1. Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
- Author
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Malapelle, Umberto, Pisapia, Pasquale, Iaccarino, Antonino, Barberis, Massimo, Bellevicine, Claudio, Brunnstrom, Hans, de Biase, Dario, De Maglio, Giovanna, Lindquist, Kajsa Ericson, Fassan, Matteo, Fontanini, Gabriella, Gruppioni, Elisa, Hofman, Paul, Merkelbach-Bruse, Sabine, Vila, Miguel A. Molina, Pujals, Anais, Rapa, Ida, Righi, Luisella, Rosell, Rafael, Schildgen, Oliver, Schildgen, Verena, Schmitt, Fernando C., Tallini, Giovanni, Vander Borght, Sara, Vigliar, Elena, Volante, Marco, Wagener-Ryczek, Svenja, Weynand, Birgit, Troncone, Giancarlo, Malapelle, Umberto, Pisapia, Pasquale, Iaccarino, Antonino, Barberis, Massimo, Bellevicine, Claudio, Brunnstrom, Hans, de Biase, Dario, De Maglio, Giovanna, Lindquist, Kajsa Ericson, Fassan, Matteo, Fontanini, Gabriella, Gruppioni, Elisa, Hofman, Paul, Merkelbach-Bruse, Sabine, Vila, Miguel A. Molina, Pujals, Anais, Rapa, Ida, Righi, Luisella, Rosell, Rafael, Schildgen, Oliver, Schildgen, Verena, Schmitt, Fernando C., Tallini, Giovanni, Vander Borght, Sara, Vigliar, Elena, Volante, Marco, Wagener-Ryczek, Svenja, Weynand, Birgit, and Troncone, Giancarlo
- Abstract
Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
- Published
- 2021