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3. ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I

Author

Gaidukov, Leonid, Viji, R.I, Rosenblat, Mira, Yacobson, Shiri, Aviram, Michael, and Tawfik, Dan S.

Subjects
Apolipoproteins -- Research, High density lipoproteins -- Research, Oxidation-reduction reaction -- Analysis, Protein-protein interactions -- Analysis, Biological sciences, Chemistry
Abstract

A study was conducted to examine the association of serum paraoxonase (PON1) with reconstituted high-density lipoprotein (rHDL) carrying apolipoprotein E, and its consequences on the stability and enzymatic activity of PON1, and on its anti-atherogenic potential. The reconstituted HDL particles prepared with two most common isoforms of apoE (apoE3 and apoE4) was found to associate with rePON1 in a mode and affinity similar to those of apoA-I and the reconstituted apoE-HDL exhibited properties similar to those of apoA-I-HDL, but with a lower capacity to stabilize PON1 and to induce its anti-atherogenic functions.

Published
2010

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