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42 results on '"Vilela, Fabiana C."'

11. Perinatal exposure to glyphosate‐based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring

Author

de Oliveira, Maria A. L., primary, Rojas, Viviana C. T., additional, de Sá, Josiane C., additional, de Novais, Cíntia O., additional, Silva, Mariana S., additional, de Almeida Paula, Hudsara Aparecida, additional, Kirsten, Thiago B., additional, Bernardi, Maria Martha, additional, Pinheiro, Lucas Cézar, additional, Giusti‐Paiva, Alexandre, additional, and Vilela, Fabiana C., additional

Published
2022
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24. Anxiety-like behavior and neuroendocrine changes in offspring resulting from gestational post-traumatic stress disorder

Author

Chagas, Luana A., primary, Batista, Tatiane H., additional, Ribeiro, Ana Cláudia A.F., additional, Ferrari, Mariela S., additional, Vieira, Jádina S., additional, Rojas, Viviana C.T., additional, Kalil-Cutti, Bruna, additional, Elias, Lucila L.K., additional, Giusti-Paiva, Alexandre, additional, and Vilela, Fabiana C., additional

Published
2021
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25. Prostaglandins mediate zymosan-induced sickness behavior in mice

Author

Lima, Juliana B. M., Veloso, Clarice C., Vilela, Fabiana C., and Giusti-Paiva, Alexandre

Subjects
Prostaglandins -- Analysis -- Behavior -- Health aspects, Inflammation -- Analysis -- Health aspects, Dexamethasone -- Analysis -- Health aspects, Corticosterone -- Analysis -- Behavior -- Health aspects, Indomethacin -- Health aspects -- Analysis, Psychology and mental health
Abstract

Previous studies have demonstrated that zymosan, a cell wall component of the yeast Saccharomyces cerevisiae, induces inflammation in experimental models. However, few studies have evaluated the potential of zymosan to induce sickness behavior, a central motivational state that allows an organism to cope with infection. To determine whether zymosan administration results in sickness behavior, mice were submitted to the forced swim (FST) and open field (OFT) tests 2, 6, and 24 h after treatment with zymosan (1, 10, or 100 mg/kg). Additionally, to evaluate the possible relationship between zymosan-induced sickness behavior and prostaglandin synthesis, mice were pretreated with the cyclooxygenase inhibitors indomethacin (10 mg/kg) and nimesulide (5 mg/kg) and the glucocorticoid drug dexamethasone (1 mg/kg). Zymosan induced time-dependent decreases in locomotor activity in the OFT, and an increase in immobility in the FST, and increased plasma levels of corticosterone at 2 h. Pretreatment with indomethacin, nimesulide, or dexamethasone blocked zymosan-induced behavioral changes in both the FST and OFT at 2 h post administration. These findings confirm previous observations that zymosan induces sickness behavior. Furthermore, our results provide new evidence that prostaglandin synthesis is necessary for this effect, as anti-inflammatory drugs that inhibit prostaglandin synthesis attenuated zymosan-induced behavioral changes. Keywords: Cyclooxygenase, Fungal infection, Prostaglandin, Saccharomyces cerevisiae, Sickness behavior, Zymosan, Author(s): Juliana B. M. Lima[sup.1], Clarice C. Veloso[sup.2], Fabiana C. Vilela[sup.2] and Alexandre Giusti-Paiva[sup.2] Introduction Physiological and behavioral changes induced by infection and inflammation can be induced in experimental animals [...]

Published
2016
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33. Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol

Author

César da Silva, Rodrigo, Veiga, Fabiano, Vilela, Fabiana C., Pereira, André Victor, Tavares da Silva Cunha, Thayssa, Tesch, Roberta, Viegas Jr., Claudio, Dias, Danielle Ferreira, Giusti-Paiva, Alexandre, Veloso, Marcia Paranho, and Fraga, Carlos A. M.

Abstract

Background: A new series of O-benzyloximes derived from eugenol was synthesized and was evaluated for its antinociceptive and anti-inflammatory properties. Methods: The target compounds were obtained in good global 25-28% yields over 6 steps, which led us to identify compounds (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-(4- (methylthio)benzyloxime (8b), (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- bromobenzyloxime (8d) and (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- (methylsulfonyl)benzyloxime (8f) as promising bioactive prototypes. Results: These compounds have significant analgesic and anti-inflammatory effects, as evidenced by formalin-induced mice paw edema and carrageenan-induced mice paw edema tests. In the formalin test, compounds 8b and 8f evidenced both anti-inflammatory and direct analgesic activities and in the carrageenan-induced paw edema, with compounds 8c, 8d, and 8f showing the best inhibitory effects, exceeding the standard drugs indomethacin and celecoxib. Conclusion: Molecular docking studies have provided additional evidence that the pharmacological profile of these compounds may be related to inhibition of COX enzymes, with slight preference for COX-1. These results led us to identify the new O-benzyloxime ethers 8b, 8d and 8f as orally bioactive prototypes, with a novel structural pattern capable of being explored in further studies aiming at their optimization and development as drug candidates.

Published
2019
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42. Cannabinoid CB1 receptors mediate the effects of dipyrone.

Author

Crunfli, Fernanda, Vilela, Fabiana C, and Giusti‐Paiva, Alexandre

Subjects
*DIPYRONE, *ANTI-inflammatory agents, *CANNABINOIDS, *ANALGESICS, *ARACHIDONIC acid
Abstract

Dipyrone is a non-steroidal anti-inflammatory drug used primarily as an analgesic and antipyretic. Some hypothesize that dipyrone activity can modulate other pathways, including endocannabinoid signalling. Thus, the aim of the present study was to evaluate the possible role of endocannabinoids in mediating dipyrone activity. This study is based on the tetrad effects of cannabinoids, namely an antinociceptive and cataleptic state, hypolocomotion and hypothermia. Dipyrone (500 mg/kg, i.p.) treatment decreased locomotor activity, increased the latency to a thermal analgesic response and induced a cataleptic and hypothermic state. These reactions are similar to the tetrad effects caused by the cannabinoid agonist WIN 55,212-2 (3 mg/kg, i.p.). The cannabinoid CB1 receptor antagonist AM251 (10 mg/kg, i.p.) reversed the effects of dipyrone on locomotor activity, the cataleptic response and thermal analgesia. Both AM251 (10 mg/kg, i.p.) and the transient receptor potential vanilloid 1 (TRPV1) antagonist capsazepine (10 mg/kg, i.p.) accentuated the reduction in body temperature caused by dipyrone. However, the CB2 receptor antagonist AM630 did not alter the hypothermic response to dipyrone. These results indicate involvement of the endocannabinoid system, especially CB1 receptors, in the analgesic and cataleptic effects of dipyrone, as well as hypolocomotion. However, cannabinoid receptors and TRPV1 were not involved in the hypothermic effects of dipyrone. We hypothesize that the mechanism of action of dipyrone may involve inhibition of cyclo-oxygenase and fatty acid amide hydrolase, which together provide additional arachidonic acid as substrate for endocannabinoid synthesis or other related molecules. This increase in endocannabinoid availability enhances CB1 receptor stimulation, contributing to the observed effects. [ABSTRACT FROM AUTHOR]

Published
2015
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