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Byline: Atul. Vijay, Akshy. Kumar, Shivani. Saini, Shail. Agarwal Sir, Ichthyosis bullosa of Siemens (IBS), type of bullous ichthyosis, is distinguished from more severe and deeper bullous congenital ichthyosiform erythroderma [...]

Introduction: Warts are caused by the human papillomavirus (HPV), which infects the epidermal cell layers leading to their hyperproliferation. The concept of immunotherapy has recently come to light. It acts by mounting delayed cell-mediated and humoral immunity against the HPV in the host. Objective: This study aimed to evaluate the efficacy and safety of the intralesional PPD versus intralesional vitamin D3 for the management of recalcitrant warts. Materials and Methods: This prospective randomized trial was conducted on patients between the ages of 12 and 65 years with two or more recalcitrant extragenital warts. The subjects were randomly divided into two groups, namely, group A (PPD) and group B (vitamin D3). In group A, a purified protein derivative (PPD) of tuberculin was employed without any prior pre-sensitization testing. Each patient in group I received 0.1--0.2 mL of antigen at the base of the largest wart. In group B, the patients received 0.1--0.2 mL in a similar manner. Results: In group A, 39 (78%) patients had complete clearance while, in group B, 38 (76%) had complete clearance in injected warts (p = 0.8). As far as distant warts were concerned, in group A, 35 (70%) had a complete response while, in group B, 29 (48%) had a complete response. There was a statistically significant difference between the two groups with a greater degree of clearance in distant warts with the tuberculin PPD (p = 0.04). Conclusion: Both the tuberculin PPD and vitamin D3 are reliable and safe management options for recalcitrant, treatment-resistant, and extensive warts. [ABSTRACT FROM AUTHOR]

Background: Parthenium dermatitis is caused by friable plant extracts of Parthenium hysterophorus and related species. Approximately 40% of cases of plant dermatitis in India are contributed by this single species. Materials and Methods: This was a cross-sectional, observational study conducted in the Department of Dermatology of Jhalawar Medical College. Ninety-nine consecutive patch test positive parthenium dermatitis human subjects of age more than 16 and either sex were included. The study period was 11 months between September 2019 and August 2020. Sociodemographic, clinical profile parthenium dermatitis severity score (PDSS) and Dermatology life quality index (DLQI) were obtained from each patient. Correlation between PDSS and DLQI was obtained using Pearson's two-tailed coefficients. Results: Our study included 62 men and 37 women (1.67:1). The mean age was 51 ± 10.27 years. Mean duration of disease was 8.47 ± 4.45 years, and mean PDSS was 57.25 ± 17.65, mean DLQI was 17.14 ± 5.56. ABCD with CAD was the most common clinical subtype (45.45%). A significant positive correlation was observed between PDSS and DLQI. Conclusion: In this study, a significant impairment in quality of life (QoL) was observed in patients with higher score of PDSS and increasing duration, emphasizing that the disease needs specialized care including multiple indoor admission at the time of flare-up of disease. [ABSTRACT FROM AUTHOR]

Computed tomography scan of the head was normal, but magnetic resonance imaging (MRI) brain showed multiple scalp hemangiomas, the largest being in the right posterior parietal region (size 16 mm × 6 mm), while underlying skull vault appears normal [Figure 3]. The red-colored raised lesion initially appeared in multiple mustard size, round, firm lesions, which progressed to almost pea-sized pedunculated lesions in 2-5 days and bled on touch/slightest trauma. There was the presence of a raised solid skin-colored lesion of size 2 cm and rubbery consistency over the right posterior parietal scalp diagnosed clinically as infantile hemangioma. [Extracted from the article]

Plica neuropathica is a rare scalp condition, which is manifested as a compact mass of scalp hair. Previously, it has been found to be associated with a variety of dermatological disorders. We report a case of 15-year-old female presenting with alopecia areata associated with plica neuropathica. [ABSTRACT FROM AUTHOR]