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Your search keyword '"Villatoro, F.R."' showing total 13 results
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13 results on '"Villatoro, F.R."'

4. A Modular Synthetic Device to Calibrate Promoters

Author

Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada, Universitat Politècnica de València. Instituto Universitario de Matemática Pura y Aplicada - Institut Universitari de Matemàtica Pura i Aplicada, Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Generalitat Valenciana, Universitat Rovira i Virgili, Ministerio de Educación y Ciencia, Ministerio de Ciencia e Innovación, Gamermann, Daniel, Montagud Aquino, Arnau, Aparicio, P., Navarro-Peris, Emilio, Triana, J., Villatoro, F.R., Urchueguía Schölzel, Javier Fermín, Fernández de Córdoba, Pedro, Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada, Universitat Politècnica de València. Instituto Universitario de Matemática Pura y Aplicada - Institut Universitari de Matemàtica Pura i Aplicada, Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada, Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada, Generalitat Valenciana, Universitat Rovira i Virgili, Ministerio de Educación y Ciencia, Ministerio de Ciencia e Innovación, Gamermann, Daniel, Montagud Aquino, Arnau, Aparicio, P., Navarro-Peris, Emilio, Triana, J., Villatoro, F.R., Urchueguía Schölzel, Javier Fermín, and Fernández de Córdoba, Pedro

Abstract

[EN] In this contribution, a design of a synthetic calibration genetic circuit to characterize the relative strength of different sensing promoters is proposed and its specifications and performance are analyzed via an effective mathematical model. Our calibrator device possesses certain novel and useful features like modularity (and thus the possibility of being used in many different biological contexts), simplicity, being based on a single cell, high sensitivity and fast response. To uncover the critical model parameters and the corresponding parameter domain at which the calibrator performance will be optimal, a sensitivity analysis of the model parameters was carried out over a given range of sensing protein concentrations (acting as input). Our analysis suggests that the half saturation constants for repression, sensing and difference in binding cooperativity (Hill coefficients) for repression are the key to the performance of the proposed device. They furthermore are determinant for the sensing speed of the device, showing that it is possible to produce detectable differences in the repression protein concentrations and in turn in the corresponding fluorescence in less than two hours. This analysis paves the way for the design, experimental construction and validation of a new family of functional genetic circuits for the purpose of calibrating promoters.

Published
2012

13. FORCES ON SOLITONS IN FINITE, NONLINEAR, PLANAR WAVEGUIDES.

Author

Ramos, J.I. and Villatoro, F.R.

Subjects
*SOLITONS, *NONLINEAR theories, *THEORY of wave motion, *BOUNDARY value problems, *DIFFERENTIAL equations
Abstract

The forces acting on and the energies of solitons governed by the nonlinear Schrödinger equation in finite planar waveguides with periodic and with homogeneous Dirichlet, Neumann, and Robin boundary conditions are determined by means of a quantum analogy. It is shown that these densities have S-shaped profiles and increase as the hardness of the boundary conditions increases. [ABSTRACT FROM AUTHOR]

Published
1994
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