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1. The effect of breakfast skipping and sleep disorders on glycemic control, cardiovascular risk, and weight loss in type 2 diabetes

Author

Minari, Tatiana Palotta, Manzano, Carolina Freitas, Yugar, Louise Buonalumi Tácito, Sedenho-Prado, Luis Gustavo, de Azevedo Rubio, Tatiane, Tácito, Lúcia Helena Bonalumi, Pires, Antônio Carlos, Vilela-Martin, José Fernando, Cosenso-Martin, Luciana Neves, Ludovico, Nelson Dinamarco, Fattori, André, Yugar-Toledo, Juan Carlos, Moreno, Heitor, and Pisani, Luciana Pellegrini

Published
2025
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2. Carotid intima-media thickness is associated with cognitive deficiency in hypertensive patients with elevated central systolic blood pressure

Author

Dias Eros da Mota, Giollo Luiz, Martinelli Débora, Mazeti Camila, Júnior Heitor, Vilela-Martin José, and Yugar-Toledo Juan

Subjects
Hypertension, Cognitive impairment, Intima-media thickness, Central systolic blood pressure, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The role of hypertension in the loss of cognitive function is controversial. Relationships between hypertension and increases in cerebral vascular resistance, diffused lesions and multiple lacunar infarcts of the white matter are well known. Thus, the objectives of this study were: to evaluate the relationship between hypertension and cognitive dysfunction (CD), identify risk factors and determine the association between early markers of vascular disease and CD in hypertensive individuals. Methods Two hundred individuals aged between 40 and 80 years old were evaluated in this cross-sectional prospective study. Fifty participants were controls (CT). The remaining 150 hypertensive patients were subdivided into two groups, those with CD (HCD) and those without CD (HNCD). All participants underwent clinical evaluations and biochemical blood tests were performed. CD was investigated using the Mini Mental State Examination (MMSE) following the guidelines for its use in Brazil. The impact of hypertension on the arterial bed was assessed by identifying and measuring changes in the intima-media thickness (IMT) by vascular ultrasonography of the carotid arteries and analyses of the central blood pressure and Augmentation Index by applanation tonometry of the radial artery. Results There were no significant differences in the total cholesterol, high-density lipoprotein cholesterol and triglycerides plasma concentrations between the three groups. The serum creatinine and estimated glomerular filtration rate were within normal ranges for all three groups. A significantly lower MMSE score was recorded for the HCD Group compared to the HNCD and CT Groups (p-value The IMT was significantly different between the HNCD and HCD Groups (p-value = 0.0124). A significant difference in the IMT was also observed between hypertensive patients and the CT Group (p-value The central systolic pressure was significantly higher in the HCD and HNCD Groups compared to CT Group (p-value Conclusions Hypertensive patients with CD have changes in the vascular morphology characterized by an increased carotid IMT, enhanced atherosclerotic lipid profile and impaired hemodynamic functional manifested by elevated central systolic blood pressure.

Published
2012
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3. Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-prevention trial

Author

Neto José, Pereira e Silva Ricardo, Filho Dario, Alves João, Chaves Hilton, Mota Marco, Scala Luiz, Neto Abrahão, Jardim Paulo, Ribeiro Antônio, de Sousa Marcos R, Brandão Andréa, Franco Roberto, Cesarino Evandro, Moreno Heitor, Vilela-Martin José F, Coelho Eduardo, Nobre Fernando, Consolim-Colombo Fernanda, Bortoloto Luiz, Mion Décio, Poli-de-Figueiredo Carlos E, Nóbrega Antônio C, Gus Miguel, Moreira Leila B, Fuchs Sandra C, Fuchs Flávio D, Irigoyen Maria, Castro Iran, Steffens André, Schlatter Rosane, de Mello Renato, Mosele Francisca, Ghizzoni Flávia, and Berwanger Otávio

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Blood pressure (BP) within pre-hypertensive levels confers higher cardiovascular risk and is an intermediate stage for full hypertension, which develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of age. Non-drug interventions to prevent hypertension have had low effectiveness. In individuals with previous cardiovascular disease or diabetes, the use of BP-lowering agents reduces the incidence of major cardiovascular events. In the absence of higher baseline risk, the use of BP agents reduces the incidence of hypertension. The PREVER-prevention trial aims to investigate the efficacy, safety and feasibility of a population-based intervention to prevent the incidence of hypertension and the development of target-organ damage. Methods This is a randomized, double-blind, placebo-controlled clinical trial, with participants aged 30 to 70 years, with pre-hypertension. The trial arms will be chlorthalidone 12.5 mg plus amiloride 2.5 mg or identical placebo. The primary outcomes will be the incidence of hypertension, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new sub-clinical atherosclerosis, and sudden death. The study will last 18 months. The sample size was calculated on the basis of an incidence of hypertension of 14% in the control group, a size effect of 40%, power of 85% and P alpha of 5%, resulting in 625 participants per group. The project was approved by the Ethics committee of each participating institution. Discussion The early use of blood pressure-lowering drugs, particularly diuretics, which act on the main mechanism of blood pressure rising with age, may prevent cardiovascular events and the incidence of hypertension in individuals with hypertension. If this intervention shows to be effective and safe in a population-based perspective, it could be the basis for an innovative public health program to prevent hypertension in Brazil. Trial Registration Clinical Trials NCT00970931.

Published
2011
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4. A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial

Author

Figueiredo Neto José A, e Silva Ricardo, Sobral Filho Dario C, Alves João, Chaves Hilton, Mota Marco, Scala Luiz, Neto Abrahão, Jardim Paulo, Pinho Ribeiro Antônio, de Sousa Marcos R, Brandão Andréa, Franco Roberto, Cesarino Evandro, Moreno Heitor, Vilela-Martin José F, Coelho Eduardo, Nobre Fernando, Consolim-Colombo Fernanda, Bortolotto Luiz, Mion Décio, Poli-de-Figueiredo Carlos E, Nóbrega Antônio C, Gus Miguel, Moreira Leila B, Fuchs Sandra C, Fuchs Flávio D, Irigoyen Maria, Castro Iran, Steffens André, Schlatter Rosane, de Mello Renato, Mosele Francisca, Ghizzoni Flávia, and Berwanger Otávio

Subjects
Medicine (General), R5-920
Abstract

Abstract Background Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted. Methods/design This is a randomized, double-blind, clinical trial, comparing the association of chlorthalidone and amiloride with losartan as first drug option in patients aged 30 to 70 years, with stage I hypertension. The primary outcomes will be variation of blood pressure by time, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new subclinical atherosclerosis and sudden death. The study will last 18 months. The sample size will be of 1200 participants for group in order to confer enough power to test for all primary outcomes. The project was approved by the Ethics committee of each participating institution. Discussion The putative pleiotropic effects of ARB agents, particularly renal protection, have been disputed, and they have been scarcely compared with diuretics in large clinical trials, despite that they have been at least as efficacious as newer agents in managing hypertension. Even if the null hypothesis is not rejected, the information will be useful for health care policy to treat hypertension in Brazil. Clinical trials registration number ClinicalTrials.gov: NCT00971165

Published
2011
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5. The Possible Impact of COVID-19 on Glycated Hemoglobin and Systolic Blood Pressure in Type 2 Diabetes and Obesity.

Author

Minari, Tatiana Palotta, Manzano, Carolina Freitas, Tácito Yugar, Louise Buonalumi, Sedenho-Prado, Luis Gustavo, Rubio, Tatiane de Azevedo, Tácito, Lúcia Helena Bonalumi, Pires, Antônio Carlos, Vilela-Martin, José Fernando, Cosenso-Martin, Luciana Neves, Ludovico, Nelson Dinamarco, Fattori, André, Yugar-Toledo, Juan Carlos, Moreno, Heitor, and Pisani, Luciana Pellegrini

Subjects
SYSTOLIC blood pressure, COVID-19, TYPE 2 diabetes, GLYCOSYLATED hemoglobin, MEDICAL care
Abstract

Background: There are still discrepancies in the literature as to whether COVID-19 infection could impact biochemical, anthropometric, and cardiovascular markers. The purpose of this study was firstly to observe the effects of COVID-19 infection over 12 months on Type 2 diabetes (T2D) and obesity. Secondarily, we analyzed the individual influence of COVID-19 infection on changes in biochemical, anthropometric, and cardiovascular markers. Methods: This study is part of a secondary analysis of a recently published article. The research involved 84 participants with T2D, divided into two groups: the control group (40 participants) received only medical care, while the intervention group (44 participants) received both medical care and nutritional assessment. Consultations were held quarterly over 12 months, with a follow-up after 3 months. Data Analysis: For influence analysis, non-normal variables were compared using the Mann–Whitney test, and normal variables were compared using unpaired t-tests. For all cases, α = 0.05 and p < 0.05 were considered significant. Results: The analysis revealed a high percentage of patients in both groups who had a COVID-19 infection (70% control and 72.7% intervention) over 12 months. Regarding the influence analysis, participants in the intervention group who were infected with COVID-19 showed smaller reductions in glycated hemoglobin (HbA1c) (p = 0.0120) and systolic blood pressure (SBP) (p = 0.0460). For the other biochemical, anthropometric, and cardiovascular markers, in both groups, no significant differences were found (p > 0.05). Conclusion: COVID-19 possibly influenced SBP and HbA1c levels over 12 months in people with T2D and obesity. However, caution should be exercised in generalizing these results due to the limitations of this study. Additionally, influence analysis does not establish a causal relationship, and more clinical trials in different populations are needed to fully analyze this topic. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers

Author

Casas, Alberto de Almeida Las, Costa, Altamiro Reis da, Assis, Amberson Vieira de, Durães, André Rodrigues, Pereira-Barretto, Antonio Carlos, Ravessa, Antonio Delduque de Araujo, Macedo, Ariane Vieira Scarlatelli, Biselli, Bruno, Pinto, Carolina Maria Nogueira, Filho, Conrado Roberto Hoffmann, Costantini, Costantino Roberto, Almeida, Dirceu Rodrigues, Santos, Edval Gomes dos, Jr, Soliva, Erwin, Junior, Figueiredo, Estevão Lanna, Albuquerque, Felipe Neves de, Paulitsch, Felipe, Neuenschwander, Fernando Carvalho, Figueiredo, José Albuquerque de, Neto, Brito, Flavio de Souza, Lopes, Heno Ferreira, Villacorta, Humberto, Souza, João David de, Neto, Sepulveda, João Mariano, Ayoub, José Carlos Aidar, Vilela-Martin, José F., Cardoso, Juliano Novaes, Uemura, Laercio, Moura, Lidia Zytynski, Maia, Lilia Nigro, Oliveira, Lucia Brandão de, Maia, Lucimir, Silva, Luís Beck da, Gowdak, Luís Henrique Wolff, Danzmann, Luiz Claudio, Andrade, Marcus, Braile-Sternieri, Maria Christiane Valeria Braga, Moreira, Maria da Consolação Vieira, França, Olimpio R, Neto, Filho, Otavio Rizzi Coelho, Esteves, Paulo Frederico, Raupp-da-Rosa, Priscila, Silva, Ricardo Jorge de Queiroz e, Mourilhe-Rocha, Ricardo, Viégas, Ruy Felipe Melo, Rassi, Salvador, Mangili, Sandrigo, Kaiser, Sergio Emanuel, Martins, Silvia Marinho, Kawabata, Vitor Sergio, Bocchi, Edimar Alcides, Moreira, Henrique Turin, Nakamuta, Juliana Sanajotti, and Simões, Marcus Vinicius

Published
2021
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7. EFFECT OF SEQUENTIAL NEPHRON BLOCKADE X DUAL RENIN-ANGIOTENSIN SYSTEM BLOCKADE + BISOPROLOL IN THE TREATMENT OF RESISTANT HYPERTENSION, A RANDOMIZED CONTROLLED TRIAL (RESHYPOT)

Author

Cestario, Elizabeth Do Esp, primary, Vilela-martin, José Fernando, additional, Cosenso-martin, Luciana Neves, additional, Rubio, Tatiane Azevedo, additional, Uyemura, Jessica Rodrigue Roma, additional, Da Silva Lopes, Valquiria, additional, Fernandes, Letícia Aparecid Barufi, additional, Tacito, Lucia Helena Bonalume, additional, Junior, Heitor Moreno, additional, and Yugar-toledo, Juan Carlos, additional

Published
2024
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8. The Impact of a Nutritional Intervention on Glycemic Control and Cardiovascular Risk Markers in Type 2 Diabetes

Author

Minari, Tatiana Palotta, primary, Manzano, Carolina Freitas, additional, Tácito, Lúcia Helena Bonalume, additional, Yugar, Louise Buonalumi Tácito, additional, Sedenho-Prado, Luis Gustavo, additional, Rubio, Tatiane de Azevedo, additional, Pires, Antônio Carlos, additional, Vilela-Martin, José Fernando, additional, Cosenso-Martin, Luciana Neves, additional, Moreno, Heitor, additional, and Yugar-Toledo, Juan Carlos, additional

Published
2024
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9. Effects of Mindful Eating in Patients with Obesity and Binge Eating Disorder

Author

Minari, Tatiana Palotta, primary, Araújo-Filho, Gerardo Maria de, additional, Tácito, Lúcia Helena Bonalume, additional, Yugar, Louise Buonalumi Tácito, additional, Rubio, Tatiane de Azevedo, additional, Pires, Antônio Carlos, additional, Vilela-Martin, José Fernando, additional, Cosenso-Martin, Luciana Neves, additional, Fattori, André, additional, Yugar-Toledo, Juan Carlos, additional, and Moreno, Heitor, additional

Published
2024
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10. Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

Author

Fuchs, Flávio D., Scala, Luiz C. N., Vilela-Martin, José F., Whelton, Paul K., Poli-de-Figueiredo, Carlos E., Pereira E Silva, Ricardo, Gus, Miguel, Bortolotto, Luiz A., Consolim-Colombo, Fernanda M., Schlatter, Rosane P., Cesarino, José E., Castro, Iran, Figueiredo Neto, José A., Chaves, Hilton, Steffens, André A., Alves, João G., Brandão, Andréa A., de Sousa, Marcos R., Jardim, Paulo C., Moreira, Leila B., Franco, Roberto S., Gomes, Marco M., Afiune Neto, Abrahão, Fuchs, Felipe C., Sobral Filho, Dario C., Nóbrega, Antônio C., Nobre, Fernando, Berwanger, Otávio, and Fuchs, Sandra C.

Published
2021
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12. Brazilian Guidelines for In-office and Out-of-office Blood Pressure Measurement – 2023

Author

Feitosa, Audes Diogenes de Magalhães, primary, Barroso, Weimar Kunz Sebba, additional, Mion Junior, Decio, additional, Nobre, Fernando, additional, Mota-Gomes, Marco Antonio, additional, Jardim, Paulo Cesar Brandão Veiga, additional, Amodeo, Celso, additional, Oliveira, Adriana Camargo, additional, Alessi, Alexandre, additional, Sousa, Ana Luiza Lima, additional, Brandão, Andréa Araujo, additional, Pio-Abreu, Andrea, additional, Sposito, Andrei C., additional, Pierin, Angela Maria Geraldo, additional, Paiva, Annelise Machado Gomes de, additional, Spinelli, Antonio Carlos de Souza, additional, Machado, Carlos Alberto, additional, Poli-de-Figueiredo, Carlos Eduardo, additional, Rodrigues, Cibele Isaac Saad, additional, Forjaz, Claudia Lucia de Moraes, additional, Sampaio, Diogo Pereira Santos, additional, Barbosa, Eduardo Costa Duarte, additional, Freitas, Elizabete Viana de, additional, Cestario, Elizabeth do Espirito Santo, additional, Muxfeldt, Elizabeth Silaid, additional, Lima Júnior, Emilton, additional, Campana, Erika Maria Gonçalves, additional, Feitosa, Fabiana Gomes Aragão Magalhães, additional, Consolim-Colombo, Fernanda Marciano, additional, Almeida, Fernando Antônio de, additional, Silva, Giovanio Vieira da, additional, Moreno Júnior, Heitor, additional, Finimundi, Helius Carlos, additional, Guimarães, Isabel Cristina Britto, additional, Gemelli, João Roberto, additional, Barreto-Filho, José Augusto Soares, additional, Vilela-Martin, José Fernando, additional, Ribeiro, José Marcio, additional, Yugar-Toledo, Juan Carlos, additional, Magalhães, Lucélia Batista Neves Cunha, additional, Drager, Luciano F., additional, Bortolotto, Luiz Aparecido, additional, Alves, Marco Antonio de Melo, additional, Malachias, Marcus Vinícius Bolívar, additional, Neves, Mario Fritsch Toros, additional, Santos, Mayara Cedrim, additional, Dinamarco, Nelson, additional, Moreira Filho, Osni, additional, Passarelli Júnior, Oswaldo, additional, Vitorino, Priscila Valverde de Oliveira, additional, Miranda, Roberto Dischinger, additional, Bezerra, Rodrigo, additional, Pedrosa, Rodrigo Pinto, additional, Paula, Rogerio Baumgratz de, additional, Okawa, Rogério Toshiro Passos, additional, Póvoa, Rui Manuel dos Santos, additional, Fuchs, Sandra C., additional, Lima, Sandro Gonçalves de, additional, Inuzuka, Sayuri, additional, Ferreira-Filho, Sebastião Rodrigues, additional, Fillho, Silvio Hock de Paffer, additional, Jardim, Thiago de Souza Veiga, additional, Guimarães Neto, Vanildo da Silva, additional, Koch, Vera Hermina Kalika, additional, Gusmão, Waléria Dantas Pereira, additional, Oigman, Wille, additional, and Nadruz Junior, Wilson, additional

Published
2024
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13. Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023

Author

Feitosa, Audes Diogenes de Magalhães, primary, Barroso, Weimar Kunz Sebba, additional, Mion Junior, Decio, additional, Nobre, Fernando, additional, Mota-Gomes, Marco Antonio, additional, Jardim, Paulo Cesar Brandão Veiga, additional, Amodeo, Celso, additional, Oliveira, Adriana Camargo, additional, Alessi, Alexandre, additional, Sousa, Ana Luiza Lima, additional, Brandão, Andréa Araujo, additional, Pio-Abreu, Andrea, additional, Sposito, Andrei C., additional, Pierin, Angela Maria Geraldo, additional, Paiva, Annelise Machado Gomes de, additional, Spinelli, Antonio Carlos de Souza, additional, Machado, Carlos Alberto, additional, Poli-de-Figueiredo, Carlos Eduardo, additional, Rodrigues, Cibele Isaac Saad, additional, Forjaz, Claudia Lucia de Moraes, additional, Sampaio, Diogo Pereira Santos, additional, Barbosa, Eduardo Costa Duarte, additional, Freitas, Elizabete Viana de, additional, Cestario, Elizabeth do Espirito Santo, additional, Muxfeldt, Elizabeth Silaid, additional, Lima Júnior, Emilton, additional, Campana, Erika Maria Gonçalves, additional, Feitosa, Fabiana Gomes Aragão Magalhães, additional, Consolim-Colombo, Fernanda Marciano, additional, Almeida, Fernando Antônio de, additional, Silva, Giovanio Vieira da, additional, Moreno Júnior, Heitor, additional, Finimundi, Helius Carlos, additional, Guimarães, Isabel Cristina Britto, additional, Gemelli, João Roberto, additional, Barreto-Filho, José Augusto Soares, additional, Vilela-Martin, José Fernando, additional, Ribeiro, José Marcio, additional, Yugar-Toledo, Juan Carlos, additional, Magalhães, Lucélia Batista Neves Cunha, additional, Drager, Luciano F., additional, Bortolotto, Luiz Aparecido, additional, Alves, Marco Antonio de Melo, additional, Malachias, Marcus Vinícius Bolívar, additional, Neves, Mario Fritsch Toros, additional, Santos, Mayara Cedrim, additional, Dinamarco, Nelson, additional, Moreira Filho, Osni, additional, Passarelli Júnior, Oswaldo, additional, Vitorino, Priscila Valverde de Oliveira, additional, Miranda, Roberto Dischinger, additional, Bezerra, Rodrigo, additional, Pedrosa, Rodrigo Pinto, additional, Paula, Rogerio Baumgratz de, additional, Okawa, Rogério Toshiro Passos, additional, Póvoa, Rui Manuel dos Santos, additional, Fuchs, Sandra C., additional, Lima, Sandro Gonçalves de, additional, Inuzuka, Sayuri, additional, Ferreira-Filho, Sebastião Rodrigues, additional, Fillho, Silvio Hock de Paffer, additional, Jardim, Thiago de Souza Veiga, additional, Guimarães Neto, Vanildo da Silva, additional, Koch, Vera Hermina Kalika, additional, Gusmão, Waléria Dantas Pereira, additional, Oigman, Wille, additional, and Nadruz Junior, Wilson, additional

Published
2024
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14. Nutritional Strategies for the Management of Type 2 Diabetes Mellitus: A Narrative Review

Author

Minari, Tatiana Palotta, primary, Tácito, Lúcia Helena Bonalume, additional, Yugar, Louise Buonalumi Tácito, additional, Ferreira-Melo, Sílvia Elaine, additional, Manzano, Carolina Freitas, additional, Pires, Antônio Carlos, additional, Moreno, Heitor, additional, Vilela-Martin, José Fernando, additional, Cosenso-Martin, Luciana Neves, additional, and Yugar-Toledo, Juan Carlos, additional

Published
2023
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18. Correction to: Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

Author

Fuchs, Flávio D., Scala, Luiz C. N., Vilela-Martin, José F., Whelton, Paul K., Poli-de-Figueiredo, Carlos E., Pereira E Silva, Ricardo, Gus, Miguel, Bortolotto, Luiz A., Consolim-Colombo, Fernanda M., Schlatter, Rosane P., Cesarino, Evandro J., Castro, Iran, Figueiredo Neto, José A., Chaves, Hilton, Steffens, André A., Alves, João G., Brandão, Andréa A., de Sousa, Marcos R., Jardim, Paulo C., Moreira, Leila B., Franco, Roberto S., Gomes, Marco M., Afiune Neto, Abrahão, Fuchs, Felipe C., Sobral Filho, Dario C., Nóbrega, Antônio C., Nobre, Fernando, Berwanger, Otávio, and Fuchs, Sandra C.

Published
2021
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19. Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension – study protocol for a randomized controlled trial

Author

Cestário, Elizabeth do Espirito Santo, Fernandes, Letícia Aparecida Barufi, Giollo-Júnior, Luiz Tadeu, Uyemura, Jéssica Rodrigues Roma, Matarucco, Camila Suemi Sato, Landim, Manoel Idelfonso Paz, Cosenso-Martin, Luciana Neves, Tácito, Lúcia Helena Bonalume, Moreno Jr., Heitor, Vilela-Martin, José Fernando, and Yugar-Toledo, Juan Carlos

Published
2018
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20. Parâmetros da Hemodinâmica Central como Novos Biomarcadores de Risco Cardiovascular

Author

Vilela-Martin, José Fernando

Subjects
Adult, Male, Fatores de Risco, Pressão Sanguínea, Minieditorial, Blood Pressure, Hemodinâmica, Pulse Wave Analysis, Carotid Intima-Media Thickness, Vascular Diseases/prevention and control, Risk Factors, Humans, Diseases of the circulatory (Cardiovascular) system, Hemodynamic, Aged, Retrospective Studies, Middle Aged, Doenças Vasculares/prevenção e controle, Cross-Sectional Studies, RC666-701, Hypertension, Female, Short Editorial, Biomarkers, Análise da Onda de Pulso, Hipertensão
Abstract

The relationship between pulse wave velocity (PWV) and biomarkers of structural changes of the left ventricle and carotid arteries remains poorly understood.To investigate the relationship between PWV and these biomarkers.This was an analytical, retrospective, cross-sectional study. Medical records of patients with diabetes mellitus, dyslipidemia, and pre-hypertension or hypertension, who underwent central blood pressure (CBP) measurement using Mobil-O-Graph®, and carotid doppler or echocardiography three months before and after the CBPM were analyzed. Statistical analysis was performed using Pearson or Spearman correlation, linear bivariate and multiple regression analysis, and the t test (independent) or Mann-Whitney test. A p0.05 indicated statistical significance.Medical records of 355 patients were analyzed, mean age 56.1 (±14.8) years, 51% male. PWV was correlated with intima-media thickness (IMT) of carotids (r=0.310) and left ventricular septal thickness (r=0.191), left ventricular posterior wall thickness (r=0.215), and left atrial diameter (r=0.181). IMT was associated with PWV adjusted by age and peripheral systolic pressure (p=0.0004); IMT greater than 1 mm increased the chance of having PWV above 10 m/s by 3.94 times. PWV was significantly higher in individuals with left ventricular hypertrophy (p=0.0001), IMT1 mm (p=0.006), carotid plaque (p=0.0001), stenosis ≥ 50% (p=0.003), and target-organ damage (p=0.0001).PWV was correlated with IMT and echocardiographic parameters, and independently associated with IMT. This association was stronger in individuals with left ventricular hypertrophy, increased IMT, carotid plaque, stenosis ≥ 50%, and target organ damage. (Arq Bras Cardiol. 2020; 115(6):1125-1132).A relação entre velocidade de onda de pulso (VOP) e biomarcadores de mudanças estruturais do ventrículo esquerdo e artérias carótidas ainda é pouco elucidada.Investigar a relação entre VOP e esses biomarcadores.Estudo transversal, retrospectivo e analítico. Revisamos prontuários médicos de pacientes com diabetes mellitus, dislipidemia, e pré-hipertensão ou hipertensão, que realizaram medida de pressão arterial central (PAC) utilizando o Mobil-O-Graph®, e doppler de carótida ou ecocardiografia três meses antes ou após a medida da PAC. Análise estatística realizada por correlação de Pearson ou de Spearman, análise de regressão múltipla e de regressão bivariada, e teste t (independente) ou de Mann-Whitney. Um p0,05 indicou significância estatística.Prontuários de 355 pacientes foram avaliados, 56,1 ±14,8 anos, 51% homens. A VOP correlacionou-se com espessuras da íntima média (EIM) das carótidas (r=0,310) do septo do ventrículo esquerdo (r=0,191) e da parede posterior do ventrículo esquerdo (r=0.215), e com diâmetro do átrio esquerdo (r=0,181). A EIM associou-se com VOP ajustada por idade e pressão sistólica periférica (p=0,0004); uma EIM maior que 1mm aumentou em 3,94 vezes a chance de se apresentar VOP acima de 10m/s. A VOP foi significativamente maior em indivíduos com hipertrofia do ventrículo esquerdo (p=0,0001), EIM1 mm (p=0,006), placa de carótida (p=0,0001), estenose ≥ 50% (p=0,003), e lesões de órgãos-alvo (p=0,0001).A VOP correlacionou-se com a EIM e com parâmetros ecocardiográficos, e se associou independentemente com EIM. Essa associação foi mais forte em pacientes com hipertrofia do ventrículo esquerdo, EIM aumentada, placa de carótida, estenose ≥ 50%, e lesões de órgãos-alvo. (Arq Bras Cardiol. 2020; 115(6):1125-1132).

Published
2021

23. RESISTANT HYPERTENSION ON TREATMENT (RESHYPOT) TRIAL: SEQUENTIAL NEPHRON BLOCKADE COMPARED TO DUAL BLOCKADE OF THE RENIN- ANGIOTENSIN-ALDOSTERONE SYSTEM PLUS BISOPROLOL

Author

Yugar-Toledo, Juan Carlos, primary, Cestari, Elizabeth do Espirito Santo, additional, Souza, Maira Regina de, additional, Rubio, Tatiane de Azevedo, additional, Mello, Priscilla Galisteu de, additional, Gonzales, Elizangela Gianini, additional, Uyemura, Jéssia Rodrigues, additional, Martin, Luciana Nesves Cosenso, additional, Tacito, Lúcia Helena Buonalumi, additional, J, Heitor Moreno, additional, Cunha, Pedro, additional, and Vilela-Martin, José Fernendo, additional

Published
2021
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24. Diretrizes Brasileiras de Hipertensão Arterial – 2020

Author

Barroso, Weimar Kunz Sebba, primary, Rodrigues, Cibele Isaac Saad, additional, Bortolotto, Luiz Aparecido, additional, Mota-Gomes, Marco Antônio, additional, Brandão, Andréa Araujo, additional, Feitosa, Audes Diógenes de Magalhães, additional, Machado, Carlos Alberto, additional, Poli-de-Figueiredo, Carlos Eduardo, additional, Amodeo, Celso, additional, Mion, Décio, additional, Barbosa, Eduardo Costa Duarte, additional, Nobre, Fernando, additional, Guimarães, Isabel Cristina Britto, additional, Vilela-Martin, José Fernando, additional, Yugar-Toledo, Juan Carlos, additional, Magalhães, Maria Eliane Campos, additional, Neves, Mário Fritsch Toros, additional, Jardim, Paulo César Brandão Veiga, additional, Miranda, Roberto Dischinger, additional, Póvoa, Rui Manuel dos Santos, additional, Fuchs, Sandra C, additional, Alessi, Alexandre, additional, Lucena, Alexandre Jorge Gomes de, additional, Avezum, Alvaro, additional, Sousa, Ana Luiza Lima, additional, Pio-Abreu, Andrea, additional, Sposito, Andrei Carvalho, additional, Pierin, Angela Maria Geraldo, additional, Paiva, Annelise Machado Gomes de, additional, Spinelli, Antonio Carlos de Souza, additional, Nogueira, Armando da Rocha, additional, Dinamarco, Nelson, additional, Eibel, Bruna, additional, Forjaz, Cláudia Lúcia de Moraes, additional, Zanini, Claudia Regina de Oliveira, additional, Souza, Cristiane Bueno de, additional, Souza, Dilma do Socorro Moraes de, additional, Nilson, Eduardo Augusto Fernandes, additional, Costa, Elisa Franco de Assis, additional, Freitas, Elizabete Viana de, additional, Duarte, Elizabeth da Rosa, additional, Muxfeldt, Elizabeth Silaid, additional, Lima, Emilton, additional, Campana, Erika Maria Gonçalves, additional, Cesarino, Evandro José, additional, Marques, Fabiana, additional, Argenta, Fábio, additional, Consolim-Colombo, Fernanda Marciano, additional, Baptista, Fernanda Spadotto, additional, Almeida, Fernando Antonio de, additional, Borelli, Flávio Antonio de Oliveira, additional, Fuchs, Flávio Danni, additional, Plavnik, Frida Liane, additional, Salles, Gil Fernando, additional, Feitosa, Gilson Soares, additional, Silva, Giovanio Vieira da, additional, Guerra, Grazia Maria, additional, Moreno, Heitor, additional, Finimundi, Helius Carlos, additional, Back, Isabela de Carlos, additional, Oliveira, João Bosco de, additional, Gemelli, João Roberto, additional, Mill, José Geraldo, additional, Ribeiro, José Marcio, additional, Lotaif, Leda A. Daud, additional, Costa, Lilian Soares da, additional, Magalhães, Lucélia Batista Neves Cunha, additional, Drager, Luciano Ferreira, additional, Martin, Luis Cuadrado, additional, Scala, Luiz César Nazário, additional, Almeida, Madson Q., additional, Gowdak, Marcia Maria Godoy, additional, Klein, Marcia Regina Simas Torres, additional, Malachias, Marcus Vinícius Bolívar, additional, Kuschnir, Maria Cristina Caetano, additional, Pinheiro, Maria Eliete, additional, Borba, Mario Henrique Elesbão de, additional, Moreira, Osni, additional, Passarelli, Oswaldo, additional, Coelho, Otavio Rizzi, additional, Vitorino, Priscila Valverde de Oliveira, additional, Ribeiro, Renault Mattos, additional, Esporcatte, Roberto, additional, Franco, Roberto, additional, Pedrosa, Rodrigo, additional, Mulinari, Rogerio Andrade, additional, Paula, Rogério Baumgratz de, additional, Okawa, Rogério Toshiro Passos, additional, Rosa, Ronaldo Fernandes, additional, Amaral, Sandra Lia do, additional, Ferreira-Filho, Sebastião R., additional, Kaiser, Sergio Emanuel, additional, Jardim, Thiago de Souza Veiga, additional, Guimarães, Vanildo, additional, Koch, Vera H., additional, Oigman, Wille, additional, and Nadruz, Wilson, additional

Published
2021
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26. Evidence of Nonadherence in Cases of Pseudoresistant Hypertension

Author

Zanatta, João Marcos de Menezes, primary, Cosenso-Martin, Luciana Neves, additional, da Silva Lopes, Valquíria, additional, Roma Uyemura, Jéssica Rodrigues, additional, Polegati Santos, Aleandra Marton, additional, Paz Landim, Manoel Ildefonso, additional, Yugar-Toledo, Juan Carlos, additional, and Vilela-Martin, José Fernando, additional

Published
2021
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27. Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers

Author

Bocchi, Edimar Alcides, primary, Moreira, Henrique Turin, additional, Nakamuta, Juliana Sanajotti, additional, Simões, Marcus Vinicius, additional, Casas, Alberto de Almeida Las, additional, Costa, Altamiro Reis da, additional, Assis, Amberson Vieira de, additional, Durães, André Rodrigues, additional, Pereira-Barretto, Antonio Carlos, additional, Ravessa, Antonio Delduque de Araujo, additional, Macedo, Ariane Vieira Scarlatelli, additional, Biselli, Bruno, additional, Pinto, Carolina Maria Nogueira, additional, Filho, Conrado Roberto Hoffmann, additional, Costantini, Costantino Roberto, additional, Almeida, Dirceu Rodrigues, additional, Santos, Edval Gomes dos, additional, Soliva, Erwin, additional, Figueiredo, Estevão Lanna, additional, Albuquerque, Felipe Neves de, additional, Paulitsch, Felipe, additional, Neuenschwander, Fernando Carvalho, additional, Figueiredo, José Albuquerque de, additional, Brito, Flavio de Souza, additional, Lopes, Heno Ferreira, additional, Villacorta, Humberto, additional, Souza, João David de, additional, Sepulveda, João Mariano, additional, Ayoub, José Carlos Aidar, additional, Vilela-Martin, José F., additional, Cardoso, Juliano Novaes, additional, Uemura, Laercio, additional, Moura, Lidia Zytynski, additional, Maia, Lilia Nigro, additional, Oliveira, Lucia Brandão de, additional, Maia, Lucimir, additional, Silva, Luís Beck da, additional, Gowdak, Luís Henrique Wolff, additional, Danzmann, Luiz Claudio, additional, Andrade, Marcus, additional, Braile-Sternieri, Maria Christiane Valeria Braga, additional, Moreira, Maria da Consolação Vieira, additional, França, Olimpio R, additional, Filho, Otavio Rizzi Coelho, additional, Esteves, Paulo Frederico, additional, Raupp-da-Rosa, Priscila, additional, Silva, Ricardo Jorge de Queiroz e, additional, Mourilhe-Rocha, Ricardo, additional, Viégas, Ruy Felipe Melo, additional, Rassi, Salvador, additional, Mangili, Sandrigo, additional, Kaiser, Sergio Emanuel, additional, Martins, Silvia Marinho, additional, and Kawabata, Vitor Sergio, additional

Published
2021
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29. Avaliação do Seguimento de 1 Ano dos Pacientes Incluídos no Registro da Prática Clínica em Pacientes de Alto Risco Cardiovascular (REACT)

Author

Silva, Pedro Gabriel Melo de Barros e, primary, Berwanger, Otavio, additional, Precoma, Dalton Bertolim, additional, Cavalcante, Margaret Assad, additional, Vilela-Martin, José Fernando, additional, Figueiredo, Estêvão Lanna, additional, Lopes, Renato Delascio, additional, Bodanese, Luiz Carlos, additional, Guimarães, Jorge Ilha, additional, Andrade, Jadelson Pinheiro de, additional, Paola, Angelo Amato Vincenzo de, additional, Malachias, Marcus Vinicius Bolivar, additional, Mattos, Luiz Alberto Piva e, additional, Bacal, Fernando, additional, and Dutra, Oscar Pereira, additional

Published
2020
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30. Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

Author

Fuchs, Flávio D., primary, Scala, Luiz C. N., additional, Vilela-Martin, José F., additional, Whelton, Paul K., additional, Poli-de-Figueiredo, Carlos E., additional, Pereira E Silva, Ricardo, additional, Gus, Miguel, additional, Bortolotto, Luiz A., additional, Consolim-Colombo, Fernanda M., additional, Schlatter, Rosane P., additional, Cesarino, José E., additional, Castro, Iran, additional, Figueiredo Neto, José A., additional, Chaves, Hilton, additional, Steffens, André A., additional, Alves, João G., additional, Brandão, Andréa A., additional, de Sousa, Marcos R., additional, Jardim, Paulo C., additional, Moreira, Leila B., additional, Franco, Roberto S., additional, Gomes, Marco M., additional, Afiune Neto, Abrahão, additional, Fuchs, Felipe C., additional, Sobral Filho, Dario C., additional, Nóbrega, Antônio C., additional, Nobre, Fernando, additional, Berwanger, Otávio, additional, and Fuchs, Sandra C., additional

Published
2020
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31. Posicionamento Luso-Brasileiro de Emergências Hipertensivas – 2020

Author

Vilela-Martin, José Fernando, primary, Yugar-Toledo, Juan Carlos, additional, Rodrigues, Manuel de Carvalho, additional, Barroso, Weimar Kunz Sebba, additional, Carvalho, Luís Carlos Bronze S., additional, González, Francisco José Torres, additional, Amodeo, Celso, additional, Dias, Vitor Manuel Margarido Paixão, additional, Pinto, Fernando Carvalho Moreira, additional, Martins, Luís Filipe Reis, additional, Malachias, Marcus Vinícius Bolívar, additional, Jardim, Paulo Cesar Veiga, additional, Souza, Dilma do Socorro Moraes de, additional, Passarelli, Oswaldo, additional, Barbosa, Eduardo Costa Duarte, additional, Polonia, Jorge Junqueira, additional, and Póvoa, Rui Manoel dos Santos, additional

Published
2020
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33. Posicionamento Brasileiro sobre Hipertensão Arterial Resistente – 2020

Author

Yugar-Toledo, Juan Carlos, primary, Moreno Júnior, Heitor, additional, Gus, Miguel, additional, Rosito, Guido Bernardo Aranha, additional, Scala, Luiz César Nazário, additional, Muxfeldt, Elizabeth Silaid, additional, Alessi, Alexandre, additional, Brandão, Andrea Araújo, additional, Moreira Filho, Osni, additional, Feitosa, Audes Diógenes de Magalhães, additional, Passarelli Júnior, Oswaldo, additional, Souza, Dilma do Socorro Moraes de, additional, Amodeo, Celso, additional, Barroso, Weimar Kunz Sebba, additional, Gomes, Marco Antônio Mota, additional, Paiva, Annelise Machado Gomes de, additional, Barbosa, Eduardo Costa Duarte, additional, Miranda, Roberto Dischinger, additional, Vilela-Martin, José Fernando, additional, Nadruz Júnior, Wilson, additional, Rodrigues, Cibele Isaac Saad, additional, Drager, Luciano Ferreira, additional, Bortolotto, Luiz Aparecido, additional, Consolim-Colombo, Fernanda Marciano, additional, Sousa, Márcio Gonçalves de, additional, Borelli, Flávio Antonio de Oliveira, additional, Kaiser, Sérgio Emanuel, additional, Salles, Gil Fernando, additional, Azevedo, Maria de Fátima de, additional, Magalhães, Lucélia Batista Neves Cunha, additional, Póvoa, Rui Manoel dos Santos, additional, Malachias, Marcus Vinícius Bolívar, additional, Nogueira, Armando da Rocha, additional, Jardim, Paulo César Brandão Veiga, additional, and Jardim, Thiago de Souza Veiga, additional

Published
2020
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35. Additional file 2: of Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension – study protocol for a randomized controlled trial

Author

Cestário, Elizabeth Do Espirito Santo, Fernandes, Letícia, Luiz Giollo-Júnior, Jéssica Uyemura, Matarucco, Camila, Landim, Manoel, Cosenso-Martin, Luciana, Tácito, Lúcia, Moreno, Heitor, Vilela-Martin, José, and Yugar-Toledo, Juan

Abstract

Research Ethics Committee. Approval Nº 870 093. (PDF 180 kb)

Published
2018
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39. Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension

Author

Fuchs, Flávio D., primary, Fuchs, Sandra C., additional, Poli-de-Figueiredo, Carlos E., additional, Figueiredo Neto, José A., additional, Scala, Luiz César N., additional, Vilela-Martin, José F., additional, Moreira, Leila B., additional, Chaves, Hilton, additional, Mota Gomes, Marco, additional, de Sousa, Marcos R., additional, Silva, Ricardo Pereira e, additional, Castro, Iran, additional, Cesarino, Evandro José, additional, Sousa, Ana Luiza Lima, additional, Alves, João Guilherme, additional, Steffens, André Avelino, additional, Brandão, Andréa Araujo, additional, Bortolotto, Luiz Aparecido, additional, Afiune Neto, Abrahão, additional, Nóbrega, Antônio C., additional, Franco, Roberto Silva, additional, Sobral Filho, Dario C., additional, Nobre, Fernando, additional, Schlatter, Rosane, additional, Gus, Miguel, additional, De David, Caroline Nespolo, additional, Rafaelli, Leticia, additional, Sesin, Guilhermo Prates, additional, Berwanger, Otávio, additional, and Whelton, Paul K., additional

Published
2018
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40. I Luso-Brazilian Positioning on Central Arterial Pressure

Author

Brandão, Andréa A., Amodeo, Celso, Alcântara, Cristina, Barbosa, Eduardo, Nobre, Fernando, Pinto, Fernando, Vilela-Martin, José Fernando, Bastos, José Mesquita, Yugar-Toledo, Juan Carlos, Mota-Gomes, Marco Antônio, Neves, Mario Fritsch Toros, Malachias, Marcus Vinícius Bolívar, Rodrigues, Manuel de Carvalho, Passarelli Junior, Oswaldo, Jardim, Paulo César B. Veiga, Cunha, Pedro Guimarães, Póvoa, Rui, Fonseca, Teresa, Dias, Vitor Paixão, Barroso, Weimar Sebba, and Oigman, Wille

Subjects
Fatores de Risco, Cardiovascular Diseases/physiopathology, Doenças Cardiovasculares/fisiopatologia, Aterosclerose, Risk Factors, Endotélio Vascular, Arterial Pressure, Endothelium, Vascular, Pressão Arterial, Doença das Coronárias/fisiopatologia, Atherosclerosis, Coronary Diseases/physiopathology
Published
2017

41. Task Force of the Latin American Society of Hypertension

Author

Burlando, Guillermo, Gonzalez, Claudio, Piskorz, Daniel, Ramirez, Agustín J., Sanchez, Ramiro A., Simsolo, Rosa, Voto, Liliana, Alessi, Alexandre, Amodeo, Celso, Araujo Brandáo, Andrea, Baiocchi, Sergio, Barbosa, Eduardo, Barreto Filho, José Augusto, Brandaó Veiga, Paulo César, Brasil, David, Dischinger Miranda, Roberto, Fritsch, Mario, Kalil, Marcio, Machado, Carlos Alberto, Magalhaés Feitosa, Audes, Bolivar Malachias, Marcus Vinicius, Malta, Deborah, Decio Mion, Jr., Moreno, Heitor, Mota Gomes, Marco, Nobre, Fernando, Nogueira, Armando, Oigman, Wille, Passarelli Jr., Oswaldo, Ribeiro, José Márcio, Santos Póvoa, Rui Manoel, Schmid, Helena, Sebba Barroso, Weimar Kunz, Veiga Jardim, Thiago, Vilela-Martin, José Fernando, Cobos, Leonardo, Lanas, Fernando, Villar Moya, Raul, Accini Mendoza, José Luis, Garcia-Ortiz, Luis Hernando, López-Jaramillo, Patricio, Molina, Dora Ines, Sanchez, Gregorio, Urina – Triana, Miguel, Morales-Salinas, Alberto, Lara, Joffre, Stuardo Wyss, Fernando, Alcocer, Luis, Gonzalez Caamanó, Angel, Parra-Carrillo, Jose Z., Ortellado, José, Bryce Moncloa, Alfonso, Senclen Santisteban, Segundo, Diaz, Margarita E., Hernandez Hernandez, Rafael, Lopez, Jesús, Machado, Livia T., and Ponte-Negretti, Carlos

Subjects
Latin America, Hypertension, Guidelines, Comorbidities
Abstract

ABI, ankle-brachial index; ABPM, ambulatory blood pressure monitoring; ACCORD, Action to Control Cardiovascular Risk in Diabetes; ACE-I, angiotensin-converting-enzyme-inhibitors; ARB, AT1 blockers; BP, blood pressure; CARMELA, Cardiovascular Risk Factor Multiple Evaluation in Latin America; CARMEN, Community Actions for Multifactorial Reduction of Non- Communicable Diseases; CCB, calcium channel blocker; CCM, Wagner’s Chronic Care Model; CDC, Chronic Disease Center; CTA, computed tomography angiography; CV, cardiovascular; DALY, disability-adjusted life year; DPP- 4, dipeptidyl-peptidase-4; GLP-1, glucagon-like peptide 1; HBPM, home blood pressure monitoring; HOPE, Heart Outcomes Prevention Evaluation; HOT, Hypertension Optimal Treatment; HT, hypertension; LA, Latin America; LASH, Latin American Society of Hypertension; MRA, magnetic resonance angiography; NCD, noncommunicable disease; OSAS, obstructive apnea–hypopnea syndrome; PAD, peripheral artery disease; PAHO, Pan American Health Organization; RAAS, renin–angiotensin–aldosterone system; RISS, Redes Integradas de Servicios de Salud; SGLUT2, sodium–glucose cotransporter-2; SPRINT, SBP Intervention Trial; UKPDS, United Kingdom Prospective Diabetes Study; VIDA, Veracruz Initiative for Diabetes Awareness

Published
2017

43. Additional file 1: of Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Author

Vilela-Martin, José, Luiz Giollo-Junior, Chiappa, Gaspar, Cipriano-Junior, Gerson, Vieira, Paulo, Fábio Dos Santos Ricardi, Paz-Landim, Manoel, Days De Andrade, Cestário, Elizabeth Do Espírito Santo, Cosenso-Martin, Luciana, Yugar-Toledo, Juan, and Cipullo, José

Abstract

Research Ethics Committee. Declaration of Research Ethics Committee of the Medical School in São José do Rio Preto (FAMERP). (PDF 182 kb)

Published
2016
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44. Additional file 2: of Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Author

Vilela-Martin, José, Luiz Giollo-Junior, Chiappa, Gaspar, Cipriano-Junior, Gerson, Vieira, Paulo, Fábio Dos Santos Ricardi, Paz-Landim, Manoel, Days De Andrade, Cestário, Elizabeth Do Espírito Santo, Cosenso-Martin, Luciana, Yugar-Toledo, Juan, and Cipullo, José

Abstract

SPIRIT. Checklist of study protocol data and related documents according to SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials). (PDF 105 kb)

Published
2016
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47. Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis

Author

Andrade, Days Oliveira, primary, Santos, Sara Patrícia O, additional, Pinhel, Marcela Augusta S, additional, Valente, Flávia Mariana, additional, Giannini, Marcela Cavichiolo, additional, Gregório, Michele Lima, additional, De Godoy, Moacir Fernandes, additional, Souza, Dorotéia Rossi S, additional, and Vilela-Martin, José Fernando, additional

Published
2017
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48. DPP-4 Inhibitor Reduces Central Blood Pressure in a Diabetic and Hypertensive Patient

Author

Cosenso-Martin, Luciana Neves, Giollo-Junior, Luiz Tadeu, and Vilela-Martin, José Fernando

Subjects
Blood Glucose, Vildagliptin, Dipeptidyl-Peptidase IV Inhibitors, Pyrrolidines, Adamantane, Blood Pressure, Middle Aged, Vascular Stiffness, Diabetes Mellitus, Type 2, Hypertension, Nitriles, Humans, Hypoglycemic Agents, Female, Clinical Case Report, circulatory and respiratory physiology, Research Article
Abstract

Hypertension and type 2 diabetes mellitus (DM) are among the main risk factors for the development of cardiovascular disease. Pharmacotherapy for DM should not only improve blood glucose control, but also provide beneficial glucose-independent cardiovascular effects. The central systolic blood pressure (SBP) has become more important than the brachial SBP in the assessment of cardiovascular risk. This case report describes the effect of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, on the central SBP in a 54-year-old woman with hypertension and DM. She was submitted to applanation tonometry (AT) before and after vildagliptin association. AT of the radial artery is a non-invasive method that indirectly assesses arterial stiffness by calculating the central SBP and the augmentation index (AIx). After 3 months of follow-up using vildagliptin, central SBP and AIx were improved. Moreover, she presented better glycemic control. This case suggests an effect of DPP-4 inhibitor on arterial stiffness parameter (central SBP) in a hypertensive and diabetic patient, which shows a glucose-independent beneficial cardiovascular effect of this group of drugs.

Published
2015

49. I Luso-Brazilian Positioning on Central Arterial Pressure

Author

Brandão, Andréa A., primary, Amodeo, Celso, additional, Alcântara, Cristina, additional, Barbosa, Eduardo, additional, Nobre, Fernando, additional, Pinto, Fernando, additional, Vilela-Martin, José Fernando, additional, Bastos, José Mesquita, additional, Yugar-Toledo, Juan Carlos, additional, Mota-Gomes, Marco Antônio, additional, Neves, Mario Fritsch Toros, additional, Malachias, Marcus Vinícius Bolívar, additional, Rodrigues, Manuel de Carvalho, additional, Passarelli Junior, Oswaldo, additional, Jardim, Paulo César B. Veiga, additional, Cunha, Pedro Guimarães, additional, Póvoa, Rui, additional, Fonseca, Teresa, additional, Dias, Vitor Paixão, additional, Barroso, Weimar Sebba, additional, and Oigman, Wille, additional

Published
2017
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50. Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER‐Prevention Randomized Clinical Trial

Author

Fuchs, Sandra Costa, primary, Poli‐de‐Figueiredo, Carlos E., additional, Figueiredo Neto, José A., additional, Scala, Luiz César N., additional, Whelton, Paul K., additional, Mosele, Francisca, additional, de Mello, Renato Bandeira, additional, Vilela‐Martin, José F., additional, Moreira, Leila B., additional, Chaves, Hilton, additional, Mota Gomes, Marco, additional, de Sousa, Marcos R., additional, Silva, Ricardo Pereira e, additional, Castro, Iran, additional, Cesarino, Evandro José, additional, Jardim, Paulo Cesar, additional, Alves, João Guilherme, additional, Steffens, André Avelino, additional, Brandão, Andréa Araujo, additional, Consolim‐Colombo, Fernanda M., additional, de Alencastro, Paulo Ricardo, additional, Neto, Abrahão Afiune, additional, Nóbrega, Antônio C., additional, Franco, Roberto Silva, additional, Sobral Filho, Dario C., additional, Bordignon, Alexandro, additional, Nobre, Fernando, additional, Schlatter, Rosane, additional, Gus, Miguel, additional, Fuchs, Felipe C., additional, Berwanger, Otávio, additional, and Fuchs, Flávio D., additional

Published
2016
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