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3. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019

Author

D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele Di, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arisoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A., Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Lopez, Jesús S Jimenez, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T., Gorina, Ksenia A., de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Morales Roselló, José, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tustas, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moros, Daskalakis, George, Antsaklis, Panos, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santos, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, and Zlatohlávková, Blanka

Published
2021
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5. Hormones, Breast Disorders, and Lactation

Author

Biglia, Nicoletta, Bounous, Valentina Elisabetta, D’Alonzo, Marta, Villa, Michela, Villasco, Andrea, Lenzi, Andrea, Series Editor, Jannini, Emmanuele A., Series Editor, Petraglia, Felice, editor, and Fauser, Bart C., editor

Published
2020
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10. Bone modifying agents in postmenopausal breast cancer patients treated with aromatase inhibitors: beyond bone protection?

Author

Villasco, Andrea, Minella, Carola, Bounous, Valentina Elisabetta, Rosso, Roberta, and Biglia, Nicoletta

Subjects
Cancer Research, Oncology, General Medicine
Abstract

Estrogen-receptor positive tumours represent the majority of breast cancers in postmenopausal women. Adjuvant endocrine therapy with aromatase inhibitors (AIs), continued for up to 10 years in high-risk patients, reduces by 40% the risk of recurrence. However, this therapy, among other side effects, is burdened with a higher incidence of osteoporotic bone fractures. To date, both bisphosphonates and denosumab are recognized as first-line drugs in the primary prevention of osteoporotic fractures in patients treated with AIs. They have demonstrated their effectiveness in increasing bone mineral density and in reducing the incidence of fractures, but they have also been shown to improve disease free survival (DFS).

Published
2023
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13. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Author

Eran Hadar, Chiara Benedetto, Agnese Maria Chiara Rapisarda, Renato Augusto Moreira de Sá, Deena Elkafrawi, Daniela Luvero, Noa A Brzezinski Sinai, Alicia Martínez-Varea, Antonio Schiattarella, Anna Nunzia Della Gatta, Giovanni Scambia, Albert Lila, Luciano Di Tizio, Andrea Carosso, Giovanni Nazzaro, G. Schera, Giuseppe Rizzo, Giuseppe Maria Maruotti, Giusella D'Urso, Albaro José Nieto-Calvache, Ilenia Mappa, Ozlem Uyaniklar, Fabio Barra, Gilles Faron, Luigi Nappi, Jacopo Ferrari, Giulio Sozzi, Simone Ferrero, Mirjam Druškovič, Tanja Premru-Srsen, Leonardo Borrello, Fabiana Cecchini D, George Daskalakis, Giuliano Petriglia, Caroline Kadji, Felipe Mercado-Olivares, Zeliha Atak, Aylin Pelin Cil, Claudio Gustavino, Axelle Pintiaux, Pantaleo Greco, Rita Figueiredo, Stefano Cosma, Ludovica Puri, Valentina Esposito, Anupam Parange, Simone Garzon, Alessandra Gatti, Ioannis Kyvernitakis, Roberto Brunelli, Maddalena Morlando, Attilio Di Spiezio Sardo, Ignacio Cueto Hernández, Giuseppe Zoccali, Brian Rodriguez, Antonio Mollo, Flaminia Vena, Cihat Sen, Ciuhodaru Madalina, Felice Sorrentino, Francesca Di Sebastiano, Gennady T. Sukhikh, Ilma Floriana Carbone, Andrea Villasco, Blanka Zlatohlavkova, Gabriele Saccone, Erasmo Huertas, Marcel Malan, Leonardo Gucciardo, Eutalia Esposito, Otto Henrique May Feuerschuette, Sarah Dollinger, María de Los Angeles Anaya Baz, Jun Yoshimatsu, Sifa Turan, Vincente Diago, Alicia Yeliz Aykanat, Ignacio Herraiz, Javier Alfonso Schvartzman, Diego Gazzolo, Natalina Buono, Milan Stanojević, Erich Cosmi, Valentina De Robertis, Elena Costa, Angelo Cagnacci, Eleonora Valori, Nicoletta Biglia, Şerife Özlem Genç, Vincenzo Berghella, Francesco Maria Colaleo, Esther Vanessa Aguilar Galán, Gabriela Loscalzo, Marco Palumbo, Fabrizio Sandri, Irmeli Nupponen, Antonio Lanzone, Juan Antonio De León Luis, Amos Grunebaum, Giuseppe Bifulco, Marinella Lenzi, Serena Xodo, Fulvio Zullo, Ozhan Turan, Josefine Königbauer, Anna Luengo Piqueras, Nicola Volpe, Holger Maul, Chiara Taccaliti, Juan Manuel Burgos-Luna, Giovanni Sisti, Rosanna Esposito, Alfredo Ercoli, Panos Antsaklis, Dolores Esteban Oliva, Aly Youssef, Pedro Viana Pinto, Alberto Galindo, Asim Kurjak, Erhan Okuyan, Roberto Angioli, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Massimo Franchi, Maria Carmela Di Dedda, Giovanni Gerosolima, Francesco D'Antonio, Caroline Daelemans, Quintino Cesare Ianniciello, Pasquale De Franciscis, Maurizio Guida, Maria Cristina Rovellotti, Liana Ples, Frank A. Chervenak, Nicola Colacurci, Lilijana Kornhauser Cerar, Zulfiya Khodjaeva, Valentina Longo, Francesca Stollagli, Daniele Di Mascio, Mariavittoria Locci, Amadeo Sanchez, Angelo Sirico, Stefania Fieni, Rebeca Garrote Molpeceres, Pierluigi Benedetti Panici, Vito Chiantera, Esra Tustas Haberal, Liviu Cojocaru, Maria Elena Flacco, Antonella Cromi, Roberta Granese, Antonio Simone Laganà, Maria Giulia Lombana Marino, Silvia Visentin, Beatrice Bianchi, Roberta Venturella, Federica Laraud, Amanda Bermejo, Reyhan Gündüz, Marina Moucho, Zita Maria Gambacorti-Passerini, Danila Morano, Pedro Arango, Francesca Della Sala, Gaetana Di Donna, Jesús S Jimenez Lopez, Mariano Catello Di Donna, Giuliana Simonazzi, Snezana Zdjelar, Vedran Stefanovic, Cecilia Villalain, Antonio Coviello, Lars Hellmeyer, Antonella Giancotti, Elisa Bevilacqua, Igor Samardjiski, Riccardo Buscemi, Arianna Ramone, Marco Cerbone, Lorenza Driul, Danilo Buca, Tiziana Frusca, Elisa Done, Marco Liberati, José Morales Roselló, Fabio Ghezzi, Lorenzo Vasciaveo, Bernd Froessler, Alejandro Pittaro, Yolanda Cuñarro López, Andrew Carlin, Sakine Rahimli Ocakouglu, Giorgia Gattei, I. Cataneo, María José Suárez, Giada Ameli, Lamberto Manzoli, Kaisa Nelskylä, Ludovico Muzii, Peter Palm, Olus Api, Elisa Cueto, Martina Leombroni, Ksenia A. Gorina, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Children's Hospital, HUS Children and Adolescents, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Gündüz, Reyhan, Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., De Los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., De Leon Luis J.A., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Della Gatta A.N., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., Gazzolo D., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P.V., Figueiredo R., Rosello J.M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J.S.J., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., De Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N.A.B., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Cerar L.K., Druskovie M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Mollo A., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Panici P.B., Berghella V., Flacco M.E., Manzoli L., Bifulco G., Scambia G., Zullo F., D'Antonio F., Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F, Rodríguez Suárez MJ, Gambacorti-Passerini ZM, Baz MLAA, Aguilar Galán EV, López YC, De León Luis JA, Hernández IC, Herraiz I, Villalain C, Venturella R, Rizzo G, Mappa I, Gerosolima G, Hellmeyer L, Königbauer J, Ameli G, Frusca T, Volpe N, Luca Schera GB, Fieni S, Esposito E, Simonazzi G, Di Donna G, Youssef A, Della Gatta AN, Di Donna MC, Chiantera V, Buono N, Sozzi G, Greco P, Morano D, Bianchi B, Lombana Marino MG, Laraud F, Ramone A, Cagnacci A, Barra F, Gustavino C, Ferrero S, Ghezzi F, Cromi A, Laganà AS, Laurita Longo V, Stollagli F, Sirico A, Lanzone A, Driul L, Cecchini D F, Xodo S, Rodriguez B, Mercado-Olivares F, Elkafrawi D, Sisti G, Esposito R, Coviello A, Cerbone M, Morlando M, Schiattarella A, Colacurci N, De Franciscis P, Cataneo I, Lenzi M, Sandri F, Buscemi R, Gattei G, Sala FD, Valori E, Rovellotti MC, Done E, Faron G, Gucciardo L, Esposito V, Vena F, Giancotti A, Brunelli R, Muzii L, Nappi L, Sorrentino F, Vasciaveo L, Liberati M, Buca D, Leombroni M, Di Sebastiano F, Di Tizio L, Gazzolo D, Franchi M, Ianniciello QC, Garzon S, Petriglia G, Borrello L, Nieto-Calvache AJ, Burgos-Luna JM, Kadji C, Carlin A, Bevilacqua E, Moucho M, Pinto PV, Figueiredo R, Roselló JM, Loscalzo G, Martinez-Varea A, Diago V, Jimenez Lopez JS, Aykanat AY, Cosma S, Carosso A, Benedetto C, Bermejo A, May Feuerschuette OH, Uyaniklar O, Ocakouglu SR, Atak Z, Gündüz R, Haberal ET, Froessler B, Parange A, Palm P, Samardjiski I, Taccaliti C, Okuyan E, Daskalakis G, Moreira de Sa RA, Pittaro A, Gonzalez-Duran ML, Guisan AC, Genç ŞÖ, Zlatohlávková B, Piqueras AL, Oliva DE, Cil AP, Api O, Antsaklis P, Ples L, Kyvernitakis I, Maul H, Malan M, Lila A, Granese R, Ercoli A, Zoccali G, Villasco A, Biglia N, Madalina C, Costa E, Daelemans C, Pintiaux A, Cueto E, Hadar E, Dollinger S, Brzezinski Sinai NA, Huertas E, Arango P, Sanchez A, Schvartzman JA, Cojocaru L, Turan S, Turan O, Di Dedda MC, Molpeceres RG, Zdjelar S, Premru-Srsen T, Cerar LK, Druškovič M, De Robertis V, Stefanovic V, Nupponen I, Nelskylä K, Khodjaeva Z, Gorina KA, Sukhikh GT, Maruotti GM, Visentin S, Cosmi E, Ferrari J, Gatti A, Luvero D, Angioli R, Puri L, Palumbo M, D'Urso G, Colaleo F, Chiara Rapisarda AM, Carbone IF, Mollo A, Nazzaro G, Locci M, Guida M, Di Spiezio Sardo A, Panici PB, Berghella V, Flacco ME, Manzoli L, Bifulco G, Scambia G, Zullo F, D'Antonio F, Di Mascio, D., Sen, C., Saccone, G., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., De Los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., De Leon Luis, J. A., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Della Gatta, A. N., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Fabiana Cecchini, D., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Della Sala, F., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Vasciaveo, L., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Di Tizio, L., Gazzolo, D., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Pinto, P. V., Figueiredo, R., Rosello, J. M., Loscalzo, G., Martinez-Varea, A., Diago, V., Lopez, J. S. J., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., De Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Sinai, N. A. B., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Cerar, L. K., Druskovie, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Mollo, A., Nazzaro, G., Locci, M., Guida, M., Di Spiezio Sardo, A., Panici, P. B., Berghella, V., Flacco, M. E., Manzoli, L., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., Di Mascio, Daniele, Sen, Cihat, Saccone, Gabriele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Rodríguez Suárez, María José, Gambacorti-Passerini, Zita Maria, Baz, María de Los Angeles Anaya, Aguilar Galán, Esther Vanessa, López, Yolanda Cuñarro, De León Luis, Juan Antonio, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Luca Schera, Giovanni Battista, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Della Gatta, Anna Nunzia, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Lombana Marino, Maria Giulia, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini D, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado-Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Vasciaveo, Lorenzo, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Di Tizio, Luciano, Gazzolo, Diego, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto-Calvache, Albaro Josè, Burgos-Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Pinto, Pedro Viana, Figueiredo, Rita, Roselló, José Morale, Loscalzo, Gabriela, Martinez-Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, May Feuerschuette, Otto Henrique, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, Moreira de Sa, Renato Augusto, Pittaro, Alejandro, Gonzalez-Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Yapar Eyi, Elif Gül, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski Sinai, Noa A, Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru-Srsen, Tanja, Cerar, Lilijana Kornhauser, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A, Sukhikh, Gennady T, Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Chiara Rapisarda, Agnese Maria, Carbone, Ilma Floriana, Mollo, Antonio, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Di Spiezio Sardo, Attilio, Panici, Pierluigi Benedetti, Berghella, Vincenzo, Flacco, Maria Elena, Manzoli, Lamberto, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, and D'Antonio, Francesco

Subjects
COVID-19 Vaccine, Infectious Disease Transmission, Perinatal Death, Abortion, Clinical Laboratory Technique, Miscarriage, Cohort Studies, 0302 clinical medicine, COVID-19 Testing, Pregnancy, Risk Factors, 3123 Gynaecology and paediatrics, Secondary analysis, Perinatal medicine, Abortion, Spontaneou, Medicine, Vertical, 030212 general & internal medicine, Viral, Pregnancy Complications, Infectious, coronavirus, perinatal morbidity, perinatal mortality, covid-19, Coronavirus, Abortion, Spontaneous, COVID-19, COVID-19 Vaccines, Clinical Laboratory Techniques, Coronavirus Infections, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infectious Disease Transmission, Vertical, Pandemics, Pneumonia, Viral, Pregnancy Outcome, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Betacoronavirus, Fetal Death, 030219 obstetrics & reproductive medicine, Obstetrics, Infectious, Gestational age, Obstetrics and Gynecology, 3. Good health, Settore MED/40, Gestation, Human, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Coronaviru, Socio-culturale, Intrauterine device, 03 medical and health sciences, PARVOVIRUS B19 INFECTION, Coronavirus, perinatal morbidity, perinatal mortality, Adverse effect, Premature, Fetus, Betacoronaviru, Pandemic, Coronavirus Infection, business.industry, Risk Factor, Spontaneous, MORTALITY, Infant, Odds ratio, Pneumonia, medicine.disease, Newborn, Pregnancy Complications, Pediatrics, Perinatology and Child Health, Pregnancy Complications, Infectiou, Cohort Studie, business
Abstract

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6±9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8–0.9 per week increase; p Conclusions Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible.

Published
2021

14. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Author

Di Mascio Daniele, Gabriele, Saccone, Cihat, Sen, Daniele Di Mascio, Alberto, Galindo, Amos, Grünebaum, Jun, Yoshimatsu, Milan, Stanojevic, Asım, Kurjak, Frank, Chervenak, María José Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de Los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio, Herraiz, Cecilia, Villalain, Roberta, Venturella, Rizzo, GIUSEPPE DAVIDE, Ilenia, Mappa, Giovanni, Gerosolima, Lars, Hellmeyer, Josefine, Königbauer, Giada, Ameli, Tiziana, Frusca, Nicola, Volpe, Giovanni Battista Luca Schera, Stefania, Fieni, Eutalia, Esposito, Giuliana, Simonazzi, Gaetana Di Donna, Aly, Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito, Chiantera, Natalina, Buono, Giulio, Sozzi, Pantaleo, Greco, Danila, Morano, Beatrice, Bianchi, Maria Giulia Lombana Marino, Federica, Laraud, Arianna, Ramone, Angelo, Cagnacci, Fabio, Barra, Claudio, Gustavino, Ferrero, Simone, Fabio, Ghezzi, Antonella, Cromi, Antonio Simone Laganà, Valentina Laurita Longo, Francesca, Stollagli, Angelo, Sirico, Antonio, Lanzone, Lorenza, Driul, Fabiana, Cecchini, Serena, Xodo, Brian, Rodriguez, Felipe, Mercado-Olivares, Deena, Elkafrawi, Giovanni, Sisti, Rosanna, Esposito, Antonio, Coviello, Marco, Cerbone, Maddalena, Morlando, Antonio, Schiattarella, Nicola, Colacurci, Pasquale De Franciscis, Ilaria, Cataneo, Marinella, Lenzi, Fabrizio, Sandri, Riccardo, Buscemi, Giorgia, Gattei, Francesca Della Sala, Eleonora, Valori, Maria Cristina Rovellotti, Elisa, Done, Gilles, Faron, Leonardo, Gucciardo, Esposito, Valentina, Flaminia, Vena, Antonella, Giancotti, Roberto, Brunelli, Ludovico, Muzii, Luigi, Nappi, Felice, Sorrentino, Marco, Liberati, Danilo, Buca, Martina, Leombroni, Francesca Di Sebastiano, Massimo, Franchi, Quintino Cesare Ianniciello, Simone, Garzon, Giuliano, Petriglia, Leonardo, Borrello, Albaro Josè Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline, Kadji, Andrew, Carlin, Elisa, Bevilacqua, Marina, Moucho, Pedro, Viana, Rita, Figueiredo, José Morales Roselló, Gabriela, Loscalzo, Alicia, Martinez-Varea, Vincente, Diago, Jesús, S Jimenez Lopez, Alicia Yeliz Aykanat, Cosma, Stefano Domenico, Carosso, ANDREA ROBERTO, Benedetto, Chiara, Amanda, Bermejo, Otto Henrique May Feuerschuette, Ozlem, Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha, Atak, Reyhan, Gündüz, Esra Tustas Haberal, Bernd, Froessler, Anupam, Parange, Peter, Palm, Igor, Samardjiski, Chiara, Taccaliti, Erhan, Okuyan, George, Daskalakis, Renato Augusto Moreira de Sa, Alejandro, Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Şerife Özlem Genç, Blanka, Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus, Api, Panos, Antsaklis, Liana, Ples, Ioannis, Kyvernitakis, Holger, Maul, Marcel, Malan, Albert, Lila, Roberta, Granese, Alfredo, Ercoli, Giuseppe, Zoccali, Villasco, Andrea, Biglia, Nicoletta, Ciuhodaru, Madalina, Costa, Elena, Caroline, Daelemans, Axelle, Pintiaux, Elif Gül Yapar Eyi, Elisa, Cueto, Eran, Hadar, Sarah, Dollinger, Noa, A Brzezinski-Sinai, Erasmo, Huertas, Pedro, Arango, Amadeo, Sanchez, Javier Alfonso Schvartzman, Liviu, Cojocaru, Sifa, Turan, Ozhan, Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana, Zdjelar, Tanja, Premru-Srsen, Lilijana, Kornhauser-Cerar, Mirjam, Druškovič, Valentina De Robertis, Vedran, Stefanovic, Irmeli, Nupponen, Kaisa, Nelskylä, Zulfiya, Khodjaeva, Ksenia, A Gorina, Gennady, T Sukhikh, Giuseppe Maria Maruotti, Silvia, Visentin, Erich, Cosmi, Jacopo, Ferrari, Alessandra, Gatti, Daniela, Luvero, Roberto, Angioli, Ludovica, Puri, Marco, Palumbo, Giusella, D'Urso, Francesco, Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Manzoli, Lamberto, Maria Elena Flacco, Giovanni, Nazzaro, Mariavittoria, Locci, Maurizio, Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Asma, Khalil, Vincenzo, Berghella, Giuseppe, Bifulco, Giovanni, Scambia, Fulvio, Zullo, Francesco, D'Antonio, Saccone, Gabriele, Sen, Cihat, Di Mascio, Daniele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Suárez, María José Rodríguez, Gambacorti‐Passerini, Zita Maria, de los Angeles Anaya Baz, María, Galán, Esther Vanessa Aguilar, López, Yolanda Cuñarro, Luis, Juan Antonio De León, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Schera, Giovanni Battista Luca, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Gatta, Anna Nunzia Della, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado‐Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto‐Calvache, Albaro Josè, Burgos‐Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Viana Pinto, Pedro, Figueiredo, Rita, Morales Roselló, José, Loscalzo, Gabriela, Martinez‐Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, Feuerschuette, Otto Henrique May, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Gündüz, Reyhan, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, de Sa, Renato Augusto Moreira, Pittaro, Alejandro, Gonzalez‐Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Eyi, Elif Gül Yapar, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski‐Sinai, Noa A., Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru‐Srsen, Tanja, Kornhauser‐Cerar, Lilijana, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A., Sukhikh, Gennady T., Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Rapisarda, Agnese Maria Chiara, Carbone, Ilma Floriana, Manzoli, Lamberto, Flacco, Maria Elena, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Sardo, Attilio Di Spiezio, Panici, Pierluigi Benedetti, Khalil, Asma, Berghella, Vincenzo, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, D'Antonio, Francesco, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve DoğumAna Bilim Dalı, University of Helsinki, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Children and Adolescents, Children's Hospital, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Saccone, G., Sen, C., Di Mascio, D., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., de los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., Luis, J. A. D. L., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Gatta, A. N. D., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Cecchini, F., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Sala, F. D., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Viana Pinto, P., Figueiredo, R., Morales Rosello, J., Loscalzo, G., Martinez-Varea, A., Diago, V., Jimenez Lopez, J. S., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., de Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Brzezinski-Sinai, N. A., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Kornhauser-Cerar, L., Druskovic, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Manzoli, L., Flacco, M. E., Nazzaro, G., Locci, M., Guida, M., Sardo, A. D. S., Panici, P. B., Khalil, A., Berghella, V., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., José Rodríguez Suárez, María, Maria Gambacorti-Passerini, Zita, de Los Angeles Anaya Baz, María, Vanessa Aguilar Galán, Esther, Cuñarro López, Yolanda, Antonio De León Luis, Juan, Cueto Hernández, Ignacio, Battista Luca Schera, Giovanni, Nunzia Della Gatta, Anna, Catello Di Donna, Mariano, Giulia Lombana Marino, Maria, Simone Laganà, Antonio, Laurita Longo, Valentina, Mercado-Olivares, Felipe, Della Sala, Francesca, Cristina Rovellotti, Maria, Cesare Ianniciello, Quintino, Josè Nieto-Calvache, Albaro, Manuel Burgos-Luna, Juan, Viana, Pedro, Martinez-Varea, Alicia, S Jimenez Lopez, Jesú, Yeliz Aykanat, Alicia, DI BENEDETTO, Chiara, Henrique May Feuerschuette, Otto, Rahimli Ocakouglu, Sakine, Tustas Haberal, Esra, Augusto Moreira de Sa, Renato, Luisa Gonzalez-Duran, Maria, Concheiro Guisan, Ana, Özlem Genç, Şerife, Luengo Piqueras, Anna, Esteban Oliva, Dolore, Pelin Cil, Aylin, Gül Yapar Eyi, Elif, A Brzezinski-Sinai, Noa, Alfonso Schvartzman, Javier, Carmela Di Dedda, Maria, Garrote Molpeceres, Rebeca, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, A Gorina, Ksenia, T Sukhikh, Gennady, Maruotti, GIUSEPPE MARIA, Maria Chiara Rapisarda, Agnese, Floriana Carbone, Ilma, Elena Flacco, Maria, DI SPIEZIO SARDO, Attilio, Benedetti Panici, Pierluigi, Saccone G., Sen C., Di Mascio D., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., de los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., Luis J.A.D.L., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A.N.D., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Cecchini F., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Sala F.D., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Viana Pinto P., Figueiredo R., Morales Rosello J., Loscalzo G., Martinez-Varea A., Diago V., Jimenez Lopez J.S., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., de Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Brzezinski-Sinai N.A., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Kornhauser-Cerar L., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Manzoli L., Flacco M.E., Nazzaro G., Locci M., Guida M., Sardo A.D.S., Panici P.B., Khalil A., Berghella V., Bifulco G., Scambia G., Zullo F., D'Antonio F., Mother and Child, Surgical clinical sciences, Obstetrics, and Clinical sciences

Subjects
COVID19, medicine.medical_treatment, coronavirus, COVID-19, infection, pregnancy, SARS-CoV-2, Abortion, infectious diseases, law.invention, Cohort Studies, 0302 clinical medicine, law, 3123 Gynaecology and paediatrics, Pregnancy, Obstetrics and Gynaecology, 030212 general & internal medicine, Pregnancy Complications, Infectious, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, Transmission (medicine), Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, Coronavirus, SARS-COV-2, General Medicine, Disease 2019 Covid-19, Intensive care unit, 3. Good health, Hospitalization, Intensive Care Units, Maternal Mortality, Settore MED/40, Radiology Nuclear Medicine and imaging, Gestation, Female, coronavirus, Pandemics, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Respiration, Artificial, Retrospective Studies, SARS-CoV-2, COVID-19, Infant, Newborn, Intensive Care Units,Maternal Mortality, Infection, Cohort study, Adult, medicine.medical_specialty, NO, 03 medical and health sciences, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pandemics, Retrospective Studies, Mechanical ventilation, business.industry, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Respiration, Artificial, coronaviru, Reproductive Medicine, business
Abstract

WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Published
2021

15. Erratum: Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): A secondary analysis of the WAPM study on COVID-19 (Journal of Perinatal Medicine (2020) 48:9 (950-958) DOI: 10.1515/jpm-2020-0355)

Author

Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Vena F., Giancotti A., Brunelli R., Muzii L., Panici P. B., Mollo A., Berghella V., Flacco M. E., Manzoli L., Esposito R., Coviello A., Cerbone M., Maruotti G. M., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Bifulco G., Zullo F., Herraiz I., Villalain C., Suarez M. J. R., Gambacorti-Passerini Z. M., De Los Angeles Anaya Baz M., Galan E. V. A., Carbone I. F., Lopez Y. C., De Leon Luis J. A., Hernandez I. C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Frusca T., Volpe N., Schera G. B. L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A. N. D., Di Donna M. C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M. G. L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A. S., Longo V. L., Stollagli F., Puri L., Sirico A., Scambia G., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Valori E., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Rovellotti M. C., Done E., Faron G., Gucciardo L., Luigi N., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., D'Antonio F., Gazzolo D., Franchi M., Ianniciello Q. C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A. J., Burgos-Luna J. M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P. V., Figueiredo R., Rosello J. M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J. S. J., Aykanat A. Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O. H. M., Uyaniklar O., Ocakouglu S. R., Atak Z., Gunduz R., Haberal E. T., Froessler B., Parange A., Palm P., Samardjiski I., Okuyan E., Daskalakis G., Antsaklis P., De Sa R. A. M., Pittaro A., Gonzalez-Duran M. L., Guisan A. C., Genc S. O., Zlatohlavkova B., Piqueras A. L., Oliva D. E., Cil A. P., Api O., Ples L., Kyvernitakis I., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N. A. B., Huertas E., Arango P., Sanchez A., Schvartzman J. A., Cojocaru L., Turan S., Turan O., Di Dedda M. C., Molpeceres R. G., Zdjelar S., Premru-Srsen T., Cerar L. K., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K. A., Sukhikh G. T., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Palumbo M., D'Urso G., Colaleo F., Rapisarda A. M. C., Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Vena F., Giancotti A., Brunelli R., Muzii L., Panici P.B., Mollo A., Berghella V., Flacco M.E., Manzoli L., Esposito R., Coviello A., Cerbone M., Maruotti G.M., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Bifulco G., Zullo F., Herraiz I., Villalain C., Suarez M.J.R., Gambacorti-Passerini Z.M., De Los Angeles Anaya Baz M., Galan E.V.A., Carbone I.F., Lopez Y.C., De Leon Luis J.A., Hernandez I.C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A.N.D., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Puri L., Sirico A., Scambia G., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Valori E., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Rovellotti M.C., Done E., Faron G., Gucciardo L., Luigi N., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., D'Antonio F., Gazzolo D., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P.V., Figueiredo R., Rosello J.M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J.S.J., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Okuyan E., Daskalakis G., Antsaklis P., De Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Ples L., Kyvernitakis I., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N.A.B., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Cerar L.K., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Di Mascio, D., Sen, C., Saccone, G., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Panici, P. B., Mollo, A., Berghella, V., Flacco, M. E., Manzoli, L., Esposito, R., Coviello, A., Cerbone, M., Maruotti, G. M., Nazzaro, G., Locci, M., Guida, M., Di Spiezio Sardo, A., Bifulco, G., Zullo, F., Herraiz, I., Villalain, C., Suarez, M. J. R., Gambacorti-Passerini, Z. M., De Los Angeles Anaya Baz, M., Galan, E. V. A., Carbone, I. F., Lopez, Y. C., De Leon Luis, J. A., Hernandez, I. C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Gatta, A. N. D., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Puri, L., Sirico, A., Scambia, G., Lanzone, A., Driul, L., Fabiana Cecchini, D., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Valori, E., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Della Sala, F., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Luigi, N., Sorrentino, F., Vasciaveo, L., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Di Tizio, L., D'Antonio, F., Gazzolo, D., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Pinto, P. V., Figueiredo, R., Rosello, J. M., Loscalzo, G., Martinez-Varea, A., Diago, V., Lopez, J. S. J., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Okuyan, E., Daskalakis, G., Antsaklis, P., De Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Ples, L., Kyvernitakis, I., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Sinai, N. A. B., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Cerar, L. K., Druskovic, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Palumbo, M., D'Urso, G., Colaleo, F., and Rapisarda, A. M. C.

Subjects
N.A
Abstract

Due to a technical error, the author list at the end of this article is unfortunately incorrect. Elif Gül Yapar Eyi is not a co-author, and therefore, his name and affiliation should not appear in the list. The correct author list and affiliations read as follows: Daniele Di Mascio, Cihat Sen, Gabriele Saccone, Alberto Galindo, Amos Grünebaum, Jun Yoshimatsu, Milan Stanojevic, AsimKurjak, Frank Chervenak, María Jos´e Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio Herraiz, Cecilia Villalain, Roberta Venturella, Giuseppe Rizzo, Ilenia Mappa, Giovanni Gerosolima, Lars Hellmeyer, Josefine Königbauer, Giada Ameli, Tiziana Frusca, Nicola Volpe, Giovanni Battista Luca Schera, Stefania Fieni, Eutalia Esposito, Giuliana Simonazzi, Gaetana Di Donna, Aly Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito Chiantera, Natalina Buono, Giulio Sozzi, Pantaleo Greco, Danila Morano, Beatrice Bianchi, Maria Giulia Lombana Marino, Federica Laraud, Arianna Ramone, Angelo Cagnacci, Fabio Barra, Claudio Gustavino, Simone Ferrero, Fabio Ghezzi, Antonella Cromi, Antonio Simone Laganá, Valentina Laurita Longo, Francesca Stollagli, Angelo Sirico, Antonio Lanzone, Lorenza Driul, Fabiana Cecchini D, Serena Xodo, Brian Rodriguez, Felipe Mercado-Olivares, Deena Elkafrawi, Giovanni Sisti, Rosanna Esposito, Antonio Coviello, Marco Cerbone, Maddalena Morlando, Antonio Schiattarella, Nicola Colacurci, Pasquale De Franciscis, Ilaria Cataneo, Marinella Lenzi, Fabrizio Sandri, Riccardo Buscemi, Giorgia Gattei, Francesca della Sala, Eleonora Valori, Maria Cristina Rovellotti, Elisa Done, Gilles Faron, Leonardo Gucciardo, Valentina Esposito, Flaminia Vena, Antonella Giancotti, Roberto Brunelli, Ludovico Muzii, Luigi Nappi, Felice Sorrentino, Lorenzo Vasciaveo, Marco Liberati, Danilo Buca, Martina Leombroni, Francesca Di Sebastiano, Luciano Di Tizio, Diego Gazzolo, Massimo Franchi, Quintino Cesare Ianniciello, Simone Garzon, Giuliano Petriglia, Leonardo Borrello, Albaro Jos´e Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline Kadji, Andrew Carlin, Elisa Bevilacqua, Marina Moucho, Pedro Viana Pinto, Rita Figueiredo, Jos´e Morales Roselló, Gabriela Loscalzo, Alicia Martinez-Varea, Vincente Diago, Jesús S Jimenez Lopez, Alicia Yeliz Aykanat, Stefano Cosma, Andrea Carosso, Chiara Benedetto, Amanda Bermejo, Otto Henrique May Feuerschuette, Ozlem Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha Atak, Reyhan Gündüz, Esra Tustas Haberal, Bernd Froessler, Anupam Parange, Peter Palm, Igor Samardjiski, Chiara Taccaliti, Erhan Okuyan, George Daskalakis, Renato Augusto Moreira de Sa, Alejandro Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Serife Özlem Genç, Blanka Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus Api, Panos Antsaklis, Liana Ples, Ioannis Kyvernitakis, Holger Maul, Marcel Malan, Albert Lila, Roberta Granese, Alfredo Ercoli, Giuseppe Zoccali, Andrea Villasco, Nicoletta Biglia, Ciuhodaru Madalina, Elena Costa, Caroline Daelemans, Axelle Pintiaux, Elisa Cueto, Eran Hadar, Sarah Dollinger, Noa A. Brzezinski Sinai, Erasmo Huertas, Pedro Arango, Amadeo Sanchez, Javier Alfonso Schvartzman, Liviu Cojocaru, Sifa Turan, Ozhan Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana Zdjelar, Tanja Premru-Srsen, Lilijana Kornhauser Cerar, Mirjam Druškovic, Valentina De Robertis, Vedran Stefanovic, Irmeli Nupponen, Kaisa Nelskylä, Zulfiya Khodjaeva, Ksenia A. Gorina, Gennady T. Sukhikh, Giuseppe Maria Maruotti, Silvia Visentin, Erich Cosmi, Jacopo Ferrari, Alessandra Gatti, Daniela Luvero, Roberto Angioli, Ludovica Puri, Marco Palumbo, Giusella D’Urso, Francesco Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Antonio Mollo, Giovanni Nazzaro, Mariavittoria Locci, Maurizio Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Vincenzo Berghella, Maria Elena Flacco, Lamberto Manzoli, Giuseppe Bifulco, Giovanni Scambia, Fulvio Zullo and Francesco D’Antonio Flaminia Vena, Antonella Giancotti, Roberto Brunelli, Ludovico Muzii and Pierluigi Benedetti Panici, Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy Rosanna Esposito, Antonio Coviello, Marco Cerbone, Giuseppe Maria Maruotti, Giovanni Nazzaro, Mariavittoria Locci, Maurizio Guida, Attilio Di Spiezio Sardo, Giuseppe Bifulco and Fulvio Zullo, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy Ignacio Herraiz and Cecilia Villalain, Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, Complutense University of Madrid, Madrid, Spain María Jos´e Rodríguez Suárez, Hospital Universitario Central de Asturias, Asturias, Spain Zita Maria Gambacorti-Passerini, Department of Obstetrics and Gynaecology, Ciudad Real University General Hospital, Ciudad Real, Spain María de los Angeles Anaya Baz and Esther Vanessa Aguilar Galán, Department of Obstetrics and Gynaecology, Ciudad Real University General Hospital, Ciudad Real, Spain; University of Castilla-La Mancha, Ciudad Real, Spain Yolanda Cuñarro López, Juan Antonio De León Luis and Ignacio Cueto Hernández, Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Maternal and Child Health and Development Network, Gregorio Marañón Hospital, Complutense University of Madrid, Madrid, Spain Roberta Venturella, Department of Obstetrics and Gynaecology, School of Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy Giuseppe Rizzo, University of Roma Tor Vergata, Division of Maternal Fetal Medicine, Ospedale Cristo Re Roma, Rome, Italy; Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia Ilenia Mappa, University of Roma Tor Vergata, Division of Maternal Fetal Medicine, Ospedale Cristo Re Roma, Rome, Italy Giovanni Gerosolima, Department of Obstetrics and Gynaecology, Ospedale AOSG Moscati, Avellino, Italy Lars Hellmeyer, Josefine Königbauer and Giada Ameli, Department of Gynaecology and Obstetrics, Vivantes Klinikum im Friedrichshain, Berlin, Germany Tiziana Frusca, Nicola Volpe, Giovanni Battista Luca Schera and Stefania Fieni, Department of Obstetrics and Gynaecology, University of Parma, Parma, Italy Eutalia Esposito, Department of Obstetrics and Gynaecology, Ospedale di San Leonardo, Castellammare di Stabia, Italy Giuliana Simonazzi, Gaetana Di Donna, Aly Youssef and Anna Nunzia Della Gatta, Department of Obstetrics and Gynaecology, University of Bologna, Sant’Orsola- Malpighi University Hospital, Bologna, Italy Mariano Catello Di Donna, Vito Chiantera, Natalina Buono and Giulio Sozzi, Department of Gynaecologic Oncology, University of Palermo, Palermo, Sicilia, Italy Pantaleo Greco, Danila Morano, Beatrice Bianchi and Maria Giulia Lombana Marino, Department ofMedical Sciences, Section of Obstetrics and Gynaecology, Azienda Ospedaliera-Universitaria Sant’Anna, University of Ferrara, Ferrara, Italy Federica Laraud, Arianna Ramone, Angelo Cagnacci, Fabio Barra, Claudio Gustavino and Simone Ferrero, Academic Unit of Obstetrics and Gynaecology, IRCCS Ospedale Policlinico, San Martino, Genova, Italy Fabio Ghezzi, Antonella Cromi and Antonio Simone Laganà, Department of Obstetrics and Gynaecology, “Filippo Del Ponte” Hospita University of Insubria, Varese, Italy Valentina Laurita Longo, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy; Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy; and Queen Margaret University, Institute for Global Health and Development, Edinburgh, UK Francesca Stollagli and Ludovica Puri, Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy Angelo Sirico and Giovanni Scambia, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy Antonio Lanzone, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy; Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy Lorenza Driul, Fabiana Cecchini D and Serena Xodo, Clinic of Obstetrics and Gynaecology, University of Udine, Udine, Italy Brian Rodriguez, Felipe Mercado-Olivares, Deena Elkafrawi and Giovanni Sisti, Department of Obstetrics and Gynaecology, New York Health and Hospitals/Lincoln Bronx, The Bronx, NY, USA Maddalena Morlando, Antonio Schiattarella, Nicola Colacurci and Pasquale De Franciscis, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy Ilaria Cataneo, Marinella Lenzi and Fabrizio Sandri, Unit of Obstetrics and Gynaecology, Ospedale Maggiore, Bologna, Italy Riccardo Buscemi, Giorgia Gattei, Francesca della Sala and Maria Cristina Rovellotti, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy Eleonora Valori, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy; Hospital Castelli, Verbania, Italy Elisa Done, Gilles Faron and Leonardo Gucciardo, UZ Brussel, Universitair Ziekenhuis, Brussel, Belgium Valentina Esposito, University of Milan, Milan, Italy Luigi Nappi, Felice Sorrentino and Lorenzo Vasciaveo, Department of Obstetrics and Gynaecology, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

Published
2021

17. Surgery after Neoadjuvant Chemotherapy: A Clip-Based Technique to Improve Surgical Outcomes, a Single-Center Experience

Author

Carola Minella, Andrea Villasco, Marta D’Alonzo, Lisa Cellini, Francesca Accomasso, Silvia Actis, and Nicoletta Biglia

Subjects
Cancer Research, Oncology, education, breast cancer, neoadjuvant chemotherapy, conservative surgery, tissue markers, clip, cardiovascular diseases
Abstract

Background: This study aims to describe the surgical management of breast cancer patients after neoadjuvant chemotherapy, with attention to the impact on surgical outcomes of a clip-based marking technique. Methods: Patients who underwent NACT at the Breast Unit of the A. O Ordine Mauriziano of Turin from January 2018 and had a surgical intervention by January 2022 were included. Data on the feasibility of clip insertion, after-treatment visibility, and successful removal during surgery were collected prospectively. Surgical outcomes in terms of breast-conserving surgery and axillary dissection reduction were described. Results: In 51 patients who had surgery after NACT, 55 clips were placed (34 breast and 21 axillary clips). Ultrasound visibility of the clips was optimal (91%) as well as preoperative localization and retrieval within the surgical specimen. Moreover, the use of the clip positively affected surgical outcomes. In our study, clip insertion allowed to avoid mastectomy and axillary dissection in patients with a complete radiological response. Conclusions: In our findings, the use of breast and/or lymph node clips has proved to be a simple and effective method to improve surgical conservative management of breast cancer patients after NACT.

Published
2022

18. Maternal and perinatal outcomes in high vs low risk-pregnancies affected by SARS-COV-2 infection (Phase-2): The WAPM (World Association of Perinatal Medicine) working group on COVID-19

Author

D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele DI, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arısoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A, Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Jimenez Lopez, Jesús S, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T, Gorina, Ksenia A, de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Roselló, José Morales, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tustas, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moros, Daskalakis, George, Antsaklis, Panos, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Alicia Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santos, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, Zlatohlávková, Blanka, D'Antonio, Francesco, Sen, Cihat, Mascio, Daniele DI, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Arısoy, Resul, Ovayolu, Ali, Eroğlu, Hasan, Canales, Manuel Guerra, Ladella, Subhashini, Cojocaru, Liviu, Turan, Ozhan, Turan, Sifa, Hadar, Eran, Brzezinski-Sinai, Noa A, Dollinger, Sarah, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, Druškovič, Mirjam, Ples, Liana, Gündüz, Reyhan, Ağaçayak, Elif, Schvartzman, Javier Alfonso, Malbran, Mercedes Negri, Liberati, Marco, Sebastiano, Francesca Di, Oronzi, Ludovica, Cerra, Chiara, Buca, Danilo, Cagnacci, Angelo, Ramone, Arianna, Barra, Fabio, Carosso, Andrea, Benedetto, Chiara, Cosma, Stefano, Pintiaux, Axelle, Daelemans, Caroline, Costa, Elena, Özel, Ayşegül, Muhçu, Murat, Jimenez Lopez, Jesús S, Alvarado, Clara, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Schera, Giovanni Battista Luca, Volpe, Nicola, Frusca, Tiziana, Samardjiski, Igor, Simeonova, Slagjana, Papestiev, Irena Aleksioska, Hojman, Javier, Turkcuoglu, Ilgin, Cromi, Antonella, Laganà, Antonio Simone, Ghezzi, Fabio, Sirico, Angelo, Familiari, Alessandra, Scambia, Giovanni, Sukhikh, Zulfiya Khodjaeva Gennady T, Gorina, Ksenia A, de Sa, Renato Augusto Moreira, Vaz, Mariana, Feuerschuette, Otto Henrique May, Gatta, Anna Nunzia Della, Youssef, Aly, Donna, Gaetana Di, Martinez-Varea, Alicia, Loscalzo, Gabriela, Roselló, José Morale, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Ayala, Rodrigo, Molpeceres, Rebeca Garrote, Vázquez, Asunción Pino, Sandri, Fabrizio, Cataneo, Ilaria, Lenzi, Marinella, Haberal, Esra Tusta, Huertas, Erasmo, Sanchez, Amadeo, Arango, Pedro, Bermejo, Amanda, Alcantara, María Monica Gonzalez, Göynümer, Gökhan, Okuyan, Erhan, Madalina, Ciuhodaru, Guisan, Ana Concheiro, Schulte, Alejandra Martínez, Esposito, Valentina, De Robertis, Valentina, Zdjelar, Snezana, Lackovic, Milan, Mihajlovic, Sladjana, Jekova, Nelly, Saccone, Gabriele, Aslan, Mehmet Musa, Dedda, Maria Carmela Di, Chalid, Maisuri, Canache, Jose Enrique Moro, Daskalakis, George, Antsaklis, Pano, Vega, Enrique Criado, Cueto, Elisa, Taccaliti, Chiara, Aykanat, Alicia Yeliz, Özlem Genç, Şerife, Froessler, Bernd, Radulova, Petya Angelova, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Meccariello, Gabriella, Rohatgi, Bindu, Schiattarella, Antonio, Morlando, Maddalena, Colacurci, Nicola, Villasco, Andrea, Biglia, Nicoletta, Marques, Ana Luiza Santo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Pittaro, Alejandro, Lila, Albert, and Zlatohlávková, Blanka

Subjects
Asia, COVID19, SARS-CoV-2, Coronaviru, Australia, Infant, Newborn, Pregnancy Outcome, COVID-19, South America, infection, Coronavirus, Europe, Pregnancy, Intensive Care Units, Neonatal, Humans, Female, Pregnancy Complications, Infectious, SARS-COV-2, pregnancy, Original Research, Retrospective Studies
Abstract

It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations.This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data.A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03-2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07-2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41-3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42-4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19-5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15-2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02-1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90-5.11; P.001) were independently associated with adverse maternal outcomes.High-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection were at higher risk of adverse maternal outcomes than low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection.

Published
2021

19. The Role of Trastuzumab in Patients with HER2 Positive Small (pT1mi/a) Breast Cancers, a Multicenter Retrospective Study

Author

Fulvio Borella, Marta D'Alonzo, Andrea Villasco, Silvia Actis, Chiara Benedetto, Valentina Elisabetta Bounous, Corrado De Sanctis, Nicoletta Biglia, and Riccardo Ponzone

Subjects
Oncology, HER2 positive, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Disease, Breast cancer, PT1mic-pT1a, Trastuzumab, Article, Targeted therapy, law.invention, breast cancer, Randomized controlled trial, law, Internal medicine, medicine, skin and connective tissue diseases, neoplasms, RC254-282, business.industry, trastuzumab, pT1mic-pT1a, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Retrospective cohort study, medicine.disease, Immunohistochemistry, business, Adjuvant, medicine.drug
Abstract

Simple Summary Treatment of small HER2+ breast cancers with adjuvant Trastuzumab is still controversial. This study aims to measure the effect of Trastuzumab in early stages of breast cancer (pT1mic/a pN0/1mi) in terms of disease recurrence and to identify which factors most affect the prognosis of small HER2+ tumors. We retrospectively selected and reviewed 100 HER2+ pT1mic-pT1a breast cancer patients with a median follow-up of 86 months. In our study the primary outcome was the disease recurrence rate, which appeared to be significantly lower among patients who received adjuvant Trastuzumab. Among the patients who did not receive adjuvant Trastuzumab, HR− HER2+ tumors showed a risk seven times higher of relapse. The results of our study indicate that adjuvant Trastuzumab reduces the risk of developing a disease recurrence even in small HER2+ tumors. Adjuvant targeted therapy should be considered in patients with HR− HER2+ tumors, the category with the highest risk of recurrence. Abstract The treatment with adjuvant Trastuzumab in patients diagnosed with HER2+ small breast cancers is controversial: limited prospective data from randomized trials is available. This study aims to measure the effect of Trastuzumab in the early stages of breast cancer (pT1mic/a pN0/1mi) in terms of disease recurrence and to identify which are the factors that most affect the prognosis of small HER2+ tumors. One hundred HER2+ pT1mic-pT1a breast cancer patients who were treated in three Turin Breast Units between January 1998 and December 2018 were retrospectively selected and reviewed. Trastuzumab was administered to 23 patients. Clinicopathological features and disease-free survival (DFS) were compared between different subgroups. The primary outcome was the disease recurrence rate. Median follow-up time was 86 months. Compared to pT1a tumors, pT1mic lesions had a higher tumor grade (84% of pT1mic vs. 55% of pT1a; p = 0.003), a higher Ki-67 index (81% vs. 46%; p = 0.007) and were more frequently hormone receptor (HR) negative (69% vs. 36%, p = 0.001). Disease recurrence rate was significantly lower among patients who received adjuvant Trastuzumab (p = 0.02), with this therapy conferring an 85% reduction in the risk of relapse (HR 0.15; p = 0.02). Among the patients who did not receive adjuvant Trastuzumab, the only factor significantly associated with an increased risk of developing a recurrence was the immunohistochemical (IHC) subtype: in fact, HR− HER2+ tumors showed a risk seven times higher of relapsing (HR 7.29; p = 0.003). Adjuvant Trastuzumab appears to reduce the risk of disease recurrence even in small HER2+ tumors. The adjuvant targeted therapy should be considered in patients with HR− HER2+ tumors since they have the highest risk of recurrence, independently from size and grade.

Published
2021

20. Extended endocrine therapy in premenopausal breast cancer patients: Where are we now?

Author

Andrea Villasco and Marta D'Alonzo

Subjects
Oncology, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.drug_class, medicine.medical_treatment, Estrogen receptor, Breast Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, breast cancer, 0302 clinical medicine, Breast cancer, Exemestane, Internal medicine, Internal Medicine, medicine, Humans, Aromatase inhibitor, Aromatase Inhibitors, business.industry, Endometrial cancer, estrogen receptor-positive, extended endocrine therapy, premenopausal patients, medicine.disease, Tamoxifen, Premenopause, chemistry, Chemotherapy, Adjuvant, Estrogen, 030220 oncology & carcinogenesis, Female, Surgery, Neoplasm Recurrence, Local, business, Adjuvant, medicine.drug
Abstract

Approximately 25% of new breast cancers are diagnosed in premenopausal patients, 50%-70% presenting as estrogen receptor-positive (ER+) breast tumors. Five-year adjuvant endocrine therapy (ET) with Tamoxifen is the cornerstone treatment for those patients but the evidence that up to 50% of ER + breast cancer distant recurrences develop after this time has now raised some questions. ATLAS and aTTom trials are the only two studies addressing the extension of Tamoxifen beyond 5 years in premenopausal patients. They showed significant DFS and OS benefits at a cost of increased rates of endometrial cancer and pulmonary embolus. Therefore, the selection of the patients at higher recurrence risk and hence deemed to get the most benefit from an extended endocrine therapy has become a major concern. Many clinical and genomic prognostic tools have shown validity in identifying patients at high late recurrence risk, but only the BCI prognostic score was shown to also be predictive of response to extended endocrine therapy. Nevertheless, all the evidence available on extended endocrine therapy in premenopausal patients was derived from trials in which patients were treated with tamoxifen alone and are hardly applicable to the current clinical scenario. In fact, the results of the SOFT and TEXT trials demonstrated the superiority of the addition of ovarian function suppression (OFS) and its association with the aromatase inhibitor (AI) Exemestane to Tamoxifen alone. However, the introduction in the clinical practice of AI + OFS-based endocrine therapy for the premenopausal patients will very soon lead to an impasse since neither data exist on extended therapy after this treatment schedule nor is there an ongoing trial intended to obtain new evidence.

Published
2020
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21. Conjugate treatment with high concentration normobaric oxygen and hyaluronic acid for vaginal atrophy: a prospective study.

Author

BARBERO, M., VILLASCO, A., VILLA, M., BADELLINO, E., MARELLO, E., and BOTTA, G.

Abstract

OBJECTIVE: Vulvovaginal atrophy is a condition closely related to low circulating estrogen levels, with post-menopause being the main cause. However, patients of childbearing age may also present with these symptoms due to treatments that reduce estrogen production. Local estrogen therapy is the causal treatment of local symptoms, but it is not always accepted and is often abandoned by patients. In recent years, alternative therapies have been proposed: fractional CO2 laser or the conjugate treatment with normobaric oxygen and hyaluronic acid, the latter being the subject of this study. The study aimed to evaluate the effectiveness of conjugate topical treatment with normobaric oxygen and hyaluronic acid. PATIENTS AND METHODS: 50 patients were evaluated and treated with 5 applications of 15 minutes each, every 15 days, with Caressflow ®. All patients presented at least one of the symptoms related to vulvovaginal atrophy: dryness, burning, and dyspareunia. In all cases, vulvoscopy, colposcopy, and cervicovaginal cytology were performed. The patients were interviewed with an analogic scale (VAS) concerning the severity of symptoms before and after the treatment. Colposcopy and PAP-smear were assessed by mean of Vaginal Health Index Score (VHI) at baseline and at the end of the treatment. RESULTS: All patients completed the treatment scheme and presented with a significant improvement in subjective symptoms. The colposcopy and PAP-smear performed 10 days after the end of the last treatment showed a significant improvement in the appearance and elasticity of the vaginal epithelium and the cytological picture, which showed, in the sample taken after treatment, hyaluronic acid vesicles within the cell cytoplasm. CONCLUSIONS: This study corroborates the data presented in the latest published papers on the effectiveness of treatment with normobaric O2 and hyaluronic acid on vaginal atrophy. Efficacy has been confirmed both in terms of subjective symptoms reported by the patients and objective improvement at colposcopy and PAPsmear cytology. [ABSTRACT FROM AUTHOR]

Published
2023

23. Evaluation of the efficacy of Trastuzumab in patients with HER2 positive small (pT1mi/a) breast cancers. A multicenter retrospective study on 100 patients

Author

Chiara Benedetto, Nicoletta Biglia, Marta D'Alonzo, Fulvio Borella, C. De Sanctis, S. Actis, Andrea Villasco, and Riccardo Ponzone

Subjects
Oncology, medicine.medical_specialty, business.industry, Retrospective cohort study, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Trastuzumab, Internal medicine, medicine, Surgery, In patient, business, medicine.drug
Published
2021

24. Validation of CTS5 on a Retrospective Cohort of Real-Life Pre- and Postmenopausal Patients Diagnosed With Estrogen Receptor–Positive Breast Cancers: Is It Prognostic?

Author

Francesca Accomasso, Andrea Villasco, Francesca Agnelli, Piero Sismondi, Nicoletta Biglia, and Marta D'Alonzo

Subjects
Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Population, Estrogen receptor, Breast Neoplasms, CTS5, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Breast cancer follow up, Estrogen receptor positive breast cancer, Extended endocrine therapy, Late distant recurrence, Internal medicine, medicine, Clinical endpoint, Humans, Medical prescription, education, Aged, Neoplasm Staging, Retrospective Studies, education.field_of_study, business.industry, Hazard ratio, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Confidence interval, 030104 developmental biology, Premenopause, Receptors, Estrogen, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, business
Abstract

Background More than 50% of estrogen receptor (ER)-positive breast cancer (BC) distant recurrences (DR) develop after the completion of 5 years of adjuvant endocrine therapy (ET). Its extension is beneficial on disease-free survival and overall survival but increases therapy-related side effects. Selecting patients who could benefit the most from an extended regimen has become an increasing need. Clinical Treatment Score at 5 Years (CTS5) is a prognostic tool using clinicopathologic data to estimate DR risk after 5 years of ET for ER+ BC. We sought to validate the prognostic value of CTS5 in a retrospective cohort of real-life pre- and postmenopausal patients diagnosed with ER+ BC. Patients and Methods CTS5 was calculated for 603 patients diagnosed with ER+ BC at Umberto I Hospital of Turin and DR-free after 5 years of ET. Primary endpoint was late DR (LDR) rate. Results Median follow-up was 8 years (range, 6-26 years). The 426 postmenopausal women were categorized by CTS5 as follows: 152 low risk, 139 intermediate risk, and 135 high risk. LDR rates were 3.9%, 7.2%, and 15.6%, respectively. CTS5 results were prognostic for LDR: patients with CTS5-high showed a fourfold risk of developing an LDR compared to patients with CTS5-low (hazard ratio, 4.48; 95% confidence interval, 1.80-11.1). The same analysis was conducted for the 177 premenopausal women: 88 low risk, 40 intermediate risk, and 49 high risk. LDR rate were 5.6%, 7.5%, and 20.4%, respectively, proving CTS5 to be prognostic for premenopausal patients as well (CTS5-high vs. CTS5-low: hazard ratio, 3.40; 95% confidence interval, 1.06-11.0). Conclusion CTS5 was shown to be prognostic of the risk of LDR in our population of real-life pre- and postmenopausal patients. Our results support its use in clinical practice to better tailor the prescription of extended ET.

Published
2021

25. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Author

Saccone, G. Sen, C. Di Mascio, D. Galindo, A. Grünebaum, A. Yoshimatsu, J. Stanojevic, M. Kurjak, A. Chervenak, F. Suárez, M.J.R. Gambacorti-Passerini, Z.M. de los Angeles Anaya Baz, M. Galán, E.V.A. López, Y.C. Luis, J.A.D.L. Hernández, I.C. Herraiz, I. Villalain, C. Venturella, R. Rizzo, G. Mappa, I. Gerosolima, G. Hellmeyer, L. Königbauer, J. Ameli, G. Frusca, T. Volpe, N. Schera, G.B.L. Fieni, S. Esposito, E. Simonazzi, G. Di Donna, G. Youssef, A. Gatta, A.N.D. Di Donna, M.C. Chiantera, V. Buono, N. Sozzi, G. Greco, P. Morano, D. Bianchi, B. Marino, M.G.L. Laraud, F. Ramone, A. Cagnacci, A. Barra, F. Gustavino, C. Ferrero, S. Ghezzi, F. Cromi, A. Laganà, A.S. Longo, V.L. Stollagli, F. Sirico, A. Lanzone, A. Driul, L. Cecchini, F. Xodo, S. Rodriguez, B. Mercado-Olivares, F. Elkafrawi, D. Sisti, G. Esposito, R. Coviello, A. Cerbone, M. Morlando, M. Schiattarella, A. Colacurci, N. De Franciscis, P. Cataneo, I. Lenzi, M. Sandri, F. Buscemi, R. Gattei, G. Sala, F.D. Valori, E. Rovellotti, M.C. Done, E. Faron, G. Gucciardo, L. Esposito, V. Vena, F. Giancotti, A. Brunelli, R. Muzii, L. Nappi, L. Sorrentino, F. Liberati, M. Buca, D. Leombroni, M. Di Sebastiano, F. Franchi, M. Ianniciello, Q.C. Garzon, S. Petriglia, G. Borrello, L. Nieto-Calvache, A.J. Burgos-Luna, J.M. Kadji, C. Carlin, A. Bevilacqua, E. Moucho, M. Viana Pinto, P. Figueiredo, R. Morales Roselló, J. Loscalzo, G. Martinez-Varea, A. Diago, V. Jimenez Lopez, J.S. Aykanat, A.Y. Cosma, S. Carosso, A. Benedetto, C. Bermejo, A. Feuerschuette, O.H.M. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Gündüz, R. Haberal, E.T. Froessler, B. Parange, A. Palm, P. Samardjiski, I. Taccaliti, C. Okuyan, E. Daskalakis, G. de Sa, R.A.M. Pittaro, A. Gonzalez-Duran, M.L. Guisan, A.C. Genç, S.Ö. Zlatohlávková, B. Piqueras, A.L. Oliva, D.E. Cil, A.P. Api, O. Antsaklis, P. Ples, L. Kyvernitakis, I. Maul, H. Malan, M. Lila, A. Granese, R. Ercoli, A. Zoccali, G. Villasco, A. Biglia, N. Madalina, C. Costa, E. Daelemans, C. Pintiaux, A. Cueto, E. Hadar, E. Dollinger, S. Brzezinski-Sinai, N.A. Huertas, E. Arango, P. Sanchez, A. Schvartzman, J.A. Cojocaru, L. Turan, S. Turan, O. Di Dedda, M.C. Molpeceres, R.G. Zdjelar, S. Premru-Srsen, T. Kornhauser-Cerar, L. Druškovic, M. De Robertis, V. Stefanovic, V. Nupponen, I. Nelskylä, K. Khodjaeva, Z. Gorina, K.A. Sukhikh, G.T. Maruotti, G.M. Visentin, S. Cosmi, E. Ferrari, J. Gatti, A. Luvero, D. Angioli, R. Puri, L. Palumbo, M. D'Urso, G. Colaleo, F. Rapisarda, A.M.C. Carbone, I.F. Manzoli, L. Flacco, M.E. Nazzaro, G. Locci, M. Guida, M. Sardo, A.D.S. Panici, P.B. Khalil, A. Berghella, V. Bifulco, G. Scambia, G. Zullo, F. D'Antonio, F. The WAPM (World Association of Perinatal Medicine) Working Group on COVID-19

Abstract

Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology. © 2020 International Society of Ultrasound in Obstetrics and Gynecology

Published
2021

26. Erratum: Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): A secondary analysis of the WAPM study on COVID-19 (Journal of Perinatal Medicine (2020) 48:9 (950-958) DOI: 10.1515/jpm-2020-0355)

Author

Di Mascio, D. Sen, C. Saccone, G. Galindo, A. Grünebaum, A. Yoshimatsu, J. Stanojevic, M. Kurjak, A. Chervenak, F. Vena, F. Giancotti, A. Brunelli, R. Muzii, L. Panici, P.B. Mollo, A. Berghella, V. Flacco, M.E. Manzoli, L. Esposito, R. Coviello, A. Cerbone, M. Maruotti, G.M. Nazzaro, G. Locci, M. Guida, M. Di Spiezio Sardo, A. Bifulco, G. Zullo, F. Herraiz, I. Villalain, C. Suárez, M.J.R. Gambacorti-Passerini, Z.M. De Los Angeles Anaya Baz, M. Galán, E.V.A. Carbone, I.F. López, Y.C. De León Luis, J.A. Hernández, I.C. Venturella, R. Rizzo, G. Mappa, I. Gerosolima, G. Hellmeyer, L. Frusca, T. Volpe, N. Schera, G.B.L. Fieni, S. Esposito, E. Simonazzi, G. Di Donna, G. Youssef, A. Gatta, A.N.D. Di Donna, M.C. Chiantera, V. Buono, N. Sozzi, G. Greco, P. Morano, D. Bianchi, B. Marino, M.G.L. Laraud, F. Ramone, A. Cagnacci, A. Barra, F. Gustavino, C. Ferrero, S. Ghezzi, F. Cromi, A. Laganà, A.S. Longo, V.L. Stollagli, F. Puri, L. Sirico, A. Scambia, G. Lanzone, A. Driul, L. Fabiana Cecchini, D. Xodo, S. Rodriguez, B. Mercado-Olivares, F. Elkafrawi, D. Sisti, G. Morlando, M. Schiattarella, A. Colacurci, N. De Franciscis, P. Valori, E. Cataneo, I. Lenzi, M. Sandri, F. Buscemi, R. Gattei, G. Della Sala, F. Rovellotti, M.C. Done, E. Faron, G. Gucciardo, L. Luigi, N. Sorrentino, F. Vasciaveo, L. Liberati, M. Buca, D. Leombroni, M. Di Sebastiano, F. Di Tizio, L. D'Antonio, F. Gazzolo, D. Franchi, M. Ianniciello, Q.C. Garzon, S. Petriglia, G. Borrello, L. Nieto-Calvache, A.J. Burgos-Luna, J.M. Kadji, C. Carlin, A. Bevilacqua, E. Moucho, M. Pinto, P.V. Figueiredo, R. Roselló, J.M. Loscalzo, G. Martinez-Varea, A. Diago, V. Lopez, J.S.J. Aykanat, A.Y. Cosma, S. Carosso, A. Benedetto, C. Bermejo, A. Feuerschuette, O.H.M. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Gündüz, R. Haberal, E.T. Froessler, B. Parange, A. Palm, P. Samardjiski, I. Okuyan, E. Daskalakis, G. Antsaklis, P. De Sa, R.A.M. Pittaro, A. Gonzalez-Duran, M.L. Guisan, A.C. Genç, S.Ö. Zlatohlávková, B. Piqueras, A.L. Oliva, D.E. Cil, A.P. Api, O. Ples, L. Kyvernitakis, I. Lila, A. Granese, R. Ercoli, A. Zoccali, G. Villasco, A. Biglia, N. Madalina, C. Costa, E. Daelemans, C. Pintiaux, A. Cueto, E. Hadar, E. Dollinger, S. Sinai, N.A.B. Huertas, E. Arango, P. Sanchez, A. Schvartzman, J.A. Cojocaru, L. Turan, S. Turan, O. Di Dedda, M.C. Molpeceres, R.G. Zdjelar, S. Premru-Srsen, T. Cerar, L.K. Druškovic, M. De Robertis, V. Stefanovic, V. Nupponen, I. Nelskylä, K. Khodjaeva, Z. Gorina, K.A. Sukhikh, G.T. Visentin, S. Cosmi, E. Ferrari, J. Gatti, A. Luvero, D. Angioli, R. Palumbo, M. D'Urso, G. Colaleo, F. Rapisarda, A.M.C.

Abstract

Due to a technical error, the author list at the end of this article is unfortunately incorrect. Elif Gül Yapar Eyi is not a co-author, and therefore, his name and affiliation should not appear in the list. The correct author list and affiliations read as follows: Daniele Di Mascio, Cihat Sen, Gabriele Saccone, Alberto Galindo, Amos Grünebaum, Jun Yoshimatsu, Milan Stanojevic, AsimKurjak, Frank Chervenak, María Jos´e Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio Herraiz, Cecilia Villalain, Roberta Venturella, Giuseppe Rizzo, Ilenia Mappa, Giovanni Gerosolima, Lars Hellmeyer, Josefine Königbauer, Giada Ameli, Tiziana Frusca, Nicola Volpe, Giovanni Battista Luca Schera, Stefania Fieni, Eutalia Esposito, Giuliana Simonazzi, Gaetana Di Donna, Aly Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito Chiantera, Natalina Buono, Giulio Sozzi, Pantaleo Greco, Danila Morano, Beatrice Bianchi, Maria Giulia Lombana Marino, Federica Laraud, Arianna Ramone, Angelo Cagnacci, Fabio Barra, Claudio Gustavino, Simone Ferrero, Fabio Ghezzi, Antonella Cromi, Antonio Simone Laganá, Valentina Laurita Longo, Francesca Stollagli, Angelo Sirico, Antonio Lanzone, Lorenza Driul, Fabiana Cecchini D, Serena Xodo, Brian Rodriguez, Felipe Mercado-Olivares, Deena Elkafrawi, Giovanni Sisti, Rosanna Esposito, Antonio Coviello, Marco Cerbone, Maddalena Morlando, Antonio Schiattarella, Nicola Colacurci, Pasquale De Franciscis, Ilaria Cataneo, Marinella Lenzi, Fabrizio Sandri, Riccardo Buscemi, Giorgia Gattei, Francesca della Sala, Eleonora Valori, Maria Cristina Rovellotti, Elisa Done, Gilles Faron, Leonardo Gucciardo, Valentina Esposito, Flaminia Vena, Antonella Giancotti, Roberto Brunelli, Ludovico Muzii, Luigi Nappi, Felice Sorrentino, Lorenzo Vasciaveo, Marco Liberati, Danilo Buca, Martina Leombroni, Francesca Di Sebastiano, Luciano Di Tizio, Diego Gazzolo, Massimo Franchi, Quintino Cesare Ianniciello, Simone Garzon, Giuliano Petriglia, Leonardo Borrello, Albaro Jos´e Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline Kadji, Andrew Carlin, Elisa Bevilacqua, Marina Moucho, Pedro Viana Pinto, Rita Figueiredo, Jos´e Morales Roselló, Gabriela Loscalzo, Alicia Martinez-Varea, Vincente Diago, Jesús S Jimenez Lopez, Alicia Yeliz Aykanat, Stefano Cosma, Andrea Carosso, Chiara Benedetto, Amanda Bermejo, Otto Henrique May Feuerschuette, Ozlem Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha Atak, Reyhan Gündüz, Esra Tustas Haberal, Bernd Froessler, Anupam Parange, Peter Palm, Igor Samardjiski, Chiara Taccaliti, Erhan Okuyan, George Daskalakis, Renato Augusto Moreira de Sa, Alejandro Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Serife Özlem Genç, Blanka Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus Api, Panos Antsaklis, Liana Ples, Ioannis Kyvernitakis, Holger Maul, Marcel Malan, Albert Lila, Roberta Granese, Alfredo Ercoli, Giuseppe Zoccali, Andrea Villasco, Nicoletta Biglia, Ciuhodaru Madalina, Elena Costa, Caroline Daelemans, Axelle Pintiaux, Elisa Cueto, Eran Hadar, Sarah Dollinger, Noa A. Brzezinski Sinai, Erasmo Huertas, Pedro Arango, Amadeo Sanchez, Javier Alfonso Schvartzman, Liviu Cojocaru, Sifa Turan, Ozhan Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana Zdjelar, Tanja Premru-Srsen, Lilijana Kornhauser Cerar, Mirjam Druškovic, Valentina De Robertis, Vedran Stefanovic, Irmeli Nupponen, Kaisa Nelskylä, Zulfiya Khodjaeva, Ksenia A. Gorina, Gennady T. Sukhikh, Giuseppe Maria Maruotti, Silvia Visentin, Erich Cosmi, Jacopo Ferrari, Alessandra Gatti, Daniela Luvero, Roberto Angioli, Ludovica Puri, Marco Palumbo, Giusella D’Urso, Francesco Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Antonio Mollo, Giovanni Nazzaro, Mariavittoria Locci, Maurizio Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Vincenzo Berghella, Maria Elena Flacco, Lamberto Manzoli, Giuseppe Bifulco, Giovanni Scambia, Fulvio Zullo and Francesco D’Antonio Flaminia Vena, Antonella Giancotti, Roberto Brunelli, Ludovico Muzii and Pierluigi Benedetti Panici, Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy Rosanna Esposito, Antonio Coviello, Marco Cerbone, Giuseppe Maria Maruotti, Giovanni Nazzaro, Mariavittoria Locci, Maurizio Guida, Attilio Di Spiezio Sardo, Giuseppe Bifulco and Fulvio Zullo, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy Ignacio Herraiz and Cecilia Villalain, Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, Complutense University of Madrid, Madrid, Spain María Jos´e Rodríguez Suárez, Hospital Universitario Central de Asturias, Asturias, Spain Zita Maria Gambacorti-Passerini, Department of Obstetrics and Gynaecology, Ciudad Real University General Hospital, Ciudad Real, Spain María de los Angeles Anaya Baz and Esther Vanessa Aguilar Galán, Department of Obstetrics and Gynaecology, Ciudad Real University General Hospital, Ciudad Real, Spain; University of Castilla-La Mancha, Ciudad Real, Spain Yolanda Cuñarro López, Juan Antonio De León Luis and Ignacio Cueto Hernández, Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Maternal and Child Health and Development Network, Gregorio Marañón Hospital, Complutense University of Madrid, Madrid, Spain Roberta Venturella, Department of Obstetrics and Gynaecology, School of Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy Giuseppe Rizzo, University of Roma Tor Vergata, Division of Maternal Fetal Medicine, Ospedale Cristo Re Roma, Rome, Italy; Department of Obstetrics and Gynaecology, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia Ilenia Mappa, University of Roma Tor Vergata, Division of Maternal Fetal Medicine, Ospedale Cristo Re Roma, Rome, Italy Giovanni Gerosolima, Department of Obstetrics and Gynaecology, Ospedale AOSG Moscati, Avellino, Italy Lars Hellmeyer, Josefine Königbauer and Giada Ameli, Department of Gynaecology and Obstetrics, Vivantes Klinikum im Friedrichshain, Berlin, Germany Tiziana Frusca, Nicola Volpe, Giovanni Battista Luca Schera and Stefania Fieni, Department of Obstetrics and Gynaecology, University of Parma, Parma, Italy Eutalia Esposito, Department of Obstetrics and Gynaecology, Ospedale di San Leonardo, Castellammare di Stabia, Italy Giuliana Simonazzi, Gaetana Di Donna, Aly Youssef and Anna Nunzia Della Gatta, Department of Obstetrics and Gynaecology, University of Bologna, Sant’Orsola- Malpighi University Hospital, Bologna, Italy Mariano Catello Di Donna, Vito Chiantera, Natalina Buono and Giulio Sozzi, Department of Gynaecologic Oncology, University of Palermo, Palermo, Sicilia, Italy Pantaleo Greco, Danila Morano, Beatrice Bianchi and Maria Giulia Lombana Marino, Department ofMedical Sciences, Section of Obstetrics and Gynaecology, Azienda Ospedaliera-Universitaria Sant’Anna, University of Ferrara, Ferrara, Italy Federica Laraud, Arianna Ramone, Angelo Cagnacci, Fabio Barra, Claudio Gustavino and Simone Ferrero, Academic Unit of Obstetrics and Gynaecology, IRCCS Ospedale Policlinico, San Martino, Genova, Italy Fabio Ghezzi, Antonella Cromi and Antonio Simone Laganà, Department of Obstetrics and Gynaecology, “Filippo Del Ponte” Hospita University of Insubria, Varese, Italy Valentina Laurita Longo, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy; Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy; and Queen Margaret University, Institute for Global Health and Development, Edinburgh, UK Francesca Stollagli and Ludovica Puri, Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy Angelo Sirico and Giovanni Scambia, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy Antonio Lanzone, Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A Gemelli IRCCS – Università Cattolica del Sacro Cuore, Rome, Italy; Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy Lorenza Driul, Fabiana Cecchini D and Serena Xodo, Clinic of Obstetrics and Gynaecology, University of Udine, Udine, Italy Brian Rodriguez, Felipe Mercado-Olivares, Deena Elkafrawi and Giovanni Sisti, Department of Obstetrics and Gynaecology, New York Health and Hospitals/Lincoln Bronx, The Bronx, NY, USA Maddalena Morlando, Antonio Schiattarella, Nicola Colacurci and Pasquale De Franciscis, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy Ilaria Cataneo, Marinella Lenzi and Fabrizio Sandri, Unit of Obstetrics and Gynaecology, Ospedale Maggiore, Bologna, Italy Riccardo Buscemi, Giorgia Gattei, Francesca della Sala and Maria Cristina Rovellotti, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy Eleonora Valori, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy; Hospital Castelli, Verbania, Italy Elisa Done, Gilles Faron and Leonardo Gucciardo, UZ Brussel, Universitair Ziekenhuis, Brussel, Belgium Valentina Esposito, University of Milan, Milan, Italy Luigi Nappi, Felice Sorrentino and Lorenzo Vasciaveo, Department of Obstetrics and Gynaecology, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. © 2021 De Gruyter. All rights reserved.

Published
2021

27. Evaluation of the ability of the Clinical Treatment Score at 5 years (CTS5) compared to other risk stratification methods to predict the response to an extended endocrine therapy in breast cancer patients

Author

Francesca Agnelli, Nicoletta Biglia, Marta D'Alonzo, Francesca Accomasso, Andrea Villasco, and Piero Sismondi

Subjects
Oncology, Adult, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.medical_treatment, Population, Breast Neoplasms, Disease, CTS5, Risk Assessment, Breast cancer, Surgical oncology, Internal medicine, Clinical endpoint, Medicine, Humans, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Stage (cooking), education, Estrogen receptor-positive, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, business.industry, Late distant recurrence, General Medicine, Progesterone Receptor Status, Middle Aged, medicine.disease, Extended endocrine therapy, Tamoxifen, Original Article, Female, Neoplasm Recurrence, Local, business, Adjuvant, Follow-Up Studies
Abstract

Purpose Extension of adjuvant endocrine therapy (ET) reduces the risk of recurrence in women diagnosed with ER-positive breast cancers, but a significant benefit is unlikely to happen to all individual patients. This study is aimed at evaluating the ability of different clinical late distant recurrence (LDR) risk stratification methods and in particular the clinical treatment score at 5 years (CTS5) to predict the response to extended adjuvant ET. Methods 783 patients diagnosed with ER+ BC between 1988 and 2014 at Umberto I Hospital of Turin, of which 180 received an extended adjuvant ET, were retrospectively selected. They were stratified according to pT, pN, disease stage, tumor grade, Ki67 level, progesterone receptor status and CTS5. The primary endpoint was LDR rate. LDR rates according to ET duration were confronted in each subgroup. Result The median duration of extended ET was 7 years (6–10). Median follow-up from diagnosis was 9 years (6–26). Retrospective risk stratification according to tumor size, nodal status, disease stage, tumor grade, Ki67 level, and progesterone receptor status did not appear to be able to predict the response to extended ET. In the CTS5 high-risk subgroup instead, the risk of developing an LDR was significantly lower in the patients who underwent extended ET compared to standard ET (HR 0.37, 95% CI 0.15–0.91), while no significant benefit was demonstrated for low and intermediate-risk patients. Conclusions Risk stratification according to CTS5 appeared to be predictive of the response to extended endocrine therapy in our population of real-life pre and postmenopausal patients.

Published
2021

29. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019

Author

D'Antonio, F. Sen, C. Mascio, D.D. Galindo, A. Villalain, C. Herraiz, I. Arisoy, R. Ovayolu, A. Eroğlu, H. Canales, M.G. Ladella, S. Cojocaru, L. Turan, O. Turan, S. Hadar, E. Brzezinski-Sinai, N.A. Dollinger, S. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Premru-Srsen, T. Kornhauser-Cerar, L. Druškovič, M. Ples, L. Gündüz, R. Ağaçayak, E. Schvartzman, J.A. Malbran, M.N. Liberati, M. Sebastiano, F.D. Oronzi, L. Cerra, C. Buca, D. Cagnacci, A. Ramone, A. Barra, F. Carosso, A. Benedetto, C. Cosma, S. Pintiaux, A. Daelemans, C. Costa, E. Özel, A. Muhçu, M. Lopez, J.S.J. Alvarado, C. Piqueras, A.L. Oliva, D.E. Schera, G.B.L. Volpe, N. Frusca, T. Samardjiski, I. Simeonova, S. Papestiev, I.A. Hojman, J. Turkcuoglu, I. Cromi, A. Laganà, A.S. Ghezzi, F. Sirico, A. Familiari, A. Scambia, G. Sukhikh, Z.K.G.T. Gorina, K.A. de Sa, R.A.M. Vaz, M. Feuerschuette, O.H.M. Gatta, A.N.D. Youssef, A. Donna, G.D. Martinez-Varea, A. Loscalzo, G. Roselló, J.M. Stefanovic, V. Nupponen, I. Nelskylä, K. Ayala, R. Molpeceres, R.G. Vázquez, A.P. Sandri, F. Cataneo, I. Lenzi, M. Haberal, E.T. Huertas, E. Sanchez, A. Arango, P. Bermejo, A. Alcantara, M.M.G. Göynümer, G. Okuyan, E. Madalina, C. Guisan, A.C. Schulte, A.M. Esposito, V. De Robertis, V. Zdjelar, S. Lackovic, M. Mihajlovic, S. Jekova, N. Saccone, G. Aslan, M.M. Dedda, M.C.D. Chalid, M. Canache, J.E.M. Daskalakis, G. Antsaklis, P. Vega, E.C. Cueto, E. Taccaliti, C. Aykanat, Y. Özlem Genç, Ş. Froessler, B. Radulova, P.A. Morano, D. Bianchi, B. Marino, M.G.L. Meccariello, G. Rohatgi, B. Schiattarella, A. Morlando, M. Colacurci, N. Villasco, A. Biglia, N. Marques, A.L.S. Gatti, A. Luvero, D. Angioli, R. Pittaro, A. Lila, A. Zlatohlávková, B. On the behalf of the World Association of Perinatal Medicine working group on coronavirus disease 2019

Abstract

BACKGROUND: It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations. OBJECTIVE: This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection. STUDY DESIGN: This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data. RESULTS: A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03–2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07–2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41–3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42–4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19–5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15–2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02–1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90–5.11; P

Published
2021

30. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Author

Saccone, G. Sen, C. Di Mascio, D. Galindo, A. Grünebaum, A. Yoshimatsu, J. Stanojevic, M. Kurjak, A. Chervenak, F. Suárez, M.J.R. Gambacorti-Passerini, Z.M. de los Angeles Anaya Baz, M. Galán, E.V.A. López, Y.C. Luis, J.A.D.L. Hernández, I.C. Herraiz, I. Villalain, C. Venturella, R. Rizzo, G. Mappa, I. Gerosolima, G. Hellmeyer, L. Königbauer, J. Ameli, G. Frusca, T. Volpe, N. Schera, G.B.L. Fieni, S. Esposito, E. Simonazzi, G. Di Donna, G. Youssef, A. Gatta, A.N.D. Di Donna, M.C. Chiantera, V. Buono, N. Sozzi, G. Greco, P. Morano, D. Bianchi, B. Marino, M.G.L. Laraud, F. Ramone, A. Cagnacci, A. Barra, F. Gustavino, C. Ferrero, S. Ghezzi, F. Cromi, A. Laganà, A.S. Longo, V.L. Stollagli, F. Sirico, A. Lanzone, A. Driul, L. Cecchini, F. Xodo, S. Rodriguez, B. Mercado-Olivares, F. Elkafrawi, D. Sisti, G. Esposito, R. Coviello, A. Cerbone, M. Morlando, M. Schiattarella, A. Colacurci, N. De Franciscis, P. Cataneo, I. Lenzi, M. Sandri, F. Buscemi, R. Gattei, G. Sala, F.D. Valori, E. Rovellotti, M.C. Done, E. Faron, G. Gucciardo, L. Esposito, V. Vena, F. Giancotti, A. Brunelli, R. Muzii, L. Nappi, L. Sorrentino, F. Liberati, M. Buca, D. Leombroni, M. Di Sebastiano, F. Franchi, M. Ianniciello, Q.C. Garzon, S. Petriglia, G. Borrello, L. Nieto-Calvache, A.J. Burgos-Luna, J.M. Kadji, C. Carlin, A. Bevilacqua, E. Moucho, M. Viana Pinto, P. Figueiredo, R. Morales Roselló, J. Loscalzo, G. Martinez-Varea, A. Diago, V. Jimenez Lopez, J.S. Aykanat, A.Y. Cosma, S. Carosso, A. Benedetto, C. Bermejo, A. Feuerschuette, O.H.M. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Gündüz, R. Haberal, E.T. Froessler, B. Parange, A. Palm, P. Samardjiski, I. Taccaliti, C. Okuyan, E. Daskalakis, G. de Sa, R.A.M. Pittaro, A. Gonzalez-Duran, M.L. Guisan, A.C. Genç, S.Ö. Zlatohlávková, B. Piqueras, A.L. Oliva, D.E. Cil, A.P. Api, O. Antsaklis, P. Ples, L. Kyvernitakis, I. Maul, H. Malan, M. Lila, A. Granese, R. Ercoli, A. Zoccali, G. Villasco, A. Biglia, N. Madalina, C. Costa, E. Daelemans, C. Pintiaux, A. Cuet and Saccone, G. Sen, C. Di Mascio, D. Galindo, A. Grünebaum, A. Yoshimatsu, J. Stanojevic, M. Kurjak, A. Chervenak, F. Suárez, M.J.R. Gambacorti-Passerini, Z.M. de los Angeles Anaya Baz, M. Galán, E.V.A. López, Y.C. Luis, J.A.D.L. Hernández, I.C. Herraiz, I. Villalain, C. Venturella, R. Rizzo, G. Mappa, I. Gerosolima, G. Hellmeyer, L. Königbauer, J. Ameli, G. Frusca, T. Volpe, N. Schera, G.B.L. Fieni, S. Esposito, E. Simonazzi, G. Di Donna, G. Youssef, A. Gatta, A.N.D. Di Donna, M.C. Chiantera, V. Buono, N. Sozzi, G. Greco, P. Morano, D. Bianchi, B. Marino, M.G.L. Laraud, F. Ramone, A. Cagnacci, A. Barra, F. Gustavino, C. Ferrero, S. Ghezzi, F. Cromi, A. Laganà, A.S. Longo, V.L. Stollagli, F. Sirico, A. Lanzone, A. Driul, L. Cecchini, F. Xodo, S. Rodriguez, B. Mercado-Olivares, F. Elkafrawi, D. Sisti, G. Esposito, R. Coviello, A. Cerbone, M. Morlando, M. Schiattarella, A. Colacurci, N. De Franciscis, P. Cataneo, I. Lenzi, M. Sandri, F. Buscemi, R. Gattei, G. Sala, F.D. Valori, E. Rovellotti, M.C. Done, E. Faron, G. Gucciardo, L. Esposito, V. Vena, F. Giancotti, A. Brunelli, R. Muzii, L. Nappi, L. Sorrentino, F. Liberati, M. Buca, D. Leombroni, M. Di Sebastiano, F. Franchi, M. Ianniciello, Q.C. Garzon, S. Petriglia, G. Borrello, L. Nieto-Calvache, A.J. Burgos-Luna, J.M. Kadji, C. Carlin, A. Bevilacqua, E. Moucho, M. Viana Pinto, P. Figueiredo, R. Morales Roselló, J. Loscalzo, G. Martinez-Varea, A. Diago, V. Jimenez Lopez, J.S. Aykanat, A.Y. Cosma, S. Carosso, A. Benedetto, C. Bermejo, A. Feuerschuette, O.H.M. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Gündüz, R. Haberal, E.T. Froessler, B. Parange, A. Palm, P. Samardjiski, I. Taccaliti, C. Okuyan, E. Daskalakis, G. de Sa, R.A.M. Pittaro, A. Gonzalez-Duran, M.L. Guisan, A.C. Genç, S.Ö. Zlatohlávková, B. Piqueras, A.L. Oliva, D.E. Cil, A.P. Api, O. Antsaklis, P. Ples, L. Kyvernitakis, I. Maul, H. Malan, M. Lila, A. Granese, R. Ercoli, A. Zoccali, G. Villasco, A. Biglia, N. Madalina, C. Costa, E. Daelemans, C. Pintiaux, A. Cuet

Abstract

Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission se

Published
2021

31. Nipple-Sparing Mastectomy: Reliability of sub-areolar sampling and frozen section in predicting occult nipple involvement in breast cancer patients

Author

Giovanni De Rosa, Valentina Elisabetta Bounous, Paola Campisi, Nicoletta Biglia, Marta D'Alonzo, Paolo Balocco, Silvia Pecchio, and Andrea Villasco

Subjects
Adult, medicine.medical_specialty, Concordance, medicine.medical_treatment, Breast Neoplasms, 030230 surgery, Malignancy, Nipple-areola complex, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, medicine, Frozen Sections, Humans, Intraoperative examination, Margin, Nipple-Sparing Mastectomy, Surgery, Oncology, Mastectomy, Aged, Aged, 80 and over, Frozen section procedure, business.industry, Carcinoma, Ductal, Breast, Margins of Excision, Cancer, Histology, General Medicine, Middle Aged, medicine.disease, Occult, Carcinoma, Lobular, Treatment Outcome, Nipples, 030220 oncology & carcinogenesis, Female, Radiology, Breast Carcinoma In Situ, Neoplasm Grading, business
Abstract

Introduction The oncological safety of nipple-areolar complex (NAC) preservation is a concern in the mastectomies performed for cancer indication. The detection of tumor cells during the intraoperative frozen section examination (IE) of sub-areolar/nipple tissue (SAT) leads to the removal of NAC, but frequently the final histology of the nipple is negative for malignancy. This study aims to evaluate the accuracy of SAT examination in predicting occult NAC involvement in case of Nipple-Sparing Mastectomy (NSM). Methods The study includes 76 NSM. We evaluated the concordance between histopathologic features of frozen and paraffin-embedded SAT sections. Moreover, we examined the "true margin" (TM), defined as the measurement of the distance between the tumor margin and the edge of the SAT. A margin >1 mm was considered negative. Results In 26/76 cases the IE of the SAT was positive. At the final histology, the NAC was negative in 57.7% of cases. The concordance between frozen and paraffin section examination of the SAT was 92.1%. The three false-positives were low-grade DCIS at the IE, and negative or DIN1a on permanent section. A negative TM seems to predict for a negative NAC (6/6). Conclusions The detection of a low-grade DCIS at the IE of the SAT may not be confirmed at the permanent section examination; we recommend caution in removing the NAC in these cases. The evaluation of the TM may improve the accuracy of SAT analysis in predicting occult NAC involvement; in our series, a TM wider than 1 mm correlates with a negative NAC.

Published
2018
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34. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Author

Di Mascio, Daniele, primary, Sen, Cihat, additional, Saccone, Gabriele, additional, Galindo, Alberto, additional, Grünebaum, Amos, additional, Yoshimatsu, Jun, additional, Stanojevic, Milan, additional, Kurjak, Asım, additional, Chervenak, Frank, additional, Rodríguez Suárez, María José, additional, Gambacorti-Passerini, Zita Maria, additional, Baz, María de los Angeles Anaya, additional, Aguilar Galán, Esther Vanessa, additional, López, Yolanda Cuñarro, additional, De León Luis, Juan Antonio, additional, Hernández, Ignacio Cueto, additional, Herraiz, Ignacio, additional, Villalain, Cecilia, additional, Venturella, Roberta, additional, Rizzo, Giuseppe, additional, Mappa, Ilenia, additional, Gerosolima, Giovanni, additional, Hellmeyer, Lars, additional, Königbauer, Josefine, additional, Ameli, Giada, additional, Frusca, Tiziana, additional, Volpe, Nicola, additional, Luca Schera, Giovanni Battista, additional, Fieni, Stefania, additional, Esposito, Eutalia, additional, Simonazzi, Giuliana, additional, Di Donna, Gaetana, additional, Youssef, Aly, additional, Della Gatta, Anna Nunzia, additional, Di Donna, Mariano Catello, additional, Chiantera, Vito, additional, Buono, Natalina, additional, Sozzi, Giulio, additional, Greco, Pantaleo, additional, Morano, Danila, additional, Bianchi, Beatrice, additional, Lombana Marino, Maria Giulia, additional, Laraud, Federica, additional, Ramone, Arianna, additional, Cagnacci, Angelo, additional, Barra, Fabio, additional, Gustavino, Claudio, additional, Ferrero, Simone, additional, Ghezzi, Fabio, additional, Cromi, Antonella, additional, Laganà, Antonio Simone, additional, Laurita Longo, Valentina, additional, Stollagli, Francesca, additional, Sirico, Angelo, additional, Lanzone, Antonio, additional, Driul, Lorenza, additional, Cecchini D, Fabiana, additional, Xodo, Serena, additional, Rodriguez, Brian, additional, Mercado-Olivares, Felipe, additional, Elkafrawi, Deena, additional, Sisti, Giovanni, additional, Esposito, Rosanna, additional, Coviello, Antonio, additional, Cerbone, Marco, additional, Morlando, Maddalena, additional, Schiattarella, Antonio, additional, Colacurci, Nicola, additional, De Franciscis, Pasquale, additional, Cataneo, Ilaria, additional, Lenzi, Marinella, additional, Sandri, Fabrizio, additional, Buscemi, Riccardo, additional, Gattei, Giorgia, additional, Sala, Francesca della, additional, Valori, Eleonora, additional, Rovellotti, Maria Cristina, additional, Done, Elisa, additional, Faron, Gilles, additional, Gucciardo, Leonardo, additional, Esposito, Valentina, additional, Vena, Flaminia, additional, Giancotti, Antonella, additional, Brunelli, Roberto, additional, Muzii, Ludovico, additional, Nappi, Luigi, additional, Sorrentino, Felice, additional, Vasciaveo, Lorenzo, additional, Liberati, Marco, additional, Buca, Danilo, additional, Leombroni, Martina, additional, Di Sebastiano, Francesca, additional, Di Tizio, Luciano, additional, Gazzolo, Diego, additional, Franchi, Massimo, additional, Ianniciello, Quintino Cesare, additional, Garzon, Simone, additional, Petriglia, Giuliano, additional, Borrello, Leonardo, additional, Nieto-Calvache, Albaro Josè, additional, Burgos-Luna, Juan Manuel, additional, Kadji, Caroline, additional, Carlin, Andrew, additional, Bevilacqua, Elisa, additional, Moucho, Marina, additional, Pinto, Pedro Viana, additional, Figueiredo, Rita, additional, Morales Roselló, José, additional, Loscalzo, Gabriela, additional, Martinez-Varea, Alicia, additional, Diago, Vincente, additional, Jimenez Lopez, Jesús S, additional, Aykanat, Alicia Yeliz, additional, Cosma, Stefano, additional, Carosso, Andrea, additional, Benedetto, Chiara, additional, Bermejo, Amanda, additional, May Feuerschuette, Otto Henrique, additional, Uyaniklar, Ozlem, additional, Ocakouglu, Sakine Rahimli, additional, Atak, Zeliha, additional, Gündüz, Reyhan, additional, Haberal, Esra Tustas, additional, Froessler, Bernd, additional, Parange, Anupam, additional, Palm, Peter, additional, Samardjiski, Igor, additional, Taccaliti, Chiara, additional, Okuyan, Erhan, additional, Daskalakis, George, additional, Moreira de Sa, Renato Augusto, additional, Pittaro, Alejandro, additional, Gonzalez-Duran, Maria Luisa, additional, Guisan, Ana Concheiro, additional, Genç, Şerife Özlem, additional, Zlatohlávková, Blanka, additional, Piqueras, Anna Luengo, additional, Oliva, Dolores Esteban, additional, Cil, Aylin Pelin, additional, Api, Olus, additional, Antsaklis, Panos, additional, Ples, Liana, additional, Kyvernitakis, Ioannis, additional, Maul, Holger, additional, Malan, Marcel, additional, Lila, Albert, additional, Granese, Roberta, additional, Ercoli, Alfredo, additional, Zoccali, Giuseppe, additional, Villasco, Andrea, additional, Biglia, Nicoletta, additional, Madalina, Ciuhodaru, additional, Costa, Elena, additional, Daelemans, Caroline, additional, Pintiaux, Axelle, additional, Cueto, Elisa, additional, Hadar, Eran, additional, Dollinger, Sarah, additional, Brzezinski Sinai, Noa A., additional, Huertas, Erasmo, additional, Arango, Pedro, additional, Sanchez, Amadeo, additional, Schvartzman, Javier Alfonso, additional, Cojocaru, Liviu, additional, Turan, Sifa, additional, Turan, Ozhan, additional, Di Dedda, Maria Carmela, additional, Molpeceres, Rebeca Garrote, additional, Zdjelar, Snezana, additional, Premru-Srsen, Tanja, additional, Cerar, Lilijana Kornhauser, additional, Druškovič, Mirjam, additional, De Robertis, Valentina, additional, Stefanovic, Vedran, additional, Nupponen, Irmeli, additional, Nelskylä, Kaisa, additional, Khodjaeva, Zulfiya, additional, Gorina, Ksenia A., additional, Sukhikh, Gennady T., additional, Maruotti, Giuseppe Maria, additional, Visentin, Silvia, additional, Cosmi, Erich, additional, Ferrari, Jacopo, additional, Gatti, Alessandra, additional, Luvero, Daniela, additional, Angioli, Roberto, additional, Puri, Ludovica, additional, Palumbo, Marco, additional, D’Urso, Giusella, additional, Colaleo, Francesco, additional, Chiara Rapisarda, Agnese Maria, additional, Carbone, Ilma Floriana, additional, Mollo, Antonio, additional, Nazzaro, Giovanni, additional, Locci, Mariavittoria, additional, Guida, Maurizio, additional, Di Spiezio Sardo, Attilio, additional, Panici, Pierluigi Benedetti, additional, Berghella, Vincenzo, additional, Flacco, Maria Elena, additional, Manzoli, Lamberto, additional, Bifulco, Giuseppe, additional, Scambia, Giovanni, additional, Zullo, Fulvio, additional, and D’Antonio, Francesco, additional

Published
2020
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36. Hormones, Breast Disorders, and Lactation

Author

Michela Villa, Valentina Elisabetta Bounous, Nicoletta Biglia, Andrea Villasco, and Marta D'Alonzo

Subjects
medicine.anatomical_structure, business.industry, Lactation, medicine, Physiology, Breast Disorder, business, Hormone
Published
2020
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38. Axillary dissection in patients with preoperative positive nodal cytology: Genuine need or overtreatment?

Author

Riccardo Arisio, Nicoletta Biglia, Andrea Villasco, Roberta Rosso, Paola Modaffari, Viola Liberale, Marta D'Alonzo, Luca Fuso, and Corrado De Sanctis

Subjects
Image-Guided Biopsy, medicine.medical_specialty, Axillary lymph nodes, Sentinel lymph node, Breast Neoplasms, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, positive sentinel node, Cytology, Biopsy, Internal Medicine, medicine, invasive breast cancer, Humans, axillary lymph node dissection, sentinel lymph node biopsy, Ultrasonography, Interventional, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Carcinoma, Ductal, Breast, Axillary Lymph Node Dissection, Retrospective cohort study, Middle Aged, medicine.disease, Primary tumor, ultrasound FNA, body regions, Axilla, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Case-Control Studies, Lymphatic Metastasis, Lymph Node Excision, Surgery, Female, Radiology, business
Abstract

Recent studies demonstrated the possibility to avoid axillary dissection (ALND) in selected patients with one or two metastatic nodes. Otherwise, patients with positive nodal ultrasound-guided fine-needle aspiration cytology (US-FNAC) currently undergo ALDN. The aim of this study is to quantify the nodal burden in patients with positive US-FNAC treated with ALND and to evaluate if clinical or pathological characteristics associated with low nodal involvement can be identified. This is a multicentric retrospective study involving 297 patients who underwent ALND because of a positive preoperative US-FNAC. A total of 157 patients showed bulky axillary lymph nodes at diagnosis, and 70% of them had three or more metastatic nodes. One hundred and forty patients had a clinically negative axilla and in 50% of them, 4 or more metastatic nodes were found with axillary dissection. Overall, the median number of metastatic nodes was 5. Favorable pathological characteristics of tumors were found in patients with only one or two metastatic nodes: smaller primary tumor, a lower proportion of grade 3, invasive lobular carcinomas and a higher proportion of low-Ki67 tumors. In the group of patients with clinically negative axilla and potentially meeting ACOSOG Z0011 criteria, 22 (31%) showed less than three metastatic axillary nodes. A preoperative positive axillary FNAC is associated with a metastatic nodal burden significantly higher than in patients with positive sentinel lymph node biopsy (SLNB). Nevertheless, about 30% of patients with cN0 axilla, positive axillary FNAC performed because of suspicious nodes on imaging, T1-2 primary tumor and breast-conserving surgery showed less than three metastatic axillary nodes, thus meeting ACOSOG Z0011 trial's criteria and therefore would be eligible for skipping ALND according to current guidelines.

Published
2020

39. A retrospective analysis on 197 cases of breast cancer local recurrence: Biology, treatment, and prognosis

Author

Francesco Scicchitano, Riccardo Ponzone, Valentina Elisabetta Bounous, Nicoletta Biglia, Andrea Villasco, Lorenzo Novara, and Furio Maggiorotto

Subjects
Oncology, medicine.medical_specialty, Breast Cancer, recurrence, prognosis, biology, treatment, recurrence, treatment, business.industry, biology, MEDLINE, Breast Neoplasms, medicine.disease, Mastectomy, Segmental, Prognosis, Breast cancer, Text mining, Internal medicine, Breast Cancer, Internal Medicine, medicine, Retrospective analysis, Humans, Surgery, Neoplasm Recurrence, Local, business, Retrospective Studies
Published
2019

44. Axillary dissection in patients with preoperative positive nodal cytology: Genuine need or overtreatment?

Author

Liberale, Viola, Rosso, Roberta, Arisio, Riccardo, D'Alonzo, Marta, Villasco, Andrea, Fuso, Luca, De Sanctis, Corrado, Modaffari, Paola, and Biglia, Nicoletta

Subjects
LYMPH node surgery, AXILLA, CYTOLOGY, MEDICAL cooperation, NEEDLE biopsy, RESEARCH, TUMOR markers, ULTRASONIC imaging, RETROSPECTIVE studies, PREOPERATIVE period, DESCRIPTIVE statistics, SENTINEL lymph node biopsy
Abstract

Recent studies demonstrated the possibility to avoid axillary dissection (ALND) in selected patients with one or two metastatic nodes. Otherwise, patients with positive nodal ultrasound‐guided fine‐needle aspiration cytology (US‐FNAC) currently undergo ALDN. The aim of this study is to quantify the nodal burden in patients with positive US‐FNAC treated with ALND and to evaluate if clinical or pathological characteristics associated with low nodal involvement can be identified. This is a multicentric retrospective study involving 297 patients who underwent ALND because of a positive preoperative US‐FNAC. A total of 157 patients showed bulky axillary lymph nodes at diagnosis, and 70% of them had three or more metastatic nodes. One hundred and forty patients had a clinically negative axilla and in 50% of them, 4 or more metastatic nodes were found with axillary dissection. Overall, the median number of metastatic nodes was 5. Favorable pathological characteristics of tumors were found in patients with only one or two metastatic nodes: smaller primary tumor, a lower proportion of grade 3, invasive lobular carcinomas and a higher proportion of low‐Ki67 tumors. In the group of patients with clinically negative axilla and potentially meeting ACOSOG Z0011 criteria, 22 (31%) showed less than three metastatic axillary nodes. A preoperative positive axillary FNAC is associated with a metastatic nodal burden significantly higher than in patients with positive sentinel lymph node biopsy (SLNB). Nevertheless, about 30% of patients with cN0 axilla, positive axillary FNAC performed because of suspicious nodes on imaging, T1‐2 primary tumor and breast‐conserving surgery showed less than three metastatic axillary nodes, thus meeting ACOSOG Z0011 trial's criteria and therefore would be eligible for skipping ALND according to current guidelines. [ABSTRACT FROM AUTHOR]

Published
2020
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45. A retrospective analysis on 197 cases of breast cancer local recurrence: Biology, treatment, and prognosis.

Author

Bounous, Valentina Elisabetta, Novara, Lorenzo, Scicchitano, Francesco, Villasco, Andrea, Maggiorotto, Furio, Ponzone, Riccardo, and Biglia, Nicoletta

Subjects
BREAST cancer prognosis, BREAST tumor treatment, CANCER patients, CANCER relapse, MULTIVARIATE analysis, RISK assessment, RETROSPECTIVE studies, DESCRIPTIVE statistics, ODDS ratio, DISEASE risk factors
Abstract

The article reports on retrospective analysis on 197 cases of breast cancer. Topics include a retrospective study on 197 patients with operable locally breast-conserving surgery (BCS) treated at Mauriziano Hospital and Candiolo Cancer Institute- FPO, IRCCS, Italy; and LR was defined as IBTR (ipsilateral breast tumor recurrence) in patients who underwent BCS as primary surgery and CWR (chest wall recurrence) when mastectomy was performed for the primary tumor.

Published
2020
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