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1. A nanolander for a space mission to an active asteroid in the main belt

Author: Ho, T.M., Kührt, E., Zhang, X.J., Auster, U., Biele, J., Grott, M., Grundmann, J.T., He, H., Hördt, A., Huang, J.C., Ma, T., Mottola, S., Otto, K., Plettemeier, D., Qin, L., Rubin, M., Schmitz, N., Ulamec, S., and Vincent, J.B.
Published: 2023
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2. Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways

Author: aaaMcNamara, Dennis M., Fett, James D., Pisarcik, Jessica, McTiernan, Charles, Hanley-Yanez, Karen, Gorcsan, John, III, Schelbert, Erik, Alharethi, Rami, Rasmusson, Kismet, Brunisholz, Kim, Butler, Amy, Budge, Deborah, Kfoury, A.G., Horne, Benjamin, Tuinei, Joe, Brown, Heather, Damp, Julie, Naftilan, Allen J., Russell, Jill, Freehardt, Darla, Hsich, Eileen, Oblak, Cynthia, Ewald, Greg, Whitehead, Donna, Flanagan, Jean, Platts, Anne, Elkayam, Uri, Caro, Jorge, Mullin, Stephanie, Givertz, Michael M., Anello, M. Susan, Rajagopalan, Navin, Booth, David, Sandlin, Tiffany, Wijesiri, Wendy, Cooper, Leslie T., Blauwet, Lori A., Brunner, Joann, Phelps, Mary, Kempf, Ruth, Modi, Kalgi, Norwood, Tracy, Briller, Joan, Griza, Decebal Sorin, Felker, G. Michael, Kociol, Robb, Adams, Patricia, Wells, Gretchen, Thohan, Vinay, Wesley-Farrington, Deborah, Soots, Sandra, Sheppard, Richard, Michel, Caroline, Lapointe, Nathalie, Nathaniel, Heather, Kealey, Angela, Semigran, Marc, Daher, Maureen, Boehmer, John, Silber, David, Popjes, Eric, Frey, Patricia, Nicklas, Todd, Alexis, Jeffrey, Caufield, Lori, Thornton, John W., III, Gentry, Mindy, Robinson, Vincent J.B., Sharma, Gyanendra K., Holloway, Joan, Powell, Maria, Markham, David, Drazner, Mark, Fernandez, Lynn, Zucker, Mark, Baran, David A., Gimovsky, Martin L., Hochbaum, Natalia, Patel, Bharati, Adams, Laura, Ramani, Gautam, Gottlieb, Stephen, Robinson, Shawn, Fisher, Stacy, Marshall, Joanne, Haythe, Jennifer, Mancini, Donna, Bijou, Rachel, Farr, Maryjane, Marks, Marybeth, Arango, Henry, Bozkurt, Biykem, Bolos, Mariana, Mather, Paul, Rubin, Sharon, Bonita, Raphael, Eberwine, Susan, Skopicki, Hal, Stergiopoulos, Kathleen, McCathy-Santoro, Ellen, Intravaia, Jennifer, Maas, Elizabeth, Safirstein, Jordan, Kleet, Audrey, Martinez, Nancy, Corpoin, Christine, Hesari, Donna, Chaparro, Sandra, Hudson, Laura J., Ghali, Jalal K., Injic, Zora, Wittstein, Ilan S., McNamara, Dennis M., Janosko, Karen, London, Barry, Gorcsan, John, Tanaka, Hidekazu, Suffoletto, Mathew, Starling, Randall C., McNallan, Annette, Koenig, LuAnne, Pierson, Natalie, Bell, Yanique, Ervin, Alicia, Schrack, Janice, LaDuke, Pam, Torre-Amione, Guillermo, Arredondo, Jeannie, Pauly, Daniel F., Smith, Pamela C., Fuoco, Stephanie, Breton, Elayne, Wesley, Deborah, Dec, G. William, Cocca-Spofford, Diane, Markham, David W., Debes, Colleen, Zucker, Mark J., Liu, Peter, Renton, Judith, Narula, Jagat, Allen, Byron, Westberg, Elizabeth, Lovell, Jana P., Bermea, Kevin, Yu, Jinsheng, Rousseau, Sylvie, Cohen, Charles D., Bhalodia, Aashik, Zita, Marcelle Dina, Head, Richard D., Blumenthal, Roger S., Sharma, Garima, and Adamo, Luigi
Published: 2023
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3. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy

Author: McNamara, Dennis M, Fett, James D., Pisarcik, Jessica, McTiernan, Charles, Hanley-Yanez, Karen, Gorcsan, John, III, Schelbert, Erik, Alharethi, Rami, Rasmusson, Kismet, Brunisholz, Kim, Butler, Amy, Budge, Deborah, Kfoury, A.G., Horne, Benjamin, Tuinei, Joe, Brown, Heather, Damp, Julie, Naftilan, Allen J., Russell, Jill, Freehardt, Darla, Hsich, Eileen, Oblak, Cynthia, Ewald, Greg, Whitehead, Donna, Flanagan, Jean, Platts, Anne, Elkayam, Uri, Caro, Jorge, Mullin, Stephanie, Givertz, Michael M., Anello, M. Susan, Rajagopalan, Navin, Booth, David, Sandlin, Tiffany, Wijesiri, Wendy, Cooper, Leslie T., Blauwet, Lori A., Brunner, Joann, Phelps, Mary, Kempf, Ruth, Modi, Kalgi, Norwood, Tracy, Briller, Joan, Griza, Decebal Sorin, Felker, G. Michael, Kociol, Robb, Adams, Patricia, Wells, Gretchen, Thohan, Vinay, Wesley-Farrington, Deborah, Soots, Sandra, Sheppard, Richard, Michel, Caroline, Lapointe, Nathalie, Nathaniel, Heather, Kealey, Angela, Semigran, Marc, Daher, Maureen, Boehmer, John, Silber, David, Popjes, Eric, Frey, Patricia, Nicklas, Todd, Alexis, Jeffrey, Caufield, Lori, Thornton, John W., III, Gentry, Mindy, Robinson, Vincent J.B., Sharma, Gyanendra K., Holloway, Joan, Powell, Maria, Markham, David, Drazner, Mark, Fernandez, Lynn, Zucker, Mark, Baran, David A., Gimovsky, Martin L., Hochbaum, Natalia, Patel, Bharati, Adams, Laura, Ramani, Gautam, Gottlieb, Stephen, Robinson, Shawn, Fisher, Stacy, Marshall, Joanne, Haythe, Jennifer, Mancini, Donna, Bijou, Rachel, Farr, Maryjane, Marks, Marybeth, Arango, Henry, Bozkurt, Biykem, Bolos, Mariana, Mather, Paul, Rubin, Sharon, Bonita, Raphael, Eberwine, Susan, Skopicki, Hal, Stergiopoulos, Kathleen, McCathy-Santoro, Ellen, Intravaia, Jennifer, Maas, Elizabeth, Safirstein, Jordan, Kleet, Audrey, Martinez, Nancy, Corpoin, Christine, Hesari, Donna, Chaparro, Sandra, Hudson, Laura J., Ghali, Jalal K., Injic, Zora, Wittstein, Ilan S., Koczo, Agnes, Marino, Amy, Jeyabalan, Arun, Fett, James, Blauwet, Lori, Morel, Penelope A., and McNamara, Dennis M.
Published: 2019
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4. Regional unit definition for the nucleus of comet 67P/Churyumov-Gerasimenko on the SHAP7 model

Author: Thomas, N., El Maarry, M.R., Theologou, P., Preusker, F., Scholten, F., Jorda, L., Hviid, S.F., Marschall, R., Kührt, E., Naletto, G., Sierks, H., Lamy, P.L., Rodrigo, R., Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, V., Debei, S., De Cecco, M., Fornasier, S., Fulle, M., Groussin, O., Gutièrrez, P.J., Güttler, C., Ip, W.H., Keller, H.U., Knollenberg, J., Lara, L.M., Lazzarin, M., Lòpez-Moreno, J.J., Marzari, F., Tubiana, C., and Vincent, J.B.
Published: 2018
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5. Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways

Author: Lovell, Jana P., primary, Bermea, Kevin, additional, Yu, Jinsheng, additional, Rousseau, Sylvie, additional, Cohen, Charles D., additional, Bhalodia, Aashik, additional, Zita, Marcelle Dina, additional, Head, Richard D., additional, Blumenthal, Roger S., additional, Alharethi, Rami, additional, Damp, Julie, additional, Boehmer, John, additional, Alexis, Jeffrey, additional, McNamara, Dennis M., additional, Sharma, Garima, additional, Adamo, Luigi, additional, aaaMcNamara, Dennis M., additional, Fett, James D., additional, Pisarcik, Jessica, additional, McTiernan, Charles, additional, Hanley-Yanez, Karen, additional, Gorcsan, John, additional, Schelbert, Erik, additional, Rasmusson, Kismet, additional, Brunisholz, Kim, additional, Butler, Amy, additional, Budge, Deborah, additional, Kfoury, A.G., additional, Horne, Benjamin, additional, Tuinei, Joe, additional, Brown, Heather, additional, Naftilan, Allen J., additional, Russell, Jill, additional, Freehardt, Darla, additional, Hsich, Eileen, additional, Oblak, Cynthia, additional, Ewald, Greg, additional, Whitehead, Donna, additional, Flanagan, Jean, additional, Platts, Anne, additional, Elkayam, Uri, additional, Caro, Jorge, additional, Mullin, Stephanie, additional, Givertz, Michael M., additional, Anello, M. Susan, additional, Rajagopalan, Navin, additional, Booth, David, additional, Sandlin, Tiffany, additional, Wijesiri, Wendy, additional, Cooper, Leslie T., additional, Blauwet, Lori A., additional, Brunner, Joann, additional, Phelps, Mary, additional, Kempf, Ruth, additional, Modi, Kalgi, additional, Norwood, Tracy, additional, Briller, Joan, additional, Griza, Decebal Sorin, additional, Felker, G. Michael, additional, Kociol, Robb, additional, Adams, Patricia, additional, Wells, Gretchen, additional, Thohan, Vinay, additional, Wesley-Farrington, Deborah, additional, Soots, Sandra, additional, Sheppard, Richard, additional, Michel, Caroline, additional, Lapointe, Nathalie, additional, Nathaniel, Heather, additional, Kealey, Angela, additional, Semigran, Marc, additional, Daher, Maureen, additional, Silber, David, additional, Popjes, Eric, additional, Frey, Patricia, additional, Nicklas, Todd, additional, Caufield, Lori, additional, Thornton, John W., additional, Gentry, Mindy, additional, Robinson, Vincent J.B., additional, Sharma, Gyanendra K., additional, Holloway, Joan, additional, Powell, Maria, additional, Markham, David, additional, Drazner, Mark, additional, Fernandez, Lynn, additional, Zucker, Mark, additional, Baran, David A., additional, Gimovsky, Martin L., additional, Hochbaum, Natalia, additional, Patel, Bharati, additional, Adams, Laura, additional, Ramani, Gautam, additional, Gottlieb, Stephen, additional, Robinson, Shawn, additional, Fisher, Stacy, additional, Marshall, Joanne, additional, Haythe, Jennifer, additional, Mancini, Donna, additional, Bijou, Rachel, additional, Farr, Maryjane, additional, Marks, Marybeth, additional, Arango, Henry, additional, Bozkurt, Biykem, additional, Bolos, Mariana, additional, Mather, Paul, additional, Rubin, Sharon, additional, Bonita, Raphael, additional, Eberwine, Susan, additional, Skopicki, Hal, additional, Stergiopoulos, Kathleen, additional, McCathy-Santoro, Ellen, additional, Intravaia, Jennifer, additional, Maas, Elizabeth, additional, Safirstein, Jordan, additional, Kleet, Audrey, additional, Martinez, Nancy, additional, Corpoin, Christine, additional, Hesari, Donna, additional, Chaparro, Sandra, additional, Hudson, Laura J., additional, Ghali, Jalal K., additional, Injic, Zora, additional, Wittstein, Ilan S., additional, Janosko, Karen, additional, London, Barry, additional, Tanaka, Hidekazu, additional, Suffoletto, Mathew, additional, Starling, Randall C., additional, McNallan, Annette, additional, Koenig, LuAnne, additional, Pierson, Natalie, additional, Bell, Yanique, additional, Ervin, Alicia, additional, Schrack, Janice, additional, LaDuke, Pam, additional, Torre-Amione, Guillermo, additional, Arredondo, Jeannie, additional, Pauly, Daniel F., additional, Smith, Pamela C., additional, Fuoco, Stephanie, additional, Breton, Elayne, additional, Wesley, Deborah, additional, Dec, G. William, additional, Cocca-Spofford, Diane, additional, Markham, David W., additional, Debes, Colleen, additional, Zucker, Mark J., additional, Liu, Peter, additional, Renton, Judith, additional, Narula, Jagat, additional, Allen, Byron, additional, and Westberg, Elizabeth, additional
Published: 2023
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6. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy

Author: Agnes Koczo, MD, Amy Marino, MD, Arun Jeyabalan, MD, Uri Elkayam, MD, Leslie T. Cooper, MD, James Fett, MD, MPH, Joan Briller, MD, Eileen Hsich, MD, Lori Blauwet, MD, Charles McTiernan, PhD, Penelope A. Morel, MD, Karen Hanley-Yanez, BS, Dennis M. McNamara, MD, MS, Dennis M McNamara, MD, James D. Fett, MD, Jessica Pisarcik, RN, BSN, John Gorcsan, III, MD, Erik Schelbert, MD, Rami Alharethi, MD, Kismet Rasmusson, CRNP, Kim Brunisholz, Amy Butler, BS, CCRP, Deborah Budge, A.G. Kfoury, MD, Benjamin Horne, PhD, Joe Tuinei, Heather Brown, Julie Damp, MD, Allen J. Naftilan, MD, Jill Russell, RN, MSN, Darla Freehardt, LPN, BS, CCRP, Cynthia Oblak, CCRC, Greg Ewald, MD, Donna Whitehead, RN, Jean Flanagan, RN, Anne Platts, Jorge Caro, MPH, Stephanie Mullin, RN, Michael M. Givertz, MD, M. Susan Anello, RN, BS, Navin Rajagopalan, MD, David Booth, MD, Tiffany Sandlin, RN, Wendy Wijesiri, RN, Lori A. Blauwet, MD, Joann Brunner, RN, Mary Phelps, Ruth Kempf, Kalgi Modi, MD, Tracy Norwood, Decebal Sorin Griza, MD, G. Michael Felker, MD, Robb Kociol, MD, Patricia Adams, RN, Gretchen Wells, MD, Vinay Thohan, MD, Deborah Wesley-Farrington, RN, BSN, CCRC, CCA, Sandra Soots, RN, CCRC, Richard Sheppard, MD, Caroline Michel, MD, Nathalie Lapointe, RN, PhD, Heather Nathaniel, Angela Kealey, MD, Marc Semigran, MD, Maureen Daher, RN, John Boehmer, MD, David Silber, MD, Eric Popjes, MD, Patricia Frey, RN, Todd Nicklas, RN, Jeffrey Alexis, MD, Lori Caufield, RN, BSN, CCRC, John W. Thornton, III, MD, Mindy Gentry, MD, Vincent J.B. Robinson, MBBS, Gyanendra K. Sharma, MD, Joan Holloway, BS, Maria Powell, LPN, CCRC, David Markham, MD, Mark Drazner, MD, Lynn Fernandez, RN, Mark Zucker, MD, David A. Baran, MD, Martin L. Gimovsky, MD, Natalia Hochbaum, MD, Bharati Patel, RN, CCRC, Laura Adams, RN, BSN, Gautam Ramani, MD, Stephen Gottlieb, MD, Shawn Robinson, MD, Stacy Fisher, MD, Joanne Marshall, BSN, MS, Jennifer Haythe, MD, Donna Mancini, MD, Rachel Bijou, MD, Maryjane Farr, MD, Marybeth Marks, Henry Arango, Biykem Bozkurt, MD, PhD, FACC, FAHA, Mariana Bolos, Paul Mather, MD, Sharon Rubin, MD, Raphael Bonita, MD, Susan Eberwine, RN, Hal Skopicki, MD, PhD, Kathleen Stergiopoulos, MD, Ellen McCathy-Santoro, MD, Jennifer Intravaia, RN, CCRCII, Elizabeth Maas, Jordan Safirstein, MD, Audrey Kleet, RN, MS, ACNP-BC, CCRN, CCTC, Nancy Martinez, RN, Christine Corpoin, RN, Donna Hesari, RN, Sandra Chaparro, MD, Laura J. Hudson, MA, MPH, CCRC, Jalal K. Ghali, MD, Zora Injic, RN, BSc, MSA, and Ilan S. Wittstein, MD
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Summary: The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8+ T cells. However, despite elevated prolactin and cytotoxic T cell subsets, myocardial recovery was not impaired in breastfeeding women. Key Words: breastfeeding, immune activation, peripartum cardiomyopathy
Published: 2019
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7. Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study

Author: McNamara, Dennis M., Fett, James D., Pisarcik, Jessica, McTiernan, Charles, Hanley-Yanez, Karen, Gorcsan, John, III, Schelbert, Erik, Alharethi, Rami, Rasmusson, Kismet, Brunisholz, Kim, Butler, Amy, Budge, Deborah, Kfoury, A.G., Horne, Benjamin, Tuinei, Joe, Brown, Heather, Damp, Julie, Naftilan, Allen J., Russell, Jill, Freehardt, Darla, Hsich, Eileen, Oblak, Cynthia, Ewald, Greg, Whitehead, Donna, Flanagan, Jean, Platts, Anne, Elkayam, Uri, Caro, Jorge, Mullin, Stephanie, Givertz, Michael M., Anello, M. Susan, Rajagopalan, Navin, Booth, David, Sandlin, Tiffany, Wijesiri, Wendy, Cooper, Leslie T., Blauwet, Lori A., Brunner, Joann, Phelps, Mary, Kempf, Ruth, Modi, Kalgi, Norwood, Tracy, Briller, Joan, Griza, Decebal Sorin, Felker, G. Michael, Kociol, Robb, Adams, Patricia, Wells, Gretchen, Thohan, Vinay, Wesley-Farrington, Deborah, Soots, Sandra, Sheppard, Richard, Michel, Caroline, Lapointe, Nathalie, Nathaniel, Heather, Kealey, Angela, Semigran, Marc, Daher, Maureen, Boehmer, John, Silber, David, Popjes, Eric, Frey, Patricia, Nicklas, Todd, Alexis, Jeffrey, Caufield, Lori, Thornton, John W., III, Gentry, Mindy, Robinson, Vincent J.B., Sharma, Gyanendra K., Holloway, Joan, Powell, Maria, Markham, David, Drazner, Mark, Fernandez, Lynn, Zucker, Mark, Baran, David A., Gimovsky, Martin L., Hochbaum, Natalia, Patel, Bharati, Adams, Laura, Ramani, Gautam, Gottlieb, Stephen, Robinson, Shawn, Fisher, Stacy, Marshall, Joanne, Haythe, Jennifer, Mancini, Donna, Bijou, Rachel, Farr, Maryjane, Marks, Marybeth, Arango, Henry, Bozkurt, Biykem, Bolos, Mariana, Mather, Paul, Rubin, Sharon, Bonita, Raphael, Eberwine, Susan, Skopicki, Hal, Stergiopoulos, Kathleen, McCathy-Santoro, Ellen, Intravaia, Jennifer, Maas, Elizabeth, Safirstein, Jordan, Kleet, Audrey, Martinez, Nancy, Corpoin, Christine, Hesari, Donna, Chaparro, Sandra, Hudson, Laura J., Ghali, Jalal K., Injic, Zora, Wittstein, Ilan S., McTiernan, Charles F., Morel, Penelope, Thornton, John, Fett, James, and Halder, Indrani
Published: 2018
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8. Science case for the Asteroid Impact Mission (AIM): A component of the Asteroid Impact & Deflection Assessment (AIDA) mission

Author: Michel, Patrick, Cheng, A., Küppers, M., Pravec, P., Blum, J., Delbo, M., Green, S.F., Rosenblatt, P., Tsiganis, K., Vincent, J.B., Biele, J., Ciarletti, V., Hérique, A., Ulamec, S., Carnelli, I., Galvez, A., Benner, L., Naidu, S.P., Barnouin, O.S., Richardson, D.C., Rivkin, A., Scheirich, P., Moskovitz, N., Thirouin, A., Schwartz, S.R., Campo Bagatin, A., and Yu, Y.
Published: 2016
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9. Brain Natriuretic Hormone Predicts Stress-Induced Alterations in Diastolic Function

Author: Choksy, Pratik, Kapuku, Gaston K., Davis, Harry C., Harshfield, Gregory, Robinson, Vincent J.B., Januzzi, James, and Thayer, Julian
Published: 2014
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10. The effect of uniform capture molecule orientation on biosensor sensitivity: Dependence on analyte properties

Author: Trilling, Anke K., Harmsen, Michiel M., Ruigrok, Vincent J.B., Zuilhof, Han, and Beekwilder, Jules
Published: 2013
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11. Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass

Author: Gregory A. Harshfield, Shayong Su, Zsolt Bagi, Gaston Kapuku, Julian F. Thayer, Vincent J.B. Robinson, James D. Halbert, and Guang Hao
Subjects: Adult, medicine.medical_specialty, Longitudinal study, business.industry, General Medicine, 030204 cardiovascular system & hematology, RESTING HEART RATE, Left ventricular mass, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Internal medicine, Cardiac mass, Cardiology, Humans, Medicine, Clinical significance, 030212 general & internal medicine, Young adult, Child, Cardiology and Cardiovascular Medicine, business
Abstract: Little is known about the varied resting heart rate (RHR) trajectory patterns from childhood to young adulthood and their clinical significance. We aim to identify RHR trajectories from childhood to young adulthood, and to determine their relationship with left ventricular mass (LVM) index.RHR was measured up to 15 times over a 21-year period in 759 participants from childhood to young adulthood. LVM was measured using echocardiography and was normalised to body surface area to obtain LVM index in 546 participants.Using latent class models, three trajectory groups in RHR from childhood to young adulthood were identified, including high-decreasing group (HDG), moderate-decreasing group (MDG), and low-decreasing group (LDG). We found that trajectory of RHR was a significant predictor of LVM index with faster decrease of RHR associated with higher levels of total peripheral resistance (Our findings show an association between RHR trajectories from childhood to young adulthood with cardiac mass, suggesting that monitoring RHR may help identify subpopulation at high cardiovascular risk.
Published: 2021

12. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Author: Blokland, G.A., Grove, J, Chen, C.Y., Cotsapas, C., Tobet, S., Handa, R., Clair, D. St, Lencz, T., Mowry, B.J., Periyasamy, S., Cairns, M.J., Tooney, P.A., Wu, J.Q., Kelly, B., Kirov, G., Sullivan, P.F., Corvin, A., Riley, B.P., Esko, T., Milani, L., Jönsson, E.G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P.C., Iwata, N., Weinberger, D.R., Gejman, P.V., Sanders, A.R., Buxbaum, J.D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A.M., Bramon, E., Murray, R.M., Pato, M.T., Lee, J., Melle, I., Molden, E., Ophoff, R.A., McQuillin, A., Bass, N.J., Adolfsson, R., Malhotra, A.K., Martin, N.G., Fullerton, J.M., Mitchell, P.B., Schofield, P.R., Forstner, A.J., Degenhardt, F., Schaupp, S., Comes, A.L., Kogevinas, M., Guzman-Parra, J., Reif, A., Streit, F., Sirignano, L., Cichon, S., Grigoroiu-Serbanescu, M., Hauser, J., Lissowska, J., Mayoral, F., Müller-Myhsok, B., Świątkowska, B., Schulze, T.G., Nöthen, M.M., Rietschel, M., Kelsoe, J., Leboyer, M., Jamain, S., Etain, B., Bellivier, F., Vincent, J.B., Alda, M., O'Donovan, C., Cervantes, P., Biernacka, J.M., Frye, M., McElroy, S.L., Scott, L.J., Stahl, E.A., Landén, M., Hamshere, M.L., Smeland, O.B., Djurovic, S., Vaaler, A.E., Andreassen, O.A., Baune, B.T., Air, T., Preisig, M., Uher, R., Levinson, D.F., Weissman, M.M., Potash, J.B., Shi, J., Knowles, J.A., Bralten, J.B., Perlis, R.H., Lucae, S., Blokland, G.A., Grove, J, Chen, C.Y., Cotsapas, C., Tobet, S., Handa, R., Clair, D. St, Lencz, T., Mowry, B.J., Periyasamy, S., Cairns, M.J., Tooney, P.A., Wu, J.Q., Kelly, B., Kirov, G., Sullivan, P.F., Corvin, A., Riley, B.P., Esko, T., Milani, L., Jönsson, E.G., Palotie, A., Ehrenreich, H., Begemann, M., Steixner-Kumar, A., Sham, P.C., Iwata, N., Weinberger, D.R., Gejman, P.V., Sanders, A.R., Buxbaum, J.D., Rujescu, D., Giegling, I., Konte, B., Hartmann, A.M., Bramon, E., Murray, R.M., Pato, M.T., Lee, J., Melle, I., Molden, E., Ophoff, R.A., McQuillin, A., Bass, N.J., Adolfsson, R., Malhotra, A.K., Martin, N.G., Fullerton, J.M., Mitchell, P.B., Schofield, P.R., Forstner, A.J., Degenhardt, F., Schaupp, S., Comes, A.L., Kogevinas, M., Guzman-Parra, J., Reif, A., Streit, F., Sirignano, L., Cichon, S., Grigoroiu-Serbanescu, M., Hauser, J., Lissowska, J., Mayoral, F., Müller-Myhsok, B., Świątkowska, B., Schulze, T.G., Nöthen, M.M., Rietschel, M., Kelsoe, J., Leboyer, M., Jamain, S., Etain, B., Bellivier, F., Vincent, J.B., Alda, M., O'Donovan, C., Cervantes, P., Biernacka, J.M., Frye, M., McElroy, S.L., Scott, L.J., Stahl, E.A., Landén, M., Hamshere, M.L., Smeland, O.B., Djurovic, S., Vaaler, A.E., Andreassen, O.A., Baune, B.T., Air, T., Preisig, M., Uher, R., Levinson, D.F., Weissman, M.M., Potash, J.B., Shi, J., Knowles, J.A., Bralten, J.B., Perlis, R.H., and Lucae, S.
Abstract: Item does not contain fulltext, BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. RESULTS: Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10(-8)), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10(-6)) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10(-7); rs73033497, p = 8.8 × 10(-7); rs7914279, p = 6.4 × 10(-7)), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10(-7)) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10(-7)), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10(-7)) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). CONCLUSIONS: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and
Published: 2022

13. Overview of Lutetia's surface composition

Author: Barucci, M.A., Belskaya, I.N., Fornasier, S., Fulchignoni, M., Clark, B.E., Coradini, A., Capaccioni, F., Dotto, E., Birlan, M., Leyrat, C., Sierks, H., Thomas, N., and Vincent, J.B.
Published: 2012
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14. Chromium: Physiology

Author: Vincent, J.B., primary
Published: 2016
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15. Chromium: Properties and Determination

Author: Vincent, J.B., primary
Published: 2016
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16. Useful indices of thrombogenesis in the exclusion of intra‐cardiac thrombus

Author: Uzoma N. Ibebuogu, Jennifer L. Waller, Vincent J.B. Robinson, Gyanendra Sharma, Joseph H. Schafer, and Mark J. Schwade
Subjects: medicine.medical_specialty, medicine.medical_treatment, cardiac thrombus, Original Investigations, 030204 cardiovascular system & hematology, Cardioversion, Ventricular Function, Left, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Humans, Atrial Appendage, Radiology, Nuclear Medicine and imaging, Prospective Studies, cardiovascular diseases, 030212 general & internal medicine, Thrombus, Prospective cohort study, Original Investigation, Ejection fraction, Receiver operating characteristic, transesophageal echocardiography, business.industry, D‐dimer assay, Stroke Volume, Thrombosis, Atrial fibrillation, Gold standard (test), medicine.disease, Stroke, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, business, Echocardiography, Transesophageal
Abstract: Background Cardioversion in patients with atrial fibrillation (AF) can cause cardioembolic stroke, and effective clinical management is necessary to reduce morbidity and mortality. Currently, transesophageal echocardiography (TEE) is the accepted standard to diagnose cardiogenic thromboemboli; however, a negative TEE does not eliminate the possibility of left atrial thrombus. The objective of this study was to evaluate the diagnostic value of supplementing the TEE with additional noninvasive markers to ensure thrombus absence. Methods A prospective study was conducted on 59 patients who underwent TEE for suspected intra‐cardiac thrombi. The TEE indications included acute ischemic stroke (45.7%) and AF or flutter (59.3%). D‐dimer level and white blood cell counts were assessed. Results A negative D‐dimer level (
Published: 2019

17. Effects of Race, Cardiac Mass, and Cardiac Load on Myocardial Function Trajectories from Childhood to Young Adulthood: The Augusta Heart Study

Author: Gregory A. Harshfield, Vishal Doshi, Santu Ghosh, James D. Halbert, Varghese George, Melissa Howie, Brittany Ange, Zsolt Bagi, Michael Bykhovsky, Vincent J.B. Robinson, and Gaston Kapuku
Subjects: Male, Longitudinal study, Myocardial Biology, Blood Pressure, 030204 cardiovascular system & hematology, left ventricular mass, Ventricular Function, Left, 0302 clinical medicine, Risk Factors, Longitudinal cohort, Young adult, Child, Original Research, education.field_of_study, Incidence, longitudinal cohort, Interventional Cardiology, Echocardiography, Doppler, Cardiovascular Diseases, Cardiac mass, Hypertension, Cardiology, Female, Cardiology and Cardiovascular Medicine, cardiovascular risk, growth curve model, Cardiac function curve, medicine.medical_specialty, Georgia, Adolescent, midwall fractional shortening, Systole, Heart Ventricles, Population, 030209 endocrinology & metabolism, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, cardiovascular diseases, education, business.industry, Racial Groups, Stroke Volume, Decreased myocardial function, Myocardial function, Myocardial Contraction, cardiac function, business, circumferential end‐systolic stress, Follow-Up Studies, Forecasting
Abstract: Background The overall goal of this longitudinal study was to determine if the Black population has decreased myocardial function, which has the potential to lead to the early development of congestive heart failure, compared with the White population. Methods and Results A total of 673 subjects were evaluated over a period of 30 years including similar percentages of Black and White participants. Left ventricular systolic function was probed using the midwall fractional shortening (MFS). A longitudinal analysis of the MFS using a mixed effect growth curve model was performed. Black participants had greater body mass index, higher blood pressure readings, and greater left ventricular mass compared with White participants (all P Conclusions Changes in myocardial function mirror the race‐dependent variations in blood pressure, afterload, and cardiac mass, suggesting that myocardial function depression occurs early in childhood in populations at high cardiovascular risk such as Black participants.
Published: 2021

18. Ethnic and sex differences in the longitudinal association between heart rate variability and blood pressure

Author: Vincent J.B. Robinson, Gregory A. Harshfield, DP Williams, Gaston Kapuku, LaBarron K. Hill, James D. Halbert, Guang Hao, and Julian F. Thayer
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Ethnic group, Blood Pressure, 030204 cardiovascular system & hematology, Elevated blood, White People, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Internal medicine, Internal Medicine, medicine, Heart rate variability, Humans, 030212 general & internal medicine, Longitudinal Studies, Risk factor, Sex Characteristics, business.industry, General Medicine, Black or African American, Blood pressure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Elevated blood pressure is a risk factor for increased cardiovascular morbidity and mortality. Decreased vagally-mediated heart rate variability has previously been prospectively linked with increased blood pressure; however, to date, no such prospective data exist regarding this relationship among Blacks.We examined this association in 387 normotensive young adults (mean age, 23 years, 52% female, 54% Black) who participated in two laboratory evaluations spanning approximately six years. Blood pressure was measured at both timepoints with a non-invasive oscillometric device and heart rate variability was assessedIn the total sample, heart rate variability significantly predicted systolic (We report for the first time significant ethnic and sex differences in the prospective relationship between heart rate variability and blood pressure change. These findings may give clues as to the underlying mechanisms that are involved in the well-known health disparities in blood pressure and hypertension-related cardiovascular diseases.
Published: 2021

19. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Author: Mullins, N. Forstner, A.J. O’Connell, K.S. Coombes, B. Coleman, J.R.I. Qiao, Z. Als, T.D. Bigdeli, T.B. Børte, S. Bryois, J. Charney, A.W. Drange, O.K. Gandal, M.J. Hagenaars, S.P. Ikeda, M. Kamitaki, N. Kim, M. Krebs, K. Panagiotaropoulou, G. Schilder, B.M. Sloofman, L.G. Steinberg, S. Trubetskoy, V. Winsvold, B.S. Won, H.-H. Abramova, L. Adorjan, K. Agerbo, E. Al Eissa, M. Albani, D. Alliey-Rodriguez, N. Anjorin, A. Antilla, V. Antoniou, A. Awasthi, S. Baek, J.H. Bækvad-Hansen, M. Bass, N. Bauer, M. Beins, E.C. Bergen, S.E. Birner, A. Bøcker Pedersen, C. Bøen, E. Boks, M.P. Bosch, R. Brum, M. Brumpton, B.M. Brunkhorst-Kanaan, N. Budde, M. Bybjerg-Grauholm, J. Byerley, W. Cairns, M. Casas, M. Cervantes, P. Clarke, T.-K. Cruceanu, C. Cuellar-Barboza, A. Cunningham, J. Curtis, D. Czerski, P.M. Dale, A.M. Dalkner, N. David, F.S. Degenhardt, F. Djurovic, S. Dobbyn, A.L. Douzenis, A. Elvsåshagen, T. Escott-Price, V. Ferrier, I.N. Fiorentino, A. Foroud, T.M. Forty, L. Frank, J. Frei, O. Freimer, N.B. Frisén, L. Gade, K. Garnham, J. Gelernter, J. Giørtz Pedersen, M. Gizer, I.R. Gordon, S.D. Gordon-Smith, K. Greenwood, T.A. Grove, J. Guzman-Parra, J. Ha, K. Haraldsson, M. Hautzinger, M. Heilbronner, U. Hellgren, D. Herms, S. Hoffmann, P. Holmans, P.A. Huckins, L. Jamain, S. Johnson, J.S. Kalman, J.L. Kamatani, Y. Kennedy, J.L. Kittel-Schneider, S. Knowles, J.A. Kogevinas, M. Koromina, M. Kranz, T.M. Kranzler, H.R. Kubo, M. Kupka, R. Kushner, S.A. Lavebratt, C. Lawrence, J. Leber, M. Lee, H.-J. Lee, P.H. Levy, S.E. Lewis, C. Liao, C. Lucae, S. Lundberg, M. MacIntyre, D.J. Magnusson, S.H. Maier, W. Maihofer, A. Malaspina, D. Maratou, E. Martinsson, L. Mattheisen, M. McCarroll, S.A. McGregor, N.W. McGuffin, P. McKay, J.D. Medeiros, H. Medland, S.E. Millischer, V. Montgomery, G.W. Moran, J.L. Morris, D.W. Mühleisen, T.W. O’Brien, N. O’Donovan, C. Olde Loohuis, L.M. Oruc, L. Papiol, S. Pardiñas, A.F. Perry, A. Pfennig, A. Porichi, E. Potash, J.B. Quested, D. Raj, T. Rapaport, M.H. DePaulo, J.R. Regeer, E.J. Rice, J.P. Rivas, F. Rivera, M. Roth, J. Roussos, P. Ruderfer, D.M. Sánchez-Mora, C. Schulte, E.C. Senner, F. Sharp, S. Shilling, P.D. Sigurdsson, E. Sirignano, L. Slaney, C. Smeland, O.B. Smith, D.J. Sobell, J.L. Søholm Hansen, C. Soler Artigas, M. Spijker, A.T. Stein, D.J. Strauss, J.S. Świątkowska, B. Terao, C. Thorgeirsson, T.E. Toma, C. Tooney, P. Tsermpini, E.-E. Vawter, M.P. Vedder, H. Walters, J.T.R. Witt, S.H. Xi, S. Xu, W. Yang, J.M.K. Young, A.H. Young, H. Zandi, P.P. Zhou, H. Zillich, L. Adolfsson, R. Agartz, I. Alda, M. Alfredsson, L. Babadjanova, G. Backlund, L. Baune, B.T. Bellivier, F. Bengesser, S. Berrettini, W.H. Blackwood, D.H.R. Boehnke, M. Børglum, A.D. Breen, G. Carr, V.J. Catts, S. Corvin, A. Craddock, N. Dannlowski, U. Dikeos, D. Esko, T. Etain, B. Ferentinos, P. Frye, M. Fullerton, J.M. Gawlik, M. Gershon, E.S. Goes, F.S. Green, M.J. Grigoroiu-Serbanescu, M. Hauser, J. Henskens, F. Hillert, J. Hong, K.S. Hougaard, D.M. Hultman, C.M. Hveem, K. Iwata, N. Jablensky, A.V. Jones, I. Jones, L.A. Kahn, R.S. Kelsoe, J.R. Kirov, G. Landén, M. Leboyer, M. Lewis, C.M. Li, Q.S. Lissowska, J. Lochner, C. Loughland, C. Martin, N.G. Mathews, C.A. Mayoral, F. McElroy, S.L. McIntosh, A.M. McMahon, F.J. Melle, I. Michie, P. Milani, L. Mitchell, P.B. Morken, G. Mors, O. Mortensen, P.B. Mowry, B. Müller-Myhsok, B. Myers, R.M. Neale, B.M. Nievergelt, C.M. Nordentoft, M. Nöthen, M.M. O’Donovan, M.C. Oedegaard, K.J. Olsson, T. Owen, M.J. Paciga, S.A. Pantelis, C. Pato, C. Pato, M.T. Patrinos, G.P. Perlis, R.H. Posthuma, D. Ramos-Quiroga, J.A. Reif, A. Reininghaus, E.Z. Ribasés, M. Rietschel, M. Ripke, S. Rouleau, G.A. Saito, T. Schall, U. Schalling, M. Schofield, P.R. Schulze, T.G. Scott, L.J. Scott, R.J. Serretti, A. Shannon Weickert, C. Smoller, J.W. Stefansson, H. Stefansson, K. Stordal, E. Streit, F. Sullivan, P.F. Turecki, G. Vaaler, A.E. Vieta, E. Vincent, J.B. Waldman, I.D. Weickert, T.W. Werge, T. Wray, N.R. Zwart, J.-A. Biernacka, J.M. Nurnberger, J.I. Cichon, S. Edenberg, H.J. Stahl, E.A. McQuillin, A. Di Florio, A. Ophoff, R.A. Andreassen, O.A. HUNT All-In Psychiatry
Abstract: Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Published: 2021

20. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

Author: Wensink, G.E., Elferink, M.A., May, A.M., Mol, L., Hamers, P.A.H., Bakker, S.D., Creemers, G.J., Groot, J.W.B. de, Klerk, G.J. de, Haberkorn, B.C.M., Haringhuizen, A.W., Hoekstra, R., Hunting, J.C.B., Kerver, E.D., Mathijssen-van Stein, D., Polée, M.B., Pruijt, J.F., Ufford-Mannesse, P. Quarles van, Radema, S.A., Rietbroek, R.C., Simkens, L.H., Tanis, B.C., Huinink, D. Ten Bokkel, Tjin, A.T.M.L.R., Tromp-van Driel, C.S., Troost, M.M., Wouw, A.J. van de, Berkmortel, F. van den, Pas, A.J.M. van der, Velden, A.M. van der, Dijk, M.A van, Dodewaard-de Jong, J.M. van, Druten, E.B. van, Voorthuizen, T. van, Veldhuis, G., Verheul, H.M.W., Vestjens, H., Vincent, J.B., Kranenburg, O.W., Punt, C.J.A., Vink, G.R., Roodhart, J.M.L., Koopman, M., Wensink, G.E., Elferink, M.A., May, A.M., Mol, L., Hamers, P.A.H., Bakker, S.D., Creemers, G.J., Groot, J.W.B. de, Klerk, G.J. de, Haberkorn, B.C.M., Haringhuizen, A.W., Hoekstra, R., Hunting, J.C.B., Kerver, E.D., Mathijssen-van Stein, D., Polée, M.B., Pruijt, J.F., Ufford-Mannesse, P. Quarles van, Radema, S.A., Rietbroek, R.C., Simkens, L.H., Tanis, B.C., Huinink, D. Ten Bokkel, Tjin, A.T.M.L.R., Tromp-van Driel, C.S., Troost, M.M., Wouw, A.J. van de, Berkmortel, F. van den, Pas, A.J.M. van der, Velden, A.M. van der, Dijk, M.A van, Dodewaard-de Jong, J.M. van, Druten, E.B. van, Voorthuizen, T. van, Veldhuis, G., Verheul, H.M.W., Vestjens, H., Vincent, J.B., Kranenburg, O.W., Punt, C.J.A., Vink, G.R., Roodhart, J.M.L., and Koopman, M.
Abstract: Contains fulltext : 230109.pdf (Publisher’s version ) (Closed access), BACKGROUND: Metastatic colorectal cancer patients with deficient mismatch repair (dMMR mCRC) benefit from immunotherapy. Interpretation of the single-arm immunotherapy trials is complicated by insignificant survival data during systemic non-immunotherapy. We present survival data on a large, comprehensive cohort of dMMR mCRC patients, treated with or without systemic non-immunotherapy. METHODS: Two hundred and eighty-one dMMR mCRC patients (n = 54 from three prospective Phase 3 CAIRO trials; n = 227 from the Netherlands Cancer Registry). Overall survival was analysed from diagnosis of mCRC (OS), from initiation of first-line (OS1) and second-line (OS2) systemic treatment. Cox regression analysis examined prognostic factors. As comparison for OS 2746 MMR proficient mCRC patients were identified. RESULTS: Of 281 dMMR patients, 62% received first-line and 26% second-line treatment. Median OS was 16.0 months (13.8-19.6) with antitumour therapy and 2.5 months (1.8-3.5) in untreated patients. OS1 was 12.8 months (10.7-15.2) and OS2 6.2 months (5.4-8.9) in treated dMMR patients. Treated dMMR patients had a 7.6-month shorter median OS than pMMR patients. CONCLUSION: Available data from immunotherapy trials lack a control arm with standard systemic treatment. Given the poor outcome compared to the immunotherapy results, our data strongly suggest a survival benefit of immunotherapy in dMMR mCRC patients.
Published: 2021

21. The D-dimer assay: A possible tool in the evaluation of atrial thrombosis

Author: Ibebuogu, Uzoma N., Salah, Ali K., Malhotra, Surender, Calkins, Joe B., Jr, Thornton, John W., III, Mandawat, Mahendra, and Robinson, Vincent J.B.
Published: 2008
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22. De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder

Author: Mirzaa, G.M., Chong, J.X., Piton, A., Popp, B., Foss, K., Guo, Hui, Harripaul, R., Xia, K., Scheck, J., Aldinger, K.A., Sajan, S.A., Tang, S., Bonneau, D., Beck, A., White, J., Mahida, S., Harris, J., Smith-Hicks, C., Hoyer, J., Zweier, C., Reis, A., Thiel, C.T., Jamra, R.A., Zeid, N., Yang, A., Farach, L.S., Walsh, L., Payne, K., Rohena, L., Velinov, M., Ziegler, A., Schaefer, E., Gatinois, V., Genevieve, D., Simon, M.E., Kohler, J., Rotenberg, J., Wheeler, P., Larson, A., Ernst, M.E., Akman, C.I., Westman, R., Blanchet, P., Schillaci, L.A., Vincent-Delorme, C., Gripp, K.W., Mattioli, F., Guyader, G.L., Gerard, B., Mathieu-Dramard, M., Morin, G., Sasanfar, R., Ayub, M., Vasli, N., Yang, S., Person, R., Monaghan, K.G., Nickerson, D.A., Binsbergen, E. van, Enns, G.M., Dries, A.M., Rowe, L.J., Tsai, A.C., Svihovec, S., Friedman, J., Agha, Z., Qamar, R., Rodan, L.H., Martinez-Agosto, J., Ockeloen, C.W., Vincent, M., Sunderland, W.J., Bernstein, J.A., Eichler, E.E., Vincent, J.B., Bamshad, M.J., Mirzaa, G.M., Chong, J.X., Piton, A., Popp, B., Foss, K., Guo, Hui, Harripaul, R., Xia, K., Scheck, J., Aldinger, K.A., Sajan, S.A., Tang, S., Bonneau, D., Beck, A., White, J., Mahida, S., Harris, J., Smith-Hicks, C., Hoyer, J., Zweier, C., Reis, A., Thiel, C.T., Jamra, R.A., Zeid, N., Yang, A., Farach, L.S., Walsh, L., Payne, K., Rohena, L., Velinov, M., Ziegler, A., Schaefer, E., Gatinois, V., Genevieve, D., Simon, M.E., Kohler, J., Rotenberg, J., Wheeler, P., Larson, A., Ernst, M.E., Akman, C.I., Westman, R., Blanchet, P., Schillaci, L.A., Vincent-Delorme, C., Gripp, K.W., Mattioli, F., Guyader, G.L., Gerard, B., Mathieu-Dramard, M., Morin, G., Sasanfar, R., Ayub, M., Vasli, N., Yang, S., Person, R., Monaghan, K.G., Nickerson, D.A., Binsbergen, E. van, Enns, G.M., Dries, A.M., Rowe, L.J., Tsai, A.C., Svihovec, S., Friedman, J., Agha, Z., Qamar, R., Rodan, L.H., Martinez-Agosto, J., Ockeloen, C.W., Vincent, M., Sunderland, W.J., Bernstein, J.A., Eichler, E.E., Vincent, J.B., and Bamshad, M.J.
Abstract: Contains fulltext : 218267.pdf (Publisher’s version ) (Closed access), PURPOSE: Intellectual disability (ID) and autism spectrum disorder (ASD) are genetically heterogeneous neurodevelopmental disorders. We sought to delineate the clinical, molecular, and neuroimaging spectrum of a novel neurodevelopmental disorder caused by variants in the zinc finger protein 292 gene (ZNF292). METHODS: We ascertained a cohort of 28 families with ID due to putatively pathogenic ZNF292 variants that were identified via targeted and exome sequencing. Available data were analyzed to characterize the canonical phenotype and examine genotype-phenotype relationships. RESULTS: Probands presented with ID as well as a spectrum of neurodevelopmental features including ASD, among others. All ZNF292 variants were de novo, except in one family with dominant inheritance. ZNF292 encodes a highly conserved zinc finger protein that acts as a transcription factor and is highly expressed in the developing human brain supporting its critical role in neurodevelopment. CONCLUSION: De novo and dominantly inherited variants in ZNF292 are associated with a range of neurodevelopmental features including ID and ASD. The clinical spectrum is broad, and most individuals present with mild to moderate ID with or without other syndromic features. Our results suggest that variants in ZNF292 are likely a recurrent cause of a neurodevelopmental disorder manifesting as ID with or without ASD.
Published: 2020

23. Time evolution of dust deposits in the Hapi region of comet 67P/Churyumov-Gerasimenko

Author: German Centre for Air and Space Travel, Centre National de la Recherche Scientifique (France), Agenzia Spaziale Italiana, Ministerio de Ciencia, Innovación y Universidades (España), Government of Sweden, Cambianica, P., Fulle, M., Cremonese, G., Simioni, E., Naletto, G., Massironi, M., Penasa, L., Lucchetti, A., Pajola, M., Bertini, I., Bodewits, D., Ceccarelli, C., Ferri, F., Fornasier, S., Frattin, E., Güttler, C., Gutiérrez, Pedro J., Keller, H.U., Kührt, E., Küppers, M., La Forgia, F., Lazzarin, M., Marzari, F., Mottola, S., Sierks, H., Toth, I., Tubiana, C., Vincent, J.B., German Centre for Air and Space Travel, Centre National de la Recherche Scientifique (France), Agenzia Spaziale Italiana, Ministerio de Ciencia, Innovación y Universidades (España), Government of Sweden, Cambianica, P., Fulle, M., Cremonese, G., Simioni, E., Naletto, G., Massironi, M., Penasa, L., Lucchetti, A., Pajola, M., Bertini, I., Bodewits, D., Ceccarelli, C., Ferri, F., Fornasier, S., Frattin, E., Güttler, C., Gutiérrez, Pedro J., Keller, H.U., Kührt, E., Küppers, M., La Forgia, F., Lazzarin, M., Marzari, F., Mottola, S., Sierks, H., Toth, I., Tubiana, C., and Vincent, J.B.
Abstract: Aims. We provide a measurement of the seasonal evolution of the dust deposit erosion and accretion in the Hapi region of comet 67P/Churyumov-Gerasimenko with a vertical accuracy of 0.2-0.9 m. Methods. We used OSIRIS Narrow Angle Camera images with a spatial scale of lower than 1.30 m px-1 and developed a tool to monitor the time evolution of 22 boulder heights with respect to the surrounding dust deposit. The tool is based on the measurement of the shadow length projected by the boulder on the surrounding pebble deposit. Assuming the position of the boulders does not change during the observational period, boulder height variations provide an indication of how the thickness of the surrounding dust layer varies over time through erosion and accretion phenomena. Results. We measured an erosion of the dust deposit of 1.7 ± 0.2 m during the inbound orbit until 12 December, 2014. This value nearly balances the fallout from the southern hemisphere during perihelion cometary activity. During the perihelion phase, the dust deposit then increased by 1.4 ± 0.8 m. This is interpreted as a direct measurement of the fallout thickness. By comparing the erosion rate and dust volume loss rate at the Hapi region measured in the coma, the fallout represents ~96% in volume of the ejecta. The amount of the eroded pristine material from the southern hemisphere, together with its subsequent transport and fallout on the nucleus, led us to discuss the pristine water ice abundance in comet 67P. We determine that the refractory-to-ice mass ratio ranges from 6 to 110 in the perihelion-eroded pristine nucleus, providing a pristine ice mass fraction of (8 ± 7)% in mass. © 2020 ESO.
Published: 2020

24. Utility of direct oral anticoagulants for left ventricular thrombus: lessons to learn from a systematic review and meta-analysis?

Author: Stephen W. Looney, Vincent J.B. Robinson, and Gyanendra Sharma
Subjects: medicine.medical_specialty, Vitamin K, business.industry, MEDLINE, Anticoagulants, Thrombosis, Left ventricular thrombus, Vitamin k, Text mining, Fibrinolytic Agents, Internal medicine, Meta-analysis, Internal Medicine, Cardiology, Humans, Medicine, business, Fibrinolytic agent
Published: 2021

25. X-ray Crystal Structure of Chromium-transferrin with Synergistic Anion Malonate

Author: Petersen, C.M., primary, Edwards, K.C., additional, Gilbert, N.C., additional, Vincent, J.B., additional, and Thompson, M.K., additional
Published: 2020
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26. Encircling reperfusion pattern on the stress-minus-delay bullʼs-eye map improves sensitivity of myocardial perfusion scans

Author: Robinson, Vincent J.B., Patel, Rakesh N., Nalamolu, Venkata R.P., Kaminski, Robert J., Dias, James K., Thornton, John W., Kersey, Terry W., and Mandawat, Mahendra K.
Published: 2008
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27. Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction

Author: Alec Davila, Istvan Czikora, Gaston Kapuku, Yuqing Huo, Vijay Patel, Neal L. Weintraub, Huabo Su, Vincent J.B. Robinson, Zsolt Bagi, Yanna Tian, and Jie Li
Subjects: Male, medicine.medical_specialty, Morpholines, Diastole, Vasodilation, Adenosine kinase, 030204 cardiovascular system & hematology, Ventricular Function, Left, Article, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Enzyme Inhibitors, Adenosine Kinase, 030304 developmental biology, Heart Failure, 0303 health sciences, biology, business.industry, Stroke Volume, Middle Aged, medicine.disease, Rats, Rats, Zucker, Disease Models, Animal, Pyrimidines, medicine.anatomical_structure, Ventricle, Heart failure, Microvessels, biology.protein, Cardiology, Female, Vascular Resistance, Cardiology and Cardiovascular Medicine, business, Heart failure with preserved ejection fraction
Abstract: Background: Heart failure with preserved ejection fraction (HFpEF) is often manifested as impaired cardiovascular reserve. We sought to determine if conducted vasodilation, which coordinates microvascular resistance longitudinally to match tissue metabolic demand, becomes compromised in HFpEF. We hypothesized that the metabolic vasodilator adenosine facilitates and that inhibition of ADK (adenosine kinase) augments conducted vasodilation for a more efficient myocardial perfusion and improved left ventricle (LV) diastolic function in HFpEF. Methods and Results: We assessed conducted vasodilation in obese ZSF1 rats that develop LV diastolic dysfunction and is used to model human HFpEF. Additionally, conducted vasodilation was measured in arterioles isolated from the right atrial appendages of patients with HFpEF. We found a markedly reduced conducted vasodilation both in obese ZSF1 rats and in patients with HFpEF. Impaired conducted vasodilation was accompanied by increased vascular ADK expression. Isolated rat and human arterioles incubated with adenosine (10 nmol/L) or ADK inhibitor ABT-702 (0.1 µmol/L) both displayed augmented conducted vasodilation. Treatment of obese ZSF1 rats with ABT-702 (1.5 mg/kg, IP for 8 weeks) prevented LV diastolic dysfunction, and in a crossover design augmented conducted vasodilation and improved LV diastolic function. ABT-702 treated obese ZSF1 rats exhibited reduced expression of myocardial carbonic anhydrase 9 and collagen, surrogate markers of myocardial hypoxia. Conclusions: Upregulation of vascular ADK mitigates adenosine-facilitated conducted vasodilation in obese ZSF1 rats and in patients with HFpEF. We propose that pharmacological inhibition of ADK could be beneficial for therapeutic augmentation of conducted vasodilation, thereby improving tissue perfusion and LV diastolic function in HFpEF.
Published: 2019

28. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author: Andlauer, T.F.M. (Till F. M.), Guzman-Parra, J. (Jose), Streit, F. (Fabian), Strohmaier, J. (Jana), González, M.J. (Maria José), Gil Flores, S. (Susana), Cabaleiro Fabeiro, F.J. (Francisco J.), del Río Noriega, F. (Francisco), Perez, F.P. (Fermin Perez), Haro González, J. (Jesus), Orozco Diaz, G. (Guillermo), Diego, Y. (Yolanda) de, Moreno-Küstner, B. (Berta), Auburger, G. (Georg), Degenhardt, F. (Franziska), Heilmann-Heimbach, S. (Stefanie), Herms, S. (Stefan), Hoffmann, P. (Per), Frank, J. (Josef), Foo, J.C. (Jerome C.), Treutlein, J. (Jens), Witt, S.H. (Stephanie H), Cichon, S. (Sven), Kogevinas, M. (Manolis), Stahl, E.A. (Eli A), Breen, G. (Gerome), Forstner, A.J. (Andreas J), McQuillin, A. (Andrew), Ripke, S. (Stephan), Trubetskoy, V. (Vassily), Mattheisen, M. (Manuel), Wang, Y. (Yunpeng), Coleman, J.R.I. (Jonathan R I), Gaspar, H.A. (Héléna A), Leeuw, C. (Christiaan) de, Steinberg, S. (Stacy), Pavlides, J.M.W. (Jennifer M Whitehead), Trzaskowski, M. (Maciej), Pers, T.H. (Tune H), Holmans, P.A. (Peter A.), Abbott, L. (Liam), Agerbo, E. (Esben), Akil, H. (Huda), Albani, D. (Diego), Alliey-Rodriguez, N. (Ney), Als, T.D. (Thomas D), Anjorin, A. (Adebayo), Antilla, V. (Verneri), Awasthi, S. (Swapnil), Badner, J.A. (Judith A), Bækvad-Hansen, M. (Marie), Barchas, J.D. (Jack D), Bass, N. (Nicholas), Bauer, M. (Michael), Belliveau, R.A. (Richard A.), Bergen, S.E. (Sarah), Pedersen, C.B. (C.), Bøen, E. (Erlend), Boks, M.P.M. (Marco), Boocock, J. (James), Budde, M. (Monika), Bunney, W.E. (William E), Burmeister, M., Bybjerg-Grauholm, J. (Jonas), Byerley, W.F. (William F), Casas, M. (Miquel), Cerrato, F. (Felecia), Cervantes, P. (Pablo), Chambert, K. (Kimberly), Charney, A.W. (Alexander W), Chen, D. (Danfeng), Churchhouse, C. (Claire), Clarke, T.-K. (Toni-Kim), Coryell, W.H. (William H), Craig, D.W. (David W), Cruceanu, C. (Cristiana), Czerski, P.M., Dale, A.M. (Anders), de Jong, S. (Simone), Del-Favero, J. (Jurgen), DePaulo, J.R. (J Raymond), Djurovic, S. (Srdjan), Dobbyn, A.L. (Amanda L), Dumont, A. (Ashley), Elvsåshagen, T. (Torbjørn), Escott-Price, V. (Valentina), Fan, C.C. (Chun Chieh), Fischer, S.B. (Sascha B), Flickinger, M. (Matthew), Foroud, T.M. (Tatiana M), Forty, L. (Liz), Fraser, C. (Christine), Luben, R.N. (Robert), Frisén, L. (Louise), Gade, K. (Katrin), Gage, D. (Diane), Garnham, J. (Julie), Giambartolomei, C. (Claudia), Pedersen, M.G. (Marianne Giørtz), Goldstein, J.I. (Jacqueline), Gordon, S.D. (Scott D), Gordon-Smith, K. (Katherine), Green, E.K. (Elaine K), Green, M.J. (Melissa J), Greenwood, T.A. (Tiffany A), Grove, J. (Jakob), Guan, W. (Weihua), Parra, J.G. (José Guzman), Hamshere, M.L. (Marian), Hautzinger, M. (Martin), Heilbronner, U. (Urs), Hipolito, M. (Maria), Holland, D. (Dominic), Huckins, L. (Laura), Jamain, S. (Stéphane), Johnson, J.S. (Jessica S), Juréus, A. (Anders), Kandaswamy, R. (Radhika), Karlsson, R. (Robert), Kennedy, J.L. (James L), Kittel-Schneider, S. (Sarah), Knowles, J.A. (James A), Koller, A.C. (Anna C), Kupka, R.W. (Ralph ), Lavebratt, C. (Catharina), Lawrence, J. (Jacob), Lawson, W.B. (William B), Leber, I. (Isabelle), Lee, P.H. (Phil H), Levy, S.E. (Shawn E), Li, J.Z. (Jun Z), Liu, C. (Chunyu), Lucae, S. (Susanne), Maaser, A. (Anna), Macintyre, D.J. (Donald J), Mahon, P.B. (Pamela B), Maier, W. (Wolfgang), Martinsson, L. (Lina), McCarroll, S.A. (Steve), McGuffin, P. (Peter), Mcinnis, M.G. (Melvin G), McKay, J.D. (James D), Medeiros, H. (Helena), Medland, S.E. (Sarah E), Meng, F. (Fan), Milani, L. (Lili), Montgomery, G.W. (Grant W), Morris, D.W. (Derek W), Mühleisen, T.W. (Thomas W), Mullins, N. (Niamh), Nguyen, H. (Hoang), Nievergelt, C.M. (Caroline M), Adolfsson, A.N. (Annelie Nordin), Nwulia, E.A. (Evaristus A), O’Donovan, C. (Claire), Loohuis, L.M.O. (Loes M Olde), Ori, A.P.S. (Anil P S), Oruc, L. (Lilijana), Ösby, U. (Urban), Perlis, R.H. (Roy H), Perry, A. (Amy), Pfennig, A. (Andrea), Potash, J.B. (James B), Purcell, S.M. (Shaun M), Regeer, E.J. (Eline Janet), Reif, A. (Andreas), Reinbold, C.S. (Céline S), Rice, J.P. (John), Richards, A. (Alex), Rivas, F. (Fabio), Rivera, M. (Margarita), Roussos, A. (Alexandra), Ruderfer, D. (Douglas), Ryu, J. (Julie), Sánchez-Mora, C. (Cristina), Schatzberg, A.F. (Alan F), Scheftner, W.A. (William A), Schork, N.J. (Nicholas), Weickert, C.S. (Cynthia Shannon), Shehktman, T. (Tatyana), Shilling, P.D. (Paul D), Sigurdsson, E. (Engilbert), Slaney, C. (Claire), Smeland, O.B. (Olav B), Sobell, J.L. (Janet L), Hansen, C.S. (Christine Søholm), Spijker, A.T. (Anne T), Clair, D.S., Steffens, M. (Michael), Strauss, J.S. (John S), Szelinger, S. (Szabolcs), Thompson, R.C. (Robert C), EThorgeirsson, T. (Thorgeir), Vedde, H. (Helmut), Wang, W. (Weiqing), Watson, S.J. (Stanley J), Weickert, T.W. (Thomas W), Xi, S. (Simon), Xu, W. (Wei), Young, A.H. (Allan H), Zandi, P.P. (Peter P), Zhang, P. (Ping), Zöllner, S. (Sebastian), Adolfsson, R., Agartz, I. (Ingrid), Alda, M. (Martin), Backlund, L. (Lena), Baune, B.T. (Bernhard T), Bellivier, F. (Frank), Berrettini, W. (Wade), Biernacka, J.M. (Joanna M), Blackwood, D.H.R. (Douglas), Boehnke, M. (Michael), Børglum, A.D. (Anders D), Corvin, A. (Aiden), Craddock, N. (Nicholas), Daly, M.J. (Mark), Dannlowski, U. (Udo), Esko, T. (Tõnu), Etain, B. (Bruno), Frye, M.A. (Mark A), Fullerton, J.M. (Janice M), Gershon, E.S. (Elliot S), Gill, M. (Michael), Goes, F. (Fernando), Grigoroiu-Serbanescu, M. (Maria), Hauser, J. (J.), Hougaard, D.M. (David M), Hultman, C.M. (Christina), Jones, I. (Ian), Jones, L.A. (Lisa A), Kahn, R. (René), Kirov, G. (George), Landén, M. (Mikael), Leboyer, M. (Marion), Lewis, C.M. (Cathryn), Li, Q.S. (Qingqin S), Lissowska, J. (Jolanta), Martin, N.G. (Nicholas), Mayoral, F. (Fermin), McElroy, S.L. (Susan L), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Melle, I. (Ingrid), Metspalu, A. (Andres), Mitchell, P.B. (Philip B), Morken, G. (Gunnar), Mors, O. (Ole), Mortensen, P.B. (Preben Bo), Müller-Myhsok, B. (Bertram), Myers, R.H. (Richard), Neale, B.M. (Benjamin), Nimgaonkar, V. (Vishwajit), Nordentoft, M. (Merete), Nöthen, M.M. (Markus), O’Donovan, M.C. (Michael C), Oedegaard, K.J. (Ketil J), Owen, M.J. (Michael J), Paciga, S.A. (Sara A), Pato, C. (Carlos), Posthuma, D. (Danielle), Ramos-Quiroga, J.A. (Josep Antoni), Ribasés, M. (Marta), Rietschel, M. (Marcella), Rouleau, G.A. (Guy A), Schalling, M. (Martin), Schofield, P.R. (Peter R), Schulze, T.G. (Thomas G), Serretti, A. (Alessandro), Smoller, J.W., Stefansson, H. (Hreinn), Zwart, J-A. (John-Anker), Stordal, E. (Eystein), Sullivan, P.F. (Patrick F), Turecki, G. (Gustavo), Vaaler, A.E. (Arne E), Vieta, E. (Eduard), Vincent, J.B. (John B), Werge, T.M. (Thomas), Nurnberger, J.I. (John I), Wray, N.R. (Naomi), Florio, A.D. (Arianna Di), Edenberg, H.J. (Howard), Ophoff, R.A. (Roel), Scott, L.J. (Laura J), Andreassen, O.A. (Ole), Kelsoe, J.R. (John), Sklar, P. (Pamela), Wray, N.R. (Naomi R), Byrne, E.M. (Enda), Abdellaoui, A. (Abdel), Adams, M.J. (Mark J), Air, T.M. (Tracy M), Bacanu, S.A. (Silviu), Beekman, A.T.F. (Aartjan), Bigdeli, T.B. (Tim B), Binder, E.B. (Elisabeth), Bryois, J. (Julien), Buttenschøn, H.N. (Henriette N), Cai, N. (Na), Castelao, E. (Enrique), Christensen, J.H. (Jane Hvarregaard), Clarke, T.-K., Colodro-Conde, L. (Lucía), Couvy-Duchesne, B. (Baptiste), Craddock, N.J. (Nick), Crawford, G.E. (Gregory E), Davies, G. (Gail), Deary, I.J. (Ian J), Degenhardt, F., Derks, E.M. (Eske M), Direk, N. (Nese), Dolan, C.V. (Conor), Dunn, E.C. (Erin C.), Eley, T.C. (T.), Kiadeh, F.F.H. (Farnush Farhadi Hassan), Finucane, H.K. (Hilary K), Foo, J.C. (Jerome C), Goes, F.S. (Fernando S), Gordon, S.D. (Scott D.), Hall, L.S. (Lynsey S), Hansen, T.F. (Thomas F), Hickie, I.B. (Ian), Homuth, G. (Georg), Horn, C. (Carsten), Hottenga, J.J. (Jouke Jan), Hougaard, D.M. (David), Howard, D.M. (David M), Ising, M. (Marcus), Jansen, R. (Rick), Jones, I., Jones, L. (Louisa), Jorgenson, E. (Eric), Kohane, I.S. (Isaac S), Kraft, J. (Julia), Kretzschmar, W.W. (Warren W.), Kutalik, Z. (Zoltán), Li, Y. (Yihan), Lind, P.A. (Penelope), MacIntyre, D.J. (Donald J), MacKinnon, D.F. (Dean F), Maier, R.M. (Robert M), Marchini, J. (Jonathan), Mbarek, H., McGrath, P. (Patrick), Mcguffin, P. (Peter), Medland, S.E. (Sarah), Mehta, D. (Divya), Middeldorp, C.M. (Christel M), Mihailov, E. (Evelin), Milaneschi, Y. (Yuri), Mondimore, F.M. (Francis M), Montgomery, G.W. (Grant), Mostafavi, S. (Sara), Nauck, M. (Matthias), Ng, B. (Bernard), Nivard, M. (Michel), Nyholt, D.R. (Dale), O’Reilly, P.F. (Paul F), Oskarsson, H. (Hogni), Owen, M.J. (Michael), Painter, J.N. (Jodie N.), Pedersen, C.B. (Carsten Bøcker), Peterson, R.E. (Roseann E), Pettersson, E. (Erik), Peyrot, W.J. (Wouter ), Pistis, G. (Giorgio), Quiroz, J.A. (Jorge A), Qvist, P. (Per), Rice, J.P. (John P), Riley, B.P. (Brien P.), Mirza, S.S. (Saira), Schoevers, R. (Robert), Schulte, E.C. (Eva C), Shen, L. (Li), Shi, J. (Jianxin), Shyn, S.I. (Stanley I), Sinnamon, G.C.B. (Grant C B), Smith, A.V. (Davey), Smith, D.J. (Daniel J), Tansey, K.E., Teismann, H. (Henning), Teumer, A. (Alexander), Thompson, W.K. (Wesley K.), Thomson, P.A. (Pippa A), Thorgeirsson, T.E. (Thorgeir E), Traylor, M. (Matthew), Uitterlinden, A.G. (André), Umbricht, D. (Daniel), Van der Auwera, S. (Sandra), van Hemert, A.M. (Albert M), Viktorin, A. (Alexander), Visscher, P.M. (Peter M), Webb, B.T. (Bradley T.), Weinsheimer, S.M. (Shantel Marie), Wellmann, J. (Jürgen), Willemsen, G.A.H.M. (Gonneke), Wu, Y. (Yang), Xi, H.S. (Hualin S), Yang, J. (Joanna), Zhang, F. (Futao), Arolt, V. (Volker), Baune, B.T., Berger, K. (Klaus), Boomsma, D.I. (Dorret), Geus, E.J.C. (Eco) de, Domenici, E. (Enrico), Domschke, K. (Katharina), Grabe, H.J. (Hans Jörgen), Hamilton, S.P. (Steven P), Hayward, C. (Caroline), Heath, A.C. (Andrew), Jablensky, A. (Assen), Kloiber, S. (Stefan), Lewis, G., Madden, P.A. (Pamela), Magnusson, P.K. (Patrik), Martin, N.G. (Nicholas G), McIntosh, A.M. (Andrew M), Mors, O., Müller-Myhsok, B. (B.), Nöthen, M.M. (Markus M), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Porteous, D.J. (David J.), Preisig, M. (Martin), Schaefer, C. (Catherine), Smoller, J.W. (Jordan W), Stefansson, K. (Kari), Tiemeier, H.W. (Henning), Uher, R. (Rudolf), Völzke, H. (Henry), Weissman, M.M., Werge, T. (Thomas), Lewis, C.M. (Cathryn M), Levinson, D.F. (Douglas F.), Borglum, A.D. (Anders), Sullivan, P.F. (Patrick), Mayoral, F. (Fermín), Muller-Myhsok, B. (B.), Forstner, A.J. (Andreas J.), Nöthen, M.M. (Markus M.), Andlauer, T.F.M. (Till F. M.), Guzman-Parra, J. (Jose), Streit, F. (Fabian), Strohmaier, J. (Jana), González, M.J. (Maria José), Gil Flores, S. (Susana), Cabaleiro Fabeiro, F.J. (Francisco J.), del Río Noriega, F. (Francisco), Perez, F.P. (Fermin Perez), Haro González, J. (Jesus), Orozco Diaz, G. (Guillermo), Diego, Y. (Yolanda) de, Moreno-Küstner, B. (Berta), Auburger, G. (Georg), Degenhardt, F. (Franziska), Heilmann-Heimbach, S. (Stefanie), Herms, S. (Stefan), Hoffmann, P. (Per), Frank, J. (Josef), Foo, J.C. (Jerome C.), Treutlein, J. (Jens), Witt, S.H. (Stephanie H), Cichon, S. (Sven), Kogevinas, M. (Manolis), Stahl, E.A. (Eli A), Breen, G. (Gerome), Forstner, A.J. (Andreas J), McQuillin, A. (Andrew), Ripke, S. (Stephan), Trubetskoy, V. (Vassily), Mattheisen, M. (Manuel), Wang, Y. (Yunpeng), Coleman, J.R.I. (Jonathan R I), Gaspar, H.A. (Héléna A), Leeuw, C. (Christiaan) de, Steinberg, S. (Stacy), Pavlides, J.M.W. (Jennifer M Whitehead), Trzaskowski, M. (Maciej), Pers, T.H. (Tune H), Holmans, P.A. (Peter A.), Abbott, L. (Liam), Agerbo, E. (Esben), Akil, H. (Huda), Albani, D. (Diego), Alliey-Rodriguez, N. (Ney), Als, T.D. (Thomas D), Anjorin, A. (Adebayo), Antilla, V. (Verneri), Awasthi, S. (Swapnil), Badner, J.A. (Judith A), Bækvad-Hansen, M. (Marie), Barchas, J.D. (Jack D), Bass, N. (Nicholas), Bauer, M. (Michael), Belliveau, R.A. (Richard A.), Bergen, S.E. (Sarah), Pedersen, C.B. (C.), Bøen, E. (Erlend), Boks, M.P.M. (Marco), Boocock, J. (James), Budde, M. (Monika), Bunney, W.E. (William E), Burmeister, M., Bybjerg-Grauholm, J. (Jonas), Byerley, W.F. (William F), Casas, M. (Miquel), Cerrato, F. (Felecia), Cervantes, P. (Pablo), Chambert, K. (Kimberly), Charney, A.W. (Alexander W), Chen, D. (Danfeng), Churchhouse, C. (Claire), Clarke, T.-K. (Toni-Kim), Coryell, W.H. (William H), Craig, D.W. (David W), Cruceanu, C. (Cristiana), Czerski, P.M., Dale, A.M. (Anders), de Jong, S. (Simone), Del-Favero, J. (Jurgen), DePaulo, J.R. (J Raymond), Djurovic, S. (Srdjan), Dobbyn, A.L. (Amanda L), Dumont, A. (Ashley), Elvsåshagen, T. (Torbjørn), Escott-Price, V. (Valentina), Fan, C.C. (Chun Chieh), Fischer, S.B. (Sascha B), Flickinger, M. (Matthew), Foroud, T.M. (Tatiana M), Forty, L. (Liz), Fraser, C. (Christine), Luben, R.N. (Robert), Frisén, L. (Louise), Gade, K. (Katrin), Gage, D. (Diane), Garnham, J. (Julie), Giambartolomei, C. (Claudia), Pedersen, M.G. (Marianne Giørtz), Goldstein, J.I. (Jacqueline), Gordon, S.D. (Scott D), Gordon-Smith, K. (Katherine), Green, E.K. (Elaine K), Green, M.J. (Melissa J), Greenwood, T.A. (Tiffany A), Grove, J. (Jakob), Guan, W. (Weihua), Parra, J.G. (José Guzman), Hamshere, M.L. (Marian), Hautzinger, M. (Martin), Heilbronner, U. (Urs), Hipolito, M. (Maria), Holland, D. (Dominic), Huckins, L. (Laura), Jamain, S. (Stéphane), Johnson, J.S. (Jessica S), Juréus, A. (Anders), Kandaswamy, R. (Radhika), Karlsson, R. (Robert), Kennedy, J.L. (James L), Kittel-Schneider, S. (Sarah), Knowles, J.A. (James A), Koller, A.C. (Anna C), Kupka, R.W. (Ralph ), Lavebratt, C. (Catharina), Lawrence, J. (Jacob), Lawson, W.B. (William B), Leber, I. (Isabelle), Lee, P.H. (Phil H), Levy, S.E. (Shawn E), Li, J.Z. (Jun Z), Liu, C. (Chunyu), Lucae, S. (Susanne), Maaser, A. (Anna), Macintyre, D.J. (Donald J), Mahon, P.B. (Pamela B), Maier, W. (Wolfgang), Martinsson, L. (Lina), McCarroll, S.A. (Steve), McGuffin, P. (Peter), Mcinnis, M.G. (Melvin G), McKay, J.D. (James D), Medeiros, H. (Helena), Medland, S.E. (Sarah E), Meng, F. (Fan), Milani, L. (Lili), Montgomery, G.W. (Grant W), Morris, D.W. (Derek W), Mühleisen, T.W. (Thomas W), Mullins, N. (Niamh), Nguyen, H. (Hoang), Nievergelt, C.M. (Caroline M), Adolfsson, A.N. (Annelie Nordin), Nwulia, E.A. (Evaristus A), O’Donovan, C. (Claire), Loohuis, L.M.O. (Loes M Olde), Ori, A.P.S. (Anil P S), Oruc, L. (Lilijana), Ösby, U. (Urban), Perlis, R.H. (Roy H), Perry, A. (Amy), Pfennig, A. (Andrea), Potash, J.B. (James B), Purcell, S.M. (Shaun M), Regeer, E.J. (Eline Janet), Reif, A. (Andreas), Reinbold, C.S. (Céline S), Rice, J.P. (John), Richards, A. (Alex), Rivas, F. (Fabio), Rivera, M. (Margarita), Roussos, A. (Alexandra), Ruderfer, D. (Douglas), Ryu, J. (Julie), Sánchez-Mora, C. (Cristina), Schatzberg, A.F. (Alan F), Scheftner, W.A. (William A), Schork, N.J. (Nicholas), Weickert, C.S. (Cynthia Shannon), Shehktman, T. (Tatyana), Shilling, P.D. (Paul D), Sigurdsson, E. (Engilbert), Slaney, C. (Claire), Smeland, O.B. (Olav B), Sobell, J.L. (Janet L), Hansen, C.S. (Christine Søholm), Spijker, A.T. (Anne T), Clair, D.S., Steffens, M. (Michael), Strauss, J.S. (John S), Szelinger, S. (Szabolcs), Thompson, R.C. (Robert C), EThorgeirsson, T. (Thorgeir), Vedde, H. (Helmut), Wang, W. (Weiqing), Watson, S.J. (Stanley J), Weickert, T.W. (Thomas W), Xi, S. (Simon), Xu, W. (Wei), Young, A.H. (Allan H), Zandi, P.P. (Peter P), Zhang, P. (Ping), Zöllner, S. (Sebastian), Adolfsson, R., Agartz, I. (Ingrid), Alda, M. (Martin), Backlund, L. (Lena), Baune, B.T. (Bernhard T), Bellivier, F. (Frank), Berrettini, W. (Wade), Biernacka, J.M. (Joanna M), Blackwood, D.H.R. (Douglas), Boehnke, M. (Michael), Børglum, A.D. (Anders D), Corvin, A. (Aiden), Craddock, N. (Nicholas), Daly, M.J. (Mark), Dannlowski, U. (Udo), Esko, T. (Tõnu), Etain, B. (Bruno), Frye, M.A. (Mark A), Fullerton, J.M. (Janice M), Gershon, E.S. (Elliot S), Gill, M. (Michael), Goes, F. (Fernando), Grigoroiu-Serbanescu, M. (Maria), Hauser, J. (J.), Hougaard, D.M. (David M), Hultman, C.M. (Christina), Jones, I. (Ian), Jones, L.A. (Lisa A), Kahn, R. (René), Kirov, G. (George), Landén, M. (Mikael), Leboyer, M. (Marion), Lewis, C.M. (Cathryn), Li, Q.S. (Qingqin S), Lissowska, J. (Jolanta), Martin, N.G. (Nicholas), Mayoral, F. (Fermin), McElroy, S.L. (Susan L), McIntosh, A.M. (Andrew), Mcmahon, F.J. (Francis J), Melle, I. (Ingrid), Metspalu, A. (Andres), Mitchell, P.B. (Philip B), Morken, G. (Gunnar), Mors, O. (Ole), Mortensen, P.B. (Preben Bo), Müller-Myhsok, B. (Bertram), Myers, R.H. (Richard), Neale, B.M. (Benjamin), Nimgaonkar, V. (Vishwajit), Nordentoft, M. (Merete), Nöthen, M.M. (Markus), O’Donovan, M.C. (Michael C), Oedegaard, K.J. (Ketil J), Owen, M.J. (Michael J), Paciga, S.A. (Sara A), Pato, C. (Carlos), Posthuma, D. (Danielle), Ramos-Quiroga, J.A. (Josep Antoni), Ribasés, M. (Marta), Rietschel, M. (Marcella), Rouleau, G.A. (Guy A), Schalling, M. (Martin), Schofield, P.R. (Peter R), Schulze, T.G. (Thomas G), Serretti, A. (Alessandro), Smoller, J.W., Stefansson, H. (Hreinn), Zwart, J-A. (John-Anker), Stordal, E. (Eystein), Sullivan, P.F. (Patrick F), Turecki, G. (Gustavo), Vaaler, A.E. (Arne E), Vieta, E. (Eduard), Vincent, J.B. (John B), Werge, T.M. (Thomas), Nurnberger, J.I. (John I), Wray, N.R. (Naomi), Florio, A.D. (Arianna Di), Edenberg, H.J. (Howard), Ophoff, R.A. (Roel), Scott, L.J. (Laura J), Andreassen, O.A. (Ole), Kelsoe, J.R. (John), Sklar, P. (Pamela), Wray, N.R. (Naomi R), Byrne, E.M. (Enda), Abdellaoui, A. (Abdel), Adams, M.J. (Mark J), Air, T.M. (Tracy M), Bacanu, S.A. (Silviu), Beekman, A.T.F. (Aartjan), Bigdeli, T.B. (Tim B), Binder, E.B. (Elisabeth), Bryois, J. (Julien), Buttenschøn, H.N. (Henriette N), Cai, N. (Na), Castelao, E. (Enrique), Christensen, J.H. (Jane Hvarregaard), Clarke, T.-K., Colodro-Conde, L. (Lucía), Couvy-Duchesne, B. (Baptiste), Craddock, N.J. (Nick), Crawford, G.E. (Gregory E), Davies, G. (Gail), Deary, I.J. (Ian J), Degenhardt, F., Derks, E.M. (Eske M), Direk, N. (Nese), Dolan, C.V. (Conor), Dunn, E.C. (Erin C.), Eley, T.C. (T.), Kiadeh, F.F.H. (Farnush Farhadi Hassan), Finucane, H.K. (Hilary K), Foo, J.C. (Jerome C), Goes, F.S. (Fernando S), Gordon, S.D. (Scott D.), Hall, L.S. (Lynsey S), Hansen, T.F. (Thomas F), Hickie, I.B. (Ian), Homuth, G. (Georg), Horn, C. (Carsten), Hottenga, J.J. (Jouke Jan), Hougaard, D.M. (David), Howard, D.M. (David M), Ising, M. (Marcus), Jansen, R. (Rick), Jones, I., Jones, L. (Louisa), Jorgenson, E. (Eric), Kohane, I.S. (Isaac S), Kraft, J. (Julia), Kretzschmar, W.W. (Warren W.), Kutalik, Z. (Zoltán), Li, Y. (Yihan), Lind, P.A. (Penelope), MacIntyre, D.J. (Donald J), MacKinnon, D.F. (Dean F), Maier, R.M. (Robert M), Marchini, J. (Jonathan), Mbarek, H., McGrath, P. (Patrick), Mcguffin, P. (Peter), Medland, S.E. (Sarah), Mehta, D. (Divya), Middeldorp, C.M. (Christel M), Mihailov, E. (Evelin), Milaneschi, Y. (Yuri), Mondimore, F.M. (Francis M), Montgomery, G.W. (Grant), Mostafavi, S. (Sara), Nauck, M. (Matthias), Ng, B. (Bernard), Nivard, M. (Michel), Nyholt, D.R. (Dale), O’Reilly, P.F. (Paul F), Oskarsson, H. (Hogni), Owen, M.J. (Michael), Painter, J.N. (Jodie N.), Pedersen, C.B. (Carsten Bøcker), Peterson, R.E. (Roseann E), Pettersson, E. (Erik), Peyrot, W.J. (Wouter ), Pistis, G. (Giorgio), Quiroz, J.A. (Jorge A), Qvist, P. (Per), Rice, J.P. (John P), Riley, B.P. (Brien P.), Mirza, S.S. (Saira), Schoevers, R. (Robert), Schulte, E.C. (Eva C), Shen, L. (Li), Shi, J. (Jianxin), Shyn, S.I. (Stanley I), Sinnamon, G.C.B. (Grant C B), Smith, A.V. (Davey), Smith, D.J. (Daniel J), Tansey, K.E., Teismann, H. (Henning), Teumer, A. (Alexander), Thompson, W.K. (Wesley K.), Thomson, P.A. (Pippa A), Thorgeirsson, T.E. (Thorgeir E), Traylor, M. (Matthew), Uitterlinden, A.G. (André), Umbricht, D. (Daniel), Van der Auwera, S. (Sandra), van Hemert, A.M. (Albert M), Viktorin, A. (Alexander), Visscher, P.M. (Peter M), Webb, B.T. (Bradley T.), Weinsheimer, S.M. (Shantel Marie), Wellmann, J. (Jürgen), Willemsen, G.A.H.M. (Gonneke), Wu, Y. (Yang), Xi, H.S. (Hualin S), Yang, J. (Joanna), Zhang, F. (Futao), Arolt, V. (Volker), Baune, B.T., Berger, K. (Klaus), Boomsma, D.I. (Dorret), Geus, E.J.C. (Eco) de, Domenici, E. (Enrico), Domschke, K. (Katharina), Grabe, H.J. (Hans Jörgen), Hamilton, S.P. (Steven P), Hayward, C. (Caroline), Heath, A.C. (Andrew), Jablensky, A. (Assen), Kloiber, S. (Stefan), Lewis, G., Madden, P.A. (Pamela), Magnusson, P.K. (Patrik), Martin, N.G. (Nicholas G), McIntosh, A.M. (Andrew M), Mors, O., Müller-Myhsok, B. (B.), Nöthen, M.M. (Markus M), Pedersen, N.L. (Nancy), Penninx, B.W.J.H. (Brenda), Porteous, D.J. (David J.), Preisig, M. (Martin), Schaefer, C. (Catherine), Smoller, J.W. (Jordan W), Stefansson, K. (Kari), Tiemeier, H.W. (Henning), Uher, R. (Rudolf), Völzke, H. (Henry), Weissman, M.M., Werge, T. (Thomas), Lewis, C.M. (Cathryn M), Levinson, D.F. (Douglas F.), Borglum, A.D. (Anders), Sullivan, P.F. (Patrick), Mayoral, F. (Fermín), Muller-Myhsok, B. (B.), Forstner, A.J. (Andreas J.), and Nöthen, M.M. (Markus M.)
Abstract: Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.
Published: 2019
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29. Surface evolution of the Anhur region on comet 67P/Churyumov-Gerasimenko from high-resolution OSIRIS images

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Fornasier, S., Feller, C., Hasselmann, P.H., Barucci, M.A., Sunshine, J, Vincent, J.B., Shi, X., Sierks, H., Naletto, G., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Ferrari, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Jorda, L., Keller, H.U., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Lucchetti, A., Marzari, F., Mottola, S., Pajola, M., Toth, I., Tubiana, C., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Fornasier, S., Feller, C., Hasselmann, P.H., Barucci, M.A., Sunshine, J, Vincent, J.B., Shi, X., Sierks, H., Naletto, G., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Ferrari, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Jorda, L., Keller, H.U., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Lucchetti, A., Marzari, F., Mottola, S., Pajola, M., Toth, I., and Tubiana, C.
Abstract: The southern hemisphere of comet 67P/Churyumov-Gerasimenko (67P) became observable by the Rosetta mission in March 2015, a few months before cometary southern vernal equinox. The Anhur region in the southern part of the comet's larger lobe was found to be highly eroded, enriched in volatiles, and highly active. Aims. We analyze high-resolution images of the Anhur region pre- and post-perihelion acquired by the OSIRIS imaging system on board the Rosetta mission. The Narrow Angle Camera is particularly useful for studying the evolution in Anhur in terms of morphological changes and color variations. Methods. Radiance factor images processed by the OSIRIS pipeline were coregistered, reprojected onto the 3D shape model of the comet, and corrected for the illumination conditions. Results. We find a number of morphological changes in the Anhur region that are related to formation of new scarps; removal of dust coatings; localized resurfacing in some areas, including boulders displacements; and vanishing structures, which implies localized mass loss that we estimate to be higher than 50 million kg. The strongest changes took place in and nearby the Anhur canyon-like structure, where significant dust cover was removed, an entire structure vanished, and many boulders were rearranged. All such changes are potentially associated with one of the most intense outbursts registered by Rosetta during its observations, which occurred one day before perihelion passage. Moreover, in the niche at the foot of a new observed scarp, we also see evidence of water ice exposure that persisted for at least six months. The abundance of water ice, evaluated from a linear mixing model, is relatively high (>20%). Our results confirm that the Anhur region is volatile-rich and probably is the area on 67P with the most pristine exposures near perihelion.© S. Fornasier et al. 2019
Published: 2019

30. Quantitative analysis of isolated boulder fields on comet 67P/Churyumov-Gerasimenko

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Cambianica, P., Cremonese, G., Naletto, G., Lucchetti, A., Pajola, M., Penasa, L., Simioni, E., Massironi, M., Ferrari, S., Bodewits, D., La Forgia, F., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Dayidsson, B, Barucci, M.A., Bertaux, J.L., Bertini, I., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Lara, Luisa María, Lazzarin, M., Lin, Zhong-Yi, López-Moreno, José Juan, Marzari, F., Mottola, S., Shi, X., Scholten, F., Toth, I., Tubiana, C., Vincent, J.B., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Cambianica, P., Cremonese, G., Naletto, G., Lucchetti, A., Pajola, M., Penasa, L., Simioni, E., Massironi, M., Ferrari, S., Bodewits, D., La Forgia, F., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Dayidsson, B, Barucci, M.A., Bertaux, J.L., Bertini, I., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Lara, Luisa María, Lazzarin, M., Lin, Zhong-Yi, López-Moreno, José Juan, Marzari, F., Mottola, S., Shi, X., Scholten, F., Toth, I., Tubiana, C., and Vincent, J.B.
Abstract: We provide a detailed quantitative analysis of isolated boulder fields situated in three different regions of comet 67P/Churyumov-Gerasimenko: Imhotep, Hapi, and Hatmehit. This is done to supply a useful method for analyzing the morphology of the boulders and to characterize the regions themselves. Methods. We used OSIRIS Narrow Angle Camera images with a spatial scale smaller than 2 mpx(-1) and analyzed the size-frequency distribution and the cumulative fractional area per boulder population. In addition, we correlated shape parameters, such as circularity and solidity, with both the spatial and the size-frequency distribution of the three populations. Results. We identified 11 811 boulders in the Imhotep, Hapi, and Hatmehit regions. We found that the Hatmehit and Imhotep areas show power indices in the range of -2.3/-2.7. These values could represent a transition between gravitational events caused by thermal weathering and sublimation, and material formed during collapses that has undergone sublimation. The Hapi area is characterized by a lower power index (-1.2/-1.7), suggesting that those boulders have a different origin. They can be the result of material formed during gravitational events and collapses that has undergone continuous fragmentation. We calculated the cumulative fractional area (CFA) in order to investigate how the area is covered by boulders as a function of their sizes. The Hatmehit and Imhotep regions show a CFA that is well fit by a power law. In contrast, the Hapi area does not show the same trend. We analyzed the fractal distributions, finding that the populations seem to be fractal at all dimensions, except for the Hapi distribution, which shows a possible fractal behavior for small dimensions only. Finally, the average values of the shape parameters reveal solid and roundish boulders in all populations we studied.© ESO 2019
Published: 2019

31. Seasonal variations in source regions of the dust jets on comet 67P/Churyumov-Gerasimenko

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Ministry of Science and Technology (Taiwan), Science and Technology Development Fund (Macau), Lai, IL, Ip, W. H., Lee, J.C., Lin, Zhong-Yi, Vincent, J.B., Oklay, N., Sierks, H., Barbieri, C, Lamy, P., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Keller, H.U., Agarwal, J., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, B., Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hofmann, M., Hviid, S.F., Jorda, L., Knollenberg, J., Kovacs, G., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Shi, X., Tubiana, C., Thomas, N, German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Ministry of Science and Technology (Taiwan), Science and Technology Development Fund (Macau), Lai, IL, Ip, W. H., Lee, J.C., Lin, Zhong-Yi, Vincent, J.B., Oklay, N., Sierks, H., Barbieri, C, Lamy, P., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Keller, H.U., Agarwal, J., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, B., Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hofmann, M., Hviid, S.F., Jorda, L., Knollenberg, J., Kovacs, G., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Shi, X., Tubiana, C., and Thomas, N
Abstract: We investigate the surface distribution of the source regions of dust jets on comet 67P/Churyumov-Gerasimenko as a function of time. Methods. The dust jet source regions were traced by the comprehensive imaging data set provided by the OSIRIS scientific camera. Results. We show in detail how the projected footpoints of the dust jets and hence the outgassing zone would move in consonance with the sunlit belt. Furthermore, a number of source regions characterized by repeated jet activity might be the result of local topographical variations or compositional heterogeneities. Conclusions. The spatial and temporal variations in source regions of the dust jets are influenced significantly by the seasonal effect. The strong dependence on the solar zenith angle and local time could be related to the gas sublimation process driven by solar insolation on a surface layer of low thermal inertia.© ESO 2019
Published: 2019

32. The Rocky-Like Behavior of Cometary Landslides on 67P/Churyumov-Gerasimenko

Author: Lucchetti, A., Penasa, L., Pajola, M., Massironi, M., Brunetti, M.T., Cremonese, G., Oklay, N., Vincent, J.B., Mottola, S., Fornasier, S., Sierks, H., Naletto, G., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barbieri, C., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cambianica, P., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Ferrari, S., Ferri, F., Franceschi, M., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, U., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Tubiana, C., Lucchetti, A., Penasa, L., Pajola, M., Massironi, M., Brunetti, M.T., Cremonese, G., Oklay, N., Vincent, J.B., Mottola, S., Fornasier, S., Sierks, H., Naletto, G., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barbieri, C., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cambianica, P., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Ferrari, S., Ferri, F., Franceschi, M., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, U., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., and Tubiana, C.
Abstract: Landslides have been identified on several solar system bodies, and different mechanisms have been proposed to explain their runout length. We analyze images from the Rosetta mission and report the global characterization of such features on comet 67P/Churyumov-Gerasimenko's surface. By assuming the height to runout length as an approximation for the friction coefficient of landslide material, we find that on comet 67P, this ratio falls between 0.50 and 0.97. Such unexpected high values reveal a rocky-type mechanical behavior that is much more akin to Earth dry landslides than to icy satellites' mass movements. This behavior indicates that 67P and likely comets in general are characterized by consolidated materials possibly rejecting the idea that they are fluffy aggregates. The variability of the runout length among 67P landslides can be attributed to the different volatile content located in the top few meters of the cometary crust, which can drive the mass movement.©2019. American Geophysical Union. All Rights Reserved.
Published: 2019

33. Bilobate comet morphology and internal structure controlled by shear deformation

Author: Matonti, C., Attree, N., Groussin, O., Jorda, L., Viseur, S., Hviid, S.F., Bouley, S., Nébouy, D., Auger, A.T., Lamy, P.L., Sierks, H., Naletto, G., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Lara, Luisa María, La Forgia, F., Lazzarin, M., Lucchetti, A., López-Moreno, José Juan, Marzari, F., Massironi, M., Mottola, S., Oklay, N., Pajola, M., Penasa, L., Preusker, F., Rickman, H., Scholten, F., Shi, X., Toth, I., Tubiana, C., Vincent, J.B., Matonti, C., Attree, N., Groussin, O., Jorda, L., Viseur, S., Hviid, S.F., Bouley, S., Nébouy, D., Auger, A.T., Lamy, P.L., Sierks, H., Naletto, G., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Lara, Luisa María, La Forgia, F., Lazzarin, M., Lucchetti, A., López-Moreno, José Juan, Marzari, F., Massironi, M., Mottola, S., Oklay, N., Pajola, M., Penasa, L., Preusker, F., Rickman, H., Scholten, F., Shi, X., Toth, I., Tubiana, C., and Vincent, J.B.
Abstract: Bilobate comets—small icy bodies with two distinct lobes—are a common configuration among comets, but the factors shaping these bodies are largely unknown. Cometary nuclei, the solid centres of comets, erode by ice sublimation when they are sufficiently close to the Sun, but the importance of a comet’s internal structure on its erosion is unclear. Here we present three-dimensional analyses of images from the Rosetta mission to illuminate the process that shaped the Jupiter-family bilobate comet 67P/Churyumov–Gerasimenko over billions of years. We show that the comet’s surface and interior exhibit shear-fracture and fault networks, on spatial scales of tens to hundreds of metres. Fractures propagate up to 500 m below the surface through a mechanically homogeneous material. Through fracture network analysis and stress modelling, we show that shear deformation generates fracture networks that control mechanical surface erosion, particularly in the strongly marked neck trough of 67P/Churyumov–Gerasimenko, exposing its interior. We conclude that shear deformation shapes and structures the surface and interior of bilobate comets, particularly in the outer Solar System where water ice sublimation is negligible.© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Published: 2019

34. Multidisciplinary analysis of the Hapi region located on Comet 67P/Churyumov-Gerasimenko

Author: European Space Agency, Swedish National Space Board, Ministerio de Educación y Ciencia (España), Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, German Centre for Air and Space Travel, Pajola, M., Lee, J.C., Oklay, N., Hviid, S.F., Penasa, L., Mottola, S., Shi, X., Fornasier, S., Davidsson, B., Giacomini, L., Lucchetti, A., Massironi, M., Vincent, J.B., Bertini, I., Naletto, G., Ip, W. H., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Keller, H.U., Agarwal, J., Barucci, M.A., Bertaux, J.L., Bodewits, D., Cambianica, P., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., El Maarry, M. R., Feller, C., Ferrari, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Lara, Luisa María, La Forgia, F., Lazzarin, M., Lin, Zhong-Yi, López-Moreno, José Juan, Marzari, F., Preusker, F., Scholten, F., Toth, I., Tubiana, C., European Space Agency, Swedish National Space Board, Ministerio de Educación y Ciencia (España), Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, German Centre for Air and Space Travel, Pajola, M., Lee, J.C., Oklay, N., Hviid, S.F., Penasa, L., Mottola, S., Shi, X., Fornasier, S., Davidsson, B., Giacomini, L., Lucchetti, A., Massironi, M., Vincent, J.B., Bertini, I., Naletto, G., Ip, W. H., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Keller, H.U., Agarwal, J., Barucci, M.A., Bertaux, J.L., Bodewits, D., Cambianica, P., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., El Maarry, M. R., Feller, C., Ferrari, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Lara, Luisa María, La Forgia, F., Lazzarin, M., Lin, Zhong-Yi, López-Moreno, José Juan, Marzari, F., Preusker, F., Scholten, F., Toth, I., and Tubiana, C.
Abstract: By using the Rosetta/OSIRIS-NAC data set taken in 2014 August, we focus on the neck region, called Hapi, located on 67P Churyumov-Gerasimenko's Northern hemisphere. The gravitational potential and slopes of Hapi, coupled with the geological unit identification and the boulder size-frequency distributions, support the interpretation that both taluses and gravitational accumulation deposits observable on Hapi are the result of multiple cliff collapses that occurred at different times. By contrast, the fine-particle deposits observable in the central part of the study area are made of aggregates coming from the Southern hemisphere and deposited during each perihelion passage. Both the consolidated terrains on the western part of Hapi, as well as the centrally aligned ridge made of boulder-like features, suggest that Hapi is in structural continuity with the onion-like structure of the main lobe of 67P. Despite the dusty blanket observable on Hapi, its terrains are characterized by water-ice-rich components that, once repeatedly and rapidly illuminated, sublimate, hence resulting in the strong jet activity observed in 2014 August.© 2019 The Author(s).
Published: 2019

35. Latex d-dimer signal in in situ femoral vein thrombus in swine and effect of minidose exogenous tissue plasminogen activator bolus *

Author: Robinson, Vincent J.B., Pineda, Guillermo E., Salah, Ali K., Pipkin, Walter L., Corley, James H., Jonah, Mary H., and Gossage, James R.
Subjects: Medical research, Medicine, Experimental, Blood clot -- Drug therapy, Thrombosis -- Drug therapy, Thrombolytic drugs -- Dosage and administration, Health, Drug therapy, Dosage and administration
Abstract: Study objectives: We created in situ femoral vein thrombi in swine to investigate the response of the latex d-dimer signal to acute in situ venous thrombosis, and to determine the [...]
Published: 2005

36. MMIC transmitter for a commercial search and rescue radar transponder

Author: Vincent, J.B. and Merwe, D.G. van der
Subjects: Microwave integrated circuits -- Design and construction, Search and rescue operations, Transponders -- Equipment and supplies, Radar systems -- Equipment and supplies, Business, Computers, Electronics, Electronics and electrical industries
Abstract: This paper reports the design and use of MMIC's in the transmitter of a commercial Search and Rescue Transponder (SART). The SART is a maritime unit operating in the frequency band 9.2-9.5 GHz. The microwave unit is integrated on a single thick film hybrid, using an optimum combination of MMIC's and discrete components. This has resulted in a highly reliable, cost-effective product. There are two MMIC's, namely the VCO and the power amplifier. The VCO MMIC has a typical linearity of better than 5-MHz deviation over a 300-MHz sweep. The power amplifier MMIC has a minimum power output of 27-dBm over the band.
Published: 1995

37. RACE/ETHNICITY DETERMINES THE RELATIONSHIPS BETWEEN OXIDATIVE STRESS MARKERS AND BLOOD PRESSURE IN INDIVIDUALS WITH HIGH CARDIOVASCULAR DISEASE RISK

Author: Frank A. Treiber, Vincent J.B. Robinson, S Young-Mayes, Gregory A. Harshfield, James D. Halbert, Gaston Kapuku, Harry Davis, and F Raouane
Subjects: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Blood Pressure, 030204 cardiovascular system & hematology, Article, White People, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Race/Ethnicity, Internal medicine, Internal Medicine, medicine, Humans, Myocardial infarction, Family history, Young adult, Video game, business.industry, Confounding, Repeated measures design, medicine.disease, United States, 3. Good health, Black or African American, Oxidative Stress, 030104 developmental biology, Endocrinology, Blood pressure, Ambulatory, Hypertension, Cardiology, Female, business
Abstract: Oxidative stress (OS) and cardiovascular (CV) reactivity are related to CV morbidity and mortality. However, little is known about the relationships between these CV risk factors and their confounders. We hypothesize that higher OS is linked to higher blood pressure (BP) reactivity to acute laboratory stressors and in the natural setting. We studied 137 subjects with a family history of hypertension and early myocardial infarction. There were 63 European Americans (EAs) (38 males) and 74 African Americans (AAs) (35 males), aged 19-36 (27.6±3.1). The protocol included a competitive video game, cold stressor and ambulatory BP recording. Blood samples were drawn six times for OS markers (8-hydroxydeoxyguanosine (8-OHdG) and 8-Isoprostane) assay. Repeated measures analyses of covariance were used to test for mean differences and Pearson correlations were used to test OS and BP associations. There were no significant race/ethnicity differences in BP reactivity to either stressor (both P's0.48). 8-OHdG levels were significantly lower across all time points for AAs than for EAs (P0.05), while levels of 8-isoprostane did not differ significantly (P0.10). Averaged 8-OHdG levels significantly correlated with systolic blood pressure (SBP) reactivity (r=0.45,0.01) and 24-h, daytime and nighttime SBP (r range=0.37-0.42, all P's0.02) for EAs but not for AAs, whereas 8-isoprostane levels were significantly correlated with reactive SBP and nighttime diastolic blood pressure (DBP) (both r's=0.38, P0.01) for AAs but not for EAs. These findings suggest a link between OS and BP changes in subjects at high risk for CV disease (CVD). Further, race/ethnicity determines which OS marker will impact BP variation implying race/ethnicity differences in OS-related mechanisms of CVD.
Published: 2016

38. Electron paramagnetic resonance studies on the high-salt form of bovine spleen purple acid phosphatase

Author: Crowder, M.W., Vincent, J.B., and Averill, B.A.
Subjects: Electron paramagnetic resonance -- Usage, Phosphatases -- Research, Enzyme inhibitors -- Research, Biological sciences, Chemistry
Abstract: Electron paramagnetic resonance (EPR) studies on the binding of inhibitors such as tetrahedral oxyanions and flouride to the high-salt form of reduced bovine spleen purple acid phosphatase elicits information on the participation of binuclear iron center on catalytic mechanisms. EPR data indicates that the high- and low-salt forms have identical EPR spectra implying unaltered electronic structures of binuclear iron centers. Further spectroscopic analysis provided evidence for the formation of a ternary complex analogous to molybdate inhibition.
Published: 1992

39. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy

Author: Koczo, Agnes, primary, Marino, Amy, additional, Jeyabalan, Arun, additional, Elkayam, Uri, additional, Cooper, Leslie T., additional, Fett, James, additional, Briller, Joan, additional, Hsich, Eileen, additional, Blauwet, Lori, additional, McTiernan, Charles, additional, Morel, Penelope A., additional, Hanley-Yanez, Karen, additional, McNamara, Dennis M., additional, McNamara, Dennis M, additional, Fett, James D., additional, Pisarcik, Jessica, additional, Gorcsan, John, additional, Schelbert, Erik, additional, Alharethi, Rami, additional, Rasmusson, Kismet, additional, Brunisholz, Kim, additional, Butler, Amy, additional, Budge, Deborah, additional, Kfoury, A.G., additional, Horne, Benjamin, additional, Tuinei, Joe, additional, Brown, Heather, additional, Damp, Julie, additional, Naftilan, Allen J., additional, Russell, Jill, additional, Freehardt, Darla, additional, Oblak, Cynthia, additional, Ewald, Greg, additional, Whitehead, Donna, additional, Flanagan, Jean, additional, Platts, Anne, additional, Caro, Jorge, additional, Mullin, Stephanie, additional, Givertz, Michael M., additional, Anello, M. Susan, additional, Rajagopalan, Navin, additional, Booth, David, additional, Sandlin, Tiffany, additional, Wijesiri, Wendy, additional, Blauwet, Lori A., additional, Brunner, Joann, additional, Phelps, Mary, additional, Kempf, Ruth, additional, Modi, Kalgi, additional, Norwood, Tracy, additional, Griza, Decebal Sorin, additional, Felker, G. Michael, additional, Kociol, Robb, additional, Adams, Patricia, additional, Wells, Gretchen, additional, Thohan, Vinay, additional, Wesley-Farrington, Deborah, additional, Soots, Sandra, additional, Sheppard, Richard, additional, Michel, Caroline, additional, Lapointe, Nathalie, additional, Nathaniel, Heather, additional, Kealey, Angela, additional, Semigran, Marc, additional, Daher, Maureen, additional, Boehmer, John, additional, Silber, David, additional, Popjes, Eric, additional, Frey, Patricia, additional, Nicklas, Todd, additional, Alexis, Jeffrey, additional, Caufield, Lori, additional, Thornton, John W., additional, Gentry, Mindy, additional, Robinson, Vincent J.B., additional, Sharma, Gyanendra K., additional, Holloway, Joan, additional, Powell, Maria, additional, Markham, David, additional, Drazner, Mark, additional, Fernandez, Lynn, additional, Zucker, Mark, additional, Baran, David A., additional, Gimovsky, Martin L., additional, Hochbaum, Natalia, additional, Patel, Bharati, additional, Adams, Laura, additional, Ramani, Gautam, additional, Gottlieb, Stephen, additional, Robinson, Shawn, additional, Fisher, Stacy, additional, Marshall, Joanne, additional, Haythe, Jennifer, additional, Mancini, Donna, additional, Bijou, Rachel, additional, Farr, Maryjane, additional, Marks, Marybeth, additional, Arango, Henry, additional, Bozkurt, Biykem, additional, Bolos, Mariana, additional, Mather, Paul, additional, Rubin, Sharon, additional, Bonita, Raphael, additional, Eberwine, Susan, additional, Skopicki, Hal, additional, Stergiopoulos, Kathleen, additional, McCathy-Santoro, Ellen, additional, Intravaia, Jennifer, additional, Maas, Elizabeth, additional, Safirstein, Jordan, additional, Kleet, Audrey, additional, Martinez, Nancy, additional, Corpoin, Christine, additional, Hesari, Donna, additional, Chaparro, Sandra, additional, Hudson, Laura J., additional, Ghali, Jalal K., additional, Injic, Zora, additional, and Wittstein, Ilan S., additional
Published: 2019
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40. Can α-Lipoic Acid Mitigate Progression of Aging-Related Decline Caused by Oxidative Stress?

Author: Maharsh K. Patel, Vincent J.B. Robinson, Stephen B. Hobbs, Miriam Cortez-Cooper, and Mary Anne Riley
Subjects: Aging, education.field_of_study, Physiological function, Thioctic Acid, business.industry, Population, General Medicine, Bioinformatics, medicine.disease_cause, Antioxidants, Oxidative Stress, Lipoic acid, chemistry.chemical_compound, chemistry, Dietary Supplements, Life expectancy, Humans, Medicine, business, education, Oxidative stress
Abstract: Aging is progressively deteriorating physiological function that leads to increasing risks of illness and death. Increases in life expectancy and the aging of a large segment of the population have made age-related disability and morbidity increasingly important issues. Supplements such as α-lipoic acid may have antiaging effects by positively affecting oxidative stress, cognitive function, and cardiovascular function.
Published: 2014

41. On deviations from free-radial outflow in the inner coma of comet 67P/Churyumov–Gerasimenko

Author: Swiss National Science Foundation, European Commission, Gerig, S. -B., Marschall, R., Thomas, N., Bertini, I., Bodewits, D., Davidsson, B., Fulle, M., Ip, W. H., Keller, H.U., Küppers, M., Preusker, F., Scholten, F., Su, C. C., Toth, I., Tubiana, C., Wu, J. -S., Sierks, H., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Agarwal, J., Barucci, M.A., Bertaux, J.L., Cremonese, G., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., Fornasier, S., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hviid, S.F., Jorda, L., Knollenberg, J., Kramm, J.R., Kührt, E., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Mottola, S., Naletto, G., Oklay, N., Vincent, J.B., Swiss National Science Foundation, European Commission, Gerig, S. -B., Marschall, R., Thomas, N., Bertini, I., Bodewits, D., Davidsson, B., Fulle, M., Ip, W. H., Keller, H.U., Küppers, M., Preusker, F., Scholten, F., Su, C. C., Toth, I., Tubiana, C., Wu, J. -S., Sierks, H., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Agarwal, J., Barucci, M.A., Bertaux, J.L., Cremonese, G., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., Fornasier, S., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hviid, S.F., Jorda, L., Knollenberg, J., Kramm, J.R., Kührt, E., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Mottola, S., Naletto, G., Oklay, N., and Vincent, J.B.
Abstract: The Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) onboard the European Space Agency's Rosetta spacecraft acquired images of comet 67P/Churyumov–Gerasimenko (67P) and its surrounding dust coma starting from May 2014 until September 2016. In this paper we present methods and results from analysis of OSIRIS images regarding the dust outflow in the innermost coma of 67P. The aim is to determine the global dust outflow behaviour and place constraints on physical processes affecting particles in the inner coma. We study the coma region right above the nucleus surface, spanning from the nucleus centre out to a distance of about 50 km comet centric distance (approximately 25 average comet radii). We primarily adopt an approach used by Thomas and Keller (1990) to study the dust outflow. We present the effects on azimuthally-averaged values of the dust reflectance of non-radial flow and non-point-source geometry, acceleration of dust particles, sublimation of icy dust particles after ejection from the surface, dust particle fragmentation, optical depth effects and the influence of gravitationally bound particles. All of these physical processes could modify the observed distribution of light scattered by the dust coma. In the image analysis, profiles of azimuthally averaged dust brightness as a function of impact parameter b (azimuthal average, “Ā-curve”) were fitted with a simple function that best fits the shape of our profile curves (f(b;u,v,w,z)=u/b+wb+z). The analytical fit parameters (u, v, w, z), which hold the key information about the dust outflow behaviour, were saved in a comprehensive database. Through statistical analysis of these information, we show that the spatial distribution of dust follows free-radial outflow behaviour (i.e. force-free radial outflow with constant velocity) beyond distances larger than ∼11.9 km from the comet centre, which corresponds to a relative distance of about 6 average comet radii from the comet centre. Hence
Published: 2018

42. Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse

Author: Ung, D.C., Iacono, G., Meziane, H., Blanchard, E, Papon, M.A., Selten, M, Rhijn, J.R. van, Montjean, R., Rucci, J., Martin, S., Fleet, A, Birling, M.C., Marouillat, S., Roepman, R., Selloum, M., Lux, A, Thepault, R.A., Hamel, P, Mittal, K, Vincent, J.B., Dorseuil, O., Stunnenberg, H., Billuart, P., Nadif Kasri, N., Herault, Y., Laumonnier, F., Ung, D.C., Iacono, G., Meziane, H., Blanchard, E, Papon, M.A., Selten, M, Rhijn, J.R. van, Montjean, R., Rucci, J., Martin, S., Fleet, A, Birling, M.C., Marouillat, S., Roepman, R., Selloum, M., Lux, A, Thepault, R.A., Hamel, P, Mittal, K, Vincent, J.B., Dorseuil, O., Stunnenberg, H., Billuart, P., Nadif Kasri, N., Herault, Y., and Laumonnier, F.
Abstract: Contains fulltext : 193089.pdf (publisher's version ) (Open Access), Synapse development and neuronal activity represent fundamental processes for the establishment of cognitive function. Structural organization as well as signalling pathways from receptor stimulation to gene expression regulation are mediated by synaptic activity and misregulated in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability (ID). Deleterious mutations in the PTCHD1 (Patched domain containing 1) gene have been described in male patients with X-linked ID and/or ASD. The structure of PTCHD1 protein is similar to the Patched (PTCH1) receptor; however, the cellular mechanisms and pathways associated with PTCHD1 in the developing brain are poorly determined. Here we show that PTCHD1 displays a C-terminal PDZ-binding motif that binds to the postsynaptic proteins PSD95 and SAP102. We also report that PTCHD1 is unable to rescue the canonical sonic hedgehog (SHH) pathway in cells depleted of PTCH1, suggesting that both proteins are involved in distinct cellular signalling pathways. We find that Ptchd1 deficiency in male mice (Ptchd1(-/y)) induces global changes in synaptic gene expression, affects the expression of the immediate-early expression genes Egr1 and Npas4 and finally impairs excitatory synaptic structure and neuronal excitatory activity in the hippocampus, leading to cognitive dysfunction, motor disabilities and hyperactivity. Thus our results support that PTCHD1 deficiency induces a neurodevelopmental disorder causing excitatory synaptic dysfunction.
Published: 2018

43. Regional unit definition for the nucleus of comet 67P/Churyumov-Gerasimenko on the SHAP7 model

Author: Swiss National Science Foundation, European Commission, State Secretariat for Education, Research and Innovation (Switzerland), Thomas, N., El Maarry, M. R., Theologou, P., Preusker, F., Scholten, F., Jorda, L., Hviid, S.F., Marschall, R., Kührt, E., Naletto, G., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Fornasier, S., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Knollenberg, J., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Tubiana, C., Vincent, J.B., Swiss National Science Foundation, European Commission, State Secretariat for Education, Research and Innovation (Switzerland), Thomas, N., El Maarry, M. R., Theologou, P., Preusker, F., Scholten, F., Jorda, L., Hviid, S.F., Marschall, R., Kührt, E., Naletto, G., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Fornasier, S., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Ip, W. H., Keller, H.U., Knollenberg, J., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Tubiana, C., and Vincent, J.B.
Abstract: The previously defined regions on the nucleus of comet 67P/Churyumov-Gerasimenko have been mapped back onto the 3D SHAP7 model of the nucleus (Preusker et al., 2017). The resulting regional definition is therefore self-consistent with boundaries that are well defined in 3 dimensions. The facets belonging to each region are provided as supplementary material. The shape model has then been used to assess inhomogeneity of nucleus surface morphology within individual regions. Several regions show diverse morphology. We propose sub-division of these regions into clearly identifiable units (sub-regions) and a comprehensive table is provided. The surface areas of each sub-region have been computed and statistics based on grouping of unit types are provided. The roughness of each region is also provided in a quantitative manner using a technique derived from computer graphics applications. The quantitative method supports the sub-region definition by showing that differences between sub-regions can be numerically justified.© 2018 The Authors
Published: 2018

44. Meter-scale thermal contraction crack polygons on the nucleus of comet 67P/Churyumov-Gerasimenko

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Auger, A.T., Groussin, O., Jorda, L., El-Maarry, M. R., Bouley, S., Séjourné, A., Gaskell, R., Capanna, C., Davidsson, B., Marchi, S., Höfner, S., Lamy, P.L., Sierks, H., Barbieri, C., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Keller, H.U., Agarwal, J., A'Hearn, M. F., Barucci, M.A., Bertaux, J.L., Bertini, I., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Hviid, S., Ip, W. H., Knollenberg, J., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Massironi, M., Michalik, H., Naletto, G., Oklay, N., Pommerol, A., Sabau, L., Thomas, N., Tubiana, C., Vincent, J.B., Wenzel, K. -P., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Auger, A.T., Groussin, O., Jorda, L., El-Maarry, M. R., Bouley, S., Séjourné, A., Gaskell, R., Capanna, C., Davidsson, B., Marchi, S., Höfner, S., Lamy, P.L., Sierks, H., Barbieri, C., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Keller, H.U., Agarwal, J., A'Hearn, M. F., Barucci, M.A., Bertaux, J.L., Bertini, I., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Fornasier, S., Fulle, M., Gutiérrez, Pedro J., Güttler, C., Hviid, S., Ip, W. H., Knollenberg, J., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Massironi, M., Michalik, H., Naletto, G., Oklay, N., Pommerol, A., Sabau, L., Thomas, N., Tubiana, C., Vincent, J.B., and Wenzel, K. -P.
Abstract: We report on the detection and characterization of more than 6300 polygons on the surface of the nucleus of comet 67P/Churyumov-Gerasimenko, using images acquired by the OSIRIS camera onboard Rosetta between August 2014 and March 2015. They are found in consolidated terrains and grouped in localized networks. They are present at all latitudes (from North to South) and longitudes (head, neck, and body), sometimes on pit walls or following lineaments. About 1.5% of the observed surface is covered by polygons. Polygons have an homogeneous size across the nucleus, with 90% of them in the size range 1 – 5 m and a mean size of 3.0 ± 1.4 m. They show different morphologies, depending on the width and depth of their trough. They are found in networks with 3- or 4-crack intersection nodes. The polygons observed on 67P are consistent with thermal contraction crack polygons formed by the diurnal or seasonal temperature variations in a hard (MPa) and consolidated sintered layer of water ice, located a few centimeters below the surface. Our thermal analysis shows an evolution of thermal contraction crack polygons according to the local thermal environment, with more evolved polygons (i.e. deeper and larger troughs) where the temperature and the diurnal and seasonal temperature range are the highest. Thermal contraction crack polygons are young surface morphologies that probably formed after the injection of 67P in the inner solar system, typically 100,000 years ago, and could be as young as a few orbital periods, following the decreasing of its perihelion distance in 1959 from 2.7 to 1.3 a.u. Meter scale thermal contraction crack polygons should be common features on the nucleus of Jupiter family comets.© 2017 Elsevier Inc.
Published: 2018

45. Coma morphology of comet 67P controlled by insolation over irregular nucleus

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Shi, X., Hu, X., Mottola, S., Sierks, H., Keller, H.U., Rose, M., Güttler, C., Fulle, M., Fornasier, S., Agarwal, J., Pajola, M., Tubiana, C., Bodewits, D., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Barucci, M.A., Bertaux, J.L., Bertini, I., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, B., Debei, S., De Cecco, M., Deller, J., Groussin, O., Gutiérrez, Pedro J., Hviid, S.F., Ip, W. H., Jorda, L., Knollenberg, J., Kovacs, G., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Oklay, N., Toth, I., Vincent, J.B., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Shi, X., Hu, X., Mottola, S., Sierks, H., Keller, H.U., Rose, M., Güttler, C., Fulle, M., Fornasier, S., Agarwal, J., Pajola, M., Tubiana, C., Bodewits, D., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Barucci, M.A., Bertaux, J.L., Bertini, I., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, B., Debei, S., De Cecco, M., Deller, J., Groussin, O., Gutiérrez, Pedro J., Hviid, S.F., Ip, W. H., Jorda, L., Knollenberg, J., Kovacs, G., Kramm, J.R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Oklay, N., Toth, I., and Vincent, J.B.
Abstract: While the structural complexity of cometary comae is already recognizable from telescopic observations, the innermost region, within a few radii of the nucleus, was not resolved until spacecraft exploration became a reality. The dust coma displays jet-like features of enhanced brightness superposed on a diffuse background . Some features can be traced to specific areas on the nucleus, and result conceivably from locally enhanced outgassing and/or dust emission. However, diffuse or even uniform activity over topographic concavity can converge to produce jet-like features. Therefore, linking observed coma morphology to the distribution of activity on the nucleus is difficult. Here, we study the emergence of dust activity at sunrise on comet 67P/Churyumov-Gerasimenko using high-resolution, stereo images from the OSIRIS camera onboard the Rosetta spacecraft, where the sources and formation of the jet-like features are resolved. We perform numerical simulations to show that the ambient dust coma is driven by pervasive but non-uniform water outgassing from the homogeneous surface layer. Physical collimations of gas and dust flows occur at local maxima of insolation and also via topographic focusing. Coma structures are projected to exhibit jet-like features that vary with the perspective of the observer. For an irregular comet such as 67P/Churyumov-Gerasimenko, near-nucleus coma structures can be concealed in the shadow of the nucleus, which further complicates the picture.© 2018 The Author(s).
Published: 2018

46. The big lobe of 67P/Churyumov-Gerasimenko comet: Morphological and spectrophotometric evidences of layering as from OSIRIS data

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Ferrari, S., Penasa, L., La Forgia, F., Massironi, M., Naletto, G., Lazzarin, M., Fornasier, S., Hasselmann, P.H., Lucchetti, A., Pajola, M., Ferri, F., Cambianica, P., Oklay, N., Tubiana, C., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Franceschi, M., Frattin, E., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hviid, S.F., Ip, W. H., Jorda, L., Keller, H.U., Knollenberg, J., Kührt, E., Küppers, M., Lara, Luisa María, López-Moreno, José Juan, Marzari, F., Shi, X., Simioni, E., Thomas, N., Vincent, J.B., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Ferrari, S., Penasa, L., La Forgia, F., Massironi, M., Naletto, G., Lazzarin, M., Fornasier, S., Hasselmann, P.H., Lucchetti, A., Pajola, M., Ferri, F., Cambianica, P., Oklay, N., Tubiana, C., Sierks, H., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Davidsson, B., Barucci, M.A., Bertaux, J.L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, Vania, Debei, S., De Cecco, M., Deller, J., Franceschi, M., Frattin, E., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Güttler, C., Hviid, S.F., Ip, W. H., Jorda, L., Keller, H.U., Knollenberg, J., Kührt, E., Küppers, M., Lara, Luisa María, López-Moreno, José Juan, Marzari, F., Shi, X., Simioni, E., Thomas, N., and Vincent, J.B.
Abstract: Between 2014 and 2016, ESA's Rosetta OSIRIS cameras acquired multiple-filters images of the layered nucleus of comet 67P/Churyumov-Gerasimenko, ranging from ultraviolet to near-infrared wavelengths. No correlation between layers disposition and surface spectral variegation has been observed so far. This paper investigates possible spectral differences among decametre-thickness outcropping layers of the biggest lobe of the comet by means of OSIRIS image dataset. A two-classes maximum likelihood classification was applied on consolidated outcrops and relative deposits identified on post-perihelion multispectral images of the big lobe. We distinguished multispectral data on the basis of the structural elevation of the onion-shell Ellipsoidal Model of 67P. The spatial distribution of the two classes displays a clear dependence on the structural elevation, with the innermost class resulting over 50 per cent brighter than the outermost one. Consolidated cometarymaterials located at different structural levels are characterized by different brightness and revealed due to the selective removal of large volumes. This variegation can be attributed to a different texture of the outcrop surface and/or to a different content of refractory materials.© 2018 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society.
Published: 2018

47. Exposed bright features on the comet 67P/Churyumov-Gerasimenko: Distribution and evolution

Author: German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Ministerio de Educación y Ciencia (España), European Space Agency, Swedish National Space Board, Deshapriya, J.D.P., Barucci, M.A., Fornasier, S., Hasselmann, P.H., Feller, C., Sierks, H., Lucchetti, A., Pajola, M., Oklay, N., Mottola, S., Masoumzadeh, N., Tubiana, C., Güttler, C., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Bertaux, J.L., Bertini, I., Bodewits, D., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, Björn J. R., Debei, S., Cecco, M.D., Deller, J., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Hoang, H. V., Hviid, S.F., Ip, W. H., Jorda, L., Keller, H.U., Knollenberg, J., Kramm, R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Preusker, F., Shi, X., Thomas, N., Vincent, J.B., German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Ministerio de Educación y Ciencia (España), European Space Agency, Swedish National Space Board, Deshapriya, J.D.P., Barucci, M.A., Fornasier, S., Hasselmann, P.H., Feller, C., Sierks, H., Lucchetti, A., Pajola, M., Oklay, N., Mottola, S., Masoumzadeh, N., Tubiana, C., Güttler, C., Barbieri, C., Lamy, P.L., Rodrigo Montero, Rafael, Koschny, D., Rickman, H., Bertaux, J.L., Bertini, I., Bodewits, D., Boudreault, S., Cremonese, G., Da Deppo, Vania, Davidsson, Björn J. R., Debei, S., Cecco, M.D., Deller, J., Fulle, M., Groussin, O., Gutiérrez, Pedro J., Hoang, H. V., Hviid, S.F., Ip, W. H., Jorda, L., Keller, H.U., Knollenberg, J., Kramm, R., Kührt, E., Küppers, M., Lara, Luisa María, Lazzarin, M., López-Moreno, José Juan, Marzari, F., Naletto, G., Preusker, F., Shi, X., Thomas, N., and Vincent, J.B.
Abstract: Context. Since its arrival at the comet 67P/Churyumov-Gerasimenko in August 2014, the Rosetta spacecraft followed the comet as it went past the perihelion and beyond until September 2016. During this time there were many scientific instruments operating on board Rosetta to study the comet and its evolution in unprecedented detail. In this context, our study focusses on the distribution and evolution of exposed bright features that have been observed by OSIRIS, which is the scientific imaging instrument aboard Rosetta. Aims. We envisage investigating various morphologies of exposed bright features and the mechanisms that triggered their appearance. Methods. We co-registered multi-filter observations of OSIRIS images that are available in reflectance. The Lommel-Seeliger disk function was used to correct for the illumination conditions and the resulting colour cubes were used to perform spectrophotometric analyses on regions of interest. Results. We present a catalogue of 57 exposed bright features observed on the nucleus of the comet, all of which are attributed to the presence of HO ice on the comet. Furthermore, we categorise these patches under four different morphologies and present geometric albedos for each category. Conclusions. Although the nucleus of 67P/Churyumov-Gerasimenko appears to be dark in general, there are localised HO ice sources on the comet. Cometary activity escalates towards the perihelion passage and reveals such volatile ices. We propose that isolated HO ice patches found in smooth terrains in regions, such as Imhotep, Bes, and Hapi, result from frost as an aftermath of the cessation of the diurnal water cycle on the comet as it recedes from perihelion. Upon the comet's return to perihelion, such patches are revealed when sublimation-driven erosion removes the thin dust layers that got deposited earlier. More powerful activity sources such as cometary outbursts are capable of revealing much fresher, less contaminated HO ice that is preserved
Published: 2018

48. Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study

Author: Charles F. McTiernan, Penelope Morel, Leslie T. Cooper, Navin Rajagopalan, Vinay Thohan, Mark Zucker, John Boehmer, Biykem Bozkurt, Paul Mather, John Thornton, Jalal K. Ghali, Karen Hanley-Yanez, James Fett, Indrani Halder, Dennis M. McNamara, James D. Fett, Jessica Pisarcik, Charles McTiernan, John Gorcsan, Erik Schelbert, Rami Alharethi, Kismet Rasmusson, Kim Brunisholz, Amy Butler, Deborah Budge, A.G. Kfoury, Benjamin Horne, Joe Tuinei, Heather Brown, Julie Damp, Allen J. Naftilan, Jill Russell, Darla Freehardt, Eileen Hsich, Cynthia Oblak, Greg Ewald, Donna Whitehead, Jean Flanagan, Anne Platts, Uri Elkayam, Jorge Caro, Stephanie Mullin, Michael M. Givertz, M. Susan Anello, David Booth, Tiffany Sandlin, Wendy Wijesiri, Lori A. Blauwet, Joann Brunner, Mary Phelps, Ruth Kempf, Kalgi Modi, Tracy Norwood, Joan Briller, Decebal Sorin Griza, G. Michael Felker, Robb Kociol, Patricia Adams, Gretchen Wells, Deborah Wesley-Farrington, Sandra Soots, Richard Sheppard, Caroline Michel, Nathalie Lapointe, Heather Nathaniel, Angela Kealey, Marc Semigran, Maureen Daher, David Silber, Eric Popjes, Patricia Frey, Todd Nicklas, Jeffrey Alexis, Lori Caufield, John W. Thornton, Mindy Gentry, Vincent J.B. Robinson, Gyanendra K. Sharma, Joan Holloway, Maria Powell, David Markham, Mark Drazner, Lynn Fernandez, David A. Baran, Martin L. Gimovsky, Natalia Hochbaum, Bharati Patel, Laura Adams, Gautam Ramani, Stephen Gottlieb, Shawn Robinson, Stacy Fisher, Joanne Marshall, Jennifer Haythe, Donna Mancini, Rachel Bijou, Maryjane Farr, Marybeth Marks, Henry Arango, Mariana Bolos, Sharon Rubin, Raphael Bonita, Susan Eberwine, Hal Skopicki, Kathleen Stergiopoulos, Ellen McCathy-Santoro, Jennifer Intravaia, Elizabeth Maas, Jordan Safirstein, Audrey Kleet, Nancy Martinez, Christine Corpoin, Donna Hesari, Sandra Chaparro, Laura J. Hudson, Zora Injic, and Ilan S. Wittstein
Subjects: 0301 basic medicine, Adult, Cellular immunity, Peripartum cardiomyopathy, T cell, Pregnancy Complications, Cardiovascular, Cardiomyopathy, 030204 cardiovascular system & hematology, CD16, CD38, Monocytes, Ventricular Function, Left, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, Pregnancy, T-Lymphocyte Subsets, Peripartum Period, Medicine, Humans, Immunity, Cellular, business.industry, Puerperal Disorders, medicine.disease, Flow Cytometry, Killer Cells, Natural, 030104 developmental biology, medicine.anatomical_structure, Immunology, Female, Cardiology and Cardiovascular Medicine, business, Cardiomyopathies
Abstract: OBJECTIVE: The aim of this work was to evaluate the hypothesis that the distribution of circulating immune cell subsets, or their activation state, is significantly different between peripartum cardiomyopathy (PPCM) and healthy postpartum (HP) women. BACKGROUND: PPCM is a major cause of maternal morbidity and mortality, and an immune-mediated etiology has been hypothesized. Cellular immunity, altered in pregnancy and the peripartum period, has been proposed to play a role in PPCM pathogenesis. METHODS: The Investigation of Pregnancy-Associated Cardiomyopathy (IPAC) study enrolled 100 women presenting with a left ventricular ejection fraction of
Published: 2017

49. Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study

Author: McTiernan, Charles F., primary, Morel, Penelope, additional, Cooper, Leslie T., additional, Rajagopalan, Navin, additional, Thohan, Vinay, additional, Zucker, Mark, additional, Boehmer, John, additional, Bozkurt, Biykem, additional, Mather, Paul, additional, Thornton, John, additional, Ghali, Jalal K., additional, Hanley-Yanez, Karen, additional, Fett, James, additional, Halder, Indrani, additional, McNamara, Dennis M., additional, Fett, James D., additional, Pisarcik, Jessica, additional, McTiernan, Charles, additional, Gorcsan, John, additional, Schelbert, Erik, additional, Alharethi, Rami, additional, Rasmusson, Kismet, additional, Brunisholz, Kim, additional, Butler, Amy, additional, Budge, Deborah, additional, Kfoury, A.G., additional, Horne, Benjamin, additional, Tuinei, Joe, additional, Brown, Heather, additional, Damp, Julie, additional, Naftilan, Allen J., additional, Russell, Jill, additional, Freehardt, Darla, additional, Hsich, Eileen, additional, Oblak, Cynthia, additional, Ewald, Greg, additional, Whitehead, Donna, additional, Flanagan, Jean, additional, Platts, Anne, additional, Elkayam, Uri, additional, Caro, Jorge, additional, Mullin, Stephanie, additional, Givertz, Michael M., additional, Anello, M. Susan, additional, Booth, David, additional, Sandlin, Tiffany, additional, Wijesiri, Wendy, additional, Blauwet, Lori A., additional, Brunner, Joann, additional, Phelps, Mary, additional, Kempf, Ruth, additional, Modi, Kalgi, additional, Norwood, Tracy, additional, Briller, Joan, additional, Griza, Decebal Sorin, additional, Felker, G. Michael, additional, Kociol, Robb, additional, Adams, Patricia, additional, Wells, Gretchen, additional, Wesley-Farrington, Deborah, additional, Soots, Sandra, additional, Sheppard, Richard, additional, Michel, Caroline, additional, Lapointe, Nathalie, additional, Nathaniel, Heather, additional, Kealey, Angela, additional, Semigran, Marc, additional, Daher, Maureen, additional, Silber, David, additional, Popjes, Eric, additional, Frey, Patricia, additional, Nicklas, Todd, additional, Alexis, Jeffrey, additional, Caufield, Lori, additional, Thornton, John W., additional, Gentry, Mindy, additional, Robinson, Vincent J.B., additional, Sharma, Gyanendra K., additional, Holloway, Joan, additional, Powell, Maria, additional, Markham, David, additional, Drazner, Mark, additional, Fernandez, Lynn, additional, Baran, David A., additional, Gimovsky, Martin L., additional, Hochbaum, Natalia, additional, Patel, Bharati, additional, Adams, Laura, additional, Ramani, Gautam, additional, Gottlieb, Stephen, additional, Robinson, Shawn, additional, Fisher, Stacy, additional, Marshall, Joanne, additional, Haythe, Jennifer, additional, Mancini, Donna, additional, Bijou, Rachel, additional, Farr, Maryjane, additional, Marks, Marybeth, additional, Arango, Henry, additional, Bolos, Mariana, additional, Rubin, Sharon, additional, Bonita, Raphael, additional, Eberwine, Susan, additional, Skopicki, Hal, additional, Stergiopoulos, Kathleen, additional, McCathy-Santoro, Ellen, additional, Intravaia, Jennifer, additional, Maas, Elizabeth, additional, Safirstein, Jordan, additional, Kleet, Audrey, additional, Martinez, Nancy, additional, Corpoin, Christine, additional, Hesari, Donna, additional, Chaparro, Sandra, additional, Hudson, Laura J., additional, Injic, Zora, additional, and Wittstein, Ilan S., additional
Published: 2018
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50. Myocardial infarction after physical exertion in a healthy young patient with coronary artery ectasia and sickle cell trait

Author: Xu Wang, Vincent J.B. Robinson, Mahendra K. Mandawat, and Ali Dahhan
Subjects: medicine.medical_specialty, Sickle cell trait, business.industry, Coronary artery ectasia, Inflammation, medicine.disease, Internal medicine, medicine, Cardiology, Exertion, Myocardial infarction, Endothelial dysfunction, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published: 2015

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