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28. El peso de la comorbilidad del paciente se correlaciona con la gravedad de la disfunción eréctil

Author

García-Cruz, E., primary, Carrión, A., additional, Ajami, T., additional, Álvarez, M., additional, Correas, M.Á., additional, García, B., additional, García, J.V., additional, González, C., additional, Portillo, J.A., additional, Romero-Otero, J., additional, Simón, C., additional, Torremadé, J., additional, Vigués, F., additional, and Alcaraz, A., additional

Published
2018
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30. Opciones terapéuticas y factores predictivos de recurrencia y mortalidad cáncer-específica en pacientes con tumor vesical después de trasplante renal: análisis multiinstitucional

Author

Rodriguez Faba, O., primary, Palou, J., additional, Vila Reyes, H., additional, Guirado, L., additional, Palazzetti, A., additional, Gontero, P., additional, Vigués, F., additional, Garcia-Olaverri, J., additional, Fernández Gómez, J.M., additional, Olsburg, J., additional, Terrone, C., additional, Figueiredo, A., additional, Burgos, J., additional, Lledó, E., additional, and Breda, A., additional

Published
2017
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33. El peso de la comorbilidad del paciente se correlaciona con la gravedad de la disfunción eréctil

Author

García-Cruz, E., Carrión, A., Ajami, T., Álvarez, M., Correas, M.Á., García, B., García, J.V., González, C., Portillo, J.A., Romero-Otero, J., Simón, C., Torremadé, J., Vigués, F., and Alcaraz, A.

Abstract

Explorar la relación entre la disfunción eréctil (DE), los niveles de testosterona y el Índice de comorbilidad de Charlson (ICC).

Published
2024
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39. 721 Treatment options and predictive factors for recurrence and cancer specific mortality in bladder cancer after renal transplantation: A multiinstitutional analysis

Author

Rodriguez Faba, O., primary, Palou, J., additional, Palazzetti, A., additional, Gontero, P., additional, García-Olaverri, J., additional, Fernández Gómez, J.M., additional, Olsburg, J., additional, Terrone, C., additional, Figueiredo, A., additional, Vigués, F., additional, Burgos, J., additional, Lledó, E., additional, and Breda, A., additional

Published
2016
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42. Effect of different preservation solutions on adenine nucleotide content and metabolism in human kidney transplantation

Author

N. Serrallach, M. A. Lopez, Ramon Bartrons, L. Riera, Santiago Ambrosio, Mercedes Campillo, E. Franco, J.M. Griño, and Vigués F

Subjects
Adult, Adenosine, Allopurinol, Hypertonic Solutions, Organ Preservation Solutions, Cold storage, Kidney, chemistry.chemical_compound, Raffinose, Adenine nucleotide, medicine, Humans, Insulin, Transplantation, Homologous, Mannitol, Viaspan, Inosine, Purine metabolism, Chromatography, High Pressure Liquid, Hypoxanthine, Transplantation, Adenine Nucleotides, business.industry, Kidney metabolism, Nucleosides, Organ Preservation, Glutathione, Kidney Transplantation, Molecular biology, Biochemistry, chemistry, Energy Metabolism, business, medicine.drug
Abstract

Differences in purine metabolism produced by three preservation solutions were studied by determining the adenine nucleotide (ATP, ADP, AMP, and IMP) and nucleoside (adenosine, inosine, and hypoxanthine) levels in human kidney cortical biopsies. Forty kidney allografts were studied using University of Wisconsin (UW) solution (n = 20), Euro-Collins (EC) solution (n = 12), and modified EC solution with mannitol (M; n = 8). No significant differences were found between the three solutions studied with regard to ATP, ADP, or AMP changes. The mean ATP level (nmol/mg prot +/- SEM) at the end of preservation in the UW group was 2.7 +/- 0.3 nmol/mg, in the EC group 3.8 +/- 0.7 nmol/mg, and in the M group 2.3 +/- 0.4 nmol/mg. ATP 30 min after reperfusion in the UW, EC, and M groups was 5.7 +/- 0.8 nmol/mg, 6.4 +/- 1.0 nmol/mg, and 4.6 +/- 0.5 nmol/mg, respectively. However, an important difference appeared in the catabolic products determined. Kidneys perfused with UW solution had a significantly higher level of adenosine (2.6 +/- 0.6 nmol/mg), inosine (11.8 +/- 2.2 nmol/mg), and hypoxanthine (18.1 +/- 2.1 nmol/mg) at the end of cold storage than those perfused with EC (0.4 +/- 0.1 nmol/mg, 2.0 +/- 0.8 nmol/mg, and 7.1 +/- 1.4 nmol/mg) and M solutions (0.2 +/- 0.05 nmol/mg, 0.5 +/- 0.1 nmol/mg, and 5.2 +/- 0.6 nmol/mg; P < 0.05). These levels returned to initial values 30 min postreperfusion and there were no differences with the EC or M solution groups at that time.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1994
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45. Assessment of purine metabolism in human renal transplantation

Author

Vigués F, Ramon Bartrons, Santiago Ambrosio, and E. Franco

Subjects
Inosine monophosphate, medicine.medical_specialty, Adenosine, Kidney Cortex, Biopsy, Adenylate kinase, Cold storage, Biology, chemistry.chemical_compound, Adenosine Triphosphate, Adenine nucleotide, Internal medicine, medicine, Humans, Energy charge, Inosine, Acute tubular necrosis, Hypoxanthine, Transplantation, Organ Preservation, Kidney Tubular Necrosis, Acute, medicine.disease, Kidney Transplantation, Adenosine Monophosphate, Adenosine Diphosphate, Cold Temperature, Endocrinology, chemistry, Purines, Hypoxanthines, Reperfusion, Energy Metabolism, medicine.drug
Abstract

Cortical levels of nucleotides and their degradation products from 42 transplanted human kidneys have been studied. Biopsies were performed during renal harvesting just before cooling, at the end of cold storage, and following reinstallment of renal blood circulation. ATP levels fell, and AMP and degradation products (inosine monophosphate [IMP], inosine, adenosine, and hypoxanthine) increased during cold storage and returned to near-normal values 30 min after recirculation. The major degradation product found was hypoxanthine, indicating very poor xanthine oxidase activity in human kidneys. The sum of adenine nucleotides (ATP+ADP+AMP) did not significantly decrease after cold storage, but adenylate energy charge (ATP+1/2ADP/ATP+ADP+AMP) was reduced to half, being recovered in implanted kidneys. The sum of adenine nucleotides was significantly reduced after implantation. The rate of acute tubular necrosis was higher in kidneys preserved for more than 30 hr. Kidneys with acute tubular necrosis had significantly lower levels of the total pool of adenine nucleotides at reperfusion, but there was no correlation between incidence of acute tubular necrosis and ATP or other metabolite levels in the kidneys before or during cold preservation. The success of human kidney transplantation does not seem to depend only on the pool of residual nucleotides at the end of cold storage but on other factors that determine the ability of the cell to recover a normal energy state after reperfusion.

Published
1993

46. 279 DUAL KIDNEY TRANSPLANTATION: 9-YEARS OUTCOME

Author

Riera, L., primary, Suárez, F.J., additional, Francés, A., additional, Cruzado, J.M., additional, Fumadó, L., additional, Vigués, F., additional, Rodriguez, J., additional, Contreras, J., additional, Serrallach, M., additional, Aguiló, F., additional, and Franco, E., additional

Published
2007
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