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19 results on '"Vilela, Márcia Carvalho"'

4. Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents

Author

Vilas-Boas, Fabrício de Almeida Souza, da Silva, Aristóbolo Mendes, de Sousa, Lirlândia Pires, Lima, Kátia Maciel, Vago, Juliana Priscila, Bittencourt, Lucas Felipe Fernandes, Dantas, Arthur Estanislau, Gomes, Dawidson Assis, Vilela, Márcia Carvalho, Teixeira, Mauro Martins, and Barcelos, Lucíola Silva

Published
2016
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10. Dengue-3 encephalitis promotes anxiety-like behavior in mice

Author

de Miranda, Aline Silva, Rodrigues, David Henrique, Amaral, Débora Cristina Guerra, de Lima Campos, Roberta Dayrell, Cisalpino, Daniel, Vilela, Márcia Carvalho, Lacerda-Queiroz, Norinne, de Souza, Kátia Paulino Ribeiro, Vago, Juliana Priscila, Campos, Marco Antônio, Kroon, Erna Geesien, da Glória de Souza, Danielle, Teixeira, Mauro Martins, Teixeira, Antônio Lúcio, and Rachid, Milene Alvarenga

Published
2012
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11. Neuroinflammation is associated with reduced SOCS2 and SOCS3 expression during intracranial HSV-1 infection

Author

Toscano, Eliana Cristina de Brito, primary, Sousa, Larissa Fonseca da Cunha, additional, Lima, Graciela Kunrath, additional, Mesquita, Leonardo Antunes, additional, Vilela, Márcia Carvalho, additional, Rodrigues, David Henrique, additional, Ferreira, Rodrigo Novaes, additional, Soriani, Frederico Marianetti, additional, Campos, Marco Antônio, additional, Kroon, Erna Geessien, additional, Teixeira, Mauro Martins, additional, de Miranda, Aline Silva, additional, Rachid, Milene Alvarenga, additional, and Teixeira, Antônio Lúcio, additional

Published
2020
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13. Absence of CCR5 increases neutrophil recruitment in severe herpetic encephalitis

Author

Vilela, Márcia Carvalho, primary, Lima, Graciela Kunrath, additional, Rodrigues, David Henrique, additional, Lacerda-Queiroz, Norinne, additional, Pedroso, Vinicius Sousa Pietra, additional, Miranda, Aline Silva, additional, Rachid, Milene Alvarenga, additional, Kroon, Erna Geessien, additional, Campos, Marco Antônio, additional, Teixeira, Mauro Martins, additional, Sellner, Johann, additional, and Teixeira, Antonio Lucio, additional

Published
2013
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15. Plasmodium berghei NK65 induces cerebral leukocyte recruitment in vivo: An intravital microscopic study

Author

Lacerda-Queiroz, Norinne, primary, Lima, Onésia Cristina Oliveira, additional, Carneiro, Cláudia Martins, additional, Vilela, Márcia Carvalho, additional, Teixeira, Antônio Lúcio, additional, Carvalho, Andrea Teixeira-, additional, Araújo, Márcio Sobreira Silva, additional, Martins-Filho, Olindo Assis, additional, Braga, Érika Martins, additional, and Carvalho-Tavares, Juliana, additional

Published
2011
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16. Role of IL-4 in an experimental model of encephalitis induced by intracranial inoculation of herpes simplex virus-1 (HSV-1)

Author

Vilela, Márcia Carvalho, primary, Campos, Roberta Dayrell de Lima, additional, Mansur, Daniel Santos, additional, Rodrigues, David Henrique, additional, Queiroz, Norinne Lacerda, additional, Lima, Graciela Kunrath, additional, Rachid, Milene Alvarenga, additional, Kroon, Erna Geessien, additional, Campos, Marco Antônio, additional, and Teixeira, Antônio Lúcio, additional

Published
2011
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17. Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice

Author

Lacerda-Queiroz, Norinne, primary, Rodrigues, David Henrique, additional, Vilela, Márcia Carvalho, additional, Miranda, Aline Silva de, additional, Amaral, Débora Cristina Guerra, additional, Camargos, Elizabeth Ribeiro da Silva, additional, Carvalho, Leonardo José de Moura, additional, Howe, Charles L, additional, Teixeira, Mauro Martins, additional, and Teixeira, Antônio Lúcio, additional

Published
2010
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18. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis

Author

Vilela, Márcia Carvalho, primary, Lima, Graciela Kunrath, additional, Rodrigues, David Henrique, additional, Lacerda-Queiroz, Norinne, additional, Mansur, Daniel Santos, additional, Miranda, Aline Silva de, additional, Rachid, Milene Alvarenga, additional, Kroon, Erna Geessien, additional, Vieira, Leda Quercia, additional, Campos, Marco Antônio, additional, Teixeira, Mauro Martins, additional, and Teixeira, Antônio Lúcio, additional

Published
2010
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19. Traffic of leukocytes in the central nervous system is associated with chemokine up-regulation in a severe model of herpes simplex encephalitis: An intravital microscopy study

Author

Vilela, Márcia Carvalho, Mansur, Daniel Santos, Lacerda-Queiroz, Norinne, Rodrigues, David Henrique, Arantes, Rosa Maria Esteves, Kroon, Erna Geessien, Campos, Marco Antônio, Teixeira, Mauro Martins, and Teixeira, Antônio Lúcio

Subjects
*CENTRAL nervous system diseases, *CHEMOKINES, *LEUCOCYTES, *ENCEPHALITIS
Abstract

Abstract: Herpes simplex virus type 1 (HSV-1) is a human pathogen that may cause severe encephalitis. The development of experimental models of HSV-1 encephalitis is relevant for the comprehension of the immune mechanisms involved in this infection. C57BL/6 mice were inoculated intracranially with 104 PFU of neurotropic HSV-1. All animals developed signs of encephalitis and died until day 6 post-infection (pi). Using intravital microscopy, we demonstrated increased leukocyte rolling and adhesion in the brain microvasculature of infected mice at days 1, 3 and 5 pi. The infection was followed by a significant increase in chemokine levels, including CCL2, CCL3, CCL5, CXCL1 and CXCL9. TNF-α also showed a significant increase at day 3 pi. Histological analyses demonstrated diffuse meningoencephalitis characterized mainly by mononuclear cell infiltrates. The present model of HSV-1 encephalitis exhibits high mortality in the very first days of infection. Accordingly, there were increased rolling and adhesion of leukocytes along the brain endothelium wall and a high expression of chemokines in the central nervous system. These results corroborate the role of chemokines in leukocyte recruitment following HSV-1 infection in the central nervous system. [Copyright &y& Elsevier]

Published
2008
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