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2. Membrane guanylyl cyclase receptors: an update

Author

John C. Burnett, Barbara Barylko, Ted D. Chrisman, Vincent Bielinski, Phi Wiegn, Joseph P. Albanesi, Margaret M. Redfield, David L. Garbers, and Takeshi Katafuchi

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Cellular differentiation, Cell, Immune receptor, Biology, Models, Biological, Article, Extracellular matrix, Endocrinology, Osteogenesis, Sphingosine, Cell surface receptor, Internal medicine, Natriuretic Peptide, Brain, medicine, Animals, Humans, Natriuretic Peptides, Receptor, Natriuretic Peptide, C-Type, Cell biology, Intestines, medicine.anatomical_structure, Receptors, Guanylate Cyclase-Coupled, Guanylate Cyclase, Tumor progression, Lysophospholipids, Signal transduction, Receptors, Atrial Natriuretic Factor, Atrial Natriuretic Factor, Signal Transduction
Abstract

Recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. Additionally, cell differentiation, and even tumor progression, can be profoundly influenced by one or more of these receptors. Some of these receptors also mediate important communication between the heart and intestine, and the kidney to regulate blood volume and Na + balance.

Published
2006
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