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5. Functional attributes of bioactive peptides of bovine milk origin and application of in silico approaches for peptide prediction and functional annotations.

Author

Dhar, Hena, Verma, Subhash, Dogra, Sarita, Katoch, Shailja, Vij, Rishika, Singh, Geetanjali, and Sharma, Mandeep

Subjects
DIETARY bioactive peptides, AMINO acid sequence, ANTIMICROBIAL peptides, PEPTIDES, BIOLOGICAL databases, WHEY proteins, MILK proteins, CD26 antigen
Abstract

Bovine milk peptides are the protein fragments with diverse bioactive properties having antioxidant, anticarcinogenic, other therapeutic and nutraceutical potentials. These peptides are formed in milk by enzymatic hydrolysis, gastrointestinal digestion and fermentation processes. They have significant health impact with high potency and low toxicity making them a suitable natural alternative for preventing and managing diseases. Antibiotic resistance has increased the quest for better peptide candidates with antimicrobial effects. This article presents a comprehensive review on well documented antimicrobial, immunological, opioid, and anti-hypertensive activities of bovine milk peptides. It also covers the usage of computational biology tools and databases for prediction and analysis of the food-derived bioactive peptides. In silico analysis of amino acid sequences of Bos taurus milk proteins have been predicted to generate peptides with dipeptidyl peptidase IV inhibitory and ACE inhibitory properties, making them favorable candidates for developing blood sugar lowering drugs and anti-hypertensives. In addition to the prediction of new bioactive peptides, application of bioinformatics tools to predict novel functions of already known peptides is also discussed. Overall, this review focuses on the reported as well as predicted biologically active peptide of casein and whey proteins of bovine milk that can be utilized to develop therapeutic agents. [ABSTRACT FROM AUTHOR]

Published
2024
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12. List of Contributors

Author

García Yu, Irene Ai-Ling, primary, Alavi, Farhad, additional, AL-Ayadhi, Laila, additional, Albenzio, Marzia, additional, Alférez, Maria J.M., additional, Anadón, Arturo, additional, Ares, Irma, additional, Barancelli, Giovana V., additional, Bauman, Dale E., additional, Beck, Kathryn L., additional, Birch, John, additional, Bremer, Phil, additional, Burrow, Keegan, additional, Caldwell, Kathleen L., additional, Cardoso, Felipe C., additional, Carminati, Domenico, additional, Carne, Alan, additional, Caroprese, Mariangela, additional, Chia, Jade, additional, Chilibeck, Philip D., additional, Coad, Jane, additional, Collier, Robert J., additional, Conte, Giuseppe, additional, Corassin, Carlos H., additional, Da Silva, Marine S., additional, Day, Li, additional, de Melo Pereira, Gilberto V., additional, de Moreno de LeBlanc, Alejandra, additional, de Oliveira, Carlos Augusto F., additional, Diaz-Castro, Javier, additional, Duff, Whitney, additional, Bekhit, Alaa El-Din A., additional, Emam-Djomeh, Zahra, additional, Fernandes, Maurício J., additional, Galdeano, Carolina M., additional, Galhotra, Rohin, additional, Ghiasvand, Reza, additional, Gonçalves, Bruna L., additional, Halepoto, Dost M., additional, Hettinga, Kasper, additional, Iqbal, Furhan, additional, Jones, Robert L., additional, Kalebich, Caroline C., additional, Kalyankar, Shrikant D., additional, Kanca, Halit, additional, Kapila, Rajeev, additional, Kapila, Suman, additional, Khatoon, Humera, additional, Khedkar, Chaitali C., additional, Khedkar, Chandraprakash D., additional, Kontulainen, Saija, additional, Kumar, Naresh, additional, LeBlanc, Jean Guy, additional, Lee, Sarah H.I., additional, Levit, Romina, additional, López-Aliaga, Inmaculada, additional, Makhmudov, Amir, additional, Martínez-Larrañaga, María R., additional, Martínez, María A., additional, Mason, Sue, additional, McConnell, Michelle, additional, Mele, Marcello, additional, Miraghajani, Maryam, additional, Mizelman, Eliran, additional, Mohammadian, Mehdi, additional, Moreno-Fernandez, Jorge, additional, Morton, James D., additional, Najam, Rahela, additional, Nuñez, Ivanna N., additional, Oey, Indrawati, additional, Ozturkoglu-Budak, Sebnem, additional, Pagnoncelli, Maria G.B., additional, Parker, Alyssa M., additional, Patel, Ami R., additional, Perdigón, Gabriela, additional, Pereira, Paula C., additional, Polito, Anna N., additional, Pourmasoumi, Makan, additional, Raghavendra, Midathala, additional, Rashidinejad, Ali, additional, Recio-Rodríguez, José I., additional, Rudkowska, Iwona, additional, Salami, Maryam, additional, Samuelsson, Linda, additional, Sánchez-Aguadero, Natalia, additional, Santillo, Antonella, additional, Savoy de Giori, Graciela, additional, Serra, Andrea, additional, Shahbazi, Yasser, additional, Singal, Hari R., additional, Soccol, Carlos R., additional, Tanobe, Valcineide O.A., additional, Tidona, Flavio, additional, Tokas, Jayanti, additional, Turkmen, Nazli, additional, van Valenberg, Hein, additional, Vance, Kathryn A., additional, Vicente, Filipa, additional, Vij, Rishika, additional, Wang, Ye, additional, Watson, Ronald Ross, additional, Xiao, Yao, additional, and Young, Wayne, additional

Published
2018
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23. Haematological, Acid-Base, Blood Gas and Electrolyte Profile of Chegu Kids.

Author

Sharma, Ankur, Vij, Rishika, Katoch, Ajay, Negi, Manoj, and Mandial, R. K.

Abstract

The article presents research on haematology of kids of Chegu pashmina goats maintained at Palampur, Himachal Pradesh, India. It discusses parameters estimated including haemoglobin, packed cell volume, total erythrocytic count, total leucocytic count and erytbrocytic indices. It also mentions acid base, blood gas and electrolyte status of kids of Chegu goats.

Published
2015

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