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1. Perspectives in noninvasive imaging for chronic coronary syndromes

Author

Morrone, Doralisa, Gentile, Francesco, Aimo, Alberto, Cameli, Matteo, Barison, Andrea, Picoi, Maria Elena, Guglielmo, Marco, Villano, Angelo, DeVita, Antonio, Mandoli, Giulia Elena, Pastore, Maria Concetta, Barillà, Francesco, Mancone, Massimo, Pedrinelli, Roberto, Indolfi, Ciro, Filardi, Pasquale Perrone, Muscoli, Saverio, Tritto, Isabella, Bergamaschi, Luca, Pizzi, Carmine, Camici, Paolo G., Marzilli, Mario, Crea, Filippo, Caterina, Raffaele De, Pontone, Gianluca, Neglia, Danilo, and Lanza, Gaetano A.

Published
2022
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9. Coronary microvascular dysfunction and findings of heart failure with preserved ejection fraction in patients with microvascular angina

Author

FILICE, Monica, primary, GOLINO, Michele, additional, DENORA, Marialessia, additional, RUSCIO, Eleonora, additional, INGRASCIOTTA, Gessica, additional, LAMENDOLA, Priscilla, additional, MANFREDONIA, Laura, additional, VILLANO, Angelo, additional, BISIGNANI, Antonio, additional, RAVENNA, Salvatore E., additional, DE VITA, Antonio, additional, LANZA, Oreste, additional, CREA, Filippo, additional, and LANZA, Gaetano A., additional

Published
2022
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14. Relation of endothelial and cardiac autonomic function with left ventricle diastolic function in patients with type 2 diabetes mellitus

Author

Tremamunno, Saverio, primary, De Vita, Antonio, additional, Villano, Angelo, additional, Melita, Veronica, additional, Ingrasciotta, Gessica, additional, Ruscio, Eleonora, additional, Filice, Monica, additional, Bisignani, Antonio, additional, Ravenna, Salvatore Emanuele, additional, Tartaglione, Linda, additional, Rizzo, Gaetano Emanuele, additional, Di Leo, Mauro, additional, Felici, Tamara, additional, Pitocco, Dario, additional, and Lanza, Gaetano Antonio, additional

Published
2021
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16. Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Author

Paneni, Francesco, Costantino, Sarah, Castello, Lorenzo, Battista, Rodolfo, Capretti, Giuliana, Chiandotto, Sergio, DʼAmario, Domenico, Scavone, Giuseppe, Villano, Angelo, Rustighi, Alessandra, Crea, Filippo, Pitocco, Dario, Lanza, Gaetano, Volpe, Massimo, Del Sal, Giannino, Lüscher, Thomas F., and Cosentino, Francesco

Published
2015
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23. Relation of endothelial and cardiac autonomic function with left ventricle diastolic function in patients with type 2 diabetes mellitus.

Author

Tremamunno, Saverio, De Vita, Antonio, Villano, Angelo, Melita, Veronica, Ingrasciotta, Gessica, Ruscio, Eleonora, Filice, Monica, Bisignani, Antonio, Ravenna, Salvatore Emanuele, Tartaglione, Linda, Rizzo, Gaetano Emanuele, Di Leo, Mauro, Felici, Tamara, Pitocco, Dario, and Lanza, Gaetano Antonio

Subjects
TYPE 2 diabetes, HEART beat, CARDIAC patients, DYSAUTONOMIA
Abstract

Background and Aims: Diabetes mellitus (DM) is a risk factor for left ventricle (LV) diastolic dysfunction. Aim of this study was to investigate whether endothelial and/or autonomic dysfunction are associated with LV diastolic dysfunction in DM patients.Methods: We studied 84 non-insulin-dependent type 2 DM (T2DM) patients with no heart disease by assessing: 1) LV diastolic function by echocardiography; 2) peripheral vasodilator function, by measuring flow-mediated dilation (FMD) and nitrate-mediate dilation (NMD); 3) heart rate variability (HRV) on 24-h Holter electrocardiographic monitoring.Results: Twenty-five patients (29.8%) had normal LV diastolic function, while 47 (55.9%) and 12 (14.3%) showed a mild and moderate/severe diastolic dysfunction, respectively. FMD in these 3 groups was 5.25 ± 2.0, 4.95 ± 1.6 and 4.43 ± 1.8% (p = 0.42), whereas NMD was 10.8 ± 2.3, 8.98 ± 3.0 and 8.82 ± 3.2%, respectively (p = 0.02). HRV variables did not differ among groups. However, the triangular index tended to be lower in patients with moderate/severe diastolic dysfunction (p = 0.09) and a significant correlation was found between the E/e' ratio and both the triangular index (r = -0.26; p = 0.022) and LF amplitude (r = -0.29; p = 0.011).Conclusions: In T2DM patients an impairment of endothelium-independent, but not endothelium-dependent, dilatation seems associated with LV diastolic dysfunction. The possible role of cardiac autonomic dysfunction in diastolic dysfunction deserves investigation in larger populations of patients. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome

Author

Lanza, Gaetano Antonio, primary, Ruscio, Eleonora, additional, Ingrasciotta, Gessica, additional, Felici, Tamara, additional, Filice, Monica, additional, De Vita, Antonio, additional, Tremamunno, Saverio, additional, Villano, Angelo, additional, and Crea, Filippo, additional

Published
2020
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26. Endothelial dysfunction and cardiovascular outcome in asymptomatic patients with type 2 diabetes: A pilot study

Author

Villano, Angelo, primary, Mencarelli, Erica, additional, Melita, Veronica, additional, Rizzi, Alessandro, additional, Lamendola, Priscilla, additional, De Vita, Antonio, additional, Manfredonia, Laura, additional, Ravenna, Salvatore Emanuele, additional, Pitocco, Dario, additional, Lanza, Gaetano Antonio, additional, and Crea, Filippo, additional

Published
2019
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30. Relation of vascular dilator function and cardiac autonomic function with coronary angiography findings in patients with non-ST segment elevation acute coronary syndrome

Author

Lanza, Gaetano Antonio, Ruscio, Eleonora, Ingrasciotta, Gessica, Felici, Tamara, Filice, Monica, De Vita, Antonio, Tremamunno, Saverio, Villano, Angelo, and Crea, Filippo

Abstract

Background A sizeable number of patients with a diagnosis of non-ST segment elevation acute coronary syndrome show non-obstructive coronary artery disease. In this study we assessed whether differences in vascular and cardiac autonomic function exist between non-ST segment elevation acute coronary syndrome patients with obstructive or non-obstructive coronary artery disease.Methods and results Systemic endothelium-dependent and independent vascular dilator function (assessed by flow-mediated dilation and nitrate-mediated dilation of the brachial artery, respectively) and cardiac autonomic function (assessed by time-domain and frequency-domain heart rate variability parameters) were assessed on admission in 120 patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Patients were divided into two groups according to coronary angiography findings: (a) 59 (49.2%) with obstructive coronary artery disease (≥50% stenosis in any epicardial arteries); (b) 61 (50.8%) with non-obstructive coronary artery disease. No significant differences between the two groups were found in both flow-mediated dilation (5.03 ± 2.6 vs. 5.40 ± 2.5%, respectively; P= 0.37) and nitrate-mediated dilatation (6.79 ± 2.8 vs. 7.30 ± 3.4%, respectively; P= 0.37). No significant differences were also observed between the two groups both in time-domain and frequency-domain heart rate variability variables, although the triangular index tended to be lower in obstructive coronary artery disease patients (30.2 ± 9.5 vs. 33.9 ± 11.6, respectively; P= 0.058). Neither vascular nor heart rate variability variables predicted the recurrence of angina, requiring emergency room admission or re-hospitalisation, during 11.3 months of follow-up.Conclusions Among patients admitted with a diagnosis of non-ST segment elevation acute coronary syndrome we found no significant differences in systemic vascular dilator function and cardiac autonomic function between those with obstructive coronary artery disease and those with non-obstructive coronary artery disease.

Published
2024
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35. Primary Stable Microvascular Angina

Author

Lanza, Gaetano Antonio, primary, Filice, Monica, additional, De Vita, Antonio, additional, Lamendola, Priscilla, additional, Villano, Angelo, additional, Spera, Francesco, additional, Golino, Michele, additional, Rota, Elisabetta, additional, Argirò, Alessia, additional, and Crea, Filippo, additional

Published
2017
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40. Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus

Author

Paneni, Francesco, primary, Costantino, Sarah, additional, Battista, Rodolfo, additional, Castello, Lorenzo, additional, Capretti, Giuliana, additional, Chiandotto, Sergio, additional, Scavone, Giuseppe, additional, Villano, Angelo, additional, Pitocco, Dario, additional, Lanza, Gaetano, additional, Volpe, Massimo, additional, Lüscher, Thomas F., additional, and Cosentino, Francesco, additional

Published
2015
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42. Abstract 11684: Impaired Cortical Pain Processing in Patients With Silent Myocardial Ischemia

Author

Di Franco, Antonino, primary, Lanza, Gaetano A, additional, Valeriani, Massimiliano, additional, Villano, Angelo, additional, Russo, Giulio, additional, Sestito, Alfonso, additional, Virdis, Daniela, additional, Pazzaglia, Costanza, additional, Sarullo, Filippo M, additional, Rossini, Paolo M, additional, Crea, Filippo, additional, and Vollono, Catello, additional

Published
2014
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43. Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Author

Paneni, Francesco, primary, Costantino, Sarah, additional, Castello, Lorenzo, additional, Battista, Rodolfo, additional, Capretti, Giuliana, additional, Chiandotto, Sergio, additional, D'Amario, Domenico, additional, Scavone, Giuseppe, additional, Villano, Angelo, additional, Rustighi, Alessandra, additional, Crea, Filippo, additional, Pitocco, Dario, additional, Lanza, Gaetano, additional, Volpe, Massimo, additional, Del Sal, Giannino, additional, Lüscher, Thomas F., additional, and Cosentino, Francesco, additional

Published
2014
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44. Endothelial and Platelet Function in Children With Previous Kawasaki Disease

Author

Laurito, Marianna, primary, Stazi, Alessandra, additional, Delogu, Angelica B., additional, Milo, Maria, additional, Battipaglia, Irma, additional, Scalone, Giancarla, additional, Infusino, Fabio, additional, Villano, Angelo, additional, Russo, Giulio, additional, Iannotta, Rossella, additional, Saracino, Annalisa, additional, Parrinello, Rossella, additional, Figliozzi, Stefano, additional, Sestito, Alfonso, additional, Romagnoli, Costantino, additional, Lanza, Gaetano A., additional, and Crea, Filippo, additional

Published
2013
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45. Effect of ranolazine on arterial endothelial function in patients with type 2 diabetes mellitus

Author

Lamendola, Priscilla, primary, Nerla, Roberto, additional, Pitocco, Dario, additional, Villano, Angelo, additional, Scavone, Giuseppe, additional, Stazi, Alessandra, additional, Russo, Giulio, additional, Di Franco, Antonino, additional, Sestito, Alfonso, additional, Ghirlanda, Giovanni, additional, Lanza, Gaetano A., additional, and Crea, Filippo, additional

Published
2013
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46. Endothelial dysfunction and cardiovascular outcome in asymptomatic patients with type 2 diabetes: A pilot study.

Author

Villano, Angelo, Mencarelli, Erica, Melita, Veronica, Rizzi, Alessandro, Lamendola, Priscilla, De Vita, Antonio, Manfredonia, Laura, Ravenna, Salvatore Emanuele, Pitocco, Dario, Lanza, Gaetano Antonio, and Crea, Filippo

Subjects
TYPE 2 diabetes, CARDIOVASCULAR diseases risk factors, ENDOTHELIUM diseases, BRACHIAL artery, CARDIOVASCULAR diseases, PILOT projects, BLOOD sugar analysis, ENDOTHELIUM, PROGNOSIS, DISEASE incidence, LONGITUDINAL method
Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular events, but risk stratification of asymptomatic T2DM patients remains a challenging issue. We conducted a pilot study to assess whether endothelial dysfunction might help identify, among asymptomatic T2DM patients, those at increased risk of cardiovascular events.Methods: We studied 61 consecutive T2DM patients with no evidence of cardiovascular disease and no insulin therapy. Endothelial function was assessed by flow-mediated dilation (FMD) of the right brachial artery. The primary endpoint was a combination of major cardiovascular events (MACE: cardiovascular death, acute coronary events, coronary interventions, and acute cerebrovascular accidents). FMD was repeated at follow-up in 48 patients (79%).Results: A total of 10 MACE (16.4%) occurred during a mean follow-up of 48 months, including three acute myocardial infarctions, five coronary revascularizations for stable angina, and two acute ischaemic strokes. FMD at enrolment was lower in patients with compared with patients without MACE (3.78 ± 0.97% vs 4.70 ± 1.33%, respectively; P = .04). No other clinical or laboratory variables (age, diabetes duration, glycated haemoglobin, cardiovascular risk factors, drug therapy, and nitrate-mediated dilation) were associated with MACE. FMD at follow-up was also lower in patients with (n = 10) compared with those without (n = 38) MACE (3.66 ± 1.29 vs 4.85 ± 1.92; P = .006).Conclusions: Our data suggest that assessment of FMD might be helpful to identify patients at increased risk of MACE among individuals with asymptomatic T2DM; accordingly, a large study is warranted to adequately define the clinical utility of FMD assessment in the management of T2DM patients. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Author

Massimo Volpe, Giuseppe Scavone, Rodolfo Battista, Angelo Villano, Sergio Chiandotto, Giuliana Capretti, Giannino De Sal, Thomas F. Lüscher, Lorenzo Del Castello, Francesco Cosentino, Alessandra Rustighi, Sarah Costantino, Filippo Crea, Francesco Paneni, Domenico D'Amario, Gaetano Antonio Lanza, Dario Pitocco, University of Zurich, Cosentino, Francesco, Paneni, Francesco, Costantino, Sarah, Castello, Lorenzo, Battista, Rodolfo, Capretti, Giuliana, Chiandotto, Sergio, D'Amario, Domenico, Scavone, Giuseppe, Villano, Angelo, Rustighi, Alessandra, Crea, Filippo, Pitocco, Dario, Lanza, Gaetano, Volpe, Massimo, DEL SAL, Giannino, and Lüscher, Thomas F

Subjects
Male, Mitochondrial Diseases, Shc Signaling Adaptor Protein, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, Mitochondrion, medicine.disease_cause, Inbred C57BL, Mice, Diabetes mellitus, Enos, Mitochondrial Disease, Endothelial dysfunction, Cells, Cultured, Aorta, Chemokine CCL2, Endothelial Cell, Cultured, biology, NF-kappa B, Cytochromes c, Peptidylprolyl Isomerase, Intercellular Adhesion Molecule-1, Cell biology, Up-Regulation, Nitric oxide synthase, Gene Knockdown Techniques, 10209 Clinic for Cardiology, medicine.symptom, Case-Control Studie, Reactive Oxygen Specie, Cardiology and Cardiovascular Medicine, Human, Vasculitis, Diabetes mellitu, medicine.medical_specialty, Src Homology 2 Domain-Containing, Transforming Protein 1, Nitric Oxide Synthase Type III, Diabetic Angiopathie, Cells, Vascular Cell Adhesion Molecule-1, Inflammation, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, Internal medicine, Vascular, medicine, Animals, Humans, Endothelium, Endothelial function, Oxidative stress, Analysis of Variance, Case-Control Studies, Diabetic Angiopathies, Endothelial Cells, Endothelium, Vascular, Glucose, Hyperglycemia, Mice, Inbred C57BL, Nitric Oxide Synthase, Oxidative Stress, Reactive Oxygen Species, Shc Signaling Adaptor Proteins, Peptidylprolyl isomerase, Animal, business.industry, Vascular disease, Oxidative Stre, medicine.disease, biology.organism_classification, NIMA-Interacting Peptidylprolyl Isomerase, Endocrinology, Gene Knockdown Technique, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, biology.protein, business
Abstract

AIM: Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease. METHODS AND RESULTS: In human aortic endothelial cells (HAECs) exposed to high glucose, up-regulation of Pin1-induced mitochondrial translocation of pro-oxidant adaptor p66(Shc) and subsequent organelle disruption. In this setting, Pin1 recognizes Ser-116 inhibitory phosphorylation of endothelial nitric oxide synthase (eNOS) leading to eNOS-caveolin-1 interaction and reduced NO availability. Pin1 also mediates hyperglycaemia-induced nuclear translocation of NF-κB p65, triggering VCAM-1, ICAM-1, and MCP-1 expression. Indeed, gene silencing of Pin1 in HAECs suppressed p66(Shc)-dependent ROS production, restored NO release and blunted NF-kB p65 nuclear translocation. Consistently, diabetic Pin1(-/-) mice were protected against mitochondrial oxidative stress, endothelial dysfunction, and vascular inflammation. Increased expression and activity of Pin1 were also found in peripheral blood monocytes isolated from diabetic patients when compared with age-matched healthy controls. Interestingly, enough, Pin1 up-regulation was associated with impaired flow-mediated dilation, increased urinary 8-iso-prostaglandin F2α and plasma levels of adhesion molecules. CONCLUSIONS: Pin1 drives diabetic vascular disease by causing mitochondrial oxidative stress, eNOS dysregulation as well as NF-kB-induced inflammation. These findings provide molecular insights for novel mechanism-based therapeutic strategies in patients with diabetes.

Published
2015

49. Corrigendum: Assessment of the Ischaemic Effects of Myocardial Bridge by Echocardiographic Exercise Stress Test.

Author

Lamendola P, Cambise N, Di Renzo A, Tinti L, De Vita A, Tremamunno S, Pastena P, Belmusto A, Montone RA, Rinaldi R, Villano A, and Lanza GA

Abstract

[This corrects the article DOI: 10.15420/ecr.2024.03.]., Competing Interests: Disclosure:The authors have no conflicts of interest to declare., (Copyright © The Author(s), 2024. Published by Radcliffe Group Ltd.)

Published
2024
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50. Assessment of the Ischaemic Effects of Myocardial Bridge by Echocardiographic Exercise Stress Test.

Author

Lamendola P, Cambise N, Di Renzo A, Tinti L, De Vita A, Tremamunno S, Pastena P, Belmusto A, Montone R, Rinaldi R, Villano A, and Lanza GA

Abstract

Background: Detection of myocardial bridge (MB) at angiography suggests it has a role in ischaemic-related symptoms in patients with angina without obstructive coronary artery disease. However, evidence that MB may cause myocardial ischaemia is limited., Methods: We studied 41 patients with MB of the left anterior descending coronary artery and otherwise normal coronary arteries. Fourteen patients with normal coronary arteries and without MB served as controls. All subjects underwent a maximal treadmill exercise stress test (EST) under ECG monitoring. Standard and speckle-tracking echocardiography were performed at baseline and immediately after peak EST., Results: EST duration and peak heart rate and systolic pressure were similar in the two groups. A positive EST (ST-segment depression .1 mm) was found in 18 patients in the MB group (43.9%) and none in the control group (p=0.001). No abnormalities in both left ventricle systolic and diastolic function were found between the two groups in the standard echocardiographic evaluation. Global and segmental (anterior, inferior) longitudinal strain (LS) did not differ at baseline between the groups. There was a small increase in global LS during EST in MB patients but not in the control group (p=0.01). Similar trends were found for regional LSs, with differences being significant for the medium (p=0.028) and apical (p=0.032) anterior segments. No differences in echocardiographic parameters and both global and segmental LSs were observed between MB patients with ischaemic ECG changes during EST versus those without., Conclusion: Our findings do not support the notion that MB results in significant degrees of myocardial ischaemia during maximal myocardial work., Competing Interests: Disclosure: GAL is on the European Cardiology Review editorial board; this did not influence peer review. All other authors have no conflicts of interest to declare. Data availability: Data are available on request from the corresponding author Authors’ contributions: Conceptualisation: GAL; data curation: NC, ST, PP, RM; formal analysis: GAL, ADV; investigation: PL; ADR, LT, RR; software: AV, AB; writing: GAL. Ethics: Ethical approval was obtained from the Ethics Committee of Fondazione Policlinico a. Gemelli IRCCS – Università Cattolica del Sacro Cuore (PRVOKE study; prot. 5804). The study was carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki). Consent: Written informed consent was obtained from each patient who agreed to participate., (Copyright © The Author(s), 2024. Published by Radcliffe Group Ltd.)

Published
2024
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