31 results on '"Villanueva, C. M."'
Search Results
2. Assessment of Lifetime Exposure to Trihalomethanes through Different Routes
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Villanueva, C. M., Cantor, K. P., Grimalt, J. O., Castaño-Vinyals, G., Malats, N., Silverman, D., Tardon, A., Garcia-Closas, R., Serra, C., Carrato, A., Rothman, N., Real, F. X., Dosemeci, M., and Kogevinas, M.
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- 2006
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3. Atrazine in Municipal Drinking Water and Risk of Low Birth Weight, Preterm Delivery, and Small-for-Gestational-Age Status
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Villanueva, C. M., Durand, G., Coutté, M-B., Chevrier, C., and Cordier, S.
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- 2005
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4. Meta-Analysis of Studies on Individual Consumption of Chlorinated Drinking Water and Bladder Cancer
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Villanueva, C. M., Fernández, F., Malats, N., Grimalt, J. O., and Kogevinas, M.
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- 2003
5. Trihalomethanes in drinking water and bladder cancer burden in the European Union
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Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), Villanueva, C. M. (Cristina M.), Evlampidou, I. (Iro), Font-Ribera, L. (Laia), Rojas-Rueda, D. (David), Gracia-Lavedan, E. (Esther), Costet, N. (Nathalie), Pearce, N. (Neil), Vineis, P. (Paolo), Jaakkola, J. J. (Jouni J. K.), Delloye, F. (Francis), Makris, K. C. (Konstantinos C.), Stephanou, E. G. (Euripides G.), Kargaki, S. (Sophia), Kozisek, F. (Frantisek), Sigsgaard, T. (Torben), Hansen, B. (Birgitte), Schullehner, J. (Jörg), Nahkur, R. (Ramon), Galey, C. (Catherine), Zwiener, C. (Christian), Vargha, M. (Marta), Righi, E. (Elena), Aggazzotti, G. (Gabriella), Kalnina, G. (Gunda), Grazuleviciene, R. (Regina), Polanska, K. (Kinga), Gubkova, D. (Dasa), Bitenc, K. (Katarina), Goslan, E. H. (Emma H.), Kogevinas, M. (Manolis), and Villanueva, C. M. (Cristina M.)
- Abstract
Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer. Methods: We collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure–response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the mean THM level in each country (relative to no exposure), population-attributable fraction (PAF), and number of attributable bladder cancer cases in different scenarios using incidence rates and population from the Global Burden of Disease study of 2016. Results: We obtained 2005–2018 THM data from EU26, covering 75% of the population. Data coverage and accuracy were heterogeneous among countries. The estimated population-weighted mean THM level was 11.7μg/L [standard deviation (SD) of 11.2]. The estimated bladder cancer PAF was 4.9% [95% confidence interval (CI): 2.5, 7.1] overall (range: 0–23%), accounting for 6,561 (95% CI: 3,389, 9,537) bladder cancer cases per year. Denmark and the Netherlands had the lowest PAF (0.0% each), while Cyprus (23.2%), Malta (17.9%), and Ireland (17.2%) had the highest among EU26. In the scenario where no country would exceed the current EU mean, 2,868 (95% CI: 1,522, 4,060; 43%) annual attributable bladder cancer cases could potentially be avoided. Discussion: Efforts have been made to reduce THM levels in the European Union. However, assuming a causal association, current levels in certain countries still could lead to a considerable burden of bladder cancer
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- 2020
6. Comparación histológica de las superficies radiculares acondicionadas con acido citrico y EDTA previo raspaje.
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Castro, R. D. Scipión, Ramos, M. R. Valenzuela, Guevara, M. G. Añaños, Murillo, P. O. Mendoza, Del Carpio, P. I. Agüero, and Villanueva, C. M. Revilla
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Copyright of Avances en Odontoestomatologia is the property of Ediciones Avances SL and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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7. A case-control study of the relation between plasma selenium and asthma in European populations: a GA2LEN project
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Burney, P., Potts, J., Makowska, J., Kowalski, M., Phillips, J., Gnatiuc, L., Shaheen, S., Joos, G., Van Cauwenberge, P., van Zele, T., Verbruggen, K., van Durme, Y., Derudder, I., Wohrl, S., Godnic-Cvar, J., Salameh, B., Skadhauge, L., Thomsen, G., Zuberbier, T., Bergmann, K. C., Heinzerling, L., Renz, H., Al-Fakhri, N., Kosche, B., Hildenberg, A., Papadopoulos, N. G., Xepapadaki, P., Zannikos, K., Gjomarkaj, M., Bruno, A., Pace, E., Bonini, S., Bresciani, M., Gramiccioni, C., Fokkens, W., Weersink, E. J. M., Carlsen, K.-H., Bakkeheim, E., Loureiro, C., Villanueva, C. M., Sanjuas, C., Zock, J.-P., Lundback, B., and Janson, C.
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- 2008
8. Genetic and epigenetic methylation defects and implication of the ERMN gene in autism spectrum disorders
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Homs, A, primary, Codina-Solà, M, additional, Rodríguez-Santiago, B, additional, Villanueva, C M, additional, Monk, D, additional, Cuscó, I, additional, and Pérez-Jurado, L A, additional
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- 2016
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9. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
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Bustamante, M. Danileviciute, A. Espinosa, A. Gonzalez, J. R. Subirana, I. Cordier, S. Chevrier, C. Chatzi, L. and Grazuleviciene, R. Sunyer, J. Ibarluzea, J. Ballester, F. and Villanueva, C. M. Nieuwenhuijsen, M. Estivill, X. and Kogevinas, M.
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Please cite this paper as: Bustamante M, Danileviciute A, Espinosa A, Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG 2012;119:11411146. A nested casecontrol association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.510.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.071.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
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- 2012
10. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
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Bustamante, M., Danileviciute, A., Espinosa, A., Gonzalez, J. R., Subirana, I., Cordier, Sylvaine, Chevrier, Cécile, Chatzi, L., Grazuleviciene, R., Sunyer, J., Ibarluzea, J., Ballester, F., Villanueva, C. M., Nieuwenhuijsen, M., Estivill, X., Kogevinas, M., Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), IMIM-Hospital del Mar, Generalitat de Catalunya, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Center for Public Health Research (CSISP), University of Valencia, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
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MESH: Premature Birth ,DNA Copy Number Variations ,Genotype ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Polymorphism, Single Nucleotide ,MESH: Genotype ,small for gestational age ,MESH: Pregnancy ,Fetus ,Cytochrome P-450 Enzyme System ,Pregnancy ,mental disorders ,Humans ,copy number variant ,glutathione s-transferase ,Glutathione Transferase ,MESH: Glutathione Transferase ,MESH: Humans ,MESH: Polymorphism, Single Nucleotide ,Pregnancy Outcome ,MESH: Fetus ,MESH: Haplotypes ,MESH: Pregnancy Outcome ,MESH: Case-Control Studies ,Haplotypes ,Case-Control Studies ,MESH: Cytochrome P-450 Enzyme System ,Premature Birth ,MESH: DNA Copy Number Variations ,Female ,preterm ,MESH: Female - Abstract
Please cite this paper as: Bustamante M, Danileviciute A, Espinosa A, Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M, Estivill X, Kogevinas M. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG 2012;119:11411146. A nested casecontrol association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.510.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.071.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
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- 2012
11. Water disinfection by-products and bladder cancer: is there a European specificity? A pooled and meta-analysis of European case-control studies
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Costet, N. Villanueva, C. M. Jaakkola, J. J. K. Kogevinas, M. Cantor, K. P. King, W. D. Lynch, C. F. and Nieuwenhuijsen, M. J. Cordier, S.
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Several epidemiological studies suggested an association between the risk of bladder cancer and the exposure to trihalomethanes (THMs), the main disinfection by-products (DBPs) of chlorinated water. A previous pooled analysis of case-control studies from North America and Europe estimated a summarized dose-response relation. For policy guidance of drinking water disinfection in Europe and because major differences exist in water disinfection practices and DBPs occurrence between both continents, specific risk estimates for bladder cancer in relation to DBPs exposure for European populations were needed. We conducted a pooled and a two-stage random-effect meta-analyses of three European case-control studies from France, Finland, and Spain (5467 individuals: 2381 cases and 3086 controls). Individual exposure to THMs was calculated combining information on residential history, estimates of the average total THMs (TTHM) level in tap water at the successive residences and personal water consumption. A significant odds-ratio was observed for men exposed to an average residential TTHM level > 50 mu g/l (OR=1.47 (1.05; 2.05)) when compared to men exposed to levels
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- 2011
12. The relation between paracetamol use and asthma : a GA2LEN European case-control study
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Shaheen, S., Potts, J., Gnatiuc, L., Makowska, J., Kowalski, M. L., Joos, G., van Zele, T., van Durme, Y., De Rudder, I., Wöhrl, S., Godnic-Cvar, J., Skadhauge, L., Thomsen, G., Zuberbier, T., Bergmann, K. C., Heinzerling, L., Gjomarkaj, M., Bruno, A., Pace, E., Bonini, S., Fokkens, W., Weersink, E. J. M., Loureiro, C., Todo-Bom, A., Villanueva, C. M., Sanjuas, C., Zock, J-P., Janson, Christer, Burney, P., Shaheen, S., Potts, J., Gnatiuc, L., Makowska, J., Kowalski, M. L., Joos, G., van Zele, T., van Durme, Y., De Rudder, I., Wöhrl, S., Godnic-Cvar, J., Skadhauge, L., Thomsen, G., Zuberbier, T., Bergmann, K. C., Heinzerling, L., Gjomarkaj, M., Bruno, A., Pace, E., Bonini, S., Fokkens, W., Weersink, E. J. M., Loureiro, C., Todo-Bom, A., Villanueva, C. M., Sanjuas, C., Zock, J-P., Janson, Christer, and Burney, P.
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Studies from the UK and USA suggest that frequent use of paracetamol (acetaminophen) may increase the risk of asthma, but data across Europe are lacking. As part of a multicentric case-control study organised by the Global Allergy and Asthma European Network (GA(2)LEN), it was examined whether or not frequent paracetamol use is associated with adult asthma across Europe. The network compared 521 cases with a diagnosis of asthma and reporting of asthma symptoms within the last 12 months with 507 controls with no diagnosis of asthma and no asthmatic symptoms within the last 12 months across 12 European centres. All cases and controls were selected from the same population, defined by age (20-45 yrs) and place of residence. In a random effects meta-analysis, weekly use of paracetamol, compared with less frequent use, was strongly positively associated with asthma after controlling for confounders. There was no evidence for heterogeneity across centres. No association was seen between use of other analgesics and asthma. These data add to the increasing and consistent epidemiological evidence implicating frequent paracetamol use in asthma in diverse populations.
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- 2008
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13. Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
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Tomlinson, I P M, primary, Dunlop, M, additional, Campbell, H, additional, Zanke, B, additional, Gallinger, S, additional, Hudson, T, additional, Koessler, T, additional, Pharoah, P D, additional, Niittymäki, I, additional, Tuupanen, S, additional, Aaltonen, L A, additional, Hemminki, K, additional, Lindblom, A, additional, Försti, A, additional, Sieber, O, additional, Lipton, L, additional, van Wezel, T, additional, Morreau, H, additional, Wijnen, J T, additional, Devilee, P, additional, Matsuda, K, additional, Nakamura, Y, additional, Castellví-Bel, S, additional, Ruiz-Ponte, C, additional, Castells, A, additional, Carracedo, A, additional, Ho, J W C, additional, Sham, P, additional, Hofstra, R M W, additional, Vodicka, P, additional, Brenner, H, additional, Hampe, J, additional, Schafmayer, C, additional, Tepel, J, additional, Schreiber, S, additional, Völzke, H, additional, Lerch, M M, additional, Schmidt, C A, additional, Buch, S, additional, Moreno, V, additional, Villanueva, C M, additional, Peterlongo, P, additional, Radice, P, additional, Echeverry, M M, additional, Velez, A, additional, Carvajal-Carmona, L, additional, Scott, R, additional, Penegar, S, additional, Broderick, P, additional, Tenesa, A, additional, and Houlston, R S, additional
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- 2010
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14. COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
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Tomlinson, I P M, primary, Dunlop, M, additional, Campbell, H, additional, Zanke, B, additional, Gallinger, S, additional, Hudson, T, additional, Koessler, T, additional, Pharoah, P D, additional, Niittymäkix, I, additional, Tuupanenx, S, additional, Aaltonen, L A, additional, Hemminki, K, additional, Lindblom, A, additional, Försti, A, additional, Sieber, O, additional, Lipton, L, additional, van Wezel, T, additional, Morreau, H, additional, Wijnen, J T, additional, Devilee, P, additional, Matsuda, K, additional, Nakamura, Y, additional, Castellví-Bel, S, additional, Ruiz-Ponte, C, additional, Castells, A, additional, Carracedo, A, additional, Ho, J W C, additional, Sham, P, additional, Hofstra, R M W, additional, Vodicka, P, additional, Brenner, H, additional, Hampe, J, additional, Schafmayer, C, additional, Tepel, J, additional, Schreiber, S, additional, Völzke, H, additional, Lerch, M M, additional, Schmidt, C A, additional, Buch, S, additional, Moreno, V, additional, Villanueva, C M, additional, Peterlongo, P, additional, Radice, P, additional, Echeverry, M M, additional, Velez, A, additional, Carvajal-Carmona, L, additional, Scott, R, additional, Penegar, S, additional, Broderick, P, additional, Tenesa, A, additional, and Houlston, R S, additional
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- 2009
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15. Three Authors Reply
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Villanueva, C. M., primary, Silverman, D. T., additional, and Kogevinas, M., additional
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- 2009
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16. Determinants of Quality of Interview and Impact on Risk Estimates in a Case-Control Study of Bladder Cancer
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Villanueva, C. M., primary, Silverman, D. T., additional, Malats, N., additional, Tardon, A., additional, Garcia-Closas, R., additional, Serra, C., additional, Carrato, A., additional, Fortuny, J., additional, Rothman, N., additional, Dosemeci, M., additional, and Kogevinas, M., additional
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- 2009
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17. Swimming pool attendance and risk of asthma and allergic symptoms in children
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Font-Ribera, L., primary, Kogevinas, M., additional, Zock, J-P., additional, Nieuwenhuijsen, M. J., additional, Heederik, D., additional, and Villanueva, C. M., additional
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- 2009
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18. The relation between paracetamol use and asthma: a GA2LEN European case-control study
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Shaheen, S., primary, Potts, J., additional, Gnatiuc, L., additional, Makowska, J., additional, Kowalski, M. L., additional, Joos, G., additional, van Zele, T., additional, van Durme, Y., additional, De Rudder, I., additional, Wohrl, S., additional, Godnic-Cvar, J., additional, Skadhauge, L., additional, Thomsen, G., additional, Zuberbier, T., additional, Bergmann, K. C., additional, Heinzerling, L., additional, Gjomarkaj, M., additional, Bruno, A., additional, Pace, E., additional, Bonini, S., additional, Fokkens, W., additional, Weersink, E. J. M., additional, Loureiro, C., additional, Todo-Bom, A., additional, Villanueva, C. M., additional, Sanjuas, C., additional, Zock, J-P., additional, Janson, C., additional, and Burney, P., additional
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- 2008
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19. Sources of Variability in Levels and Exposure to Trihalomethanes
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Villanueva, C M., primary, Gagniere, B, additional, Monfort, C, additional, and Cordier, S, additional
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- 2006
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20. Measurement of Drinking Water Contaminants and Water Use Activities During Pregnancy in a Cohort Study in Spain
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Villanueva, C M., primary, Grimalt, J O., additional, Ballester, F, additional, Ibarluzea, J, additional, Tardón, A, additional, Romero, E, additional, Fernández, M, additional, and Kogevinas, M, additional
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- 2006
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21. Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools
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Villanueva, C. M., primary, Cantor, K. P., additional, Grimalt, J. O., additional, Malats, N., additional, Silverman, D., additional, Tardon, A., additional, Garcia-Closas, R., additional, Serra, C., additional, Carrato, A., additional, Castano-Vinyals, G., additional, Marcos, R., additional, Rothman, N., additional, Real, F. X., additional, Dosemeci, M., additional, and Kogevinas, M., additional
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- 2006
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22. Lifetime Swimming Pool Attendance, Asthma, Eczema and Respiratory Symptoms in School-Age Children.
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Font-Ribera, L, Villanueva, C M, Zock, J, Nieuwenhuijsen, M, Heederik, D, and Grimalt, J O
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- 2008
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23. Acute Exposure to Disinfection By-Products in Swimming Pools and Short-Term Changes in Respiratory Biomarkers.
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Villanueva, C M, Font-Ribera, L, Gómez, F P, Barreiro, E, Zock, J, Nieuwenhuijsen, M J, Heederik, D, Grimalt, J O, and Kogevinas, M
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- 2008
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24. Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain
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Jordi Sunyer, Esther Gracia-Lavedan, Mariana F. Fernández, Loreto Santa Marina, Fernando Goñi, Ferran Ballester, Cristina M. Villanueva, Sabrina Llop, Jesús Ibarluzea, Manolis Kogevinas, Xavier Basagaña, Carmen Freire, Adonina Tardón, Joan O. Grimalt, [Villanueva,CM, Gracia-Lavedán,E, Basagaña,X, Kogevinas, M, Sunyer,J.] Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. [Villanueva,CM, Sunyer,J] IMIM (Hospital del Mar Research Institute), Barcelona, Spain. [Villanueva,C. M, Sunyer,J.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ibarluzea,J, Santa Marina, L.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ibarluzea,J, Santa Marina, L.] Subdirección de Salud Pública, Gipuzkoa, Spain. [Ballester, F.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ballester, F.] Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. [Ballester, F.]Universitat de València, València, Spain. [Llop,S, Tardón, A.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Llop,S, Tardón, A.] Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. [Fernández,M.F, Freire,C.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Fernández,M.F, Freire,C.] Hospital Universitario San Cecilio, Universidad de Granada, Granada, Spain. [Goñi, F.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Goñi, F.] Laboratorio de Salud Pública, Gobierno Vasco, Spain. [Kogevinas, M.] National School of Public Health, Athens, Greece [Grimalt, J.O.] Institute of Environmental Assessment and Water Research (IDAEA), Centro Superior de Investigaciones Científicas (CSIC), Barcelona, Spain, This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, from Fondo de Investigación Sanitaria (FIS): FIS-FEDER (Fondo Europeo de Desarrollo Regional) 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, PI080533, FIS-PI041436, FIS-PI06/0867, FIS-PI081151, FIS-S09-PS09/02311), CIBER (AA08_012), Generalitat de Catalunya-CIRIT (1999SGR 00241), Departamento de Sanidad del Gobierno Vasco (BIOEF06/002), Diputación Foral de Gipuzkoa (DFG06/004), Consejería de Salud, Junta de Andalucía (PI-0183/2007), Conselleria de Sanitat Generalitat Valenciana, Fundació Roger Torné, and and HI-WATE (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water) project (FP6-2005-FOOD-4B, reg. 036224).
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Pediatrics ,Fetus -- Creixement ,Bathing ,Health, Toxicology and Mutagenesis ,España ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Cohort Studies ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical [Medical Subject Headings] ,small for gestational age ,Pregnancy ,newborn ,Femeninos ,Exposición a Riesgos Ambientales ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings] ,Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] ,water pollution ,Infeccions respiratòries -- Epidemiologia ,Adulto ,disinfection by-products ,Named Groups::Persons::Age Groups::Infant::Infant, Newborn::Infant, Low Birth Weight [Medical Subject Headings] ,Modelos Teóricos ,Environmental exposure ,premature birth ,Nacimiento Prematuro ,Humanos ,Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models [Medical Subject Headings] ,Premature birth ,Infant, Small for Gestational Age ,Gestation ,Named Groups::Persons::Age Groups::Infant::Infant, Newborn::Infant, Low Birth Weight::Infant, Small for Gestational Age [Medical Subject Headings] ,Female ,epidemiology ,medicine.symptom ,Aigua -- Depuració ,Adult ,medicine.medical_specialty ,trihalomethanes ,Contaminantes Químicos del Agua ,Embarazo ,Birth weight ,Named Groups::Persons::Age Groups::Infant::Infant, Newborn [Medical Subject Headings] ,Embaràs -- Aspectes nutricionals ,Recién nacido ,Recién Nacido Pequeño para la Edad Gestacional ,Environmental health ,medicine ,Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] ,cohort study ,Modelos Logísticos ,Humans ,low birth weight ,Epidemiologia ,Recién Nacido de Bajo Peso ,Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Halogenated::Trihalomethanes [Medical Subject Headings] ,business.industry ,Trihalometano ,Research ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,birth weight ,Environmental Exposure ,Infant, Low Birth Weight ,Models, Theoretical ,medicine.disease ,Low birth weight ,Logistic Models ,Check Tags::Female [Medical Subject Headings] ,Spain ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,Small for gestational age ,Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Water Pollutants::Water Pollutants, Chemical [Medical Subject Headings] ,Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor, Premature::Premature Birth [Medical Subject Headings] ,business ,Estudios de Cohortes ,Water Pollutants, Chemical - Abstract
Background: Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. Objective: We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. Methods: Mother–child cohorts set up in five Spanish areas during the years 2000–2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. Results: Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was –0.45 g (95% confidence interval: –1.36, 0.45 g) for chloroform and 0.16 g (–1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. Conclusions: Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain., We particularly thank all the participants for their generous collaboration. A full roster of the Infancia y Medio Ambiente (INMA) Project investigators can be found at http://www.proyectoinma.org/presentacion-inma/listado-investigadores/en_listado-investigadores.html. We are also grateful to G.J. Álvarez Alija for contributing to the fieldwork.
25. Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.
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Bustamante M, Danileviciute A, Espinosa A, Gonzalez JR, Subirana I, Cordier S, Chevrier C, Chatzi L, Grazuleviciene R, Sunyer J, Ibarluzea J, Ballester F, Villanueva CM, Nieuwenhuijsen M, Estivill X, and Kogevinas M
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- Case-Control Studies, Female, Genotype, Haplotypes, Humans, Pregnancy, Pregnancy Outcome, Cytochrome P-450 Enzyme System genetics, DNA Copy Number Variations genetics, Fetus enzymology, Glutathione Transferase genetics, Polymorphism, Single Nucleotide genetics, Premature Birth genetics
- Abstract
A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner., (© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.)
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- 2012
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- View/download PDF
26. COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
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Tomlinson IP, Dunlop M, Campbell H, Zanke B, Gallinger S, Hudson T, Koessler T, Pharoah PD, Niittymäki I, Tuupanen S, Aaltonen LA, Hemminki K, Lindblom A, Försti A, Sieber O, Lipton L, van Wezel T, Morreau H, Wijnen JT, Devilee P, Matsuda K, Nakamura Y, Castellví-Bel S, Ruiz-Ponte C, Castells A, Carracedo A, Ho JW, Sham P, Hofstra RM, Vodicka P, Brenner H, Hampe J, Schafmayer C, Tepel J, Schreiber S, Völzke H, Lerch MM, Schmidt CA, Buch S, Moreno V, Villanueva CM, Peterlongo P, Radice P, Echeverry MM, Velez A, Carvajal-Carmona L, Scott R, Penegar S, Broderick P, Tenesa A, and Houlston RS
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- Genetic Predisposition to Disease, Humans, Penetrance, Prognosis, Risk, Risk Factors, Colorectal Neoplasms genetics, Polymorphism, Genetic
- Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
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- 2010
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27. Haloacetic acids and trihalomethanes in finished drinking waters from heterogeneous sources.
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Villanueva CM, Kogevinas M, and Grimalt JO
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- Spain, Acetic Acid analysis, Acetic Acid chemistry, Trihalomethanes analysis, Water Pollutants, Chemical analysis, Water Purification, Water Supply standards
- Abstract
Trihalomethanes (THM) and haloacetic acids (HAA) are the most frequent chlorination by-products (CBP) in finished drinking waters. Traditionally, THM have been used as surrogates for CBP although the quantitative association between THM and other CBP is not well established. This problem is addressed in the present study from the analysis of THM and HAA in drinking water samples from four Spanish regions, representing areas with very different CBP composition, e.g. between 86 and 8.0 microg/l of THM and 50-3.0 microg/l of HAA. The resulting dataset exhibit a statistically significant correlation between total THM and HAA (Pearson's correlation coefficient, r(p)=0.815,p<0.0005). Furthermore, specific HAA are highly correlated with specific THM or their combinations. Accordingly, multivariate linear regression analysis of the concentrations observed show that the levels in total and specific HAA can be predicted from the THM content. These results are relevant for epidemiological studies on health effects from CBP exposure since they usually involve comparison of populations consuming waters of very distinct quality.
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- 2003
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28. [Drinking water chlorination and adverse health effects: review of epidemiological studies].
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Villanueva CM, Kogevinas M, and Grimalt JO
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- Colonic Neoplasms epidemiology, Female, Humans, Male, Pancreatic Neoplasms chemically induced, Pancreatic Neoplasms epidemiology, Pregnancy, Prenatal Exposure Delayed Effects, Rectal Neoplasms epidemiology, Urinary Bladder Neoplasms epidemiology, Water Pollutants, Chemical analysis, Chlorides adverse effects, Colonic Neoplasms chemically induced, Rectal Neoplasms chemically induced, Urinary Bladder Neoplasms chemically induced, Water Purification methods
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- 2001
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29. [Chlorination of drinking water in Spain and bladder cancer].
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Villanueva CM, Kogevinas M, and Grimalt JO
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- Humans, Risk Assessment, Spain epidemiology, Drinking Water analysis, Halogenation, Trihalomethanes adverse effects, Trihalomethanes analysis, Urinary Bladder Neoplasms chemically induced, Urinary Bladder Neoplasms epidemiology
- Abstract
Objectives: Drinking water chlorination generates trihalomethanes and other by-products with mutagenic and carcinogenic properties in animal experiments. Epidemiological studies have associated trihalomethanes to an increased risk of bladder cancer. We evaluate trihalomethane levels in four Spanish areas and calculate the bladder cancer risk attributable to this exposure., Methods: Trihalomethanes have been analysed in 111 drinking water samples from four Spanish areas using gas chromatography. Water utilities were contacted and information on drinking water consumption in Spain has been collected. We reviewed the epidemiological studies that assess the association between bladder cancer risk and exposure to chlorination by-products. Attributable risk was calculated on the basis of these levels, mortality data per area and risk estimates obtained from the literature., Results: Mediterranean areas present the highest levels of trihalomethanes with 81, 80, 61 and 52 µg/l in Sabadell, Alicante, Barcelona and Manresa respectively. Lower levels are found in Tenerife and Asturias with 7 and 20 µg/l respectively. The bladder cancer attributable risk in high trihalomethane exposure areas may be, on average, around 20%., Conclusions: The trihalomethane levels found are high compared to those of other European Union countries. In the high exposure areas, drinking water chlorination may generate a considerable number of bladder cancer cases. These estimations have to be carefully interpreted and verified with more extensive studies.
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- 2001
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30. [Conflictive relatives?].
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Batista-Miranda JE and Prieto-Villanueva CM
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- Humans, Communication, Physician-Patient Relations, Professional-Family Relations
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- 1994
31. [Treatment of bronchial asthma in winter using controlled-release salbutamol].
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Rico FG, Espinoza JL, Montero P, Espinoza F, Mancilla A, Sánchez A, and Villanueva CM
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- Adolescent, Adult, Asthma physiopathology, Delayed-Action Preparations, Female, Humans, Male, Middle Aged, Seasons, Albuterol therapeutic use, Asthma drug therapy
- Abstract
This paper presents results about comparative study in winter season, in a statistics design AB and BA on 20 patients that were treated with salbutamol (Group B) and with salbutamol of controlled liberation (Group B) at random. Results showed that patients of Group B had improvement in symptomatology and had less exacerbations than those patients of group A with statistical significance. It was concluded that salbutamol tablets of controlled liberation is a therapeutic method adequate to control chronic phase of asthmatic patients in winter season.
- Published
- 1990
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