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13 results on '"Villamil-Ramirez, Hugo"'

2. Prediction of eye, hair and skin colour in Latin Americans

Author

Palmal, Sagnik, Adhikari, Kaustubh, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Silva de Cerqueira, Caio Cesar, Bonfante, Betty, Chacón-Duque, Juan Camilo, Sohail, Anood, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Jaramillo, Claudia, Arias, William, Lozano, Rodrigo Barquera, Everardo-Martínez, Paola, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hünemeier, Tábita, Ramallo, Virginia, Parolin, Maria-Laura, Gonzalez-José, Rolando, Schüler-Faccini, Lavinia, Bortolini, Maria-Cátira, Acuña-Alonzo, Victor, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Bedoya, Gabriel, Rothhammer, Francisco, Balding, David, Faux, Pierre, and Ruiz-Linares, Andrés

Published
2021
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3. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Author

Xiong, Xuelian, Kuang, Henry, Ansari, Sahar, Liu, Tongyu, Gong, Jianke, Wang, Shuai, Zhao, Xu-Yun, Ji, Yewei, Li, Chuan, Guo, Liang, Zhou, Linkang, Chen, Zhimin, Leon-Mimila, Paola, Chung, Meng Ting, Kurabayashi, Katsuo, Opp, Judy, Campos-Pérez, Francisco, Villamil-Ramírez, Hugo, Canizales-Quinteros, Samuel, Lyons, Robert, Lumeng, Carey N., Zhou, Beiyan, Qi, Ling, Huertas-Vazquez, Adriana, Lusis, Aldons J., Xu, X.Z. Shawn, Li, Siming, Yu, Yonghao, Li, Jun Z., and Lin, Jiandie D.

Published
2019
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4. Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease

Author

Macias-Kauffer, Luis R., Villamil-Ramírez, Hugo, León-Mimila, Paola, Jacobo-Albavera, Leonor, Posadas-Romero, Carlos, Posadas-Sánchez, Rosalinda, López-Contreras, Blanca E., Morán-Ramos, Sofía, Romero-Hidalgo, Sandra, Acuña-Alonzo, Víctor, del-Río-Navarro, Blanca E., Bortolini, Maria-Cátira, Gallo, Carla, Bedoya, Gabriel, Rothhammer, Francisco, González-Jose, Rolando, Ruiz-Linares, Andrés, Stephens, Christopher R., Velazquez-Cruz, Rafael, Fernández del Valle-Laisequilla, Cecilia, Reyes-García, Juan G., Barranco Garduño, Lina M., Carrasco-Portugal, Miriam del C., Flores-Murrieta, Francisco J., Vargas-Alarcón, Gilberto, Aguilar-Salinas, Carlos A., Villarreal-Molina, Teresa, and Canizales-Quinteros, Samuel

Published
2019
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5. Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

Author

Faux, Pierre, Ding, Li, Miguel Ramirez-Aristeguieta, Luis, Chacón-Duque, J. Camilo, Comini, Maddalena, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Jaramillo, Claudia, Arias, William, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Barquera, Rodrigo, Everardo-Martinez, Paola, Quinto-Sanchez, Mirsha, Gomez-Valdes, Jorge, Villamil-Ramirez, Hugo, Silva de Cerqueira, Caio C., Hunemeier, Tabita, Ramallo, Virginia, Gonzalez-Jose, Rolando, Schuler-Faccini, Lavinia, Bortolini, Maria-Catira, Acuna-Alonzo, Victor, Canizales-Quinteros, Samuel, Poletti, Giovanni, Gallo, Carla, Rothhammer, Francisco, Rojas, Winston, Schmid, Annina B., Adhikari, Kaustubh, Bennett, David L., Ruiz-Linares, Andres, Faux, Pierre, Ding, Li, Miguel Ramirez-Aristeguieta, Luis, Chacón-Duque, J. Camilo, Comini, Maddalena, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Jaramillo, Claudia, Arias, William, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Barquera, Rodrigo, Everardo-Martinez, Paola, Quinto-Sanchez, Mirsha, Gomez-Valdes, Jorge, Villamil-Ramirez, Hugo, Silva de Cerqueira, Caio C., Hunemeier, Tabita, Ramallo, Virginia, Gonzalez-Jose, Rolando, Schuler-Faccini, Lavinia, Bortolini, Maria-Catira, Acuna-Alonzo, Victor, Canizales-Quinteros, Samuel, Poletti, Giovanni, Gallo, Carla, Rothhammer, Francisco, Rojas, Winston, Schmid, Annina B., Adhikari, Kaustubh, Bennett, David L., and Ruiz-Linares, Andres

Abstract

The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of similar to 123kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function. Neanderthal-derived variants in the SCN9A gene (encoding the voltage gated sodium channel, Nav1.7) are associated with enhanced experimental mechanical pain sensitivity in modern humans.

Published
2023
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6. A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity

Author

León-Mimila, Paola, Vega-Badillo, Joel, Gutiérrez-Vidal, Roxana, Villamil-Ramírez, Hugo, Villareal-Molina, Teresa, Larrieta-Carrasco, Elena, López-Contreras, Blanca E., Kauffer, Luis R. Macías, Maldonado-Pintado, Diana G., Méndez-Sánchez, Nahúm, Tovar, Armando R., Hernández-Pando, Rogelio, Velázquez-Cruz, Rafael, Campos-Pérez, Francisco, Aguilar-Salinas, Carlos A., and Canizales-Quinteros, Samuel

Published
2015
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7. A dysregulated bile acids pool is associated with metabolic syndrome and gut microbial dysbiosis in early adolescence.

Author

Mancera‐Hurtado, Yesenia, Lopez‐Contreras, Blanca E., Flores‐Lopez, Regina, Villamil‐Ramirez, Hugo, del Rio‐Navarro, Blanca E., Canizales‐Quinteros, Samuel, and Moran‐Ramos, Sofia

Subjects
METABOLIC syndrome, BILE acids, LIQUID chromatography-mass spectrometry, DYSBIOSIS, GUT microbiome
Abstract

Objective: The increased prevalence of childhood metabolic syndrome (MetS) is a public health issue. It has been shown that a dysregulated bile acid (BA) profile could be involved in the development of MetS, in which the gut microbiota could have a significant role in BA levels. This study aimed to evaluate differences in serum BA levels in children with and without MetS and whether these levels were associated with gut microbial composition. Methods: A total of 100 children aged 10 to 12 years were enrolled in this study, 42 children with MetS (cases) and 58 control participants. Serum BAs were measured by liquid chromatography‐tandem mass spectrometry and gut microbiota was determined by 16S ribosomal RNA gene sequencing. Results: Children with MetS showed higher levels of total, secondary, and 12α‐hydroxylated BAs, as well as deoxycholic acid, and these were associated with dyslipidemia and insulin resistance markers. Interestingly, total BAs were negatively correlated with gut bacterial diversity (Shannon index: rho = −0.218, p = 0.035), whereas total, 12α‐hydroxylated, and secondary BAs, as well as deoxycholic acid, showed negative correlations with genera known for their potential health effects, including Bifidobacterium, Akkermansia, and Faecalibacterium. Conclusions: This study suggests that childhood MetS is associated with a dysregulated BA pool and that these alterations could influence the abundance of potentially beneficial bacteria, thus contributing to gut microbial dysbiosis. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children

Author

Flores-Dorantes, Teresa, Arellano-Campos, Olimpia, Posadas-Sánchez, Rosalinda, Villarreal-Molina, Teresa, Medina-Urrutia, Aida, Romero-Hidalgo, Sandra, Yescas-Gómez, Petra, Pérez-Méndez, Oscar, Jorge-Galarza, Esteban, Tusié-Luna, Teresa, Villalobos-Comparán, Marisela, Jacobo-Albavera, Leonor, Villamil-Ramírez, Hugo, López-Contreras, Blanca E., Aguilar-Salinas, Carlos A., Posadas-Romero, Carlos, and Canizales-Quinteros, Samuel

Published
2010
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9. Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults

Author

Martinez-Medina, Jennifer N., primary, Flores-Lopez, Regina, additional, López-Contreras, Blanca E., additional, Villamil-Ramirez, Hugo, additional, Guzman-Muñoz, Daniela, additional, Macias-Kauffer, Luis R., additional, León-Mimila, Paola, additional, Granados-Portillo, Omar, additional, Del-Rio-Navarro, Blanca E., additional, Gómez-Perez, Francisco J., additional, Aguilar-Salinas, Carlos A., additional, Torres, Nimbe, additional, Tovar, Armando R., additional, Canizales-Quinteros, Samuel, additional, and Moran-Ramos, Sofia, additional

Published
2021
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10. Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: A population-based study

Author

Moran-Ramos, Sofia, primary, Lopez-Contreras, Blanca E., additional, Villarruel-Vazquez, Ricardo, additional, Ocampo-Medina, Elvira, additional, Macias-Kauffer, Luis, additional, Martinez-Medina, Jennifer N., additional, Villamil-Ramirez, Hugo, additional, León-Mimila, Paola, additional, Del Rio-Navarro, Blanca E., additional, Ibarra-Gonzalez, Isabel, additional, Vela-Amieva, Marcela, additional, Gomez-Perez, Francisco J, additional, Velazquez-Cruz, Rafael, additional, Salmeron, Jorge, additional, Reyes-Castillo, Zyanya, additional, Aguilar-Salinas, Carlos, additional, and Canizales-Quinteros, Samuel, additional

Published
2020
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11. Serum Branched Chain and Aromatic Amino Acids Are Associated to Overweight, Obesity and Metabolic Alterations in School‐Aged Children

Author

Ocampo‐Medina, Elvira, primary, Moran‐Ramos, Sofia, additional, Macias‐Kauffer, Luis, additional, Lopez‐Contreras, Blanca E, additional, Villamil‐Ramirez, Hugo, additional, Leon‐Mimila, Paola, additional, Villarruel‐Vazquez, Ricardo, additional, Ibarra‐Gonzalez, Isabel, additional, Vela‐Amieva, Marcela, additional, and Canizales‐Quinteros, Samuel, additional

Published
2017
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12. The Influence of Habitual Food Intake on Fecal Microbiota in Mexican School‐Age Children

Author

MARTINEZ‐MEDINA, JENNIFER NAZAT, primary, López‐Contreras, Blanca Estela, additional, Ocampo‐Medina, Elvira, additional, Villarruel‐Vazquez, Ricardo, additional, Villamil‐Ramirez, Hugo, additional, Leon‐Mimila, Paola, additional, Grey‐Lievanos, Paola, additional, Canizales‐Quinteros, Samuel, additional, and Moran‐Ramos, Sofia, additional

Published
2017
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