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44 results on '"Vilaverde, Joana"'

1. Efficacy and safety of SGLT2 inhibitors in individuals with type 1 diabetes under continuous subcutaneous insulin infusion: a real-world study

Author

Silva Vania Benido, Fonseca Liliana, Duarte Diana Borges, Puga Francisca Marques, Assuncao Guilherme, Garrido Susana, Teixeira Sofia, Vilaverde Joana, and Cardoso Maria Helena

Subjects
continuous subcutaneous insulin infusion, type 1 diabetes, sodium-glucose co-transport 2 inhibitors, diabetic ketoacidosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective. Adjuvant therapy with sodium-glucose cotransport 2 inhibitors (SGLT2i) in type 1 diabetes (T1D) is associated with an improvement in glycemic control, but increases the risk of diabetic ketoacidosis (DKA). However, real-life studies in individuals with T1D under continuous subcutaneous insulin infusion (CSII) are still scarce. We present the first real-life study performed in patients with T1D exclusively treated with CSII. The aim of the present study was to assess the metabolic impact and safety of SGLT2i in T1D individuals under CSII.

Published
2023
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6. Inappropriate gestational weight gain impact on maternofetal outcomes in gestational diabetes.

Author

Santos Monteiro, Sílvia, S. Santos, Tiago, Fonseca, Liliana, Saraiva, Miguel, Pichel, Fernando, Pinto, Clara, Pereira, Maria T., Vilaverde, Joana, Almeida, Maria C., and Dores, Jorge

Subjects
WEIGHT gain, GESTATIONAL diabetes, PREGNANCY outcomes, PREGNANT women, OBESITY in women
Abstract

To evaluate the association between the dimension of deviation from appropriate gestational weight gain (GWG) and adverse maternofetal outcomes in women with gestational diabetes mellitus (GDM). We performed a multicentric retrospective study based on the Portuguese GDM Database. Women were classified as within GWG, insufficient (IGWG) or excessive (EGWG) than the Institute of Medicine recommendations. EGWG and IGWG were calculated for each prepregnancy BMI category. Large-for-gestational-age (LGA) and macrosomia were defined as a birthweight more than the 90th percentile for the gestational age and newborn weight greater than 4000 g, respectively. Logistic regression models (adjusted odds ratio [aOR] plus 95% confidence interval [95%CI]) were derived to evaluate the association between EGWG or IGWG and adverse maternofetal outcomes. A total of 18961 pregnant women were included: 39.7% with IGWG and 27.8% with EGWG. An EGWG over 3 kg was associated with a higher risk of LGA infants (aOR 1.95, 95%CI 1.17–3.26) and macrosomia (aOR 2.01, 95%CI 1.23–3.27) in prepregnancy normal weight women. An EGWG greater than 4 kg was associated with a higher risk of LGA infants (aOR 1.67, 95%CI 1.23–2.23) and macrosomia (aOR 1.90, 95%CI 1.38–2.61) in obese women. In overweight women, an EGWG above 3.5 kg was associated with a higher risk of LGA infants (aOR 1.65, 95%CI 1.16–2.34), macrosomia (aOR 1.85, 95%CI 1.30–2.64), preeclampsia (aOR 2.40, 95%CI 1.45–3.98) and pregnancy-induced hypertension (aOR 2.21, 95%CI 1.52–3.21). An IGWG below −3.1 kg or −3kg was associated with a higher risk of small-for-gestational-age [SGA] infants in women with normal (OR 1.40, 95%CI 1.03–1.90) and underweight (OR 2.29, 95%CI 1.09–4.80), respectively. Inappropriate gestational weight gain seems to be associated with an increased risk for adverse maternofetal outcomes, regardless of prepregnancy BMI. Beyond glycemic control, weight management in women with GDM must be a focus of special attention to prevent adverse pregnancy outcomes. The dimension of deviation from appropriate gestational weight gain was associated with an increased risk for adverse maternofetal outcomes among women with gestational diabetes. Weight management must be a focus of special attention in women with gestational diabetes to prevent adverse pregnancy outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Letter to the Editor: Successful Prenatal Management of Inherited Congenital Non-Autoimmune Hyperthyroidism

Author

Monteiro, Sílvia Santos, primary, Monteiro, Mariana P., additional, Inocêncio, Gonçalo, additional, Borges, Teresa, additional, Garrido, Susana, additional, Pereira, Maria Teresa, additional, Vilaverde, Joana, additional, Sales, Marta, additional, Pinto, Clara, additional, Rodrigues, Maria do Céu, additional, Guedes-Martins, Luís, additional, Dores, Jorge, additional, and Reis, Cláudia Falcão, additional

Published
2023
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11. Simultaneous pancreas-kidney transplantation: long-term survival and metabolic profile analysis among functioning pancreatic graft patients - A 20 year experience from a center in Portugal

Author

Maia, Ariana, primary, Saraiva, Miguel, additional, Sala, Ines, additional, Soares, Daniela, additional, Borges, Soares Diana, additional, Monteiro, Silvia, additional, Vilaverde, Joana, additional, Ferreira, Lia, additional, Martins, La Salete, additional, and Dores, Jorge, additional

Published
2022
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15. Clinical presentation, phenotype, and germline variants of pheochromocytoma and paraganglioma: A three-decade clinical experience

Author

Duarte, Diana Borges, primary, Saraiva, Miguel, additional, Ferreira, Marta Almeida, additional, Ferreira, Lia, additional, Pereira, Maria Teresa, additional, André, Carvalho, additional, Cláudia, Amaral, additional, Vilaverde, Joana, additional, Cláudia, Freitas, additional, Dores, Jorge, additional, Carvalho, Rui, additional, and Palma, Isabel, additional

Published
2021
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23. Figure 1 from: Luz R, Cordeiro R, Vilaverde J, Raposeiro PM, Fonseca A, Gonçalves V (2020) Cyanobacteria from freshwater lakes in the Azores archipelago, Portugal: data from long term phytoplankton monitoring. Biodiversity Data Journal 8: e51928. https://doi.org/10.3897/BDJ.8.e51928

Author

Luz, Rúben, primary, Cordeiro, Rita, additional, Vilaverde, Joana, additional, Raposeiro, Pedro, additional, Fonseca, Amélia, additional, and Gonçalves, Vítor, additional

Published
2020
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25. Ecosystem impacts of human arrival in the Azores: a comparative study of high-resolution multi-proxy lake sediment records

Author

de Boer, E.J., Rull, Valentí, Van Leeuwen, Jaqueline FN, Amaral-Zettler, Linda, Bao, Roberto, Benavente-Marín, Mario, Gonçalves, Vítor, Hernández, Armand, Marques, Helena, Pimentel, Christopher, Pla-Rabes, Sergi, Raposeiro, Pedro Miguel, Richter, Nora, Ritter, C., Rubio-Ingles, M. J., Sáez, Alberto, Trigo, Ricardo M., Vázquez-Loureiro, D., Vilaverde, Joana, Giralt, Santiago, Ministerio de Economía y Competitividad (España), and Fundação Luso-Americana para o Desenvolvimento

Subjects
Quaternary, ecosystem impact, human
Abstract

20th Congress of the International Union for Quaternary Research (INQUA) in Dublin, Ireland, 25-31 july 2019, Human settlement of uninhabited land masses can dramatically transform local ecosystems and its endemic biota around the world. These changes are particularly evident on islands, where human settlement usually marked a period of large-scale habitat destruction and extinctions of local flora and fauna. Historical records specify that the Azores archipelago in the North Atlantic Ocean was settled in the mid-15th century CE. The human footprint in the Azores was large and widespread: within six centuries of colonization more than 95% of the original native forests were destroyed. Paleoecological and geochemical reconstructions from the Azores have allowed us to compare ecosystem processes and dynamics before and after colonization. To document the cultural evolution of human settlement in the Azores archipelago, we studied lake sediment records from four distant islands, located in the Western (Flores), Central (Pico and Terceira) and Eastern (São Miguel) group of islands. In particular, we investigated the role of the Medieval Warm Period and the Little Ice Age climatic periods as external driving forces for human displacement and potential triggers for cultural transformations. A suite of proxies – pollen, diatoms, chironomids, cladocerans, hydrogen isotopes, macroscopic charcoal, organic matter, inorganic composition (XRF scanning and X-ray diffractions), and lithofacies – were used to distinguish between different signals of climate change, landscape and ecosystem dynamics, and their local lacustrine responses. A comprehensive multi-disciplinary analysis of all the proxies provides strong indications that the Azores were colonized more than two centuries earlier than currently recognised. These early colonizers first reached the Central group of islands around 1100 yr CE and the Eastern group before the end of the 13th Century. The Western group was subsequently reached around 1300 yr CE. Early human activities included the introduction of domestic animals, land clearance and small-scale agriculture, and extractive forestry mostly for charcoal production. The origin of the early colonizers is further discussed during the presentation., This research is funded by the Juan de la Cierva-formación postdoctoral grant (FJCI-2015-26199), the Fundação LUSO-Americana, Crossing the Atlantic Program, and through the funded research projects PaleoNAO (CGL2010-15767), RapidNAO (CGL2013-40608-R), PaleoModes (CGL2016-75281-C2) and DISCOVERAZORES (PTDC/CTA-AMB/28511/2017).

Published
2019

26. Catastrophic vs. Gradual Ecological Change in a Coastal Back-barrier Perched Lake as a Function of Climate-forced Barrier Breaching in the Last 2,700 yr

Author

Bao, Roberto, Buchaca, Teresa, Carballeira, Rafael, Castro, D., Fernández-Pena, Pablo, Gonzalez-Villanueva, Rita, Hernández, Armand, Leira, Manel, Otero Perez, X. L., Pontevedra Pombal, Xabier, Prego, R., Raposeiro, P. M., Sáez, Alberto, Santos, Luisa, Sar, Noé, Souto, Martín, Vázquez-Loureiro, D., Vilaverde, Joana, Bao, Roberto, Buchaca, Teresa, Carballeira, Rafael, Castro, D., Fernández-Pena, Pablo, Gonzalez-Villanueva, Rita, Hernández, Armand, Leira, Manel, Otero Perez, X. L., Pontevedra Pombal, Xabier, Prego, R., Raposeiro, P. M., Sáez, Alberto, Santos, Luisa, Sar, Noé, Souto, Martín, Vázquez-Loureiro, D., and Vilaverde, Joana

Abstract

Ecological resistance and resilience of freshwater coastal back-barrier perched lakes are intimately linked to the stability of the sand-barrier enclosing them, which controls the inflow of seawater. We address the long-term ecological changes (2,700 cal yr BP to present) in one of these systems in NW Spain (Doniños, A Coruña) from a multi-proxy paleoecological reconstruction based on biological, physical, and chemical analyses of its lacustrine sedimentary record, as well as on GPR surveys of the sand barrier. Although human intervention cannot be completely disregarded, AMS 14C and OSL datings show that ecological changes were synchronous with the main climatic periods of the studied interval. The ancient freshwater lake was catastrophically emptied due to barrier breaching coinciding with the increase of storms within the Dark Ages (350-750 CE) and the Little Ice Age (LIA, 1500-1930 CE), the latter characterized by an active retrograding sand barrier. Erosion induced by storms and increased rainfall generated two hiatuses which left no record of the ecological recovery of the system. By contrast, the transition from the Medieval Climate Anomaly to the LIA (1100-1500 CE) shows a gradual ecological transformation from an isolated lake towards a transitional shallow choked lagoon and, finally, an intermittent tidal lagoon, which lasted approx. 200 yr. Although determining whether an observed ecosystem change represents a regime shift in the framework of the Alternative Stable States Hypothesis is difficult in highly variable systems, this gradual change is here not ascribed as a sudden non-linear ecological regime shift. A 210Pb age-model for the upper sediments shows that the current freshwater lake was established c. 1945 CE, after the dune fields stabilized in the region associated to the known decrease in storm and wind intensities. Changes in the main North Atlantic atmospheric patterns in the last decades are considered the ultimate agents of the complete isol

Published
2019

27. Ecosystem impacts of human arrival in the Azores: a comparative study of high-resolution multi-proxy lake sediment records

Author

Ministerio de Economía y Competitividad (España), Fundação Luso-Americana para o Desenvolvimento, de Boer, E.J., Rull, Valentí, Van Leeuwen, Jaqueline FN, Amaral-Zettler, Linda, Bao, Roberto, Benavente-Marín, Mario, Gonçalves, Vítor, Hernández, Armand, Marques, Helena, Pimentel, Christopher, Pla-Rabes, Sergi, Raposeiro, Pedro Miguel, Richter, Nora, Ritter, C., Rubio-Ingles, M. J., Sáez, Alberto, Trigo, Ricardo M., Vázquez-Loureiro, D., Vilaverde, Joana, Giralt, Santiago, Ministerio de Economía y Competitividad (España), Fundação Luso-Americana para o Desenvolvimento, de Boer, E.J., Rull, Valentí, Van Leeuwen, Jaqueline FN, Amaral-Zettler, Linda, Bao, Roberto, Benavente-Marín, Mario, Gonçalves, Vítor, Hernández, Armand, Marques, Helena, Pimentel, Christopher, Pla-Rabes, Sergi, Raposeiro, Pedro Miguel, Richter, Nora, Ritter, C., Rubio-Ingles, M. J., Sáez, Alberto, Trigo, Ricardo M., Vázquez-Loureiro, D., Vilaverde, Joana, and Giralt, Santiago

Abstract

Human settlement of uninhabited land masses can dramatically transform local ecosystems and its endemic biota around the world. These changes are particularly evident on islands, where human settlement usually marked a period of large-scale habitat destruction and extinctions of local flora and fauna. Historical records specify that the Azores archipelago in the North Atlantic Ocean was settled in the mid-15th century CE. The human footprint in the Azores was large and widespread: within six centuries of colonization more than 95% of the original native forests were destroyed. Paleoecological and geochemical reconstructions from the Azores have allowed us to compare ecosystem processes and dynamics before and after colonization. To document the cultural evolution of human settlement in the Azores archipelago, we studied lake sediment records from four distant islands, located in the Western (Flores), Central (Pico and Terceira) and Eastern (São Miguel) group of islands. In particular, we investigated the role of the Medieval Warm Period and the Little Ice Age climatic periods as external driving forces for human displacement and potential triggers for cultural transformations. A suite of proxies – pollen, diatoms, chironomids, cladocerans, hydrogen isotopes, macroscopic charcoal, organic matter, inorganic composition (XRF scanning and X-ray diffractions), and lithofacies – were used to distinguish between different signals of climate change, landscape and ecosystem dynamics, and their local lacustrine responses. A comprehensive multi-disciplinary analysis of all the proxies provides strong indications that the Azores were colonized more than two centuries earlier than currently recognised. These early colonizers first reached the Central group of islands around 1100 yr CE and the Eastern group before the end of the 13th Century. The Western group was subsequently reached around 1300 yr CE. Early human activities included the introduction of domestic animals, land cl

Published
2019

28. Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Author

Figueiredo, Catarina Matos, Falcão, Inês, Vilaverde, Joana, Freitas, Joana, Oliveira, Maria João, Godinho, Cristina, Dores, Jorge, Rodrigues, Maria Céu, Carvalho, Carmen, and Borges, Teresa

Subjects
endocrine system, endocrine system diseases, Article Subject
Abstract

Fetal goiter is a rare disorder not expected to be found during a healthy woman’s pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks’ gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without polyhydramnios. Maternal thyroid function was normal and thyroid antibodies were negative. Two intra-amniotic levothyroxine infusions were performed at 32 and 33 weeks. Serial imaging control showed no progression of the mass. Elective caesarean section was performed at 38 weeks. The male newborn was admitted to the intensive care unit due to cardiorespiratory insufficiency with pulmonary hypertension. Hormonal assays revealed primary congenital hypothyroidism and ultrasonography confirmed diffuse goiter. Levothyroxine was started. Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene.

Published
2018
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30. Diabetes Eruditus: Characteristics of type 1 diabetes of long duration

Author

Duarte, Diana Borges, primary, Amaral, Claudia, additional, Amado, Ana, additional, Teixeira, Sofia, additional, Carvalho, Andre, additional, Vilaverde, Joana, additional, Freitas, Claudia, additional, Palma, Isabel, additional, Dores, Jorge, additional, Carvalho, Rui, additional, Bacelar, Conceicao, additional, Ramos, Helena, additional, and Cardoso, Helena, additional

Published
2019
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31. HIPOCALCEMIA NO SERVIÇO DE URGÊNCIA: REVISÃO DE 4 ANOS.

Author

Lages, Dídia, Vilaverde, Joana, and Borges, Fátima

Abstract

Copyright of Revista de Medicina e Saúde de Brasília is the property of Revista de Medicina e Saude de Brasilia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

33. Kallmann syndrome: about eleven clinical cases

Author

Fonseca, Liliana, primary, Amaral, Claudia, additional, Dores, Jorge, additional, Palma, Isabel, additional, Carvalho, Rui, additional, Cardoso, Helena, additional, Vilaverde, Joana, additional, and Borges, Fatima, additional

Published
2017
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41. Un caso poco habitual de diabetes.

Author

Matos, Rita, Ferreira, Marta, and Vilaverde, Joana

Subjects
TYPE 2 diabetes, BIOMARKERS, GENETIC testing, ETIOLOGY of diseases, DISEASE progression, GENETIC counseling
Abstract

Patients with Maturity Onset Diabetes of the Young (MODY) are often misclassified as having type 1 or type 2 diabetes and, as a result, are given inappropriate therapy. This case report aims to draw attention to MODY as a possible diagnosis in young diabetic patients. Biomarkers in combination with clinical characteristics, can help identify patients who should receive genetic testing. Rapid referral for genetic testing can avoid insulin use and establish optimal treatment. Furthermore, the knowledge of the genetic etiology will enable more-appropriate treatment, better prediction of disease progression, screening of family members and genetic counseling. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dyshormonogenesis

Author

Matos Figueiredo, Catarina, Falcão, Inês, Vilaverde, Joana, Freitas, Joana, João Oliveira, Maria, Godinho, Cristina, Dores, Jorge, Céu Rodrigues, Maria, Carvalho, Carmen, and Borges, Teresa

Abstract

Fetal goiter is a rare disorder not expected to be found during a healthy woman’s pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks’ gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without polyhydramnios. Maternal thyroid function was normal and thyroid antibodies were negative. Two intra-amniotic levothyroxine infusions were performed at 32 and 33 weeks. Serial imaging control showed no progression of the mass. Elective caesarean section was performed at 38 weeks. The male newborn was admitted to the intensive care unit due to cardiorespiratory insufficiency with pulmonary hypertension. Hormonal assays revealed primary congenital hypothyroidism and ultrasonography confirmed diffuse goiter. Levothyroxine was started. Currently, he is 6 years old with adequate growth and normal psychomotor development. Genetic study found a heterozygous mutation in the TPO gene.

Published
2018
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44. [Evaluation of diabetic foot amputation rate].

Author

Horta C, Vilaverde J, Mendes P, Gonçalves I, Serra L, Pinto PS, Almeida R, Carvalho R, Dores J, and Serra MB

Subjects
Aged, Diabetic Foot etiology, Diabetic Nephropathies complications, Female, Humans, Male, Middle Aged, Retrospective Studies, Amputation, Surgical statistics & numerical data, Diabetic Foot surgery
Abstract

In 1987, it was created the first portuguese Diabetic Foot Clinic in Oporto, at the Hospital Geral de Santo António. The distinction between neuropathic and ischaemic foot was the key stone to reduce drastically the rate of major amputations in the first two years of activity. Since then and until 1995 the rate of major amputations had stabilised around 8%. The aim of the present study was to evaluate if there was any change in the last three years. A retrospective study was performed reviewing the clinical files of 843 new patients between 1998 and 2000. The 593 patients who presented with a foot ulcer with or without infection were selected: 60.4% with neuropathic foot and 39.6% with ischaemic one. Overall, 31 of the 593 patients with ulcer or infection were treated with major amputation (5.2%). There was a statistical difference between the major amputation outcome among the two types of foot (p < 0.001). Necrosis showed to carry a poor prognosis (30.7% in ischaemic foot vs 8,3% in neuropathic, p = 0.024). There was no further statistical significance for age, sex, type or duration of diabetes as risk factors for major amputation. This retrospective study has showed a slight reduction in the rate of major amputations since 1995. Poor prognosis was related to necrosis and ischaemic foot. Further improvement requires harder investment in patients' education, as well as in alerting the primary health care physicians, for the most unpredictable catastrophic complication of diabetes.

Published
2003

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