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Your search keyword '"Vigoda, Myles"' showing total 5 results
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5 results on '"Vigoda, Myles"'

1. Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

Author

Vigoda, Myles, primary, Mathieson, Chase, additional, Evans, Nathaniel, additional, Hale, Carolyn, additional, Jennings, Jennifer, additional, Lucero, Olivia, additional, Jeng, Sophia, additional, Bottomly, Daniel, additional, Clayburgh, Daniel, additional, Andersen, Peter, additional, Li, Ryan, additional, Petrisor, Daniel, additional, Tyner, Jeffrey W., additional, McWeeney, Shannon, additional, and Kulesz-Martin, Molly, additional

Published
2022
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2. Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma

Author

Anderson, Ashley N., primary, McClanahan, Danielle, additional, Jacobs, James, additional, Jeng, Sophia, additional, Vigoda, Myles, additional, Blucher, Aurora S., additional, Zheng, Christina, additional, Yoo, Yeon Jung, additional, Hale, Carolyn, additional, Ouyang, Xiaoming, additional, Clayburgh, Daniel, additional, Andersen, Peter, additional, Tyner, Jeffrey W., additional, Bar, Anna, additional, Lucero, Olivia M., additional, Leitenberger, Justin J., additional, McWeeney, Shannon K., additional, and Kulesz-Martin, Molly, additional

Published
2020
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3. Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma

Author

Choonoo, Gabrielle, primary, Blucher, Aurora S., additional, Higgins, Samuel, additional, Boardman, Mitzi, additional, Jeng, Sophia, additional, Zheng, Christina, additional, Jacobs, James, additional, Anderson, Ashley, additional, Chamberlin, Steven, additional, Evans, Nathaniel, additional, Vigoda, Myles, additional, Cordier, Benjamin, additional, Tyner, Jeffrey W., additional, Kulesz-Martin, Molly, additional, McWeeney, Shannon K., additional, and Laderas, Ted, additional

Published
2019
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5. Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma.

Author

Anderson AN, McClanahan D, Jacobs J, Jeng S, Vigoda M, Blucher AS, Zheng C, Yoo YJ, Hale C, Ouyang X, Clayburgh D, Andersen P, Tyner JW, Bar A, Lucero OM, Leitenberger JJ, McWeeney SK, and Kulesz-Martin M

Subjects
Aged, Aged, 80 and over, Carcinoma, Squamous Cell metabolism, Cell Survival genetics, Disease Progression, Gene Expression genetics, Gene Expression Regulation, Neoplastic genetics, Genomics methods, Humans, Male, Middle Aged, Mutation genetics, Receptor, EphA6 antagonists & inhibitors, Receptor, EphA6 metabolism, Receptor, EphA7 antagonists & inhibitors, Receptor, EphA7 metabolism, Signal Transduction genetics, Skin Neoplasms genetics, Small Molecule Libraries pharmacology, Exome Sequencing methods, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology
Abstract

Although cutaneous squamous cell carcinoma (cSCC) is treatable in the majority of cases, deadly invasive and metastatic cases do occur. To date there are neither reliable predictive biomarkers of disease progression nor FDA-approved targeted therapies as standard of care. To address these issues, we screened patient-derived primary cultured cells from invasive/metastatic cSCC with 107 small-molecule inhibitors. In-house bioinformatics tools were used to cross-analyze drug responses and DNA mutations in tumors detected by whole-exome sequencing (WES). Aberrations in molecular pathways with evidence of potential drug targets were identified, including the Eph-ephrin and neutrophil degranulation signaling pathways. Using a screening panel of siRNAs, we identified EPHA6 and EPHA7 as targets within the Eph-ephrin pathway responsible for mitigating decreased cell viability. These studies form a plausible foundation for detecting biomarkers of high-risk progressive disease applicable in dermatopathology and for patient-specific therapeutic options for invasive/metastatic cSCC., (© 2020 Anderson et al.; Published by Cold Spring Harbor Laboratory Press.)

Published
2020
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