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Your search keyword '"Vince G. Amoroso"' showing total 4 results
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4 results on '"Vince G. Amoroso"'

1. Epigenetic aging of the demographically non-aging naked mole-rat

Author

Csaba Kerepesi, Margarita V. Meer, Julia Ablaeva, Vince G. Amoroso, Sang-Goo Lee, Bohan Zhang, Maxim V. Gerashchenko, Alexandre Trapp, Sun Hee Yim, Ake T. Lu, Morgan E. Levine, Andrei Seluanov, Steve Horvath, Thomas J. Park, Vera Gorbunova, and Vadim N. Gladyshev

Subjects
Science
Abstract

The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.

Published
2022
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2. Naked Mole-Rats Demonstrate Profound Tolerance to Low Oxygen, High Carbon Dioxide, and Chemical Pain

Author

Vince G. Amoroso, Aishi Zhao, Isabel Vargas, and Thomas J. Park

Subjects
naked mole-rat, hypoxia, anoxia, pain, NaV1.7, HIF-1a, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

Naked mole-rats (Heterocephalus glaber) are very unusual among subterranean mammals in that they live in large colonies and are extremely social, spending large amounts of time gathered together in underground nests more than a meter below the surface. Many respiring individuals resting in deep, poorly ventilated nests deplete the oxygen supply and increase the concentration of carbon dioxide. Consistent with living in that atmosphere, naked mole-rats tolerate levels of low oxygen and high carbon dioxide that are deadly to most surface-dwelling mammals. Naked mole-rats appear to have evolved a number of remarkable adaptations to be able to thrive in this harsh atmosphere. In order to successfully survive low oxygen atmospheres, they conserve energy utilization by reducing the physiological activity of all organs, manifest by reduced heart rate and brain activity. Amazingly, they resort to the anaerobic metabolism of fructose rather than glucose as a fuel to generate energy when challenged by anoxia. Similarly, high carbon dioxide atmospheres normally cause tissue acidosis, while naked mole-rats have a genetic mutation preventing both acid-induced pain and pulmonary edema. Together, these putative adaptations and the tolerances they provide make the naked mole-rat an important model for studying a host of biomedical challenges.

Published
2023
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3. PPARα and PPARγ Signaling Is Enhanced in the Brain of the Naked Mole-Rat, a Mammal that Shows Intrinsic Neuroprotection from Oxygen Deprivation

Author

Wenping Li, Thomas J. Park, Stephanie M. Cologna, Vince G. Amoroso, Melissa R Pergande, Emily N. Vice, and Thu T A Nguyen

Subjects
chemistry.chemical_classification, Proteomics, Reactive oxygen species, Mole Rats, Peroxisome proliferator-activated receptor, Brain, General Chemistry, Peroxisome, Biochemistry, Neuroprotection, Cell biology, Lipid peroxidation, Oxygen, PPAR gamma, chemistry.chemical_compound, Mice, chemistry, Docosahexaenoic acid, Animals, Arachidonic acid, PPAR alpha, Docosapentaenoic acid, Polyunsaturated fatty acid
Abstract

Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases including neurodegeneration and cancer. Additionally, NMRs have a profound ability to consume reactive oxygen species (ROS) and survive long periods of oxygen deprivation. Here, we evaluated the unique proteome across selected brain regions of NMRs at different ages. Compared to mice, we observed numerous differentially expressed proteins related to altered mitochondrial function in all brain regions, suggesting that the mitochondria in NMRs may have adapted to compensate for energy demands associated with living in a harsh, underground environment. Keeping in mind that ROS can induce polyunsaturated fatty acid peroxidation under periods of neuronal stress, we investigated docosahexaenoic acid (DHA) and arachidonic acid (AA) peroxidation under oxygen-deprived conditions and observed that NMRs undergo DHA and AA peroxidation to a far less extent compared to mice. Further, our proteomic analysis also suggested enhanced peroxisome proliferator-activated receptor (PPAR)-retinoid X receptor (RXR) activation in NMRs via the PPARα-RXR and PPARγ-RXR complexes. Correspondingly, we present several lines of evidence supporting PPAR activation, including increased eicosapetenoic and omega-3 docosapentaenoic acid, as well as an upregulation of fatty acid-binding protein 3 and 4, known transporters of omega-3 fatty acids and PPAR activators. These results suggest enhanced PPARα and PPARγ signaling as a potential, innate neuroprotective mechanism in NMRs.

Published
2021

4. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Author

Ole Eigenbrod, Wiebke Hamann, Richard D. Minshall, Tetiana Kosten, Christin Zasada, Victoria M Gavaghan, Michael Gotthardt, Stefan Kempa, Gary R. Lewin, Bethany L. Peterson, John Larson, Heike Lutermann, Nigel C. Bennett, P. Henning J. L. Kuich, Vince G. Amoroso, Thomas J. Park, Ewan St. John Smith, Daniel T. Applegate, Brigitte M. Browe, Michael H. Radke, Vidya Govind, Jane Reznick, Gregory R.C. Blass, Damir Omerbašić, Valérie Bégay, Smith, Ewan St John [0000-0002-2699-1979], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Sucrose, 02 engineering and technology, Fructose, Biology, Fructokinases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Respiration, medicine, Animals, Glycolysis, Anaerobiosis, Lactic Acid, Naked mole-rat, Multidisciplinary, Glucose Transporter Type 5, Mole Rats, Myocardium, Brain, Hypoxia (medical), 021001 nanoscience & nanotechnology, biology.organism_classification, Adaptation, Physiological, Oxygen, 030104 developmental biology, chemistry, Biochemistry, biology.protein, medicine.symptom, 0210 nano-technology, Anaerobic exercise, GLUT5, Phosphofructokinase
Abstract

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248

Published
2017

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