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465 results on '"Vinberg, M."'

1. Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss

Author

Vinberg M, McIntyre RS, Giraldi A, and Coello K

Subjects
biomarkers, childhood maltreatment, mood disorders, biosignatures, biotype., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Maj Vinberg,1,2 Roger S McIntyre,3,4 Annamaria Giraldi,2,5,* Klara Coello6,* 1Mental Health Centre Northern Zealand, the Early Multimodular Prevention, and Intervention Research Institution (EMPIRI) – Mental Health Services CPH, Copenhagen, Denmark; 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, University Health Network, Toronto, ON, Canada; 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 5Sexological Clinic, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; 6Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg, Denmark*These authors contributed equally to this workCorrespondence: Maj Vinberg, Dyrehavevej 48, Hillerød, 3400, Denmark, Tel +453864 3227, Email maj.vinberg@regionh.dkAbstract: The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.Keywords: biomarkers, childhood maltreatment, mood disorders, biosignatures, biotype

Published
2024

27. Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives

Author

Kjaerstad, HL, Mistarz, N, Coello, K, Stanislaus, S, Melbye, S, Harmer, CJ, Vinberg, M, Miskowiak, K, Kessing, L, and Harmer, C

Subjects
Adult, Male, Elementary cognitive task, Bipolar Disorder, Endophenotypes, emotion, Affective cognition, Neuropsychological Tests, neurocognition regulation, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, medicine, Humans, Genetic Predisposition to Disease, Bipolar disorder, Association (psychology), Applied Psychology, bipolar disorder, Facial expression, business.industry, Siblings, Recognition, Psychology, medicine.disease, endophenotypes, 030227 psychiatry, Facial Expression, Psychiatry and Mental health, Cross-Sectional Studies, Case-Control Studies, Endophenotype, Etiology, Female, business, Neurocognitive, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundPatients with bipolar disorder (BD) experience persistent impairments in both affective and non-affective cognitive function, which is associated with a worse course of illness and poor functional outcomes. Nevertheless, the temporal progression of cognitive dysfunction in BD remains unclear and the identification of objective endophenotypes can inform the aetiology of BD.MethodsThe present study is a cross-sectional investigation of cognitive baseline data from the longitudinal Bipolar Illness Onset-study. One hundred seventy-two remitted patients newly diagnosed with BD, 52 of their unaffected relatives (UR), and 110 healthy controls (HC) were compared on a large battery of behavioural cognitive tasks tapping into non-affective (i.e. neurocognitive) and affective (i.e. emotion processing and regulation) cognition.ResultsRelative to HCs, patients with BD exhibited global neurocognitive deficits (ps < 0.001), as well as aberrant emotion processing and regulation (ps ⩽ 0.011); including decreased emotional reactivity to positive social scenarios, impaired ability to down-regulate positive emotion, as well as a specific deficit in the ability to recognise surprised facial expressions. Their URs also showed a trend towards difficulties identifying surprised faces (p = 0.075). No other differences in cognitive function were found for URs compared to HCs.ConclusionsNeurocognitive deficits and impairments within emotion processing and regulation may be illness-related deficits of BD that present after illness-onset, whereas processing of emotional faces may represent an early risk marker of BD. However, longitudinal studies are needed to examine the association between cognitive impairments and illness progression in BD.

Published
2019

29. Development and implementation of guidelines for the management of depression: a systematic review, développement et mise en œuvre des directives pour la gestion de la dépression: revue systématique, elaboración e implementación de directrices para el tratamiento de la depresión: una revisión sistemática

Author

Lee, Y., Brietzke, E., Cao, B., Chen, Y., Linnaranta, O., Mansur, R.B., Cortes, P., Kosters, M., Majeed, A., Tamura, J.K., Lui, L.M.W., Vinberg, M., Keinanen, J., Kisely, S., Naveed, S., Barbui, C., Parker, G., Owolabi, M., Nishi, D., Lee, J., Srisurapanont, M., Gill, H., Guo, L., Balanza-Martinez, V., Partonen, T., Nolen, W.A., Lee, J.H., Kim, J.H., Chavannes, N.H., Ewais, T., Atienza-Carbonell, B., Silven, A.V., Yasuma, N., Gil, A., Novikov, A., Lacey, C., Versluis, A., Malortie, S. von, Chan, L.F., Waqas, A., Purgato, M., Aardoom, J.J., Ly-Uson, J.T., Sim, K., Tuineag, M., Kleij, R.M.J.J. van der, Luenen, S. van, Suttajit, S., Hajek, T., Lee, Y.W., Porter, R.J., Alsuwaidan, M., Rosenblat, J.D., Ravindran, A.V., Lam, R.W., McIntyre, R.S., and Global Alliance Chronic Dis GACD

Published
2020

33. Mood, activity, and sleep measured via daily smartphone-based self-monitoring in young patients with newly diagnosed bipolar disorder, their unaffected relatives and healthy control individuals

Author

Melbye, S.A., Stanislaus, S., Vinberg, M., Frost, M., Bardram, J. E., Sletved, K., Coello, K, Kjærstad, H. L., Christensen, E. M., Faurholt-Jepsen, M., and Kessing, L. V.

Abstract

Diagnostic evaluations and early interventions of patients with bipolar disorder (BD) rely on clinical evaluations. Smartphones have been proposed to facilitate continuous and fine-grained self-monitoring of symptoms. The present study aimed to (1) validate daily smartphone-based self-monitored mood, activity, and sleep, against validated questionnaires and clinical ratings in young patients with newly diagnosed BD, unaffected relatives (UR), and healthy controls persons (HC).

Published
2020

42. P.654 Central oxidative stress of RNA damage in patients with bipolar disorder and healthy control individuals. A prospective longitudinal case-control study

Author

Knorr, U., primary, Simonsen, A.H., additional, Roos, P., additional, Weimann, A., additional, Henriksen, T., additional, Christensen, E.M., additional, Vinberg, M., additional, Mikkelsen, R.L., additional, Kirkegaard, T., additional, Jensen, R.N., additional, Akhøj, M., additional, Forman, J., additional, Poulsen, H.E., additional, Hasselbalch, S.G., additional, and Kessing, L.V., additional

Published
2019
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