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A Rubéola é uma infeção viral aguda e contagiosa que pode ser prevenida pela vacinação. A infeção pelo vírus da Rubéola em crianças e adultos provoca sintomas como febre ligeira e exantema. No entanto, a infeção durante a gravidez, especialmente durante o primeiro trimestre, pode provocar aborto, morte fetal, nado-morto, ou crianças com malformações congénitas. Em Portugal, a vacina contra a Rubéola foi introduzida no Plano Nacional de Vacinação (PNV) em 1982 e nos últimos 7 anos foram notificados 3 casos de rubéola congénita, dois dos quais importados e um autóctone. Todos os casos resultaram de infeções sintomáticas em mulheres não vacinadas. O Programa Nacional de Avaliação Externa da Qualidade (PNAEQ) implementou em 1994 o programa de serologia para diagnóstico laboratorial da Rubéola e conta com peritos na área. O objetivo deste trabalho é avaliar o desempenho dos laboratórios participantes no PNAEQ na determinação de IgG, IgM e avidez da IgG para rubéola no período 2015 a 2017. N/A

Objetivo: Este estudo tem como objetivo descrever os casos prováveis de sarampo enviados ao INSA para confirmação laboratorial entre 2011 e 2013 em Portugal.

Objetivo: Analisar os resultados do diagnóstico laboratorial de casos suspeitos de rubéola congénita recebidos no Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) entre 2009 e 2015, ao abrigo do Programa de Eliminação do Sarampo, da Rubéola e da Rubéola Congénita na Região Europeia da Organização Mundial da Saúde (OMS).

Objetivo: Analisar os resultados do diagnóstico laboratorial de casos suspeitos de infeção a Enterovirus recebidos no INSA ao abrigo do Programa de Erradicação da Poliomielite (Vigilância Laboratorial da PFA e de Enterovirus) entre 2010 e 2013.

Este estudo tem como objetivo descrever as características demográficas e o quadro clínico e imunitário de doentes com suspeita de infeção viral neurotrópica e analisar a frequência das infeções por CMV nas patologias do SNC, cujo diagnóstico foi confirmado no Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) entre janeiro de 2010 e abril de 2014.

publicado em: ESCV2011-Program Book / European Society of Clinical Virology, p. 73. Disponível em: http://escv.ivdnews.net/public/show_abstract/1126 The incidence of HIV infections in gestational age is an important Public Health issue as are concerns about co-infection with opportunistic viruses, such as CMV/HCV. Several authors refer higher ratios of congenital CMV infection in children born to HIV infected mother than in uninfected. In the case of HCV, perinatal transmission increases in cases of mothers co-infected with HIV. Aims:To study CMV/HCV infection/co-infection in HIV/non-HIV women and their newborns between 2006-2010, according to epidemiological, laboratory and clinical data; to evaluate frequency of CMV/HIV/HCV maternal-fetal transmission and analyse risk factors for infections. Methods:Plasma and/or urine of 137 HIV and 140 non-HIV women, attending a Lisbon Hospital and their 140 newborns were analysed at NIH. HIV-1 and/or HIV-2 proviral DNA nested-PCR was performed on HIV mothers and their newborn’s plasma. Maternal plasma was screened for CMV and HCV antibodies; RNA determination, genotyping and viral load were performed on women with HCV antibodies, their newborn’s plasma was also screened for HCV. Newborn’s urine was inoculated for CMV detection. Data analysis was performed using SPSS 17.0 and Fisher's exact test. Results:HIV1 vertical transmission was diagnosed in 3/140(2.1%) cases. CMV congenital infection was diagnosed in 4(2.9%) newborns from HIV women and no congenital CMV infection was diagnosed in newborns from non-HIV women. 2/137(1.5%) HIV women and 14/140(10.0%) non-HIV women were CMV seronegative. HCV infection was detected in 6(4.4%) HIV women; all had HCV positive viral load; different genotypes were found. One case of HCV perinatal transmission was diagnosed. No HCV antibodies were found in non-HIV women. No children were HIV/HCV or CMV/HCV coinfected but 2 were HIV/CMV coinfected. There is evidence of significant statistical associations with race/ethnicity and time of pregnancy. Conclusion:In this study HIV women had higher CMV/HCV antibody prevalence and frequency of maternal-fetal transmission than non-HIV women. 2/137 HIV seronegative newborns and 2/3 HIV newborns were CMV congenitally infected; this difference should be further studied, as the consequences of CMV/HCV infections may become increasingly serious and complex in the presence of HIV. This specific group is not representative of the Portuguese infected women, nevertheless the significant risk factors found and other risk factors studied without strong associations should be considered in larger studies.