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Breast cancer is the most aggressive and rapidly growing cancer worldwide. It is classified into several subtypes among which triple negative breast cancer (TNBC) is the most aggressive. Oncogene regulation leads to increased signal activity in the cells and contributes to the tumorigenic phenotype. Such signals generate a large number of proteins that provoke cell growth and inhibit cell death. Transcription factors, such as miR-27a, NF-κB, and FOXM1, are proteins that are conserved across species, abundantly found in the nucleus, bind to DNA, and enforce specific target genes. Oncogenic transcription factors arising from mutation accompanying aberrant gene expression transfer signals to the nucleus and interrupts transcription patterns and stimulation of oncogenic transcription factors consistent with cell cycle regulation, apoptosis, proliferation, and cell differentiation. This review gives a detailed framework about the treatment opportunities and highlights the importance of few transcription factors which may act as an important biomarker specifically for TNBC.