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4. Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project)

Author

Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, Villari, D, Mari A., Campi R., Schiavina R., Amparore D., Antonelli A., Artibani W., Barale M., Bertini R., Borghesi M., Bove P., Brunocilla E., Capitanio U., Da Pozzo L., Daja J., Gontero P., Larcher A., Li Marzi V., Longo N., Mirone V., Montanari E., Pisano F., Porpiglia F., Simeone C., Siracusano S., Tellini R., Trombetta C., Volpe A., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Celia A., Costantini E., Di Maida F., Falsaperla M., Fiori C., Furlan M., Marson F., Montorsi F., Morgia G., Porreca A., Roscigno M., Schips L., Selli C., Simonato A., Terrone C., Vespasiani G., Villari D., Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, Villari, D, Mari A., Campi R., Schiavina R., Amparore D., Antonelli A., Artibani W., Barale M., Bertini R., Borghesi M., Bove P., Brunocilla E., Capitanio U., Da Pozzo L., Daja J., Gontero P., Larcher A., Li Marzi V., Longo N., Mirone V., Montanari E., Pisano F., Porpiglia F., Simeone C., Siracusano S., Tellini R., Trombetta C., Volpe A., Ficarra V., Carini M., Minervini A., Altieri V., Berardinelli F., Celia A., Costantini E., Di Maida F., Falsaperla M., Fiori C., Furlan M., Marson F., Montorsi F., Morgia G., Porreca A., Roscigno M., Schips L., Selli C., Simonato A., Terrone C., Vespasiani G., and Villari D.

Abstract

Objective: To identify meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy (PN). Patients and Methods: We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumours, between 2013 and 2016, at 26 Italian urological centres (RECORd 2 project). A multivariable logistic regression for surgical complications was performed. A nomogram was created from the multivariable model. Internal validation processes were performed using bootstrapping with 1000 repetitions. Results: Overall, 2584 patients who underwent PN were evaluated for the final analyses. The median (interquartile [IQR]) American Society of Anesthesiologists (ASA) score was 2 (2–3). In all, 72.4% of patients had clinical T1a (cT1a) stage tumours. The median (IQR) Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score was 7 (6–8). Overall, 34.3%, 27.7%, 38% of patients underwent open PN (OPN), laparoscopic PN (LPN), and robot-assisted PN (RAPN). Overall and major postoperative surgical complications were recorded in 10.2% and 2.5% of patients, respectively. At multivariable analysis, age, ASA score, cT2 vs cT1a stage, PADUA score, preoperative anaemia, OPN and LPN vs RAPN, were significant predictive factors of postoperative surgical complications. We used these variables to construct a nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%. Conclusion: Several clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.

Published
2019

5. Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project)

Author

Mari, A., Campi, R., Schiavina, R., Amparore, D., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Borghesi, M., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Daja, J., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Pisano, F., Porpiglia, F., Simeone, C., Siracusano, S., Tellini, R., Trombetta, C., Volpe, A., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Celia, A., Costantini, E., Di Maida, F., Falsaperla, M., Fiori, C., Furlan, M., Marson, F., Montorsi, F., Morgia, G., Porreca, A., Roscigno, M., Schips, L., Selli, C., Simonato, A., Terrone, C., Vespasiani, G., Villari, D., Mari A, Campi R, Schiavina R, Amparore D, Antonelli A, Artibani W, Barale M, Bertini R, Borghesi M, Bove P, Brunocilla E, Capitanio U, Da Pozzo L, Daja J, Gontero P, Larcher A, Li Marzi V, Longo N, Mirone V, Montanari E, Pisano F, Porpiglia F, Simeone C, Siracusano S, Tellini R, Trombetta C, Volpe A, Ficarra V, Carini M, Minervini A, Mari, Andrea, Campi, Riccardo, Schiavina, Riccardo, Amparore, Daniele, Antonelli, Alessandro, Artibani, Walter, Barale, Maurizio, Bertini, Roberto, Borghesi, Marco, Bove, Pierluigi, Brunocilla, Eugenio, Capitanio, Umberto, Da Pozzo, Luigi, Daja, Julian, Gontero, Paolo, Larcher, Alessandro, Li Marzi, Vincenzo, Longo, Nicola, Mirone, Vincenzo, Montanari, Emanuele, Pisano, Francesca, Porpiglia, Francesco, Simeone, Claudio, Siracusano, Salvatore, Tellini, Riccardo, Trombetta, Carlo, Volpe, Alessandro, Ficarra, Vincenzo, Carini, Marco, Minervini, Andrea, Mari, A., Campi, R., Schiavina, R., Amparore, D., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Borghesi, M., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Daja, J., Gontero, P., Larcher, A., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Pisano, F., Porpiglia, F., Simeone, C., Siracusano, S., Tellini, R., Trombetta, C., Volpe, A., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Celia, A., Costantini, E., Di Maida, F., Falsaperla, M., Fiori, C., Furlan, M., Marson, F., Montorsi, F., Morgia, G., Porreca, A., Roscigno, M., Schips, L., Selli, C., Simonato, A., Terrone, C., Vespasiani, G., Villari, D., Mari, A, Campi, R, Schiavina, R, Amparore, D, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Borghesi, M, Bove, P, Brunocilla, E, Capitanio, U, Da Pozzo, L, Daja, J, Gontero, P, Larcher, A, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Pisano, F, Porpiglia, F, Simeone, C, Siracusano, S, Tellini, R, Trombetta, C, Volpe, A, Ficarra, V, Carini, M, Minervini, A, Altieri, V, Berardinelli, F, Celia, A, Costantini, E, Di Maida, F, Falsaperla, M, Fiori, C, Furlan, M, Marson, F, Montorsi, F, Morgia, G, Porreca, A, Roscigno, M, Schips, L, Selli, C, Simonato, A, Terrone, C, Vespasiani, G, and Villari, D

Subjects
partial nephrectomy, complications, Male, medicine.medical_specialty, renal cell carcinoma, nephron-sparing surgery, nomogram, robot-assisted partial nephrectomy, medicine.medical_treatment, Urology, 030232 urology & nephrology, complication, Logistic regression, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Interquartile range, Renal cell carcinoma, complications, nephron-sparing surgery, nomogram, partial nephrectomy, renal cell carcinoma, robot-assisted partial nephrectomy, Medicine, Humans, In patient, Prospective Studies, Stage (cooking), Aged, business.industry, Nomogram, postoperative surgical complications, partial nephrectomy, RECORd 2 project, Kidney Neoplasm, Nomogram, Middle Aged, medicine.disease, Kidney Neoplasms, Surgery, Editorial Commentary, Nomograms, Settore MED/24, 030220 oncology & carcinogenesis, partial nephrectomy, complications, Observational study, Female, Postoperative Complication, business, Human
Abstract

Objective To identify meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy (PN). Patients and methods We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumours, between 2013 and 2016, at 26 Italian urological centres (RECORd 2 project). A multivariable logistic regression for surgical complications was performed. A nomogram was created from the multivariable model. Internal validation processes were performed using bootstrapping with 1000 repetitions. Results Overall, 2584 patients who underwent PN were evaluated for the final analyses. The median (interquartile [IQR]) American Society of Anesthesiologists (ASA) score was 2 (2-3). In all, 72.4% of patients had clinical T1a (cT1a) stage tumours. The median (IQR) Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) score was 7 (6-8). Overall, 34.3%, 27.7%, 38% of patients underwent open PN (OPN), laparoscopic PN (LPN), and robot-assisted PN (RAPN). Overall and major postoperative surgical complications were recorded in 10.2% and 2.5% of patients, respectively. At multivariable analysis, age, ASA score, cT2 vs cT1a stage, PADUA score, preoperative anaemia, OPN and LPN vs RAPN, were significant predictive factors of postoperative surgical complications. We used these variables to construct a nomogram for predicting the risk of postoperative surgical complications. At decision curve analysis, the nomogram led to superior outcomes for any decision associated with a threshold probability of >5%. Conclusion Several clinical predictors have been associated with postoperative surgical complications after PN. We used this information to develop and internally validate a nomogram to predict such risk.

Published
2019

7. Safety and efficacy during learning curve of en bloc HoLEP: experience of a single surgeon

Author

Spatafora, P., primary, Corti, F., additional, Liaci, A., additional, Morselli, S., additional, Verdelli, L., additional, Bisegna, C., additional, Polverino, P., additional, Zaccaro, C., additional, Campi, R., additional, Sessa, F., additional, Vignolini, G., additional, Gacci, M., additional, Villari, D., additional, Sebastianelli, A., additional, Tuccio, A., additional, Giancane, S., additional, and Serni, S., additional

Published
2021
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9. Perioperative Outcomes of Open, Laparoscopic, and Robotic Partial Nephrectomy: A Prospective Multicenter Observational Study (The RECORd 2 Project)

Author

Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., Altieri, V., Berardinelli, F., Borghesi, M., Celia, A., Cindolo, L., Costantini, E., Daja, J., Falsaperla, M., Furlan, M., Morgia, G., Porreca, A., Roscigno, M., Selli, C., Simonato, A., Tellini, R., Vespasiani, G., Villari, D., Bravi, C, Larcher, A, Capitanio, U, Mari, A, Antonelli, A, Artibani, W, Barale, M, Bertini, R, Bove, P, Brunocilla, E, Da Pozzo, L, Di Maida, F, Fiori, C, Gontero, P, Li Marzi, V, Longo, N, Mirone, V, Montanari, E, Porpiglia, F, Schiavina, R, Schips, L, Simeone, C, Siracusano, S, Terrone, C, Trombetta, C, Volpe, A, Montorsi, F, Ficarra, V, Carini, M, Minervini, A, Bravi, C. A., Larcher, A., Capitanio, U., Mari, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., Minervini, A., and Bravi CA, Larcher A, Capitanio U, Mari A, Antonelli A, Artibani W, Barale M, Bertini R, Bove P, Brunocilla E, Da Pozzo L, Di Maida F, Fiori C, Gontero P, Li Marzi V, Longo N, Mirone V, Montanari E, Porpiglia F, Schiavina R, Schips L, Simeone C, Siracusano S, Terrone C, Trombetta C, Volpe A, Montorsi F, Ficarra V, Carini M, Minervini A

Subjects
Male, medicine.medical_specialty, Urology, medicine.medical_treatment, 030232 urology & nephrology, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Robotic Surgical Procedures, Ischemia, Medicine, Humans, Minimally Invasive Surgical Procedures, Prospective Studies, Perioperative Period, Aged, medicine.diagnostic_test, business.industry, renal carcinoma, Odds ratio, Perioperative, Middle Aged, medicine.disease, Confidence interval, Kidney Neoplasms, Surgery, Settore MED/24, 030220 oncology & carcinogenesis, Female, Acute kidney injury, Laparoscopy, Partial nephrectomy, Perioperative outcomes, Renal cell carcinoma, Robotic surgery, Trifecta, business, Perioperative outcome
Abstract

Background: Partial nephrectomy (PN) has a non-negligible perioperative morbidity. Comparative evidence of the available surgical techniques is limited. Objective: To compare the perioperative outcomes of open, laparoscopic, and robotic PN. Methods: Data of 2331 patients treated with PN for cT1 renal tumors were extracted from the RECORd2 database, a prospective multicenter project. Multivariable regression models assessed the relationship between surgical technique and surgical margins, warm ischemia time, postoperative complications, and acute kidney injury (AKI). The probability of achieving a modified trifecta (negative margins, warm ischemia time

Published
2021

12. Transperitoneal vs retroperitoneal minimally invasive partial nephrectomy: comparison of perioperative outcomes and functional follow-up in a large multi-institutional cohort (the record 2 project)

Author

Mari, A., primary, Amparore, D., additional, Tellini, R., additional, Fiori, C., additional, Antonelli, A., additional, Artibani, W., additional, Bove, P., additional, Brunocilla, E., additional, Capitanio, U., additional, Da Pozzo, L., additional, Di Maida, F., additional, Gontero, P., additional, Longo, N., additional, Marra, G., additional, Rocco, B., additional, Schiavina, R., additional, Simeone, C., additional, Siracusano, S., additional, Terrone, C., additional, Villari, D., additional, Ficarra, V., additional, Carini, M., additional, Porpiglia, F., additional, and Minervini, A., additional

Published
2020
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13. Clinical, surgical, pathological and follow-up features of kidney cancer in patients with Von Hippel-Lindau syndrome: Novel insights from a large European consortium

Author

Capitanio, U., primary, Selcuk, E., additional, Rowe, I., additional, Onder, K., additional, Roussel, E., additional, Campi, R., additional, Villari, D., additional, Klatte, T., additional, Kriegmair, M., additional, Bertolo, R., additional, Ouzaid, I., additional, Mir, M.C., additional, Larcher, A., additional, and Salonia, A., additional

Published
2020
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22. Endoscopic Management of Attic Cholesteatoma: Long-Term Results

Author

Alicandri-Ciufelli M., Marchioni D., Kakehata S., Presutti L., Villari D., Alicandri-Ciufelli M., Marchioni D., Kakehata S., Presutti L., and Villari D.

Subjects
Attic retraction, Recurrence, Transcanal endoscopic approach, Residual, otorhinolaryngologic diseases, Cholesteatoma, Middle ear surgery
Abstract

The main application of endoscopic surgery relies on the middle ear cholesteatoma surgical treatment, although for a definitive validation and acceptance by scientific community, long-term results are needed about recurrent and residual rates of the pathology. The aim of the present paper was to analyze the single institution experience with the long-term results of surgical treatment of attic cholesteatoma.

Published
2016

25. SC155 - Transperitoneal vs retroperitoneal minimally invasive partial nephrectomy: comparison of perioperative outcomes and functional follow-up in a large multi-institutional cohort (the record 2 project)

Author

Mari, A., Amparore, D., Tellini, R., Fiori, C., Antonelli, A., Artibani, W., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Di Maida, F., Gontero, P., Longo, N., Marra, G., Rocco, B., Schiavina, R., Simeone, C., Siracusano, S., Terrone, C., Villari, D., Ficarra, V., Carini, M., Porpiglia, F., and Minervini, A.

Published
2020
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27. Enuresis and urinary infections in childhood: Bad 'news' for young women?

Author

Illiano, Ester, Appignani, Antonino, Giannitsas, K, Balsamo, R, Giannantoni, Antonella, Mirone, V, Natale, F, Maruccia, S, Salvini, Eleonora, Carbone, A, Pastore, A, Prestipino, M, Fragalà, E, Filocamo, Mt, Villari, D, Bini V, V, and Costantini, Elisabetta

Subjects
Enuresis, urinary infections, Enuresis, urinary infections
Published
2016

29. Enuresis and urinary infections in childhood. Bad 'news' for young women?

Author

Illiano, E., Appignani, A., Giannitsas, K., Balsamo, R., Giannantoni, A., Mirone, V., Natale, F., Mariuccia, S., Salvini, E., Carbone, Antonio, Pastore, ANTONIO LUIGI, Bevacqua, M., Prestipino, M., Fragalà, E., Filocamo, M. T., Villari, D., Bini, V., and Costantini, E.

Published
2016

31. IS UROLOGICAL DYSFUNCTIONS IN YOUNG WOMEN AN INHERITANCE OF CHILDHOOD?

Author

Illiano, Ester, Appignani, Antonino, Giannitsas, K, Balsamo, R, Giannantoni, Antonella, Mirone, V, Natale, F, Mariuccia, S, Salvini, Eleonora, Carbone, A, Pastore, A, Bevacqua, M, Prestipino, M, Fragala, E, Filocamo, Mt, Villari, D, Bini, Vittorio, and Costantini, Elisabetta

Subjects
urological dysfunctions
Published
2016

32. Results of endoscopic middle ear surgery for cholesteatoma treatment: a systematic review

Author

Presutti L, Fm, Gioacchini, Matteo Alicandri-Ciufelli, Villari D, Marchioni D, Presutti L., Gioacchini F.M., Alicandri-Ciufelli M., Villari D., and Marchioni D.

Subjects
Cholesteatoma, Middle Ear, cholestatoma, review, Endoscopy, Review, Endoscopic ear surgery, cholestatoma, Treatment Outcome, Recurrence, Residual, Cholesteatoma, Humans, Otologic Surgical Procedures, otorhinolaryngologic diseases
Abstract

Traditional surgery for cholesteatoma of the middle ear is performed by microscopic approaches. However, in recent years endoscopic instrumentation, techniques and knowledge have greatly improved, and in our opinion endoscopic surgical techniques will gain increasing importance in otologic surgery in the future. The aim of this study was to focus on outcomes obtained using endoscopic surgery for the treatment of middle ear cholesteatoma. A systematic review of the literature was performed. A total of 7 articles comprising 515 patients treated exclusively with endoscope or with a combined technique were found. During post-surgical follow-up, 48 (9.3%) patients showed a residual or recurrent pathology. Despite the small number of patients analyzed in our review, the outcomes of this technique appear to be promising. In particular, concerning the rates of recurrences and residual disease, endoscopic middle ear surgery appears to guarantee similar results in comparison to classic microscopic approaches with the advantage of performing minimally invasive surgery.La chirurgia tradizionale per il colesteatoma dell'orecchio medio è praticata mediante approcci microscopici. Comunque durante gli anni più recenti la strumentazione endoscopica, le tecniche, e la coscienza sono nettamente migliorate, e secondo il nostro parere in futuro, le tecniche di chirurgia endoscopica acquisiranno importanza nella otochirurgia. L'obiettivo di questo studio è stato quello di focalizzare i risultati ottenuti mediante l'uso della chirurgia endoscopica nel trattamento del colesteatoma dell'orecchio medio. È stata eseguita una revisione sistematica della letteratura. Sono stati trovati un totale di sette articoli che comprendevano 515 pazienti trattati esclusivamente con l'endoscopio o con una tecnica combinata. Complessivamente durante il follow-up post chirurgico, 48 (9,3%) pazienti hanno mostrato una recidiva o un residuo di malattia. Nonostante il piccolo numero di pazienti analizzati nella nostra revisione, i risultati di questa tecnica sembrano essere promettenti. In particolare, riguardo alle percentuali di recidive e residui di malattia, la chirurgia endoscopica dell'orecchio medio sembra garantire risultati simili a confronto di quelli ottenuti con i classici approcci microscopici avendo però anche il grande vantaggio di poter eseguire una chirurgia mini invasiva.

Published
2013

34. LE DISFUNZIONI UROLOGICHE NELLE DONNE GIOVANI: UN’EREDITà DELL’INFANZIA? PARTE I

Author

Costantini, Elisabetta, Illiano, Ester, Mirone, V., Balsamo, R., Natale, F., Marucci, S., Maglia, Daniele, Carbone, A., Bevacqua, M., Prestipino, M., Fragalà, E., Filocamo, M., Villari, D., Bini, Vittorio, and Appignani, Antonino

Subjects
urologia pediatrica, incontinenza urinaria, disfunzioni urologiche, disfunzioni urologiche, enuresi, incontinenza urinaria, urologia pediatrica, enuresi
Published
2015

35. NEOPLASIE RENALI E STILE DI VITA: DIFFERENZE TRA I DUE SESSI. ANALISI DESCRITTIVA DI UNA SERIE PROSPETTICA DI PAZIENTI SOTTOPOSTI A CHIRURGIA PER NEOPLASIA RENALE

Author

Costantini, Elisabetta, Filocamo, M., Cini, C., Vitelli, F., Luka, M., Giannessi, C., Balsamo, R., Maruccia, S., Maglia, Daniele, Fragala', E., Andretta, E., Illiano, Ester, Mariotti, G., and Villari, D.

Subjects
Tumori del rene, stili di vita, fattori prognostici, stili di vita, fattori prognostici, Tumori del rene
Published
2015

36. Tissue-resonance interaction method for the noninvasive diagnosis of prostate cancer: analysis of a multicentre clinical evaluation

Author

Da Pozzo, L, Scattoni, V, Mazzoccoli, B, Rigatti, P, Manferrari, F, Martorana, G, Pietropaolo, F, Belgrano, E, Prezioso, D, Lotti, T, Villari, D, Nicita, G, Da Pozzo L, Scattoni V, Mazzoccoli B, Rigatti P, Manferrari F, Martorana G, Pietropaolo F, Belgrano E, Prezioso D, Lotti T, Villari D, Nicita G, Da Pozzo, L, Scattoni, V, Mazzoccoli, B, Rigatti, P, Manferrari, F, Martorana, G, Pietropaolo, F, Belgrano, E, Prezioso, D, Lotti, T, Villari, D, Nicita, G, Da Pozzo L, Scattoni V, Mazzoccoli B, Rigatti P, Manferrari F, Martorana G, Pietropaolo F, Belgrano E, Prezioso D, Lotti T, Villari D, and Nicita G

Abstract

OBJECTIVE To determine, in a multicentre prospective study, the accuracy of the tissue‐resonance interaction method (TRIMprob, new technology developed for the noninvasive analysis of electromagnetic anisotropy in biological tissues) in the diagnosis of prostate cancer. PATIENTS AND METHODS Two hundred patients (mean age 67.4 years) scheduled to have prostatic biopsies (because of a prostate‐specific, PSA, antigen level of ≥4 ng/mL or a suspicious digital rectal examination, DRE) were preliminarily examined while unaware of their clinical details using TRIMprob in five different centres. The final diagnosis obtained with TRIMprob was compared with the final histological diagnosis after extended biopsies. RESULTS Of the 188 evaluable patients (mean PSA level 9.3 ng/mL, sd 8.8; mean prostate volume 62.0 mL, sd 32.4), 61 (32.4%) had a positive biopsy for adenocarcinoma of the prostate. The overall sensitivity, specificity, positive predictive value, negative predictive value (NPV) and accuracy of TRIMprob were 80%, 51%, 44%, 84% and 60%, respectively. The prostate cancer detection rate after biopsy was significantly higher in patients with a positive examination (49/111, 44%) than in patients with a negative TRIMprob (12/77, 15%; P < 0.001). When TRIMprob results were combined with DRE findings the sensitivity and NPV both increased to 92%. CONCLUSION TRIMprob seems to be a useful tool in the diagnosis of prostate cancer and can increase the accuracy of PSA or DRE results. The high NPV suggests that this new technology might be useful to reduce the indications for prostatic biopsy or repeated series of biopsies in patients suspected of having prostate cancer.

Published
2007

38. Transnasal endoscopic treatment of cerebrospinal fluid leak: 17 years' experience

Author

Presutti L, Mattioli F, Villari D, Marchioni D, Matteo Alicandri-Ciufelli, Presutti L., Mattioli F., Villari D., Marchioni D., and Alicandri-Ciufelli M.

Subjects
Male, Adolescent, Fistula, Cerebrospinal Fluid Rhinorrhea, Valsalva Maneuver, Iatrogenic Disease, Nose, Severity of Illness Index, Transplantation, Autologous, Cerebrospinal fluid leaCerebrospinal fluid leak, Endoscopic treatment, Septal mucoperichondrial graft, Intrathecal fluorescein, Lumbar drain, Young Adult, Septal mucoperichondrial graft, Postoperative Complications, Humans, Pituitary Neoplasms, Sinusitis, Nasal Septum, Intrathecal fluorescein, Lumbar drain, Endoscopic treatment, Endoscopy, Rhinology, Cerebrospinal fluid leak, Female, Follow-Up Studies, Tomography, X-Ray Computed, Cerebrospinal fluid leaCerebrospinal fluid leak
Abstract

Aim of this report is to describe the long-term results of endoscopic endonasal repair of cerebrospinal fluid leak using a septal mucoperichondrial graft. A case series of 52 patients operated for cerebrospinal fluid rhinorrhea between 1990 and 2006 is presented. All patients underwent surgical treatment for endoscopic endonasal closure of a cerebrospinal fluid leak using a septal mucoperichondrial graft. No lumbar drain and fluorescein tests were used. The intra-operative localization of the fistula was aided by Valsalva’s manoeuvre by the anaesthetist. The success rate, after the first attempt, was 88.5% (46/52 patients); for the remaining 11.5% (6/52 patients), a second attempt was necessary which proved successful in 5 cases, raising the overall success rate to 98.1% (51/52 patients). Relapse occurred in only one case (1.9%), after the second attempt. In conclusion, a free mucoperichondrial graft offered good results for cerebrospinal fluid leak repair. In the Authors’ experience, a high success rate can be achieved without the use of intrathecal fluorescein and lumbar drain.

Published
2009

41. Tissue resonance interaction method (Trimprobe TM) nella diagnosi non invasiva del carcinoma prostatico: risultati di uno studio prospettico multicentrico

Author

Da Pozzo L. F., Mazzoccoli B., Rigatti P., Pietropaolo F., Belgrano E., Prezioso D., Lotti T., Villari D., Nicita G., Vedruccio C., MANFERRARI, FABIO, MARTORANA, GIUSEPPE, Da Pozzo L.F., Mazzoccoli B., Rigatti P., Manferrari F., Martorana G., Pietropaolo F., Belgrano E., Prezioso D., Lotti T., Villari D., Nicita G., and Vedruccio C.

Published
2006

43. 534 Enuresis and urinary infections in childhood: Bad “news” for young women?

Author

Illiano, E., primary, Appignani, A., additional, Giannitsas, K., additional, Balsamo, R., additional, Giannantoni, A., additional, Mirone, V., additional, Natale, F., additional, Mariuccia, S., additional, Salvini, E., additional, Carbone, A., additional, Pastore, A., additional, Bevacqua, M., additional, Prestipino, M., additional, Fragalà, E., additional, Filocamo, M.T., additional, Villari, D., additional, Bini, V., additional, and Costantini, E., additional

Published
2016
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44. 14 Coital incontinence in women with urinary incontinence: Results from an international cross-sectional study

Author

Costantini, E., primary, Illiano, E., additional, Tienforti, D., additional, Athanasopoulos, A., additional, Giannitsas, K., additional, Balsamo, R., additional, Masiello, G., additional, Di Biase, M., additional, Natale, F., additional, Carbone, A., additional, Filocamo, M.T., additional, Villari, D., additional, Mahfouz, W., additional, Finazzi Agro’, E., additional, and Kocjancic, E., additional

Published
2016
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