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15. Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance

Author

Pilar Martin, Talbot-Wright R, Jordi Blasco, R. Gutierrez, Juan Alcover, Maria-Isabel Real, Vilardell J, Xavier Montanyà, Federico Oppenheimer, and Federico Cofán

Subjects
Male, Nephrology, medicine.medical_specialty, Time Factors, Percutaneous, medicine.medical_treatment, urologic and male genital diseases, Renal Artery, medicine.artery, Internal medicine, medicine, Humans, Renal artery, Kidney transplantation, Transplantation, Kidney, business.industry, medicine.disease, Embolization, Therapeutic, Kidney Transplantation, Nephrectomy, Surgery, medicine.anatomical_structure, Kidney Failure, Chronic, Female, Safety, business, Follow-Up Studies, Kidney disease
Abstract

The aim of the study was to evaluate the efficacy and safety of percutaneous renal artery embolisation of non-functioning renal allografts in patients with graft intolerance syndrome (GIS). Transcatheter artery embolisation was performed in 30 kidney transplant recipients with GIS. The duration of graft function had been 60+/-45 months. Infectious disease was ruled out in all patients. Embolisation consisted of the injection of polyvinyl alcohol microspheres followed by the insertion of a stainless steel coil in the renal artery branches. Symptoms of GIS included: fever-graft pain (44%, n=13), fever-hematuria-pain (20%, n=6), fever-hematuria (13%, n=4) and fever alone (23%, n=7). Latency time between graft failure and embolisation was 184+/-227 (17-1181) days. Embolisation was clinically successful with the prolonged disappearance of GIS in 24 patients (80%). Six patients showed initial clinical improvement, but GIS reappeared at 40+/-18 days, and graft nephrectomy was required. There were no major complications associated with embolisation and no deaths. Perirenal collateral supply was a risk factor for the reappearance of GIS. Renal vascular embolisation is a simple, safe and effective technique for treating renal allograft intolerance syndrome and could be a feasible alternative for the first-line treatment.

Published
2002

17. Pharmacokinetics and pharmacodynamics of mycophenolic acid in stable renal transplant recipients treated with low doses of mycophenolate mofetil

Author

M. Carrillo, Olga Millán, J. Corbella, Isabel Rojo, Jaume Martorell, Mercè Brunet, Frederic Oppenheimer, and Vilardell J

Subjects
Adult, Nephrology, medicine.medical_specialty, Time Factors, Adolescent, medicine.medical_treatment, Cmax, Pharmacology, Mycophenolate, Mycophenolic acid, IMP Dehydrogenase, Pharmacokinetics, Internal medicine, Humans, Medicine, Dosing, Aged, Transplantation, Dose-Response Relationship, Drug, business.industry, Immunosuppression, Middle Aged, Mycophenolic Acid, Kidney Transplantation, Area Under Curve, Pharmacodynamics, Cyclosporine, Prednisone, Drug Therapy, Combination, business, Immunosuppressive Agents, Follow-Up Studies, medicine.drug
Abstract

Suboptimal doses of mycophenolate mofetil (MMF) are frequently employed in renal transplant (Tx) patients, with drug-related side effects or low weight. The aim of this study was to compare the mycophenolic acid (MPA) pharmacokinetic profile and its pharmacodynamic effect on patients receiving either standard (2 g) or low (1.5 g or 1 g) MMF doses, in order to evaluate the therapeutic efficacy of such low doses in inhibiting IMPDH activity. Twenty-seven stable renal Tx recipients aged 18-65 years, with a post-Tx follow-up of 38.5 +/- 44.8 months (6-166 months), receiving 1 g (n = 10), 0.75 g (n = 7) and 0.5 g (n = 10) MMF twice a day in association with cyclosporine and prednisone, were included. The control group was made up of untreated healthy volunteers (n = 5). Plasma concentrations of MPA were analyzed by reverse-phase HPLC. IMPDH activity was determined in lymphocytes by the measurement of 3H release from [2,8-(3)H] hypoxantine. The mean value of areas under the concentration-time curves (AUC(0-12)) of MPA throughout the 12-h dosing interval in patients treated with 2 g was higher than the corresponding data in patients receiving 1.5 g or 1 g bid, but no statistical differences were observed between the three groups. There was no correlation between MPA-AUC(0-12) values and MMF dose (expressed in g/day or g/kg per day). Predose MPA concentrations correlated only weakly with the respective MPA-AUC(0-12) values (r2 from 0.385 to 0.655), whereas an acceptable correlation was observed between MPA Cmax and MPA-AUC(0-12) (r2 from 0.626 to 0.759) in 2 g, 1.5 g, and 1 g MMF groups. An inverse relationship between MPA concentrations and IMPDH activity was observed. In general, the maximum MPA concentration was achieved from 1 h to 2 h after dosing, and the maximum inhibition of IMPDH was also from 1 h to 2 h after dosing. The evaluation of IMPDH activity demonstrated that there was a significant statistical difference between samples from 0 to 1 h (P = 0.008) and 0 to 2 h (P = 0.04). In conclusion, concentration-time profiles of renal transplant recipients administered 0.75 g and 0.5 g twice a day are slightly lower than those from the 2 g group, but nor significantly. On the other hand, inhibition of IMPDH activity was comparable in the three groups, indicating considerable interindividual pharmacodynamic variability. Pharmacodynamic monitoring of the degree of immunosuppression and its correlation with MPA plasma concentrations will be assessed further in future studies.

Published
2000

19. Study of Kidney Rejection following Simultaneous Kidney-Pancreas Transplantation

Author

Frederic Cofan, P. Carretero, L. Fernandez-Cruz, María José Ricart, J. M. Campistol, Federico Oppenheimer, Vilardell J, and E. Astudillo

Subjects
Adult, Graft Rejection, Male, medicine.medical_specialty, Pancreatic disease, Urology, Renal function, Recurrence, Internal medicine, Diabetes Mellitus, medicine, Humans, Transplantation, Homologous, Kidney pancreas transplantation, Risk factor, Immunosuppression Therapy, Kidney, urogenital system, business.industry, General Medicine, Middle Aged, medicine.disease, Kidney Transplantation, Survival Analysis, Transplantation, medicine.anatomical_structure, Endocrinology, Evaluation Studies as Topic, Nephrology, Kidney Failure, Chronic, Female, Pancreas Transplantation, Pancreas, Complication, business
Abstract

Simultaneous kidney-pancreas (SKP) transplantation is associated with increased risk of kidney rejection (KR) due to an unknown mechanism. The aim of this study is to analyze the characteristics of KR in 44 SKP transplantations under quadruple immunosuppressive therapy and to evaluate the response to treatment and its effect on renal allograft survival and renal function. The mean follow-up was 25 +/- 14 months. Seventy-seven percent of the patients (34 of 44) presented an acute renal allograft rejection. Sixty-six percent (29 of 44) had one rejection episode and 11% (5 of 4) 2 episodes. KR was early (85% in the first month after transplantation), intense (3.7-fold increase in creatinine) and had great clinical features. Twenty-eight percent of the patients had an early relapse during the first month after treatment. KR did not affect the survival of the renal allograft in the short-term (1 and 2 years). Overall, 62% were corticosensitive (CS) and the remaining 38% were corticoresistant (CR). The group with an isolated rejection without relapse was CS in 69% of the cases, achieved complete remission in 73% and renal function was not affected at 1 and 2 years [115 +/- 26 mumol/l (1.3 +/- 0.3 mg/dl) and 150 +/- 53 mumol/l (1.7 +/- 0.6 mg/dl)] in comparison with the group without rejection [97 +/- 18 mumol/l (1.1 +/- 0.2 mg/dl) and 115 +/- 35 mumol/l (1.3 +/- 0.4 mg/dl); p = NS]. On the other hand, the group with an early relapse of the first rejection and the group with two rejections were principally CR (62 and 60%, respectively), had partial remission with treatment (50 and 60%) and had worse renal function at 1 and 2 years [212 +/- 71 mumol/l (2.4 +/- 0.8 mg/dl) and 221 +/- 53 mumol/l (2.5 +/- 0.6 mg/dl)] than in the group with isolated KR (p0.05 and p0.001). In conclusion, despite intense immunosuppressive treatment, the frequency of rejection of a renal allograft in SKP is high. The response to treatment is satisfactory and does not affect the survival of the allograft in the short-term. However, multiple episodes or early relapse of rejection are associated with higher creatinine levels.

Published
1996

22. Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: Influence of dose and stem cell source shows better outcome with rich marrow

Author

Gorin N.C., Labopin M., Rocha V., Arcese W., Beksac M., Gluckman E., Ringden O., Ruutu T., Reiffers J., Bandini G., Falda M., Zikos P., Willemze R., Frassoni F., Abecasis M., Abráhamová J., Afanassiev B.V., Aglietta M., Alabdulaaly A., Aleinikova O., Paolo Alessandrino E., Al Shemmari S.H., Amadori D., Amadori S., Amos T., Andolina M., Andreesen R., Angelucci E., Anhuf J., Arnold R., Arpaci F., Attal M., Azevedo W., Azim H.A., Baccarani M., Bacigalupo A., Barbui T., Bargetzi M., Barnard D.L., Bartsch H.H., Baruchel A., Battista C., Bay J.-O., Bayik M., Bazarbachi A., Beguin Y., López J.L.B., Benedek I., Benedetti F., Bengala C., Berrebi A., Besalduch J., Biesma D., Biron P., Björkholm M., Blaise D., Blesing N.E., Boasson M., Bobev D., Boccadoro M., Bolaman Z., Boogaerts M.A., Bordessoule D., Bosi A., Aida B.S., Bourhis J.H., Bourikas G., Bowen D.T., Bregni M., Bries G., Brinch L., Brittain D., Bron D., Brune M., Bullorsky E.O., Bunjes D., Burdach S., Burnett A.K., Buzyn A., Caballero D., Cagirgan S., Cahn J.-Y., Canepa C.O., Cao A., Carella A.M., Carrera F.D., Carret A.-S., Cascinu S., Castel V., Caswell M., Cavanna L., Cetto G.L., Chapuis B., Chasty R., Chen Y.-C., Chisesi T., Chopra R., Chybicka A., Clark R.E., Colombat P., Colovic M.D., Constenla-Figueiras M., Contreras M., Contu L., Cordonnier C., Cornelissen J.J., Cornish J., Coser P., Costa N., Coze C., Craddock C., Crown J., Culligan D.J., Danova M., Darbyshire P.J., Davies J.M., de Bock R., de Pablos Gallego J.M., De Prijck B., de Revel T., De Rossi G., De Souza C.A., Deb G., Degos L., Demuynck H., Dervenoulas I., Di Bartolomeo P., Di Renzo N., Diaz M.A., Diehl V., Diez-Martin J.L., Dincer S., Giorgio D., Dmoszynska A., Doelken G., Peter P.D., Dulley F., Easow J., Ebell W., Efremidis A., Ehninger G., Eichler H., Eimermacher H., Enno A., Errazquin L., Aguado J.E., Everaus H., Fagioli F., Fanin R., Fassas A., Fasth A., Faulkner L.B., Fauser A.A., Feldman L., Feremans W., Ferhanoglu B., Fernández M.N., Fernández-Ranada J.M., Ferrant A., Ferrara F., Finke J., Fischer A., Fischer J., Fitzsimons T., Floristan F., Forjaz de Lacerda J.M.F., Fossati-Bellani F., Fosser V., Franklin I., Freund M., Frickhofen N., Gabbas A., Gadner H., Gallamini A., Galvin M.C., López J.G., García-Conde J., Gaska T., Gastl G., Gedikoglu G., Ghavamzadeh A., Gianni A., Gibson B.E., Gil J.L., Gilleece M.H., Gisselbrecht C., Glass B., Gmür J., Göbel U., Goldman J.M., Goldstone A.H., San Miguel J.D.G., González-López M.-A., Grafakos S., Gramatzki M., Grañena A., Gratecos N., Gratwohl A., Greinix H.T., Gugliotta L., Guilhot F., Guimaraes J.E., Gülbas Z., Gulyuz O., Gurman G., Gutierrez M.M., Haas R., Hamladji R.-M., Hamon M.D., Hansen N.E., Harhalakis N., Harousseau J.L., Hartenstein R., Hartmann C.O., Hausmaninger H., Haznedar R., Heit W., Hellmann A., Herrmann R.P., Hertenstein B., Hess U., Hinterberger W., Ho A.D., Hoelzer D., Holowiecki J., Horst H.-A., Hossfeld D.K., Huebsch L., Hunter A.E., Iacopino P., Iannitto E., Indrák K., Iriondo A., Izzi T., Jackson G.L., Jacobs P., Jacobsen N., Janvier M., Jebavy L., Joensuu H., Joerg S., Jones F.G.C., Jouet J.P., Joyner M.V., Juliusson G., Jürgens H., Kalayoglu-Besisik S., Kalman N., Kalmanti M., Kansoy S., Kansu E., Kanz L., Karianakis G., Kernéis Y., Khalifeh O., Khomenko V., Kienast J., Killick S., Kirchner H.H., Klingebiel T., Knauf W., Koenigsmann M., Koistinen P., Koivunen E., Kolb H.-J., Kolbe K., Koller E., Komarnicki M., Koscielniak E., Kovacsovics T., Kowalczyk J.R., Koza V., Kozak T., Kugler J., Kuliczkowski K., Kvaloy S., Labar B., Laciura P., Palacios J.J.L., Lakota J., Lambertenghi D.G., Lange A., Lanza F., Isasti R.L., Lauria F., Le Moine F., Leblond V., Lelli G., Lenhoff S., Leon L.A., Leoncini-Franscini L., Leone G., Leoni P., Levis A., Leyvraz S., Liberati M., Link H., Linkesch W., Liso V., Lisukov I.A., Littlewood T., Ljungman P., Locatelli F., Losonczy H., Lotz J.-P., Ludwig H., Lukac J., Lutz D., Macchia P., Madrigal A., Maiolino A., Majolino I., Eloy-García J.M., Malesevic M., Mandelli F., Marc A., Marcus R., Marianska B., Markuljak I., Marsh J.C.W., Martelli M.F., Marti Tutusaus J.M., Martin S., Martin M., Martinelli G., Martínez-Rubio A.M., Martoni A., Maschan A., Maschmeyer G., Masszi T., Mazza P., McCann S., Meier C.R., Messina C., Mettivier V., Metzner B., Michallet M., Michieli M., Michon J., Milligan D.W., Milone J.H., Giuseppe G.M., Minigo H., Mistrik M., Moicean A.D., Monfardini S., Montserrat E., Moraleda Jimenez J.M., Morales-Lazaro A., Morandi S., Morra E., Mufti G.J., Musso M., Nagler A., Nalli G., Naparstek E., Narni F., Nenadov-Beck M., Neubauer A., Newland A.C., Niederwieser D., Niethammer D., Noens L.A., Nousiainen T., Novik A., Novitzky N., Occhini D., Odriozolas J., Ojanguren J.M., O’meara A., Onat H., Orchard K., Ortega J.J., Osieka R., Ossenkoppele G.J., Othman B., Ovali E., Ozcebe O.I., Ozerkan K., Ozturk A., Papatryfonos A., Parker J.E., Pastore M., Patrone F., Patton N., Pejin D., Peñarrubia M.J., Equiza E.P., Peschel C., Pession A., Pigaditou A., Pignon B., Pihkala U., Pimentel P., Pitini V., Podoltseva E., Pogliani E.M., Anna A.P., Porta F., Potter M., Powles R., Prentice G.H., Pretnar J., Ptushkin V., Quarta G., Reiter A., Remes K., Reykdal S., Santasusana J.M.R., Rifón J., Rio B., Rizzoli V., Robak T., Robinson A.J., Rodeghiero F., Rodríguez Fernández J.M., Rombos Y., Romeril K.R., Rosenmayr A., Rossi J.F., Rosti G., Rotoli B., Rowe J.M., Russell N.H., Ryzhak O., Rzepecki P., Saglio G., Salwender H., Samonigg H., Santoro A., Sanz M.A., Sayer H.G., Scanni A., Schaafsma M.R., Schaefer U.W., Schanz U., Schattenberg A., Schey S.A.M., Schlimok G., Schmoll H.-J., Schots R., Schouten H., Schwarer A.P., Schwerdtfeger R., Scimè R., Segel E., Seger R., Selleslag D., Serban M., Shamaa S., Shaw P.J., Siegert W., Siena S., Sierra J., Simonsson B., Singer C.R.J., Sirchia G., Skotnicki A.B., Slavin S., Snowden J., Sotto J.J., Tanyeli A., Tedeschi L., Tidefelt U., Tissot J.-D., Tobler A., Tomas J.F., Torres J.P., Torres G.A., Touraine J.-L., Trneny M., Uderzo C., Unal E., Unal A., Undar L., Urban C., Van den Berg H., van Marwijk K.M., Vellenga E., Venturini M., Verdonck L.F., Veys P., Vilardell J., Vinante O., Visani G., Vitek A., Vivancos P., Volpe E., Vora A., Vorlicek J., Vowels M., Vujic D., Wachowiak J., Wagner T., Wahlin A., Walewski J., Wandt H., Weissinger F., Wijermans P.W., Wiktor-Jedrzejczak W., Will A.M., Woell E., Wörmann B., Yaniv I., Yesilipek M.A., Yilmaz U., Yong A., Zachée P., Zambelli A., Zander A.R., Zintl F., Zoumbos N.C., Çukurova Üniversitesi, Maltepe Üniversitesi, and Ege Üniversitesi

Subjects
Myeloid, Male, Pathology, Time Factors, Graft vs Host Disease, Biochemistry, Gastroenterology, Blood cell, Bone Marrow, Child, Bone Marrow Transplantation, Leukemia, Remission Induction, Hematology, Middle Aged, Prognosis, Leukemia, Myeloid, Acute, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, medicine.anatomical_structure, Treatment Outcome, Child, Preschool, Female, Stem cell, InformationSystems_MISCELLANEOUS, Homologous, Adult, medicine.medical_specialty, Adolescent, Immunology, Acute, Disease-Free Survival, Internal medicine, medicine, Transplantation, Homologous, Humans, Preschool, Aged, Transplantation, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Cell Biology, medicine.disease, Peripheral blood, Histocompatibility, Multivariate Analysis, Stem Cell Transplantation, ComputingMethodologies_PATTERNRECOGNITION, Myelocytic leukemia, Bone marrow, business, Settore MED/15 - Malattie del Sangue
Abstract

PubMed ID: 12829583, Several studies have compared bone marrow (BM) and peripheral blood (PB) as stem cell sources in patients receiving allografts, but the cell doses infused have not been considered, especially for BM. Using the ALWP/EBMT registry, we retrospectively studied 881 adult patients with acute myelocytic leukemia (AML), who received a non-T-depleted allogeneic BM (n = 515) or mobilized PB (n = 366) standard transplant, in first remission (CR1), from an HLA-identical sibling, over a 5-year period from January 1994. The BM cell dose ranged from 0.17 to 29 × 10 8 /kg with a median of 2.7 × 10 8 /kg. The PB cell dose ranged from 0.02 to 77 × 10 8 /kg with a median of 9.3 × 10 8 /kg. The median dose for patients receiving BM (2.7 × 10 8 /kg) gave the greatest discrimination. In multivariate analyses, high-dose BM compared to PB was associated with lower transplant-related mortality (RR = 0.61; 95% CI, 0.39-0.98; P = .04), better leukemia-free survival (RR = 0.65; 95% CI, 0.46-0.91; P = .013), and better overall survival (RR = 0.64; 95% CI, 0.44-0. 92; P = .016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich. © 2003 by The American Society of Hematology.

Published
2003

23. Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: Influence of dose and stem cell source shows better outcome with rich marrow

Author

Gorin, N.C. Labopin, M. Rocha, V. Arcese, W. Beksac, M. Gluckman, E. Ringden, O. Ruutu, T. Reiffers, J. Bandini, G. Falda, M. Zikos, P. Willemze, R. Frassoni, F. Abecasis, M. Abráhamová, J. Afanassiev, B.V. Aglietta, M. Alabdulaaly, A. Aleinikova, O. Paolo Alessandrino, E. Al Shemmari, S.H. Amadori, D. Amadori, S. Amos, T. Andolina, M. Andreesen, R. Angelucci, E. Anhuf, J. Arnold, R. Arpaci, F. Attal, M. Azevedo, W. Azim, H.A. Baccarani, M. Bacigalupo, A. Barbui, T. Bargetzi, M. Barnard, D.L. Bartsch, H.H. Baruchel, A. Battista, C. Bay, J.-O. Bayik, M. Bazarbachi, A. Beguin, Y. López, J.L.B. Benedek, I. Benedetti, F. Bengala, C. Berrebi, A. Besalduch, J. Biesma, D. Biron, P. Björkholm, M. Blaise, D. Blesing, N.E. Boasson, M. Bobev, D. Boccadoro, M. Bolaman, Z. Boogaerts, M.A. Bordessoule, D. Bosi, A. Aida, B.S. Bourhis, J.H. Bourikas, G. Bowen, D.T. Bregni, M. Bries, G. Brinch, L. Brittain, D. Bron, D. Brune, M. Bullorsky, E.O. Bunjes, D. Burdach, S. Burnett, A.K. Buzyn, A. Caballero, D. Cagirgan, S. Cahn, J.-Y. Canepa, C.O. Cao, A. Carella, A.M. Carrera, F.D. Carret, A.-S. Cascinu, S. Castel, V. Caswell, M. Cavanna, L. Cetto, G.L. Chapuis, B. Chasty, R. Chen, Y.-C. Chisesi, T. Chopra, R. Chybicka, A. Clark, R.E. Colombat, P. Colovic, M.D. Constenla-Figueiras, M. Contreras, M. Contu, L. Cordonnier, C. Cornelissen, J.J. Cornish, J. Coser, P. Costa, N. Coze, C. Craddock, C. Crown, J. Culligan, D.J. Danova, M. Darbyshire, P.J. Davies, J.M. de Bock, R. de Pablos Gallego, J.M. De Prijck, B. de Revel, T. De Rossi, G. De Souza, C.A. Deb, G. Degos, L. Demuynck, H. Dervenoulas, I. Di Bartolomeo, P. Di Renzo, N. Diaz, M.A. Diehl, V. Diez-Martin, J.L. Dincer, S. Giorgio, D. Dmoszynska, A. Doelken, G. Peter, P.D. Dulley, F. Easow, J. Ebell, W. Efremidis, A. Ehninger, G. Eichler, H. Eimermacher, H. Enno, A. Errazquin, L. Aguado, J.E. Everaus, H. Fagioli, F. Fanin, R. Fassas, A. Fasth, A. Faulkner, L.B. Fauser, A.A. Feldman, L. Feremans, W. Ferhanoglu, B. Fernández, M.N. Fernández-Ranada, J.M. Ferrant, A. Ferrara, F. Finke, J. Fischer, A. Fischer, J. Fitzsimons, T. Floristan, F. Forjaz de Lacerda, J.M.F. Fossati-Bellani, F. Fosser, V. Franklin, I. Freund, M. Frickhofen, N. Gabbas, A. Gadner, H. Gallamini, A. Galvin, M.C. López, J.G. García-Conde, J. Gaska, T. Gastl, G. Gedikoglu, G. Ghavamzadeh, A. Gianni, A. Gibson, B.E. Gil, J.L. Gilleece, M.H. Gisselbrecht, C. Glass, B. Gmür, J. Göbel, U. Goldman, J.M. Goldstone, A.H. San Miguel, J.D.G. González-López, M.-A. Grafakos, S. Gramatzki, M. Grañena, A. Gratecos, N. Gratwohl, A. Greinix, H.T. Gugliotta, L. Guilhot, F. Guimaraes, J.E. Gülbas, Z. Gulyuz, O. Gurman, G. Gutierrez, M.M. Haas, R. Hamladji, R.-M. Hamon, M.D. Hansen, N.E. Harhalakis, N. Harousseau, J.L. Hartenstein, R. Hartmann, C.O. Hausmaninger, H. Haznedar, R. Heit, W. Hellmann, A. Herrmann, R.P. Hertenstein, B. Hess, U. Hinterberger, W. Ho, A.D. Hoelzer, D. Holowiecki, J. Horst, H.-A. Hossfeld, D.K. Huebsch, L. Hunter, A.E. Iacopino, P. Iannitto, E. Indrák, K. Iriondo, A. Izzi, T. Jackson, G.L. Jacobs, P. Jacobsen, N. Janvier, M. Jebavy, L. Joensuu, H. Joerg, S. Jones, F.G.C. Jouet, J.P. Joyner, M.V. Juliusson, G. Jürgens, H. Kalayoglu-Besisik, S. Kalman, N. Kalmanti, M. Kansoy, S. Kansu, E. Kanz, L. Karianakis, G. Kernéis, Y. Khalifeh, O. Khomenko, V. Kienast, J. Killick, S. Kirchner, H.H. Klingebiel, T. Knauf, W. Koenigsmann, M. Koistinen, P. Koivunen, E. Kolb, H.-J. Kolbe, K. Koller, E. Komarnicki, M. Koscielniak, E. Kovacsovics, T. Kowalczyk, J.R. Koza, V. Kozak, T. Kugler, J. Kuliczkowski, K. Kvaloy, S. Labar, B. Laciura, P. Palacios, J.J.L. Lakota, J. Lambertenghi, D.G. Lange, A. Lanza, F. Isasti, R.L. Lauria, F. Le Moine, F. Leblond, V. Lelli, G. Lenhoff, S. Leon, L.A. Leoncini-Franscini, L. Leone, G. Leoni, P. Levis, A. Leyvraz, S. Liberati, M. Link, H. Linkesch, W. Liso, V. Lisukov, I.A. Littlewood, T. Ljungman, P. Locatelli, F. Losonczy, H. Lotz, J.-P. Ludwig, H. Lukac, J. Lutz, D. Macchia, P. Madrigal, A. Maiolino, A. Majolino, I. Eloy-García, J.M. Malesevic, M. Mandelli, F. Marc, A. Marcus, R. Marianska, B. Markuljak, I. Marsh, J.C.W. Martelli, M.F. Marti Tutusaus, J.M. Martin, S. Martin, M. Martinelli, G. Martínez-Rubio, A.M. Martoni, A. Maschan, A. Maschmeyer, G. Masszi, T. Mazza, P. McCann, S. Meier, C.R. Messina, C. Mettivier, V. Metzner, B. Michallet, M. Michieli, M. Michon, J. Milligan, D.W. Milone, J.H. Giuseppe, G.M. Minigo, H. Mistrik, M. Moicean, A.D. Monfardini, S. Montserrat, E. Moraleda Jimenez, J.M. Morales-Lazaro, A. Morandi, S. Morra, E. Mufti, G.J. Musso, M. Nagler, A. Nalli, G. Naparstek, E. Narni, F. Nenadov-Beck, M. Neubauer, A. Newland, A.C. Niederwieser, D. Niethammer, D. Noens, L.A. Nousiainen, T. Novik, A. Novitzky, N. Occhini, D. Odriozolas, J. Ojanguren, J.M. O’meara, A. Onat, H. Orchard, K. Ortega, J.J. Osieka, R. Ossenkoppele, G.J. Othman, B. Ovali, E. Ozcebe, O.I. Ozerkan, K. Ozturk, A. Papatryfonos, A. Parker, J.E. Pastore, M. Patrone, F. Patton, N. Pejin, D. Peñarrubia, M.J. Equiza, E.P. Peschel, C. Pession, A. Pigaditou, A. Pignon, B. Pihkala, U. Pimentel, P. Pitini, V. Podoltseva, E. Pogliani, E.M. Anna, A.P. Porta, F. Potter, M. Powles, R. Prentice, G.H. Pretnar, J. Ptushkin, V. Quarta, G. Reiter, A. Remes, K. Reykdal, S. Santasusana, J.M.R. Rifón, J. Rio, B. Rizzoli, V. Robak, T. Robinson, A.J. Rodeghiero, F. Rodríguez Fernández, J.M. Rombos, Y. Romeril, K.R. Rosenmayr, A. Rossi, J.F. Rosti, G. Rotoli, B. Rowe, J.M. Russell, N.H. Ryzhak, O. Rzepecki, P. Saglio, G. Salwender, H. Samonigg, H. Santoro, A. Sanz, M.A. Sayer, H.G. Scanni, A. Schaafsma, M.R. Schaefer, U.W. Schanz, U. Schattenberg, A. Schey, S.A.M. Schlimok, G. Schmoll, H.-J. Schots, R. Schouten, H. Schwarer, A.P. Schwerdtfeger, R. Scimè, R. Segel, E. Seger, R. Selleslag, D. Serban, M. Shamaa, S. Shaw, P.J. Siegert, W. Siena, S. Sierra, J. Simonsson, B. Singer, C.R.J. Sirchia, G. Skotnicki, A.B. Slavin, S. Snowden, J. Sotto, J.J. Tanyeli, A. Tedeschi, L. Tidefelt, U. Tissot, J.-D. Tobler, A. Tomas, J.F. Torres, J.P. Torres, G.A. Touraine, J.-L. Trneny, M. Uderzo, C. Unal, E. Unal, A. Undar, L. Urban, C. Van den Berg, H. van Marwijk, K.M. Vellenga, E. Venturini, M. Verdonck, L.F. Veys, P. Vilardell, J. Vinante, O. Visani, G. Vitek, A. Vivancos, P. Volpe, E. Vora, A. Vorlicek, J. Vowels, M. Vujic, D. Wachowiak, J. Wagner, T. Wahlin, A. Walewski, J. Wandt, H. Weissinger, F. Wijermans, P.W. Wiktor-Jedrzejczak, W. Will, A.M. Woell, E. Wörmann, B. Yaniv, I. Yesilipek, M.A. Yilmaz, U. Yong, A. Zachée, P. Zambelli, A. Zander, A.R. Zintl, F. Zoumbos, N.C. The Acute Leukemia Working Party (ALWP) of the European Cooperative Group for Blood Marrow Transplantation (EBMT)

Abstract

Several studies have compared bone marrow (BM) and peripheral blood (PB) as stem cell sources in patients receiving allografts, but the cell doses infused have not been considered, especially for BM. Using the ALWP/EBMT registry, we retrospectively studied 881 adult patients with acute myelocytic leukemia (AML), who received a non-T-depleted allogeneic BM (n = 515) or mobilized PB (n = 366) standard transplant, in first remission (CR1), from an HLA-identical sibling, over a 5-year period from January 1994. The BM cell dose ranged from 0.17 to 29 × 108/kg with a median of 2.7 × 108/kg. The PB cell dose ranged from 0.02 to 77 × 10 8/kg with a median of 9.3 × 108/kg. The median dose for patients receiving BM (2.7 × 108/kg) gave the greatest discrimination. In multivariate analyses, high-dose BM compared to PB was associated with lower transplant-related mortality (RR = 0.61; 95% CI, 0.39-0.98; P = .04), better leukemia-free survival (RR = 0.65; 95% CI, 0.46-0.91; P = .013), and better overall survival (RR = 0.64; 95% CI, 0.44-0. 92; P = .016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich. © 2003 by The American Society of Hematology.

Published
2003

25. Determinación simplificada del módulo de deformación del hormigón de presas

Author

Aguado de Cea, Antonio, Agulló Fité, Luís, Gettu, Ravindra, Vilardell, J, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, Universitat Politècnica de Catalunya. TE - Tecnologia d'Estructures, and Universitat Politècnica de Catalunya. MECMAT - Mecànica de Materials

Subjects
Preses (Enginyeria), Llosa del Cavall, Pantà de la (Catalunya), Enginyeria civil::Enginyeria hidràulica, marítima i sanitària::Embassaments i preses [Àrees temàtiques de la UPC], Dams
Abstract

La determininación del módulo de elasticidad del hormigón de presas es difiícil tanto en medidas directas en la presa como mediante probetas, ya que se requieren ensayos con probetas de gran dimensión y, consecuentemente, grandes prensas de ensayo, asi como medios auxiliares de manipulación. En la presente comunicación se muestra un método altemativo de obtención del valor del módulo de deformación longitudinal del hormigón de presa. El mismo parte de ensayos convencionales con probetas cilíndricas (15x30 cm) y con probetas de mortero, a cuyos resultados se ajusta, modelos bifásicos. Los resultados obtenidos con l.os modelos se contrastan con probetas prismáticas grandes de 45x45x90 cm, fabricadas con el hormigón de presa (tamaño máximo del árido de 120 mm). Este contraste se ha hecho para edades desde 7 a 180 días, con el hormigón utilizado en la presa de la Llosa del Cavall. El conjunto de resultados ha sido bueno, permitiendo un metodo sencillo y fiable de obtención del modulo del hormigón (como material), a partir de ensayos estandar.

Published
2002

26. 768 Gene expression profile changes in response to overexpression or silencing of the hhavcr-1/kim-1 gene in the 769-p and 786-o ccRCC cell lines

Author

Trilla, E., primary, Lorente, D., additional, López-Pacios, M.A., additional, Cuadros, T., additional, Vilà, M., additional, De Torres, I., additional, Vilardell, J., additional, Ben Messaoud, N., additional, Salcedo, M., additional, Sarró, E., additional, López-Hellin, J., additional, Ramón, Y Cajal S., additional, Itarte, E., additional, Meseguer, A., additional, and Morote, J., additional

Published
2013
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27. Criterios para el diseño del pretensado de un depósito cilíndrico con una unión continua pared-solera

Author

Vilardell, J M, Aguado de Cea, Antonio|||0000-0001-5542-6365, Mirambell Arrizabalaga, Enrique|||0000-0003-2612-9104, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, and Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials

Subjects
Enginyeria civil::Materials i estructures::Materials i estructures de formigó [Àrees temàtiques de la UPC], Concrete tanks--Design and construction, Dipòsits de formigó pretesat
Abstract

La misión principal del pretensado circunferencial de la pared de un depósito cilíndrico de hormigón es la de compensar las atracciones anulares originadas por la carga de agua y, en menor medida, contrarrestar las debidas a otras solicitaciones (gradiente térmico, retracción, carga sin simetría de revolución, etc.). Cuando la unión de la pared y la solera es continua, el movimiento radial del borde inferior de la pared está impedido, y el pretensado próximo a la base no sólo no comprime apenas la pared, sino que introduce esfuerzos de flexión general importantes. Con la intención de reducir en lo posible este comportamiento de flexión, varios autores han recurrido a formular leyes óptimas de pretensado que redistribuyen los tendones de pretensado en la parte inferior del depósito para conseguir su máxima eficacia en la compresión radial de la pared. En este trabajo se presenta un estudio comparativo entre cinco funciones de pretensado, algunas de ellas propuestas en la literatura técnica y otras propuestas por los autores del presente artículo. Dicho estudio se ha llevado a cabo con un modelo de análisis analítico lineal, que considera el comportamiento conjunto pared-solera-cimentación, y se ha basado en unos requisitos comunes de diseño del pretensado, previamente establecidos. Los resultados obtenidos en el estudio han permitido determinar una función óptima de pretensado, tanto en lo que concierte a su ley de distribución como en lo que se refiere a la fuerza necesaria de pretensado. También han mostrado algunas diferencias significativas entre los resultados obtenidos en este estudio y los presentados por otros autores en la literatura técnica, debidas, principalmente, al hecho de haber estudiado el depósito con unión continua en la base con un modelo que contempla la capacidad real de movimiento de la unión.

Published
1997

28. Influence of simultaneous pancreas and kidney transplantation on renal graft survival

Author

Mj, Ricart, Mc, Bacqué, Esmatjes E, Oppenheimer F, Vilardell J, Campistol Josep M, Carretero P, and Fernández-Cruz L

Subjects
Adult, Immunosuppression Therapy, Male, Chi-Square Distribution, Time Factors, Adolescent, Histocompatibility Testing, Graft Survival, HLA-DR Antigens, Middle Aged, Kidney Transplantation, Cyclosporine, Humans, Female, Pancreas Transplantation, Follow-Up Studies, Retrospective Studies
Published
1995

30. Determinación simplificada del módulo de deformación del hormigón de presas

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, Universitat Politècnica de Catalunya. TE - Tecnologia d'Estructures, Universitat Politècnica de Catalunya. MECMAT - Mecànica de Materials, Aguado de Cea, Antonio, Agulló Fité, Luís, Gettu, Ravindra, Vilardell, J, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, Universitat Politècnica de Catalunya. TE - Tecnologia d'Estructures, Universitat Politècnica de Catalunya. MECMAT - Mecànica de Materials, Aguado de Cea, Antonio, Agulló Fité, Luís, Gettu, Ravindra, and Vilardell, J

Abstract

La determininación del módulo de elasticidad del hormigón de presas es difiícil tanto en medidas directas en la presa como mediante probetas, ya que se requieren ensayos con probetas de gran dimensión y, consecuentemente, grandes prensas de ensayo, asi como medios auxiliares de manipulación. En la presente comunicación se muestra un método altemativo de obtención del valor del módulo de deformación longitudinal del hormigón de presa. El mismo parte de ensayos convencionales con probetas cilíndricas (15x30 cm) y con probetas de mortero, a cuyos resultados se ajusta, modelos bifásicos. Los resultados obtenidos con l.os modelos se contrastan con probetas prismáticas grandes de 45x45x90 cm, fabricadas con el hormigón de presa (tamaño máximo del árido de 120 mm). Este contraste se ha hecho para edades desde 7 a 180 días, con el hormigón utilizado en la presa de la Llosa del Cavall. El conjunto de resultados ha sido bueno, permitiendo un metodo sencillo y fiable de obtención del modulo del hormigón (como material), a partir de ensayos estandar., Postprint (published version)

Published
2002

32. Increased risk of malignant tumors in renal transplant recipients receiving cyclosporine

Author

Vilardell, J., Oppenheimer, F., Talbot-Wright, R., Ricart, M. J., Andreu, J., Antonio Alcaraz Asensio, and Carretero, P.

Subjects
Adult, Immunosuppression Therapy, Male, Risk Factors, Neoplasms, Azathioprine, Cyclosporine, Humans, Prednisone, Transplantation, Homologous, Female, Kidney Transplantation, Retrospective Studies
Published
1992

34. Renal transplantation in elderly recipients

Author

Andreu J, de la Torre M, Oppenheimer F, Campistol Josep M, Mj, Ricart, Vilardell J, Talbot R, and Carretero P

Subjects
Graft Rejection, Male, Time Factors, Age Factors, Middle Aged, Kidney Transplantation, Renal Dialysis, Azathioprine, Cyclosporine, Humans, Female, Kidney Diseases, Aged, Follow-Up Studies, Retrospective Studies
Published
1992

35. Utility of pulsed Doppler in the diagnosis and follow-up of acute vascular graft rejection treated with OKT3 monoclonal antibody or antilymphocyte serum

Author

J. M. Campistol, J. Andreu, L. Bianchi, Rosa Gilabert, Vilardell J, and Concepció Brú

Subjects
Adult, Graft Rejection, Male, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Urology, Diastole, Monoclonal antibody, Kidney, Renal Circulation, medicine, Humans, Antilymphocyte Serum, Ultrasonography, Immunosuppression Therapy, Transplantation, Pulsed doppler, biology, business.industry, Biopsy, Needle, Antibodies, Monoclonal, Blood flow, Immunotherapy, Kidney Transplantation, Surgery, medicine.anatomical_structure, Creatinine, biology.protein, Acute vascular graft rejection, Female, Antibody, business, Muromonab-CD3
Abstract

Fifteen patients with severe acute vascular graft rejection (twelve of them steroid-resistant) treated with OKT3 monoclonal antibody (8) or antilymphocyte serum (7) were sequentially studied with duplex-Doppler ultrasonography (DDUS). Measurements of intrarenal resistance were obtained by means of the resistive index (RI). During rejection episodes, the intrarenal resistance was increased in all patients (RI range: 0.89–1), with absent or reversed diastolic blood flow. Normalization of diastolic blood flow was documented prior to the decrease of serum creatinine level in all patients who recovered from a rejection episode. We conclude that DDUS is a noninvasive technique useful in the diagnosis and monitoring of acute vascular graft rejection. Prediction of graft outcome after rejection treatment could probably be made based on DDUS findings.

Published
1991

36. Mycophenolic acid monitoring: evaluation of the EMIT MPA immunoassay in kidney and lung transplantation

Author

M.C Carreño, Vilardell J, M. Brunet, J. Corbella, Jaume Martorell, Frederic Oppenheimer, and M. Carrillo

Subjects
Adult, medicine.medical_specialty, medicine.medical_treatment, Urology, Mycophenolic acid, Acide mycophenolique, Enzyme Multiplied Immunoassay Technique, medicine, Humans, Lung transplantation, Chromatography, High Pressure Liquid, Transplantation, Kidney, medicine.diagnostic_test, business.industry, Reproducibility of Results, Mycophenolic Acid, Kidney Transplantation, Acido micofenolico, medicine.anatomical_structure, Therapeutic drug monitoring, Area Under Curve, Immunoassay, Immunology, Surgery, Drug Monitoring, business, Immunosuppressive Agents, Lung Transplantation, medicine.drug
Published
1999

38. Results of renal transplantation for dialysis arthropathy

Author

Campistol Josep M, Muñoz-Gomez J, Solé M, Oppenheimer F, Vilardell J, and Andreu J

Subjects
Graft Rejection, Renal Dialysis, Creatinine, Humans, Amyloidosis, Joint Diseases, Kidney Transplantation, Follow-Up Studies
Published
1990

39. [Kidney transplantation]

Author

Talbot-Wright R, Antonio Alcaraz Asensio, Carretero P, Alvarez R, Vilardell J, Ictech S, and Quiroga G

Subjects
Graft Rejection, Reoperation, Postoperative Complications, Humans, Surgical Wound Infection, Kidney Transplantation
Abstract

In a consecutive series of 639 Renal Transplants (RT) performed between January 1st 1978 and December 31st 1988, 75 Renal Transplanctectomies (RTX) were carried out. Of those, fifty-seven (76%) were due to immunological causes, 10 (13.3%) to vascular complications, 7 (9.3%) to urological problems and 1 (1.3%) to deep infection. The time elapsed between RTX and RT was as follows: 25 were performed earlier than 6 weeks, 17 between 6 weeks to 6 months, and 33 after 6 months. The higher number of complications did not happened, as it is frequently described, in the first group; on the contrary, it fell in the group that had been transplanted longer. There were 13 immunologically caused renal rhexis, 5 of which were RTX, another 5 were operated on and diagnosed at perioperation, and immediately received the appropriate treatment so they were able to keep their kidney, and finally, 3 patients were diagnosed a rejection with renal rhexis, ecographically confirmed. These patients were given only medical treatment, which was enough to allow jugulation of the picture. RTX techniques used were: extracapsular in 28 cases and intracapsular in 47. Surgical approach, except for 2 cases of simultaneous kidney and pancreas transplantation, was extraperitoneal.

Published
1990

42. Estimation of the modulus of elasticity for dam concrete

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria de la Construcció, Vilardell, J., Aguado de Cea, Antonio, Agulló Fité, Luís, Gettu, Ravindra, Universitat Politècnica de Catalunya. Departament d'Enginyeria de la Construcció, Vilardell, J., Aguado de Cea, Antonio, Agulló Fité, Luís, and Gettu, Ravindra

Abstract

The modulus of elasticity of dam concrete is difficult to determine directly from tests due to the necessity for large specimens and testing machines. In order to study the applicability of simple elastic models for predicting the modulus from standard size specimens, tests were conducted on prisms of 45×45×90 cm fabricated with dam concrete (maximum aggregate of 120 mm). The tests on standard 15×30 cm cylinders were made with the mortar and wet-screened components of this concrete. It is seen that the use of the data from these components together with estimated values of the modulus of the aggregates gives reasonable predictions of the moduli of the dam concrete. This has been verified for a range of ages, from 7 to 180 days., Peer Reviewed

Published
1998

43. Criterios para el diseño del pretensado de un depósito cilíndrico con una unión continua pared-solera

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Vilardell, J M, Aguado de Cea, Antonio, Mirambell Arrizabalaga, Enrique, Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental, Universitat Politècnica de Catalunya. EC - Enginyeria de la Construcció, Universitat Politècnica de Catalunya. ATEM - Anàlisi i Tecnologia d'Estructures i Materials, Vilardell, J M, Aguado de Cea, Antonio, and Mirambell Arrizabalaga, Enrique

Abstract

La misión principal del pretensado circunferencial de la pared de un depósito cilíndrico de hormigón es la de compensar las atracciones anulares originadas por la carga de agua y, en menor medida, contrarrestar las debidas a otras solicitaciones (gradiente térmico, retracción, carga sin simetría de revolución, etc.). Cuando la unión de la pared y la solera es continua, el movimiento radial del borde inferior de la pared está impedido, y el pretensado próximo a la base no sólo no comprime apenas la pared, sino que introduce esfuerzos de flexión general importantes. Con la intención de reducir en lo posible este comportamiento de flexión, varios autores han recurrido a formular leyes óptimas de pretensado que redistribuyen los tendones de pretensado en la parte inferior del depósito para conseguir su máxima eficacia en la compresión radial de la pared. En este trabajo se presenta un estudio comparativo entre cinco funciones de pretensado, algunas de ellas propuestas en la literatura técnica y otras propuestas por los autores del presente artículo. Dicho estudio se ha llevado a cabo con un modelo de análisis analítico lineal, que considera el comportamiento conjunto pared-solera-cimentación, y se ha basado en unos requisitos comunes de diseño del pretensado, previamente establecidos. Los resultados obtenidos en el estudio han permitido determinar una función óptima de pretensado, tanto en lo que concierte a su ley de distribución como en lo que se refiere a la fuerza necesaria de pretensado. También han mostrado algunas diferencias significativas entre los resultados obtenidos en este estudio y los presentados por otros autores en la literatura técnica, debidas, principalmente, al hecho de haber estudiado el depósito con unión continua en la base con un modelo que contempla la capacidad real de movimiento de la unión., Peer Reviewed, Postprint (published version)

Published
1997

46. Regulation of the rab17 gene promoter in transgenic Arabidopsis wild-type, ABA-deficient and ABA-insensitive mutants

Author

Vilardell, J., Martínez-Zapater, J. M., Goday, A., Arenas, C., Pagès, M., Vilardell, J., Martínez-Zapater, J. M., Goday, A., Arenas, C., and Pagès, M.

Abstract

The abscisic acid-responsive gene rab17 is induced during maize embryo maturation and in vegetative tissues under water stress conditions. To investigate how ABA is involved in the induction of the rab17 gene, we present here a genetic approach to analyse the transcriptional regulation of the 1.3 kb rab17 promoter fragment in transgenic wild-type Arabidopsis and mutants which are deficient (aba) and insensitive (abi1, abi2 and abi3) to ABA. During seed development the rab17 promoter fragment confers similar temporal and spatial regulation on the reporter gene GUS, both in transgenic wild-type and ABA-deficient and ABA-insensitive mutants. The rab17 promoter was only active in embryo and endosperm during late seed development, although the ABA-deficient embryo mutant showed a reduction in the level of GUS activity. During germination rab17 promoter activity decreases, and GUS activity is not enhanced by water stress in transgenic wild-type and mutant plants. In contrast, transcription of the Arabidopsis endogenous rab gene is stimulated by water stress, both in wild-type and ABA-insensitive mutants. Our data suggest that different molecular mechanisms mediate seed-specific expression and ABA water stress induction of the rab17 gene and indicate strong conservation of the seed-specific regulatory mechanism for rab genes in monocot and dicot plants. © 1994 Kluwer Academic Publishers.

Published
1994

47. Ribosomal proteins as novel players in tumorigenesis.

Author

Heras-Rubio, A., Perucho, L., Paciucci, R., Vilardell, J., and LLeonart, M.

Abstract

Ribosome biogenesis is the most demanding energetic and metabolic expenditure of the cell. The nucleolus, a nuclear compartment, coordinates rRNA transcription, maturation, and assembly into ribosome subunits. The transcription process is highly coordinated with ribosome biogenesis. In this context, ribosomal proteins (RPs) play a crucial role. In the last decade, an increasing number of studies have associated RPs with extraribosomal functions related to proliferation. Importantly, the expression of RPs appears to be deregulated in several human disorders due, at least in part, to genetic mutations. Although the deregulation of RPs in human malignancies is commonly observed, a more complex mechanism is believed to be involved, favoring the tumorigenic process, its progression and metastasis. This review explores the roles of the most frequently mutated oncogenes and tumor suppressor genes in human cancer that modulate ribosome biogenesis, including their interaction with RPs. In this regard, we propose a new focus for novel therapies. [ABSTRACT FROM AUTHOR]

Published
2014
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