Marco, Brugaletta, Rita, Camisa, Vincenzo, Santoro, Annapaola, Roscilli, Giuseppe, Pavoni, Emiliano, Muzi, Alessia, Magnavita, Nicola, Scutari, Rossana, Villani, Alberto, Raponi, Massimiliano, Locatelli, Franco, Perno, Carlo Federico, Zaffina, Salvatore, and Carsetti, Rita
- Published
- 2022
- Full Text
- View/download PDF
12. Liraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposure
- Author
-
Sforza, Annalisa, Vigorelli, Vera, Rurali, Erica, Perrucci, Gianluca Lorenzo, Gambini, Elisa, Arici, Martina, Metallo, Alessia, Rinaldi, Raffaella, Fiorina, Paolo, Barbuti, Andrea, Raucci, Angela, Sacco, Elena, Rocchetti, Marcella, Pompilio, Giulio, Genovese, Stefano, and Vinci, Maria Cristina
- Published
- 2022
- Full Text
- View/download PDF
13. Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study
- Author
-
Sabbatinelli, Jacopo, Castiglione, Stefania, Macrì, Federica, Giuliani, Angelica, Ramini, Deborah, Vinci, Maria Cristina, Tortato, Elena, Bonfigli, Anna Rita, Olivieri, Fabiola, and Raucci, Angela
- Published
- 2022
- Full Text
- View/download PDF
14. Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
- Author
-
Nussbaumer, Gunther, primary, Benesch, Martin, additional, Grabovska, Yura, additional, Mackay, Alan, additional, Castel, David, additional, Grill, Jacques, additional, Alonso, Marta M, additional, Antonelli, Manila, additional, Bailey, Simon, additional, Baugh, Joshua N, additional, Biassoni, Veronica, additional, Blattner Johnson, Mirjam, additional, Broniscer, Alberto, additional, Carai, Andrea, additional, Colafati, Giovanna Stefania, additional, Colditz, Niclas, additional, Corbacioglu, Selim, additional, Crampsie, Shauna, additional, Entz-Werle, Natacha, additional, Eyrich, Matthias, additional, Friker, Lea L, additional, Frühwald, Michael C, additional, Garrè, Maria Luisa, additional, Gerber, Nicolas U, additional, Giangaspero, Felice, additional, Gil-da-Costa, Maria J, additional, Graf, Norbert, additional, Hargrave, Darren, additional, Hauser, Peter, additional, Herrlinger, Ulrich, additional, Hoffmann, Marion, additional, Hulleman, Esther, additional, Izquierdo, Elisa, additional, Jacobs, Sandra, additional, Karremann, Michael, additional, Kattamis, Antonis, additional, Kebudi, Rejin, additional, Kortmann, Rolf-Dieter, additional, Kwiecien, Robert, additional, Massimino, Maura, additional, Mastronuzzi, Angela, additional, Miele, Evelina, additional, Morana, Giovanni, additional, Noack, Claudia M, additional, Pentikainen, Virve, additional, Perwein, Thomas, additional, Pfister, Stefan M, additional, Pietsch, Torsten, additional, Roka, Kleoniki, additional, Rossi, Sabrina, additional, Rutkowski, Stefan, additional, Schiavello, Elisabetta, additional, Seidel, Clemens, additional, Štěrba, Jaroslav, additional, Sturm, Dominik, additional, Sumerauer, David, additional, Tacke, Anna, additional, Temelso, Sara, additional, Valentini, Chiara, additional, van Vuurden, Dannis, additional, Varlet, Pascale, additional, Veldhuijzen van Zanten, Sophie E M, additional, Vinci, Maria, additional, von Bueren, André O, additional, Warmuth-Metz, Monika, additional, Wesseling, Pieter, additional, Wiese, Maria, additional, Wolff, Johannes E A, additional, Zamecnik, Josef, additional, Morales La Madrid, Andrés, additional, Bison, Brigitte, additional, Gielen, Gerrit H, additional, Jones, David T W, additional, Jones, Chris, additional, and Kramm, Christof M, additional
- Published
- 2024
- Full Text
- View/download PDF
15. Clinical features and comorbidity pattern of HCV infected migrants compared to native patients in care in Italy: A real-life evaluation of the PITER cohort
- Author
-
Mazzaro, Cesare, Bertola, Manuela, Schioppa, Ornella, Benedetti, Antonio, Schiadà, Laura, Cucco, Monica, Giacometti, Andrea, Brescini, Laura, Castelletti, Sefora, Fiorentini, Alessandro, Angarano, Gioacchino, Milella, Michele, Di Leo, Alfredo, Rendina, Maria, D'abramo, Fulvio Salvatore, Lillo, Chiara, Iannone, Andrea, Piazzolla, Mariano, Verucchi, Gabriella, Badia, Lorenzo, Piscaglia, Fabio, Benevento, Francesca, Serio, Ilaria, Castelli, Francesco, Zaltron, Serena, Spinetti, Angiola, Odolini, Silvia, Bruno, Raffaele, Mondelli, Mario, Chessa, Luchino, Loi, Martina, Torti, Carlo, Costa, Chiara, Mazzitelli, Maria, Pisani, Vincenzo, Scaglione, Vincenzo, Trecarichi, Enrico Maria, Zignego, Anna Linda, Monti, Monica, Madia, Francesco, Blanc, Pier Luigi, Attala, Letizia, Pierotti, Piera, Salomoni, Elena, Mariabelli, Elisa, Santantonio, Teresa Antonia, Bruno, Serena Rita, Cela, Ester Marina, Bassetti, Matteo, Mazzarello, Giovanni, Alessandrini, Anna Ida, Di Biagio, Antonio, Nicolini, Laura Ambra, Raimondo, Giovanni, Filomia, Roberto, Aghemo, Alessio, Meli, Rossella, Lazzarin, Adriano, Morsica, Giulia, Salpietro, Stefania, Galli, Massimo, Fracanzani, Anna Ludovica, Fatta, Erika, Lombardi, Rosa, Lampertico, Pietro, Borghi, Marta, D'ambrosio, Roberta, Degasperi, Elisabetta, Puoti, Massimo, Baiguera, Chiara, D'amico, Federico, Vinci, Maria, Rumi, Maria Grazia, Zuin, Massimo, Giorgini, Alessia, Zermiani, Paola, Andreone, Pietro, Caraceni, Paolo, Margotti, Marzia, Guarneri, Valeria, Villa, Erica, Bernabucci, Veronica, Bristot, Laura, Paradiso, Maria Luisa, Migliorino, Guglielmo, Beretta, Ilaria, Gambaro, Alessandra, Lapadula, Giuseppe, Spolti, Anna, Soria, Alessandro, Invernizzi, Pietro, Ciaccio, Antonio, LucÀ, Martina, Malinverno, Federica, Ratti, Laura, Coppola, Carmine, Amoruso, Daniela Caterina, Pisano, Federica, Scarano, Ferdinando, Staiano, Laura, Morisco, Filomena, Cossiga, Valentina, Gentile, Ivan, Buonomo, Antonio Riccardo, Foggia, Maria, Zappulo, Emanuela, Federico, Alessandro, Dallio, Marcello, Coppola, Nicola, Sagnelli, Caterina, Martini, Salvatore, Monari, Caterina, Nardone, Gerardo, Sgamato, Costantino, Chemello, Liliana, Cavalletto, Luisa, Sterrantino, Daniela, Russo, Francesco Paolo, Zanetto, Alberto, Zanaga, Paola, Barbaro, Francesco, Brancaccio, Giuseppina, Craxì, Antonio, Petta, Salvatore, Calvaruso, Vincenza, Crapanzano, Luciano, Madonia, Salvatore, Cannizzaro, Marco, Bruno, Erica Maria, Licata, Anna, Amodeo, Simona, Capitano, Adele Rosaria, Ferrari, Carlo, Laccabue, Diletta, Negri, Elisa, Orlandini, Alessandra, Pesci, Marco, Gulminetti, Roberto, Pagnucco, Layla, Parruti, Giustino, Di Stefano, Paola, Brunetto, Maurizia Rossana, Coco, Barbara, Massari, Marco, Corsini, Romina, Garlassi, Elisa, Andreoni, Massimo, Teti, Elisabetta, Cerva, Carlotta, Baiocchi, Lorenzo, Tata, Xhimi, Grassi, Giuseppe, Gasbarrini, Antonio, Pompili, Maurizio, De Siena, Martina, Taliani, Gloria, Biliotti, Elisa, Spaziante, Martina, Persico, Marcello, Masarone, Mario, Aglitti, Andrea, Calvanese, Gemma, Anselmo, Marco, De Leo, Pasqualina, Marturano, Monica, Saracco, Giorgio Maria, Ciancio, Alessia, Ieluzzi, Donatella, Quaranta, Maria Giovanna, Ferrigno, Luigina, D'Angelo, Franca, Saracino, Annalisa, and Kondili, Loeta A.
- Published
- 2021
- Full Text
- View/download PDF
16. Hepatitis B vaccine coverage and risk factors for lack of vaccination in subjects with HBsAg negative liver cirrhosis in Italy: still, much work should be done
- Author
-
Stroffolini, Tommaso, Lombardi, Anna, Ciancio, Alessia, Fontana, Rosanna, Colloredo, Guido, Marignani, Massimo, Vinci, Maria, Morisco, Filomena, Babudieri, Sergio, Ferrigno, Luigina, and Sagnelli, Evangelista
- Published
- 2021
- Full Text
- View/download PDF
17. MicroRNA-34a: the bad guy in age-related vascular diseases
- Author
-
Raucci, Angela, Macrì, Federica, Castiglione, Stefania, Badi, Ileana, Vinci, Maria Cristina, and Zuccolo, Estella
- Published
- 2021
- Full Text
- View/download PDF
18. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs
- Author
-
Siminovitch, Katherine A., Hirschfield, Gideon M., Mason, Andrew, Vincent, Catherine, Xie, Gang, Zhang, Jinyi, Tang, Ruqi, Ma, Xiong, Li, Zhiqiang, Shi, Yongyong, Affronti, Andrea, Almasio, Piero L., Alvaro, Domenico, Andreone, Pietro, Andriulli, Angelo, Azzaroli, Francesco, Battezzati, Pier Maria, Benedetti, Antonio, Bragazzi, MariaConsiglia, Brunetto, Maurizia, Bruno, Savino, Calvaruso, Vincenza, Cardinale, Vincenzo, Casella, Giovanni, Cazzagon, Nora, Ciaccio, Antonio, Coco, Barbara, Colli, Agostino, Colloredo, Guido, Colombo, Massimo, Colombo, Silvia, Cristoferi, Laura, Cursaro, Carmela, Crocè, Lory Saveria, Crosignani, Andrea, D’Amato, Daphne, Donato, Francesca, Elia, Gianfranco, Fabris, Luca, Fagiuoli, Stefano, Ferrari, Carlo, Floreani, Annarosa, Galli, Andrea, Giannini, Edoardo, Grattagliano, Ignazio, Lampertico, Pietro, Lleo, Ana, Malinverno, Federica, Mancuso, Clara, Marra, Fabio, Marzioni, Marco, Massironi, Sara, Mattalia, Alberto, Miele, Luca, Milani, Chiara, Morini, Lorenzo, Morisco, Filomena, Muratori, Luigi, Muratori, Paolo, Niro, Grazia A., O’Donnell, Sarah, Picciotto, Antonio, Portincasa, Piero, Rigamonti, Cristina, Ronca, Vincenzo, Rosina, Floriano, Spinzi, Giancarlo, Strazzabosco, Mario, Tarocchi, Mirko, Tiribelli, Claudio, Toniutto, Pierluigi, Valenti, Luca, Vinci, Maria, Zuin, Massimo, Nakamura, Hitomi, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Ito, Masahiro, Migita, Kiyoshi, Ohira, Hiromasa, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ota, Hajime, Komura, Takuya, Nakamura, Yoko, Shimada, Masaaki, Hirashima, Noboru, Komeda, Toshiki, Ario, Keisuke, Nakamuta, Makoto, Yamashita, Tsutomu, Furuta, Kiyoshi, Kikuchi, Masahiro, Naeshiro, Noriaki, Takahashi, Hironao, Mano, Yutaka, Tsunematsu, Seiji, Yabuuchi, Iwao, Shimada, Yusuke, Yamauchi, Kazuhiko, Sugimoto, Rie, Sakai, Hironori, Mita, Eiji, Koda, Masaharu, Tsuruta, Satoru, Kamitsukasa, Hiroshi, Sato, Takeaki, Masaki, Naohiko, Kobata, Tatsuro, Fukushima, Nobuyoshi, Ohara, Yukio, Muro, Toyokichi, Takesaki, Eiichi, Takaki, Hitoshi, Yamamoto, Tetsuo, Kato, Michio, Nagaoki, Yuko, Hayashi, Shigeki, Ishida, Jinya, Watanabe, Yukio, Kobayashi, Masakazu, Koga, Michiaki, Saoshiro, Takeo, Yagura, Michiyasu, Hirata, Keisuke, Tanaka, Atsushu, Takikawa, Hajime, Zeniya, Mikio, Abe, Masanori, Onji, Morikazu, Kaneko, Shuichi, Honda, Masao, Arai, Kuniaki, Arinaga-Hino, Teruko, Hashimoto, Etsuko, Taniai, Makiko, Umemura, Takeji, Joshita, Satoru, Nakao, Kazuhiko, Ichikawa, Tatsuki, Shibata, Hidetaka, Yamagiwa, Satoshi, Seike, Masataka, Honda, Koichi, Sakisaka, Shotaro, Takeyama, Yasuaki, Harada, Masaru, Senju, Michio, Yokosuka, Osamu, Kanda, Tatsuo, Ueno, Yoshiyuki, Kikuchi, Kentaro, Ebinuma, Hirotoshi, Himoto, Takashi, Yasunami, Michio, Murata, Kazumoto, Mizokami, Masashi, Kawata, Kazuhito, Shimoda, Shinji, Miyake, Yasuhiro, Takaki, Akinobu, Yamamoto, Kazuhide, Hirano, Katsuji, Ichida, Takafumi, Ido, Akio, Tsubouchi, Hirohito, Chayama, Kazuaki, Harada, Kenichi, Nakanuma, Yasuni, Maehara, Yoshihiko, Taketomi, Akinobu, Shirabe, Ken, Soejima, Yuji, Mori, Akira, Yagi, Shintaro, Uemoto, Shinji, H, Egawa, Tanaka, Tomohiro, Yamashiki, Noriyo, Tamura, Sumito, Sugawara, Yasuhiro, Kokudo, Norihiro, Juran, Brian D., Atkinson, Elizabeth J., Cheung, Angela, de Andrade, Mariza, Lazaridis, Konstantinos N., Chalasani, Naga, Luketic, Vel, Odin, Joseph, Chopra, Kapil, Baras, Aris, Horowitz, Julie, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Sturgess, Richard, Healey, Christopher, Yeoman, Andrew, Gunasekera, Anton VJ., Kooner, Paul, Kapur, Kapil, Sathyanarayana, V., Kallis, Yiannis, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Rooney, Paul, Ramanaden, David, Evans, Richard, Mathialahan, Thiriloganathan, Gasem, Jaber, Shorrock, Christopher, Bhalme, Mahesh, Southern, Paul, Tibble, Jeremy A., Gorard, David A., Jones, Susan, Mells, George, Mulcahy, Victoria, Srivastava, Brijesh, Foxton, Matthew R., Collins, Carole E., Elphick, David, Karmo, Mazn, Porras-Perez, Francisco, Mendall, Michael, Yapp, Tom, Patel, Minesh, Ede, Roland, Sayer, Joanne, Jupp, James, Fisher, Neil, Carter, Martyn J., Koss, Konrad, Shah, Jayshri, Piotrowicz, Andrzej, Scott, Glyn, Grimley, Charles, Gooding, Ian R., Williams, Simon, Tidbury, Judith, Lim, Guan, Cheent, Kuldeep, Levi, Sass, Mansour, Dina, Beckley, Matilda, Hollywood, Coral, Wong, Terry, Marley, Richard, Ramage, John, Gordon, Harriet M., Ridpath, Jo, Ngatchu, Theodore, Bob Grover, Vijay Paul, Shidrawi, Ray G., Abouda, George, Corless, L., Narain, Mark, Rees, Ian, Brown, Ashley, Taylor-Robinson, Simon, Wilkins, Joy, Grellier, Leonie, Banim, Paul, Das, Debasish, Heneghan, Michael A., Curtis, Howard, Matthews, Helen C., Mohammed, Faiyaz, Aldersley, Mark, Srirajaskanthan, Raj, Walker, Giles, McNair, Alistair, Sharif, Amar, Sen, Sambit, Bird, George, Prince, Martin I., Prasad, Geeta, Kitchen, Paul, Barnardo, Adrian, Oza, Chirag, Sivaramakrishnan, Nurani N., Gupta, Prakash, Shah, Amir, Evans, Chris DJ., Saha, Subrata, Pollock, Katharine, Bramley, Peter, Mukhopadhya, Ashis, Barclay, Stephen T., McDonald, Natasha, Bathgate, Andrew J., Palmer, Kelvin, Dillon, John F., Rushbrook, Simon M., Przemioslo, Robert, McDonald, Chris, Millar, Andrew, Tai, Cheh, Mitchell, Stephen, Metcalf, Jane, Shaukat, Syed, Ninkovic, Mary, Shmueli, Udi, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom JW., Ryder, Stephen, Collier, Jane, Klass, Howard, Cramp, Matthew E., Sharer, Nichols, Aspinall, Richard, Ghosh, Deb, Douds, Andrew C., Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Christie, John, Mann, Steven, Thorburn, Douglas, Marshall, Aileen, Patanwala, Imran, Ala, Aftab, Maltby, Julia, Matthew, Ray, Corbett, Chris, Vyas, Sam, Singhal, Saket, Gleeson, Dermot, Misra, Sharat, Butterworth, Jeff, George, Keith, Harding, Tim, Douglass, Andrew, Mitchison, Harriet, Panter, Simon, Shearman, Jeremy, Bray, Gary, Roberts, Michael, Butcher, Graham, Forton, Daniel, Mahmood, Zahid, Cowan, Matthew, Das, Debashis, Ch’ng, Chin Lye, Rahman, Mesbah, Whatley, Gregory C.A., Wesley, Emma, Mandal, Aditya, Jain, Sanjiv, Pereira, Stephen P., Wright, Mark, Trivedi, Palak, Gordon, Fiona H., Unitt, Esther, Palejwala, Altaf, Austin, Andrew, Vemala, Vishwaraj, Grant, Allister, Higham, Andrew D., Brind, Alison, Mathew, Ray, Cox, Mark, Ramakrishnan, Subramaniam, King, Alistair, Whalley, Simon, Fraser, Jocelyn, Thomson, S.J., Bell, Andrew, Wong, Voi Shim, Kia, Richard, Gee, Ian, Keld, Richard, Ransford, Rupert, Gotto, James, Millson, Charles, Cordell, Heather J., Fryett, James J., Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Ferreira, Manuel A.R., Sun, Dylan, Jones, David E., Flack, Steven, Spicer, Ann, Mulcahy, Victoria L., Byan, Jinyoung, Han, Younghun, Sandford, Richard N., Amos, Christopher I., Seldin, Michael F., Invernizzi, Pietro, Nakamura, Minoru, and Mells, George F.
- Published
- 2021
- Full Text
- View/download PDF
19. X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
- Author
-
Walker, Erin, Xie, Gang, Mason, Andy, Myers, Robert, Peltekian, Kevork, Ghent, Cameron, Atkinson, Elizabeth, Juran, Bruce, Lazaridis, Kostas, Lu, Yue, Gu, Xiangjun, Jing, Kaiyan, Amos, Chris, Affronti, Andrea, Brunetto, Maurizia, Coco, Barbara, Spinzi, Giancarlo, Elia, Gianfranco, Ferrari, Carlo, Lleo, Ana, Muratori, Luigi, Muratori, Paolo, Portincasa, Piero, Colli, Agostino, Bruno, Savino, Colloredo, Guido, Azzaroli, Francesco, Andreone, Pietro, Bragazzi, MariaConsiglia, Alvaro, Domenico, Cardinale, Vincenzo, Cazzagon, Nora, Rigamonti, Cristina, Floreani, Annarosa, Rosina, Floriano, Ciaccio, Antonio, Cristoferi, Laura, D’Amato, Daphne, Malinverno, Federica, Mancuso, Clara, Massironi, Sara, Milani, Chiara, O’Donnell, Sarah E., Ronca, Vincenzo, Barisani, Donatella, Lampertico, Pietro, Donato, Francesca, Fagiuoli, Stefano, Almasio, Piero L., Giannini, Edoardo, Cursaro, Carmela, Colombo, Massimo, Valenti, Luca, Miele, Luca, Andriulli, Angelo, Niro, Grazia A., Grattagliano, Ignazio, Morini, Lorenzo, Casella, Giovanni, Vinci, Maria, Battezzati, Pier Maria, Crosignani, Andrea, Zuin, Massimo, Mattalia, Alberto, Calvaruso, Vincenza, Colombo, Silvia, Benedetti, Antonio, Marzioni, Marco, Galli, Andrea, Marra, Fabio, Tarocchi, Mirko, Picciotto, Antonio, Morisco, Filomena, Fabris, Luca, Crocè, Lory Saveria, Tiribelli, Claudio, Toniutto, Pierluigi, Strazzabosco, Mario, Ch’ng, Chin Lye, Rahman, Mesbah, Yapp, Tom, Sturgess, Richard, Healey, Christopher, Czajkowski, Marek, Gunasekera, Anton, Gyawali, Pranab, Premchand, Purushothaman, Kapur, Kapil, Marley, Richard, Foster, Graham, Watson, Alan, Dias, Aruna, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Ramanaden, David, Gasem, Jaber, Evans, Richard, Mathialahan, Thiriloganathan, Shorrock, Christopher, Lipscomb, George, Southern, Paul, Tibble, Jeremy, Gorard, David, Palegwala, Altaf, Jones, Susan, Dawwas, Mohamed, Alexander, Graeme, Dolwani, Sunil, Prince, Martin, Foxton, Matthew, Elphick, David, Mitchison, Harriet, Gooding, Ian, Karmo, Mazn, Saksena, Sushma, Mendall, Mike, Patel, Minesh, Ede, Roland, Austin, Andrew, Sayer, Joanna, Hankey, Lorraine, Hovell, Christopher, Fisher, Neil, Carter, Martyn, Koss, Konrad, Piotrowicz, Andrzej, Grimley, Charles, Neal, David, Lim, Guan, Levi, Sass, Ala, Aftab, Broad, Andrea, Saeed, Athar, Wood, Gordon, Brown, Jonathan, Wilkinson, Mark, Gordon, Harriet, Ramage, John, Ridpath, Jo, Ngatchu, Theodore, Grover, Bob, Shaukat, Syed, Shidrawi, Ray, Abouda, George, Ali, Faiz, Rees, Ian, Salam, Imroz, Narain, Mark, Brown, Ashley, Taylor-Robinson, Simon, Williams, Simon, Grellier, Leonie, Banim, Paul, Das, Debasish, Chilton, Andrew, Heneghan, Michael, Curtis, Howard, Gess, Markus, Drake, Ian, Aldersley, Mark, Davies, Mervyn, Jones, Rebecca, McNair, Alastair, Srirajaskanthan, Raj, Pitcher, Maxton, Sen, Sambit, Bird, George, Barnardo, Adrian, Kitchen, Paul, Yoong, Kevin, Chirag, Oza, Sivaramakrishnan, Nurani, MacFaul, George, Jones, David, Shah, Amir, Evans, Chris, Saha, Subrata, Pollock, Katharine, Bramley, Peter, Mukhopadhya, Ashis, Fraser, Andrew, Mills, Peter, Shallcross, Christopher, Campbell, Stewart, Bathgate, Andrew, Shepherd, Alan, Dillon, John, Rushbrook, Simon, Przemioslo, Robert, Macdonald, Christopher, Metcalf, Jane, Shmueli, Udi, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom, Ryder, Stephen D., Collier, Jane, Klass, Howard, Ninkovic, Mary, Cramp, Matthew, Sharer, Nicholas, Aspinall, Richard, Goggin, Patrick, Ghosh, Deb, Douds, Andrew, Hoeroldt, Barbara, Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Stableforth, William, Ayres, Reuben, Thorburn, Douglas, Marshall, Eileen, Burroughs, Andrew, Mann, Steven, Lombard, Martin, Richardson, Paul, Patanwala, Imran, Maltby, Julia, Brookes, Matthew, Mathew, Ray, Vyas, Samir, Singhal, Saket, Gleeson, Dermot, Misra, Sharat, Butterworth, Jeff, George, Keith, Harding, Tim, Douglass, Andrew, Panter, Simon, Shearman, Jeremy, Bray, Gary, Butcher, Graham, Forton, Daniel, Mclindon, John, Cowan, Matthew, Whatley, Gregory, Mandal, Aditya, Gupta, Hemant, Sanghi, Pradeep, Jain, Sanjiv, Pereira, Steve, Prasad, Geeta, Watts, Gill, Wright, Mark, Neuberger, James, Gordon, Fiona, Unitt, Esther, Grant, Allister, Delahooke, Toby, Higham, Andrew, Brind, Alison, Cox, Mark, Ramakrishnan, Subramaniam, King, Alistair, Collins, Carole, Whalley, Simon, Li, Andy, Fraser, Jocelyn, Bell, Andrew, Wong, Voi Shim, Singhal, Amit, Gee, Ian, Ang, Yeng, Ransford, Rupert, Gotto, James, Millson, Charles, Bowles, Jane, Thomas, Caradog, Harrison, Melanie, Galaska, Roman, Kendall, Jennie, Whiteman, Jessica, Lawlor, Caroline, Gray, Catherine, Elliott, Keith, Mulvaney-Jones, Caroline, Hobson, Lucie, Van Duyvenvoorde, Greta, Loftus, Alison, Seward, Katie, Penn, Ruth, Maiden, Jane, Damant, Rose, Hails, Janeane, Cloudsdale, Rebecca, Silvestre, Valeria, Glenn, Sue, Dungca, Eleanor, Wheatley, Natalie, Doyle, Helen, Kent, Melanie, Hamilton, Caroline, Braim, Delyth, Wooldridge, Helen, Abrahams, Rachel, Paton, Alison, Lancaster, Nicola, Gibbins, Andrew, Hogben, Karen, Desousa, Phillipa, Muscariu, Florin, Musselwhite, Janine, McKay, Alexandra, Tan, LaiTing, Foale, Carole, Brighton, Jacqueline, Flahive, Kerry, Nambela, Estelle, Townshend, Paula, Ford, Chris, Holder, Sophie, Palmer, Caroline, Featherstone, James, Nasseri, Mariam, Sadeghian, Joy, Williams, Bronwen, Thomas, Carol, Rolls, Sally-Ann, Hynes, Abigail, Duggan, Claire, Jones, Sarah, Crossey, Mary, Stansfield, Glynis, MacNicol, Carolyn, Wilkins, Joy, Wilhelmsen, Elva, Raymode, Parizade, Lee, Hye-Jeong, Durant, Emma, Bishop, Rebecca, Ncube, Noma, Tripoli, Sherill, Casey, Rebecca, Cowley, Caroline, Miller, Richard, Houghton, Kathryn, Ducker, Samantha, Wright, Fiona, Bird, Bridget, Baxter, Gwen, Keggans, Janie, Hughes, Maggie, Grieve, Emma, Young, Karin, Williams, D., Ocker, Kate, Hines, Frances, Martin, Kirsty, Innes, Caron, Valliani, Talal, Fairlamb, Helen, Thornthwaite, Sarah, Eastick, Anne, Tanqueray, Elizabeth, Morrison, Jennifer, Holbrook, Becky, Browning, Julie, Walker, Kirsten, Congreave, Susan, Verheyden, Juliette, Slininger, Susan, Stafford, Lizzie, O’Donnell, Denise, Ainsworth, Mark, Lord, Susan, Kent, Linda, March, Linda, Dickson, Christine, Simpson, Diane, Longhurst, Beverley, Hayes, Maria, Shpuza, Ervin, White, Nikki, Besley, Sarah, Pearson, Sallyanne, Wright, Alice, Jones, Linda, Gunter, Emma, Dewhurst, Hannah, Fouracres, Anna, Farrington, Liz, Graves, Lyn, Marriott, Suzie, Leoni, Marina, Tyrer, David, Martin, Kate, Dali-kemmery, Lola, Lambourne, Victoria, Green, Marie, Sirdefield, Dawn, Amor, Kelly, Colley, Julie, Shinder, Bal, Jones, Jayne, Mills, Marisa, Carnahan, Mandy, Taylor, Natalie, Boulton, Kerenza, Tregonning, Julie, Brown, Carly, Clifford, Gayle, Archer, Emily, Hamilton, Maria, Curtis, Janette, Shewan, Tracey, Walsh, Sue, Warner, Karen, Netherton, Kimberley, Mupudzi, Mcdonald, Gunson, Bridget, Gitahi, Jane, Gocher, Denise, Batham, Sally, Pateman, Hilary, Desmennu, Senayon, Conder, Jill, Clement, Darren, Gallagher, Susan, Orpe, Jacky, Chan, PuiChing, Currie, Lynn, O’Donohoe, Lynn, Oblak, Metod, Morgan, Lisa, Quinn, Marie, Amey, Isobel, Baird, Yolanda, Cotterill, Donna, Cumlat, Lourdes, Winter, Louise, Greer, Sandra, Spurdle, Katie, Allison, Joanna, Dyer, Simon, Sweeting, Helen, Kordula, Jean, Aiba, Yoshihiro, Nakamura, Hitomi, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Ito, Masahiro, Kawai, Yosuke, Kohn, Seik-Soon, Gervais, Olivier, Migita, Kiyoshi, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ota, Hajime, Komura, Takuya, Nakamura, Yoko, Shimada, Masaaki, Hirashima, Noboru, Komeda, Toshiki, Ario, Keisuke, Nakamuta, Makoto, Yamashita, Tsutomu, Furuta, Kiyoshi, Kikuchi, Masahiro, Naeshiro, Noriaki, Takahashi, Hironao, Mano, Yutaka, Tsunematsu, Seiji, Yabuuchi, Iwao, Shimada, Yusuke, Yamauchi, Kazuhiko, Sugimoto, Rie, Sakai, Hironori, Mita, Eiji, Koda, Masaharu, Tsuruta, Satoru, Kamitsukasa, Hiroshi, Sato, Takeaki, Masaki, Naohiko, Kobata, Tatsuro, Fukushima, Nobuyoshi, Higuchi, Nobito, Ohara, Yukio, Muro, Toyokichi, Takesaki, Eiichi, Takaki, Hitoshi, Yamamoto, Tetsuo, Kato, Michio, Nagaoki, Yuko, Hayashi, Shigeki, Ishida, Jinya, Watanabe, Yukio, Kobayashi, Masakazu, Koga, Michiaki, Saoshiro, Takeo, Yagura, Michiyasu, Hirata, Keisuke, Takikawa, Hajime, Ohira, Hiromasa, Zeniya, Mikio, Abe, Masanori, Onji, Morikazu, Kaneko, Shuichi, Honda, Masao, Arai, Kuniaki, Arinaga-Hino, Teruko, Hashimoto, Etsuko, Taniai, Makiko, Umemura, Takeji, Joshita, Satoru, Nakao, Kazuhiko, Ichikawa, Tatsuki, Shibata, Hidetaka, Yamagiwa, Satoshi, Seike, Masataka, Honda, Koichi, Sakisaka, Shotaro, Takeyama, Yasuaki, Harada, Masaru, Senju, Michio, Yokosuka, Osamu, Kanda, Tatsuo, Ueno, Yoshiyuki, Kikuchi, Kentaro, Ebinuma, Hirotoshi, Himoto, Takashi, Yasunami, Michio, Murata, Kazumoto, Mizokami, Masashi, Shimoda, Shinji, Miyake, Yasuhiro, Takaki, Akinobu, Yamamoto, Kazuhide, Hirano, Katsuji, Ichida, Takafumi, Ido, Akio, Tsubouchi, Hirohito, Chayama, Kazuaki, Harada, Kenichi, Nakanuma, Yasuni, Maehara, Yoshihiko, Taketomi, Akinobu, Shirabe, Ken, Soejima, Yuji, Mori, Akira, Yagi, Shintaro, Uemoto, Shinji, Tanaka, Tomohiro, Yamashiki, Noriyo, Tamura, Sumito, Sugawara, Yasuhiro, Kokudo, Norihiro, Asselta, Rosanna, Paraboschi, Elvezia M., Gerussi, Alessio, Cordell, Heather J., Mells, George F., Sandford, Richard N., Jones, David E., Nakamura, Minoru, Ueno, Kazuko, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Tokunaga, Katsushi, Nagasaki, Masao, Tanaka, Atsushi, Tang, Ruqi, Li, Zhiqiang, Shi, Yongyong, Liu, Xiangdong, Xiong, Ma, Hirschfield, Gideon, Siminovitch, Katherine A., Carbone, Marco, Cardamone, Giulia, Duga, Stefano, Gershwin, M. Eric, Seldin, Michael F., and Invernizzi, Pietro
- Published
- 2021
- Full Text
- View/download PDF
20. Effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients: Results of the Italian cohort of a post-marketing observational study
- Author
-
Aghemo, Alessio, Alberti, Alfredo, Andreone, Pietro, Angelico, Mario, Brunetto, Maurizia Rossana, Chessa, Luchino, Ciancio, Alessia, Craxì, Antonio, Gaeta, Giovanni Battista, Galli, Massimo, Gasbarrini, Antonio, Giorgini, Alessia, Grilli, Elisabetta, Lampertico, Pietro, Lichtner, Miriam, Milella, Michele, Morisco, Filomena, Persico, Marcello, Pirisi, Mario, Puoti, Massimo, Raimondo, Giovanni, Romano, Antonietta, Russello, Maurizio, Sangiovanni, Vincenzo, Schiavini, Monica, Serviddio, Gaetano, Villa, Erica, Vinci, Maria, De Michina, Antonella, Gallinaro, Valentina, Gualberti, Giuliana, Roscini, Antonio Saverio, and Zignego, Anna Linda
- Published
- 2021
- Full Text
- View/download PDF
21. Real-world experience with obeticholic acid in patients with primary biliary cholangitis
- Author
-
D’Amato, Daphne, De Vincentis, Antonio, Malinverno, Federica, Viganò, Mauro, Alvaro, Domenico, Pompili, Maurizio, Picciotto, Antonino, Palitti, Valeria Pace, Russello, Maurizio, Storato, Silvia, Pigozzi, Marie Graciella, Calvaruso, Vincenza, De Gasperi, Elisabetta, Lleo, Ana, Castellaneta, Antonino, Pellicelli, Adriano, Cazzagon, Nora, Floreani, Annarosa, Muratori, Luigi, Fagiuoli, Stefano, Niro, Grazia Anna, Feletti, Valentina, Cozzolongo, Raffaele, Terreni, Natalia, Marzioni, Marco, Pellicano, Rinaldo, Pozzoni, Pietro, Baiocchi, Leonardo, Chessa, Luchino, Rosina, Floriano, Bertino, Gaetano, Vinci, Maria, Morgando, Anna, Vanni, Ester, Scifo, Gaetano, Sacco, Rodolfo, D’Antò, Maria, Bellia, Valentina, Boldizzoni, Roberto, Casella, Silvia, Omazzi, Barbara, Poggi, Guido, Cristoferi, Laura, Gerussi, Alessio, Ronca, Vincenzo, Venere, Rosanna, Ponziani, Francesca, Cannavò, Maria, Mussetto, Alessandro, Fontana, Rosanna, Losito, Francesco, Frazzetto, Evelise, Distefano, Marco, Colapietro, Francesca, Labanca, Sara, Marconi, Giulia, Grassi, Giuseppe, Galati, Giovanni, O’Donnell, Sarah Elizabeth, Mancuso, Clara, Mulinacci, Giacomo, Palermo, Andrea, Claar, Ernesto, Izzi, Antonio, Picardi, Antonio, Invernizzi, Pietro, Carbone, Marco, and Vespasiani-Gentilucci, Umberto
- Published
- 2021
- Full Text
- View/download PDF
22. Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling
- Author
-
Nazio, Francesca, Po, Agnese, Abballe, Luana, Ballabio, Claudio, Diomedi Camassei, Francesca, Bordi, Matteo, Camera, Antonio, Caruso, Simona, Caruana, Ignazio, Pezzullo, Marco, Ferraina, Caterina, Milletti, Giacomo, Gianesello, Matteo, Reddel, Sofia, De Luca, Carmen Dolores, Ceglie, Donatella, Marinelli, Sara, Campello, Silvia, Papaleo, Elena, Miele, Evelina, Cacchione, Antonella, Carai, Andrea, Vinci, Maria, Velardi, Enrico, De Angelis, Biagio, Tiberi, Luca, Quintarelli, Concetta, Mastronuzzi, Angela, Ferretti, Elisabetta, Locatelli, Franco, and Cecconi, Francesco
- Published
- 2021
- Full Text
- View/download PDF
23. Gliomatosis cerebri in children:A poor prognostic phenotype of diffuse gliomas with a distinct molecul profile
- Author
-
Nussbaumer, Gunther, Benesch, Martin, Grabovska, Yura, Mackay, Alan, Castel, David, Grill, Jacques, Alonso, Marta M., Antonelli, Manila, Bailey, Simon, Baugh, Joshua N., Biassoni, Veronica, Blattner-Johnson, Mirjam, Broniscer, Alberto, Carai, Andrea, Colafati, Giovanna Stefania, Colditz, Niclas, Corbacioglu, Selim, Crampsie, Shauna, Entz-Werle, Natacha, Eyrich, Matthias, Friker, Lea L., Frühwald, Michael C., Garrè, Maria Luisa, Gerber, Nicolas U., Giangaspero, Felice, Gil-Da-Costa, Maria J., Graf, Norbert, Hargrave, Darren, Hauser, Peter, Herrlinger, Ulrich, Hoffmann, Marion, Hulleman, Esther, Izquierdo, Elisa, Jacobs, Sandra, Karremann, Michael, Kattamis, Antonis, Kebudi, Rejin, Kortmann, Rolf Dieter, Kwiecien, Robert, Massimino, Maura, Mastronuzzi, Angela, Miele, Evelina, Morana, Giovanni, Noack, Claudia M., Pentikainen, Virve, Perwein, Thomas, Pfister, Stefan M., Pietsch, Torsten, Roka, Kleoniki, Rossi, Sabrina, Rutkowski, Stefan, Schiavello, Elisabetta, Seidel, Clemens, Štěrba, Jaroslav, Sturm, Dominik, Sumerauer, David, Tacke, Anna, Temelso, Sara, Valentini, Chiara, van Vuurden, Dannis, Varlet, Pascale, Veldhuijzen van Zanten, Sophie E.M., Vinci, Maria, von Bueren, André O., Warmuth-Metz, Monika, Wesseling, Pieter, Wiese, Maria, Wolff, Johannes E.A., Zamecnik, Josef, La Madrid, Andrés Morales, Bison, Brigitte, Gielen, Gerrit H., Jones, David T.W., Jones, Chris, Kramm, Christof M., Nussbaumer, Gunther, Benesch, Martin, Grabovska, Yura, Mackay, Alan, Castel, David, Grill, Jacques, Alonso, Marta M., Antonelli, Manila, Bailey, Simon, Baugh, Joshua N., Biassoni, Veronica, Blattner-Johnson, Mirjam, Broniscer, Alberto, Carai, Andrea, Colafati, Giovanna Stefania, Colditz, Niclas, Corbacioglu, Selim, Crampsie, Shauna, Entz-Werle, Natacha, Eyrich, Matthias, Friker, Lea L., Frühwald, Michael C., Garrè, Maria Luisa, Gerber, Nicolas U., Giangaspero, Felice, Gil-Da-Costa, Maria J., Graf, Norbert, Hargrave, Darren, Hauser, Peter, Herrlinger, Ulrich, Hoffmann, Marion, Hulleman, Esther, Izquierdo, Elisa, Jacobs, Sandra, Karremann, Michael, Kattamis, Antonis, Kebudi, Rejin, Kortmann, Rolf Dieter, Kwiecien, Robert, Massimino, Maura, Mastronuzzi, Angela, Miele, Evelina, Morana, Giovanni, Noack, Claudia M., Pentikainen, Virve, Perwein, Thomas, Pfister, Stefan M., Pietsch, Torsten, Roka, Kleoniki, Rossi, Sabrina, Rutkowski, Stefan, Schiavello, Elisabetta, Seidel, Clemens, Štěrba, Jaroslav, Sturm, Dominik, Sumerauer, David, Tacke, Anna, Temelso, Sara, Valentini, Chiara, van Vuurden, Dannis, Varlet, Pascale, Veldhuijzen van Zanten, Sophie E.M., Vinci, Maria, von Bueren, André O., Warmuth-Metz, Monika, Wesseling, Pieter, Wiese, Maria, Wolff, Johannes E.A., Zamecnik, Josef, La Madrid, Andrés Morales, Bison, Brigitte, Gielen, Gerrit H., Jones, David T.W., Jones, Chris, and Kramm, Christof M.
- Abstract
Background: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. Methods: We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization. Results: Median overall survival (OS) was 15.5 months (interquartile range, 10.9–27.7) with a 2-year survival rate of 28%. Histopathological grading correlated significantly with median OS: CNS WHO grade II: 47.8 months (25.2–55.7); grade III: 15.9 months (11.4–26.3); grade IV: 10.4 months (8.8–14.4). By DNA methylation profiling (n = 49), most tumors were classified as pediatric-type diffuse high-grade glioma (pedHGG), H3-/IDH-wild-type (n = 31/49, 63.3%) with enriched subclasses pedHGG_RTK2 (n = 19), pedHGG_A/B (n = 6), and pedHGG_MYCN (n = 5), but only one pedHGG_RTK1 case. Within the pedHGG, H3-/IDH-wild-type subgroup, recurrent alterations in EGFR (n = 10) and BCOR (n = 9) were identified. Additionally, we observed structural aberrations in chromosome 6 in 16/49 tumors (32.7%) across tumor types. In the pedHGG, H3-/IDH-wild-type subgroup TP53 alterations had a significant negative effect on OS. Conclusions: Contrary to previous studies, our representative pediatric GC study provides evidence that GC has a strong predilection to arise on the background of specific molecular features (especially pedHGG_ RTK2, pedHGG_A/B, EGFR and BCOR mutations, chromosome 6 rearrangements).
- Published
- 2024
24. The impact of vaccine hesitancy on psychological impairment among healthcare workers in a Total Worker Health© approach.
- Author
-
Di Prinzio, Reparata Rosa, Ceresi, Bianca, Arnesano, Gabriele, Dosi, Alessia, Maimone, Mariarita, Vacca, Maria Eugenia, Vinci, Maria Rosaria, Camisa, Vincenzo, Santoro, Annapaola, Raponi, Massimiliano, Tomao, Paola, Vonesch, Nicoletta, Moscato, Umberto, Zaffina, Salvatore, and Dalmasso, Guendalina
- Published
- 2024
- Full Text
- View/download PDF
25. Machine Learning Analysis in Diffusion Kurtosis Imaging for Discriminating Pediatric Posterior Fossa Tumors: A Repeatability and Accuracy Pilot Study.
- Author
-
Voicu, Ioan Paul, Dotta, Francesco, Napolitano, Antonio, Caulo, Massimo, Piccirilli, Eleonora, D'Orazio, Claudia, Carai, Andrea, Miele, Evelina, Vinci, Maria, Rossi, Sabrina, Cacchione, Antonella, Vennarini, Sabina, Del Baldo, Giada, Mastronuzzi, Angela, Tomà, Paolo, and Colafati, Giovanna Stefania
- Subjects
RANDOM forest algorithms ,GLIOMAS ,PILOT projects ,MAGNETIC resonance imaging ,INFRATENTORIAL brain tumors ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,PEDIATRICS ,RESEARCH bias ,MACHINE learning ,CANCER patient psychology ,COMPARATIVE studies - Abstract
Simple Summary: Differentiating pediatric posterior fossa (PF) tumors such as medulloblastoma (MB), ependymoma (EP), and pilocytic astrocytoma (PA) remains relevant, due to important treatment and prognostic implications. Diffusion kurtosis imaging (DKI) has not been tested to date to distinguish between pediatric PF tumors. Estimating diffusion values from whole-tumor-based (VOI) segmentations may improve the repeatability of diffusion measurements compared to conventional region-of-interest (ROI) approaches. Our purpose was twofold: to assess the repeatability of VOI DKI-derived diffusion measurements and DKI accuracy in discriminating among pediatric PF tumors, by employing conventional statistical analyses and machine learning (ML) techniques. Background and purpose: Differentiating pediatric posterior fossa (PF) tumors such as medulloblastoma (MB), ependymoma (EP), and pilocytic astrocytoma (PA) remains relevant, because of important treatment and prognostic implications. Diffusion kurtosis imaging (DKI) has not yet been investigated for discrimination of pediatric PF tumors. Estimating diffusion values from whole-tumor-based (VOI) segmentations may improve diffusion measurement repeatability compared to conventional region-of-interest (ROI) approaches. Our purpose was to compare repeatability between ROI and VOI DKI-derived diffusion measurements and assess DKI accuracy in discriminating among pediatric PF tumors. Materials and methods: We retrospectively analyzed 34 children (M, F, mean age 7.48 years) with PF tumors who underwent preoperative examination on a 3 Tesla magnet, including DKI. For each patient, two neuroradiologists independently segmented the whole solid tumor, the ROI of the area of maximum tumor diameter, and a small 5 mm ROI. The automated analysis pipeline included inter-observer variability, statistical, and machine learning (ML) analyses. We evaluated inter-observer variability with coefficient of variation (COV) and Bland–Altman plots. We estimated DKI metrics accuracy in discriminating among tumor histology with MANOVA analysis. In order to account for class imbalances, we applied SMOTE to balance the dataset. Finally, we performed a Random Forest (RF) machine learning classification analysis based on all DKI metrics from the SMOTE dataset by partitioning 70/30 the training and testing cohort. Results: Tumor histology included medulloblastoma (15), pilocytic astrocytoma (14), and ependymoma (5). VOI-based measurements presented lower variability than ROI-based measurements across all DKI metrics and were used for the analysis. DKI-derived metrics could accurately discriminate between tumor subtypes (Pillai's trace: p < 0.001). SMOTE generated 11 synthetic observations (10 EP and 1 PA), resulting in a balanced dataset with 45 instances (34 original and 11 synthetic). ML analysis yielded an accuracy of 0.928, which correctly predicted all but one lesion in the testing set. Conclusions: VOI-based measurements presented improved repeatability compared to ROI-based measurements across all diffusion metrics. An ML classification algorithm resulted accurate in discriminating PF tumors on a SMOTE-generated dataset. ML techniques based on DKI-derived metrics are useful for the discrimination of pediatric PF tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Renal safety in 3264 HCV patients treated with DAA-based regimens: Results from a large Italian real-life study
- Author
-
D’Ambrosio, Roberta, Pasulo, Luisa, Giorgini, Alessia, Spinetti, Angiola, Messina, Emanuela, Fanetti, Ilaria, Puoti, Massimo, Aghemo, Alessio, Viganò, Paolo, Vinci, Maria, Menzaghi, Barbara, Lombardi, Andrea, Pan, Angelo, Pigozzi, Marie Graciella, Grossi, Paolo, Lazzaroni, Sergio, Spinelli, Ombretta, Invernizzi, Pietro, Maggiolo, Franco, Terreni, Natalia, Monforte, Antonella D’Arminio, Poggio, Paolo Del, Taddei, Maria Teresa, Colombo, Silvia, Pozzoni, Pietro, Molteni, Chiara, Brocchieri, Alessandra, Bhoori, Sherrie, Buscarini, Elisabetta, Centenaro, Riccardo, Mendeni, Monia, Colombo, Alberto Eraldo, Di Marco, Mariella, Dionigi, Elena, Bella, Daniele, Borghi, Marta, Zuin, Massimo, Zaltron, Serena, Noventa, Franco, Annalisa, De Silvestri, Lampertico, Pietro, and Fagiuoli, Stefano
- Published
- 2020
- Full Text
- View/download PDF
27. Manipulating the tumor immune microenvironment to improve cancer immunotherapy: IGF1R, a promising target
- Author
-
Pellegrino, Marsha, primary, Secli, Valerio, additional, D’Amico, Silvia, additional, Petrilli, Lucia Lisa, additional, Caforio, Matteo, additional, Folgiero, Valentina, additional, Tumino, Nicola, additional, Vacca, Paola, additional, Vinci, Maria, additional, Fruci, Doriana, additional, and de Billy, Emmanuel, additional
- Published
- 2024
- Full Text
- View/download PDF
28. Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells
- Author
-
Beji, Sara, D’Agostino, Marco, Gambini, Elisa, Sileno, Sara, Scopece, Alessandro, Vinci, Maria Cristina, Milano, Giuseppina, Melillo, Guido, Napolitano, Monica, Pompilio, Giulio, Capogrossi, Maurizio C., Avitabile, Daniele, and Magenta, Alessandra
- Published
- 2021
- Full Text
- View/download PDF
29. Digital PCR for high sensitivity viral detection in false-negative SARS-CoV-2 patients
- Author
-
Poggio, Paolo, Songia, Paola, Vavassori, Chiara, Ricci, Veronica, Banfi, Cristina, Barbieri, Silvia Stella, Garoffolo, Gloria, Myasoedova, Veronika A., Piacentini, Luca, Raucci, Angela, Scopece, Alessandro, Sommariva, Elena, Vinci, Maria Cristina, Carcione, Davide, Biondi, Maria Luisa, Mancini, Maria Elisabetta, Formenti, Alberto, Andreini, Daniele, Assanelli, Emilio M., Agostoni, Piergiuseppe, Camera, Marina, Colombo, Gualtiero I., and Pesce, Maurizio
- Published
- 2021
- Full Text
- View/download PDF
30. Real-life effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients with previous DAA failure
- Author
-
Degasperi, Elisabetta, Spinetti, Angiola, Lombardi, Andrea, Landonio, Simona, Rossi, Maria Cristina, Pasulo, Luisa, Pozzoni, Pietro, Giorgini, Alessia, Fabris, Paolo, Romano, Antonietta, Lomonaco, Lorenzo, Puoti, Massimo, Vinci, Maria, Gatti, Federico, Carolo, Giada, Zoncada, Alessia, Bonfanti, Paolo, Russo, Francesco Paolo, Aghemo, Alessio, Soria, Alessandro, Centenaro, Riccardo, Maggiolo, Franco, Rovere, Pierangelo, Pasin, Francesca, Paon, Veronica, Faggiano, Giovanni, Vario, Alessandro, Grossi, Glenda, Soffredini, Roberta, Carriero, Canio, Paolucci, Stefania, Noventa, Franco, Alberti, Alfredo, Lampertico, Pietro, and Fagiuoli, Stefano
- Published
- 2019
- Full Text
- View/download PDF
31. HepaDisk – A new quality of life questionnaire for HCV patients
- Author
-
Fagiuoli, Stefano, Caporaso, Nicola, Morisco, Filomena, Buelli, Fabio, Gualberti, Giuliana, Saragaglia, Valeria, Chessa, Luchino, Corti, Giampaolo, Maida, Ivana, Mastroianni, Claudio M., Pirisi, Mario, Russo, Francesco P., Farina, Francesca, Giannitrapani, Lydia, Toniutto, Pierluigi, Tarquini, Pierluigi, Tundo, Paolo, Vecchiet, Jacopo, Vinci, Maria, and Taliani, Gloria
- Published
- 2019
- Full Text
- View/download PDF
32. Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C
- Author
-
D'Ambrosio, Roberta, Pasulo, Luisa, Puoti, Massimo, Vinci, Maria, Schiavini, Monica, Lazzaroni, Sergio, Soria, Alessandro, Gatti, Federico, Menzaghi, Barbara, Aghemo, Alessio, Capelli, Francesca, Rumi, Maria Grazia, Morini, Lorenzo, Giorgini, Alessia, Pigozzi, Marie Graciella, Rossini, Angelo, Maggiolo, Franco, Pan, Angelo, Memoli, Massimo, Spinelli, Ombretta, Del Poggio, Paolo, Saladino, Valeria, Spinetti, Angiola, De Bona, Anna, Capretti, Andrea, Uberti-Foppa, Caterina, Bonfanti, Paolo, Terreni, Natalia, Menozzi, Fernanda, Colombo, Alberto Eraldo, Giglio, Omar, Centenaro, Riccardo, Borghi, Marta, Baiguera, Chiara, Picciotto, Viviana, Landonio, Simona, Gori, Andrea, Magnani, Carlo, Noventa, Franco, Paolucci, Stefania, Lampertico, Pietro, and Fagiuoli, Stefano
- Published
- 2019
- Full Text
- View/download PDF
33. High Phosphate-Induced JAK-STAT Signalling Sustains Vascular Smooth Muscle Cell Inflammation and Limits Calcification
- Author
-
Macrì, Federica, primary, Vigorito, Ilaria, additional, Castiglione, Stefania, additional, Faggiano, Stefano, additional, Casaburo, Manuel, additional, Fanotti, Nadia, additional, Piacentini, Luca, additional, Vigetti, Davide, additional, Vinci, Maria Cristina, additional, and Raucci, Angela, additional
- Published
- 2023
- Full Text
- View/download PDF
34. Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients
- Author
-
Vinci, Maria Cristina, primary, Costantino, Sarah, additional, Damiano, Giulia, additional, Rurali, Erica, additional, Rinaldi, Raffaella, additional, Vigorelli, Vera, additional, Sforza, Annalisa, additional, Carulli, Ermes, additional, Pirola, Sergio, additional, Mastroiacovo, Giorgio, additional, Raucci, Angela, additional, El-Osta, Assam, additional, Paneni, Francesco, additional, and Pompilio, Giulio, additional
- Published
- 2023
- Full Text
- View/download PDF
35. Targeting the Histone Methyltransferase SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G
- Author
-
Mohammed, Shafeeq Ahmed, primary, Gorica, Era, additional, Albiero, Mattia, additional, Karsai, Gergely, additional, Mengozzi, Alessandro, additional, Caravaggi, Carlo Maria Ferdinando, additional, Ambrosini, Samuele, additional, Masi, Stefano, additional, Vinci, Maria Cristina, additional, Spinetti, Gaia, additional, Rajagopalan, Sanjay, additional, El-Osta, Assam, additional, Pelisek, Jaroslav, additional, Ruschitzka, Frank, additional, Fadini, Gian Paolo, additional, Costantino, Sarah, additional, and Paneni, Francesco, additional
- Published
- 2023
- Full Text
- View/download PDF
36. Association between sex hormones and anti-S/RBD antibody responses to COVID-19 vaccines in healthcare workers
- Author
-
Anticoli, Simona, primary, Dorrucci, Maria, additional, Iessi, Elisabetta, additional, Chiarotti, Flavia, additional, Di Prinzio, Reparata Rosa, additional, Vinci, Maria Rosaria, additional, Zaffina, Salvatore, additional, Puro, Vincenzo, additional, Colavita, Francesca, additional, Mizzoni, Klizia, additional, Meschi, Silvia, additional, Vonesch, Nicoletta, additional, Albano, Christian, additional, Ortona, Elena, additional, Ruggieri, Anna, additional, and Tomao, Paola, additional
- Published
- 2023
- Full Text
- View/download PDF
37. Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
- Author
-
Bjerke, Lynn, Mackay, Alan, Nandhabalan, Meera, Burford, Anna, Jury, Alexa, Popov, Sergey, Bax, Dorine A, Carvalho, Diana, Taylor, Kathryn R, Vinci, Maria, Bajrami, Ilirjana, McGonnell, Imelda M, Lord, Christopher J, Reis, Rui M, Hargrave, Darren, Ashworth, Alan, Workman, Paul, and Jones, Chris
- Subjects
Neurosciences ,Rare Diseases ,Brain Cancer ,Cancer ,Brain Disorders ,Genetics ,Stem Cell Research - Nonembryonic - Non-Human ,Biotechnology ,Pediatric Research Initiative ,Pediatric ,Stem Cell Research ,Adolescent ,Cell Line ,Tumor ,Child ,Chromatin Immunoprecipitation ,Cluster Analysis ,Computational Biology ,DNA Mutational Analysis ,Databases ,Nucleic Acid ,Datasets as Topic ,Gene Expression Profiling ,Gene Expression Regulation ,Neoplastic ,Genotype ,Glioblastoma ,High-Throughput Nucleotide Sequencing ,Histones ,Humans ,Mutation ,N-Myc Proto-Oncogene Protein ,Nuclear Proteins ,Oncogene Proteins ,Protein Binding ,Transcription ,Genetic ,Up-Regulation ,Oncology and Carcinogenesis - Abstract
UnlabelledChildren and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A , occurring either at or close to key residues marked by methylation for regulation of transcription—K27 and G34. Here, we show that the cerebral hemisphere-specific G34 mutation drives a distinct expression signature through differential genomic binding of the K36 trimethylation mark (H3K36me3). The transcriptional program induced recapitulates that of the developing forebrain, and involves numerous markers of stem-cell maintenance, cell-fate decisions, and self-renewal.Critically, H3F3A G34 mutations cause profound upregulation of MYCN , a potent oncogene that is causative of GBMs when expressed in the correct developmental context. This driving aberration is selectively targetable in this patient population through inhibiting kinases responsible for stabilization of the protein.SignificanceWe provide the mechanistic explanation for how the fi rst histone gene mutation inhuman disease biology acts to deliver MYCN, a potent tumorigenic initiator, into a stem-cell compartment of the developing forebrain, selectively giving rise to incurable cerebral hemispheric GBM. Using synthetic lethal approaches to these mutant tumor cells provides a rational way to develop novel and highly selective treatment strategies
- Published
- 2013
38. International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
- Author
-
Tsoli, Maria, Shen, Han, Mayoh, Chelsea, Franshaw, Laura, Ehteda, Anahid, Upton, Danielle, Carvalho, Diana, Vinci, Maria, Meel, Michael H., van Vuurden, Dannis, Plessier, Alexander, Castel, David, Drissi, Rachid, Farrell, Michael, Cryan, Jane, Crimmins, Darach, Caird, John, Pears, Jane, Francis, Stephanie, Ludlow, Louise E. A., Carai, Andrea, Mastronuzzi, Angela, Liu, Bing, Hansford, Jordan, Gottardo, Nick, Hassall, Tim, Kirby, Maria, Fouladi, Maryam, Hawkins, Cynthia, Monje, Michelle, Grill, Jacques, Jones, Chris, Hulleman, Esther, and Ziegler, David S.
- Published
- 2019
- Full Text
- View/download PDF
39. SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors
- Author
-
Giuliani, Giulio, Vumbaca, Simone, Fuoco, Claudia, Gargioli, Cesare, Giorda, Ezio, Massacci, Giorgia, Palma, Alessandro, Reggio, Alessio, Riccio, Federica, Rosina, Marco, Vinci, Maria, Castagnoli, Luisa, and Cesareni, Gianni
- Published
- 2021
- Full Text
- View/download PDF
40. High phosphate-induced JAK-STAT signalling sustains Vascular Smooth Muscle Cells inflammation and limits calcification
- Author
-
Macrì, Federica, Castiglione, Stefania, Faggiano, Stefano, Vigorito, Ilaria, Casaburo, Manuel, Fanotti, Nadia, Piacentini, Luca, Vigetti, Davide, Vinci, Maria Cristina, and Raucci, Angela
- Published
- 2024
- Full Text
- View/download PDF
41. Junctional Adhesion Molecule-A-Deficient Polymorphonuclear Cells Show Reduced Diapedesis in Peritonitis and Heart Ischemia-Reperfusion Injury
- Author
-
Corada, Monica, Chimenti, Stefano, Cera, Maria Rosaria, Vinci, Maria, Salio, Monica, Fiordaliso, Fabio, De Angelis, Noeleen, Villa, Antonello, Bossi, Mario, Staszewsky, Lidia I., Vecchi, Annunciata, Parazzoli, Dario, Motoike, Toshiyuki, Latini, Roberto, Dejana, Elisabetta, and Gimbrone,, Michael A.
- Published
- 2005
42. High-Grade Gliomas and Cancer Predisposition Syndromes in children and adolescents: Unpacking the Impact through a Single-Center Analysis
- Author
-
Mastronuzzi, Angela, primary, Baldo, Giada Del, additional, Montante, Claudio, additional, Cipri, Selene, additional, Boccuto, Luigi, additional, Agolini, Emanuele, additional, Novelli, Antonio, additional, Cacchione, Antonella, additional, Lodi, Mariachiara, additional, Ioris, Maria Antonietta, additional, Cortellessa, Fabiana, additional, Macchiaiolo, Marina, additional, Barresi, Sabina, additional, Giovannoni, Isabella, additional, Rossi, Sabrina, additional, Miele, Evelina, additional, Vinci, Maria, additional, Carai, Andrea, additional, and Locatelli, Franco, additional
- Published
- 2023
- Full Text
- View/download PDF
43. SYST-15 GENERATION AND MULTI-DIMENSIONAL PROFILING OF A CHILDHOOD CANCER CELL LINE ATLAS DEFINES NEW THERAPEUTIC OPPORTUNITIES
- Author
-
Daniel, Paul, primary, Sun, Claire Xin, additional, Bradshaw, Gabrielle, additional, Shi, Hui, additional, Loi, Melissa, additional, Chew, Nicole, additional, Parackal, Sarah, additional, Tsui, Vanessa, additional, Liang, Yuqing, additional, Koptyra, Mateusz, additional, Adjumain, Shazia, additional, Sun, Christie, additional, Chong, Wai Chin, additional, Fernando, Dasun, additional, Drinkwater, Caroline, additional, Tourchi, Motahhareh, additional, Habarakada, Dilru, additional, Carvalho, Diana, additional, Storm, Phillip B, additional, Baubet, Valerie, additional, Sayles, Leanne C, additional, Fernandez, Elisabet, additional, Zhukova, Nataliya, additional, Dun, Matthew D, additional, Ludlow, Louise E, additional, Day, Bryan, additional, Stringer, Brett W, additional, Neeman, Naama, additional, Rubens, Jeffrey A, additional, Raabe, Eric H, additional, Vinci, Maria, additional, Tyrrell, Vanessa, additional, Fletcher, Jamie I, additional, Ekert, Paul G, additional, Dumevska, Biljana, additional, Ziegler, David S, additional, Tsoli, Maria, additional, Sulaiman, Nur Farhana Syed, additional, Loh, Amos Hong Pheng, additional, Low, Sharon Yin Yee, additional, Sweet-Cordero, E Alejandro, additional, Monje, Michelle, additional, Resnick, Adam, additional, Jones, Chris, additional, Downie, Peter, additional, Williams, Bryan, additional, Rosenbluh, Joseph, additional, Gough, Daniel, additional, Cain, Jason E, additional, and Firestein, Ron, additional
- Published
- 2023
- Full Text
- View/download PDF
44. Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI
- Author
-
Boult, Jessica K.R., Box, Gary, Vinci, Maria, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, and Robinson, Simon P.
- Published
- 2017
- Full Text
- View/download PDF
45. Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study
- Author
-
Tabone, Marco, Andreoni, Massimo, Teti, Elisabetta, Angelico, Mario, Persico, Marcello, Masarone, Mario, Chiodera, Aledssandro, Solinas, Attilio, delle Monache, Marco, Cecere, Roberto, Maria Schimizzi, Anna, Piovesan, Sara, Campagnolo, Davide, Chiara Piras, Maria, Zolfino, Teresa, Paolo Russo, Francesca, Morelli, Olivia, Sangiovanni, Vincenzo, Onofrio, Mirella, Iodice, Valentina, Izzi, Antonio, Pirisi, Massimo, Danieli, Elena, Vinci, Maria, Rizzardini, Giuliano, Fagiuoli, Stefano, Pasulo, Luisa, D'Arminio Monforte, Antonella, Zuin, Massimo, Giorgini, Alessia, Simeone, Filomena, Piali, Guido, Lo Guercio, Carmela, Federico, Alessandro, Brancaccio, Giuseppina, Marrone, Aldo, Abbati, Giuseppe, Boarini, Chiara, Borghi, Vanni, Bernabucci, Veronica, Corti, Giampaolo, Monti, Monica, Rizzetto, Mario, Martini, Silvia, Andreone, Pietro, Gianstefani, Alice, Lenzi, Marco, Verucchi, Gabriella, Toniutto, Pierluigi, Borgia, Guglielmo, Caporaso, Nicola, Morisco, Filomena, Nardone, Gaetano, Angrisani, Debora, Giacometti, Andrea, Benedetti, Antonio, Tarantino, Giuseppe, Marsetti, Fabio, Tavio, Marcello, Novara, Sergio, Antonia Santantonio, Teresa, Serviddio, Gaetano, Brunetto, Maurizia, Coco, Barbara, Angarano, Gioacchino, Milella, Michele, Barone, Michele, Di Leo, Alfredo, Ettore Sansonno, Domenico, Cacciola, Irene, Boffa, Nicola, Saracco, Giorgio, Di Biagio, Antonio, Picciotto, Antonino, de Luca, Andrea, Calvaruso, Vincenza, Corradori, Silvia, Ferrari, Carlo, Orlandini, Alessandra, Maida, Ivana, Torti, Carlo, Chessa, Luchino, Felder, Martina, Vespasiani Gentilucci, Umberto, Angeli, Paolo, Romano, Antonietta, Ludovico Rapaccini, Gian, Miele, Luca, Cima, Serena, Luisa Russo, Maria, Cozzolongo, Raffaele, Onnelli, Giovanna, D'Offizi, Giampiero, Lionetti, Raffaella, Montalbano, Marzia, Guerra, Michele, Di Perri, Giovanni, Boglione, Lucio, Capra, Franco, Carolo, Giada, Ieluzzi, Donatella, Antonini, Cinzia, Termite, Antonio, Madonia, Salvatore, Tarquini, Pierluigi, Parruti, Giustino, Vecchiet, Giacomo, Falasca, Katia, Menzaghi, Barbara, Quirino, Tiziana, Dentone, Chiara, Maria Piscaglia, Anna, Rossi, Cristina, Giordani, Maria, Fontanella, Luca, Cassola, Giovanni, Russello, Maurizio, Cristaudo, Antonio, Giacomet, Vania, Colombo, Massimo, Donato, Francesca, Durante, Emanuele, Cosco, Lucio, Marignani, Massimo, Quartini, Mariano, Memoli, Massimo, Ganga, Roberto, Ponti, Laura, Soria, Alessandro, Grazia Rumi, Maria, Gulminetti, Roberto, Maserati, Renato, Mondelli, Mario, Lazzarin, Adriano, Rita Parisi, Maria, Canovari, Benedetta, Avancini, Ivo, Pravadelli, Cecilia, Blanc, Pier, Pasquazzi, Caterina, Maria Mastroianni, Claudio, Lichtner, Myriam, Distefano, Marco, Magnani, Silvia, Paganin, Simona, Erne, Elke, Gatti, Pietro, Tundi, Paolo, Calabrese, Paolo, Gasbarrini, Antonio, Grieco, Antonio, Coppola, Nicola, Del Poggio, Paolo, Levrero, Massimo, Talliani, Gloria, Vullo, Vincenzo, Cauda, Roberto, La Monica, Silvia, Potenza, Domenico, Rizzo, Salvatore, Castelli, Francesco, Marie Pigozzi, Grazielle, Ciancio, Alessia, Romagnoli, Dante, Barchetti, Federica, Ivanovic, Jelena, Longo, Olimpia, Petraglia, Sandra, Paola Trotta, Maria, Petta, Salvatore, Marzioni, Marco, Russo, Pierluigi, Aghemo, Alessio, Alberti, Alfredo, Ascione, Antonio, Antinori, Andrea, Bruno, Raffaele, Bruno, Savino, Chirianni, Antonio, Gaeta, Giovanni Battista, Giannini, Edoardo G, Merli, Manuela, Messina, Vincenzo, Montilla, Simona, Perno, Carlo Federico, Puoti, Massimo, Raimondo, Giovanni, Rendina, Maria, Silberstein, Francesca Ceccherini, Villa, Erica, Zignego, Anna Linda, Pani, Luca, and Craxì, Antonio
- Published
- 2017
- Full Text
- View/download PDF
46. Evaluating the methylation status of CXCR4 promoter: A cost-effective and sensitive two-step PCR method
- Author
-
Bianchessi, Valentina, Lauri, Andrea, Vigorelli, Vera, Toia, Martina, and Vinci, Maria Cristina
- Published
- 2017
- Full Text
- View/download PDF
47. Persistent epigenetic signals propel a senescence-associated secretory phenotype and trained innate immunity in CD34+ hematopoietic stem cells from diabetic patients.
- Author
-
Vinci, Maria Cristina, Costantino, Sarah, Damiano, Giulia, Rurali, Erica, Rinaldi, Raffaella, Vigorelli, Vera, Sforza, Annalisa, Carulli, Ermes, Pirola, Sergio, Mastroiacovo, Giorgio, Raucci, Angela, El-Osta, Assam, Paneni, Francesco, and Pompilio, Giulio
- Subjects
- *
HEMATOPOIETIC stem cells , *NATURAL immunity , *PEOPLE with diabetes , *RNA polymerase II , *CELL physiology , *HYPERGLYCEMIA , *ATHEROSCLEROSIS - Abstract
Background: Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activation and inflammation are initiated in hematopoietic stem/progenitor cells (HSPCs) and transferred to differentiated progeny. Methods and results: High glucose (HG)-exposure of cord blood (CB)-derived HSPCs induced a senescent-associated secretory phenotype (SASP) characterized by cell proliferation lowering, ROS production, telomere shortening, up-regulation of p21 and p27genes, upregulation of NFkB-p65 transcription factor and increased secretion of the inflammatory cytokines TNFα and IL6. Chromatin immunoprecipitation assay (ChIP) of p65 promoter revealed that H3K4me1 histone mark accumulation and methyltransferase SetD7 recruitment, along with the reduction of repressive H3K9me3 histone modification, were involved in NFkB-p65 upregulation of HG-HSPCs, as confirmed by increased RNA polymerase II engagement at gene level. The differentiation of HG-HSPCs into myeloid cells generated highly responsive monocytes, mainly composed of intermediate subsets (CD14hiCD16+), that like the cells from which they derive, were characterized by SASP features and similar epigenetic patterns at the p65 promoter. The clinical relevance of our findings was confirmed in sternal BM-derived HSPCs of T2DM patients. In line with our in vitro model, T2DM HSPCs were characterized by SASP profile and SETD7 upregulation. Additionally, they generated, after myeloid differentiation, senescent monocytes mainly composed of proinflammatory intermediates (CD14hiCD16+) characterized by H3K4me1 accumulation at NFkB-p65 promoter. Conclusions: Hyperglycemia induces marked chromatin modifications in HSPCs, which, once transmitted to the cell progeny, contributes to persistent and pathogenic changes in immune cell function and composition. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
48. HGG-17. SINGLE-CELL AND SPATIAL ANALYSES DECIPHER THE UNIQUE INVASIVE GROWTH PATTERN OF GLIOMATOSIS CEREBRI
- Author
-
Crampsie, Shauna, primary, Liu, Ilon, additional, Petrilli, Lucia Lisa, additional, Mackay, Alan, additional, Spinozzi, Giulio, additional, Grabovska, Yura, additional, Hack, Olivia A, additional, Kessler, Ketty, additional, Temelso, Sara, additional, Carvalho, Diana Martins, additional, Burford, Anna, additional, Sejdiu, Drenusha, additional, Molinari, Valeria, additional, Shaw, McKenzie L, additional, Mire, Hafsa M, additional, Pericoli, Giulia, additional, Cerimele, Alfredo, additional, Barry, Clémentine, additional, Cocito, Carolina, additional, Debily, Marie-Anne, additional, Kergrohen, Thomas, additional, Ajlil, Yassine, additional, Beccaria, Kévin, additional, Varlet, Pascale, additional, Tauziède-Espariat, Arnault, additional, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Giovannoni, Isabella, additional, Rossi, Sabrina, additional, Miele, Evelina, additional, Grill, Jacques, additional, Jacques, Thomas S, additional, Greenfield, Jeffery P, additional, Castel, David, additional, Vinci, Maria, additional, Filbin, Mariella G, additional, and Jones, Chris, additional
- Published
- 2023
- Full Text
- View/download PDF
49. Workplace health promotion initiatives for Italian healthcare workers demonstrate an investment for workers, the organization and the society in the context of total worker health
- Author
-
Zaffina, Salvatore, primary, Prinzio, Reparata, additional, Vinci, Maria, additional, Camisa, Vincenzo, additional, Santoro, Annapaola, additional, Bondanini, Giorgia, additional, Ceresi, Bianca, additional, Dalmasso, Guendalina, additional, and Raponi, Massimiliano, additional
- Published
- 2023
- Full Text
- View/download PDF
50. Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
- Author
-
Izquierdo, Elisa, primary, Carvalho, Diana M., primary, Mackay, Alan, primary, Temelso, Sara, primary, Boult, Jessica K.R., primary, Pericoli, Giulia, primary, Fernandez, Elisabet, primary, Das, Molina, primary, Molinari, Valeria, primary, Grabovska, Yura, primary, Rogers, Rebecca F., primary, Ajmone-Cat, Maria Antonietta, primary, Proszek, Paula Z., primary, Stubbs, Mark, primary, Depani, Sarita, primary, O'Hare, Patricia, primary, Yu, Lu, primary, Roumelioti, Georgia, primary, Choudhary, Jyoti S., primary, Clarke, Matthew, primary, Fairchild, Amy R., primary, Jacques, Thomas S., primary, Grundy, Richard G., primary, Howell, Lisa, primary, Picton, Susan, primary, Adamski, Jenny, primary, Wilson, Shaun, primary, Gray, Juliet C., primary, Zebian, Bassel, primary, Marshall, Lynley V., primary, Carceller, Fernando, primary, Grill, Jacques, primary, Vinci, Maria, primary, Robinson, Simon P., primary, Hubank, Michael, primary, Hargrave, Darren, primary, and Jones, Chris, primary
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.