8 results on '"Viktoria Gruber"'
Search Results
2. Common benign melanocytic and non-melanocytic skin tumors among the elderly. Results of the Graz Study on Health & Aging (GSHA)
- Author
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Viktoria Gruber, Rainer Hofmann-Wellenhof, Peter Wolf, Elena Lucia Hofmann-Wellenhof, Helena Schmidt, Andrea Berghold, and Andreas Wedrich
- Subjects
Dermatology - Abstract
Background and objectives: Benign skin tumors are the most common skin findings and contribute to the major reasons for consulting a dermatologist. However, the frequency of benign skin tumors concerning different body areas and their relationship with sun-related behavior have not been sufficiently characterized. We aimed to improve knowledge about the anatomic distribution of the most frequently occurring benign skin tumors among a healthy predominant elderly population. Furthermore, we investigated associations with sun-related habits. Methods: In total, 100 participants, 37 men, and 63 women (mean age: 67.2 years; range: 46-86 years) were enrolled in the Graz Study on Health & Aging (GSHA) cohort. Full body images were investigated for melanocytic nevi, seborrheic keratoses, hemangiomas, dermatofibromas, and lentigines. Information on the phenotypic trait, sun exposure, use of sun-protective measures, and history of sunburns was collected in a questionnaire. Results: Common melanocytic nevi were the most frequently encountered skin lesions. Male sex was associated with multiple common nevi on the abdomen and the presence of atypical nevi. High sun exposure in central European latitudes during adolescence was positively associated with multiple common nevi on the total body. Multiple common nevi and atypical nevi on the back correlated with frequent use of sunscreens with SPF during young adulthood and adolescence, respectively. Conclusion: Our study adds new knowledge about the most frequently occurring benign skin tumors, considering all visible body areas. This research may serve as a reference basis for following epidemiological studies.
- Published
- 2023
3. Pferd oder Zebra?
- Author
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Viktoria Gruber, Barbara Binder, and Lukas Koch
- Subjects
Dermatology - Published
- 2022
4. Ungewöhnliche Präsentation einer Psoriasis vulgaris bei einem 11-jährigen Patienten
- Author
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Viktoria Gruber, Wolfgang Weger, Lorenzo Cerroni, and Barbara Binder
- Abstract
ZusammenfassungDie Psoriasis vulgaris tritt mit einer Prävalenz von bis zu 2 % im Kindes- und Jugendalter auf. Größtenteils wird die Diagnose klinisch gestellt. Wir berichten über einen pädiatrischen Patienten, welcher uns aufgrund der für eine Psoriasis vulgaris eher untypischen Lokalisation vor eine diagnostische Herausforderung stellte. Diskutiert werden die wichtigsten Differenzialdiagnosen der verschiedenen Psoriasisformen sowie die aktuellen Therapieempfehlungen im Kindes- und Jugendalter.
- Published
- 2022
5. Horse or Zebra?
- Author
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Viktoria Gruber, Barbara Binder, and Lukas Koch
- Subjects
Dermatology - Published
- 2022
6. [Uncommon presentation of psoriasis vulgaris in an 11-year-old patient]
- Author
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Viktoria, Gruber, Wolfgang, Weger, Lorenzo, Cerroni, and Barbara, Binder
- Subjects
Diagnosis, Differential ,Adolescent ,Prevalence ,Humans ,Psoriasis ,Child - Abstract
Psoriasis vulgaris occurs with a prevalence of up to 2% in childhood and adolescence. In most cases, diagnosis can be made clinically. We report about a pediatric patient with psoriasis vulgaris who posed a diagnostic challenge due to uncharacteristic manifestation. The most important differential diagnoses of various forms of psoriasis vulgaris as well as actual treatment recommendations in childhood and adolescence are discussed.Die Psoriasis vulgaris tritt mit einer Prävalenz von bis zu 2 % im Kindes- und Jugendalter auf. Größtenteils wird die Diagnose klinisch gestellt. Wir berichten über einen pädiatrischen Patienten, welcher uns aufgrund der für eine Psoriasis vulgaris eher untypischen Lokalisation vor eine diagnostische Herausforderung stellte. Diskutiert werden die wichtigsten Differenzialdiagnosen der verschiedenen Psoriasisformen sowie die aktuellen Therapieempfehlungen im Kindes- und Jugendalter.
- Published
- 2021
7. BET bromodomain inhibitors regulate keratinocyte plasticity
- Author
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Gabi Schutzius, Michael Faller, Aimee Reynolds, Ralph Tiedt, Julia Klopp, Florian Fuchs, Laure C. Bouchez, Federico Tortelli, Nelly Leroy, Jonathan J. Turner, Guglielmo Roma, Simona Cotesta, Armin Beyerbach, Peter Drueckes, Shola M Richards, Debora Bonenfant, Heinrich Rueeger, Heinz Ruffner, Jutta Blank, Rémi Terranova, Peter Tarsa, Frederic Grandjean, Florian Nigsch, Sebastian Bergling, Natalie Dales, Alexandra Aebi, Paul W. Manley, Markus Schirle, Christian Kolter, Tewis Bouwmeester, Rene Hemmig, Sukhdeep Sahambi, Lori L. Jennings, Walter Carbone, Felix Lohmann, Alfred Zimmerlin, Jun Li, Susan Kirkland, Steffen Renner, Mathias Frederiksen, Vickie Driver, Amy Berwick, Florence Zink, Jason R. Thomas, Andrea Vaupel, Chris Dimitri, Vito Guagnano, Viktoria Gruber, Malvina Louis, Caroline Gubser Keller, and Adrian Salathe
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Keratinocytes ,Male ,Protein family ,Transcription, Genetic ,Phenotypic screening ,Primary Cell Culture ,Cell Cycle Proteins ,Wounds, Nonpenetrating ,Small Molecule Libraries ,03 medical and health sciences ,Mice ,Structure-Activity Relationship ,Re-Epithelialization ,In vivo ,Skin Ulcer ,medicine ,Fluorescence Resonance Energy Transfer ,Animals ,Humans ,Protein Isoforms ,Protein Precursors ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,integumentary system ,Epidermis (botany) ,business.industry ,030302 biochemistry & molecular biology ,Cell Biology ,In vitro ,Bromodomain ,High-Throughput Screening Assays ,Mice, Inbred C57BL ,Disease Models, Animal ,medicine.anatomical_structure ,Gene Expression Regulation ,Cancer research ,Epidermis ,Keratinocyte ,business ,Ex vivo ,Transcription Factors - Abstract
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal barrier by transitioning to an activated, migratory state, but this ability is lost in dysfunctional chronic wounds. Small-molecule regulators of keratinocyte plasticity with the potential to reverse keratinocyte malfunction in situ could offer a novel therapeutic approach in skin wound healing. Utilizing high-throughput phenotypic screening of primary keratinocytes, we identify such small molecules, including bromodomain and extra-terminal domain (BET) protein family inhibitors (BETi). BETi induce a sustained activated, migratory state in keratinocytes in vitro, increase activation markers in human epidermis ex vivo and enhance skin wound healing in vivo. Our findings suggest potential clinical utility of BETi in promoting keratinocyte re-epithelialization of skin wounds. Importantly, this novel property of BETi is exclusively observed after transient low-dose exposure, revealing new potential for this compound class.
- Published
- 2019
8. Lymphocyte activation induces cell surface expression of an immunogenic vimentin isoform
- Author
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Elisabeth Buchberger, Viktoria Gruber, Christopher Burghuber, Anna Michlmayr, Georg A. Böhmig, Senada Bilalic, and Rudolf Oehler
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Adult ,Graft Rejection ,Male ,Gene isoform ,Waiting Lists ,Immunology ,Cell ,Vimentin ,Lymphocyte Activation ,Flow cytometry ,Western blot ,Isoantibodies ,Renal Dialysis ,medicine ,Humans ,Protein Isoforms ,Immunology and Allergy ,Cells, Cultured ,Transplantation ,medicine.diagnostic_test ,biology ,Cell Membrane ,Middle Aged ,Kidney Transplantation ,Molecular biology ,Cell biology ,medicine.anatomical_structure ,Chronic Disease ,biology.protein ,Kidney Failure, Chronic ,Female ,Antibody ,Cell activation ,Protein Binding - Abstract
High titers of anti-vimentin antibodies after transplantation are known to be associated with poor long-term graft survival. Vimentin is an intracellular protein which is present in different isoforms in the cell. In a previous study with sera from hemodialysis patients on the kidney transplantation waiting list we could show that only a 49 kDa and a 60 kDa isoform are recognized by patients' anti-vimentin antibodies while the other isoforms remain undetected. However, it is still unclear whether antibodies against this intracellular protein can bind to intact cells. Here we show that vimentin can be present on the cell surface under certain conditions. Lymphocytes from healthy volunteers were used as a model for allogeneic cells. We could show by immunofluorescence microscopy, flow cytometry and Western blot experiments that concanavalin A (Con A) activated lymphocytes express a 49 kDa vimentin isoform on their cell surface while the 60 kDa isoform remains inaccessible from the outside. This expression is associated with an increased binding of sera from hemodialysis patients which were positive for anti-vimentin antibodies. These results suggest that cell activation enhances binding of anti-vimentin antibodies to intact cells which might contribute to chronic allograft nephropathy.
- Published
- 2012
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