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10 results on '"Vignati, Silvano"'

1. Association between mpMRI detected tumor apparent diffusion coefficient and 5-year biochemical recurrence risk after radical prostatectomy

Author

Alessi, Sarah, Maggioni, Roberta, Luzzago, Stefano, Summers, Paul E., Renne, Giuseppe, Zugni, Fabio, Belmonte, Maddalena, Raimondi, Sara, Vignati, Silvano, Mistretta, Francesco A., Di Meglio, Letizia, D’Ascoli, Elisa, Scarabelli, Alice, Marvaso, Giulia, De Cobelli, Ottavio, Musi, Gennaro, Jereczek-Fossa, Barbara Alicja, Curigliano, Giuseppe, and Petralia, Giuseppe

Published
2024
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2. Cardiovascular events in patients receiving immuno-oncology agents, in phase I clinical trials: CAVIO study.

Author

Zagami, Paola, primary, Nicolò, Eleonora, additional, Trapani, Dario, additional, Boscolo Bielo, Luca, additional, Valenza, Carmine, additional, Carnevale Schianca, Ambra, additional, Pellizzari, Gloria, additional, Castellano, Grazia, additional, Gandini, Sara, additional, Vignati, Silvano, additional, Massaro, Maria Angela, additional, Busacca, Chiara, additional, Marra, Antonio, additional, Taurelli Salimbeni, Beatrice, additional, Belli, Carmen, additional, Minchella, Ida, additional, Locatelli, Marzia Adelia, additional, Esposito, Angela, additional, Criscitiello, Carmen, additional, and Curigliano, Giuseppe, additional

Published
2024
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3. A Transcriptomic Analysis of Laryngeal Dysplasia.

Author

Maffini, Fausto, Lepanto, Daniela, Chu, Francesco, Tagliabue, Marta, Vacirca, Davide, De Berardinis, Rita, Gandini, Sara, Vignati, Silvano, Ranghiero, Alberto, Taormina, Sergio, Rappa, Alessandra, Cossu Rocca, Maria, Alterio, Daniela, Chiocca, Susanna, Barberis, Massimo, Preda, Lorenzo, Pagni, Fabio, Fusco, Nicola, and Ansarin, Mohssen

Subjects
EXTRACELLULAR matrix, DISEASE progression, NUCLEOTIDE sequencing, INFLAMMATION, BIOLOGY, DYSPLASIA, T cells
Abstract

This article describes how the transcriptional alterations of the innate immune system divide dysplasias into aggressive forms that, despite the treatment, relapse quickly and more easily, and others where the progression is slow and more treatable. It elaborates on how the immune system can change the extracellular matrix, favoring neoplastic progression, and how infections can enhance disease progression by increasing epithelial damage due to the loss of surface immunoglobulin and amplifying the inflammatory response. We investigated whether these dysregulated genes were linked to disease progression, delay, or recovery. These transcriptional alterations were observed using the RNA-based next-generation sequencing (NGS) panel Oncomine Immune Response Research Assay (OIRRA) to measure the expression of genes associated with lymphocyte regulation, cytokine signaling, lymphocyte markers, and checkpoint pathways. During the analysis, it became apparent that certain alterations divide dysplasia into two categories: progressive or not. In the future, these biological alterations are the first step to provide new treatment modalities with different classes of drugs currently in use in a systemic or local approach, including classical chemotherapy drugs such as cisplatin and fluorouracile, older drugs like fenretinide, and new checkpoint inhibitor drugs such as nivolumab and pembrolizumab, as well as newer options like T cell therapy (CAR-T). Following these observed alterations, it is possible to differentiate which dysplasias progress or not or relapse quickly. This information could, in the future, be the basis for determining a close follow-up, minimizing surgical interventions, planning a correct and personalized treatment protocol for each patient and, after specific clinical trials, tailoring new drug treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Multiparametric MRI-based 5-year Risk Prediction Model for Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy

Author

Luzzago, Stefano, primary, Colombo, Alberto, additional, Mistretta, Francesco A., additional, Alessi, Sarah, additional, Di Trapani, Ettore, additional, Summers, Paul E., additional, Piccinelli, Mattia Luca, additional, Raimondi, Sara, additional, Vignati, Silvano, additional, Clemente, Alfredo, additional, Rosati, Elisa, additional, di Meglio, Letizia, additional, d’Ascoli, Elisa, additional, Scarabelli, Alice, additional, Zugni, Fabio, additional, Belmonte, Maddalena, additional, Maggioni, Roberta, additional, Ferro, Matteo, additional, Fusco, Nicola, additional, de Cobelli, Ottavio, additional, Musi, Gennaro, additional, and Petralia, Giuseppe, additional

Published
2023
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5. The Genetic and Immunologic Landscape Underlying the Risk of Malignant Progression in Laryngeal Dysplasia

Author

Chu, Francesco, primary, Maffini, Fausto, additional, Lepanto, Daniela, additional, Vacirca, Davide, additional, Taormina, Sergio Vincenzo, additional, De Berardinis, Rita, additional, Gandini, Sara, additional, Vignati, Silvano, additional, Ranghiero, Alberto, additional, Rappa, Alessandra, additional, Chiocca, Susanna, additional, Barberis, Massimo, additional, Tagliabue, Marta, additional, and Ansarin, Mohssen, additional

Published
2023
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6. Prediction of the Malignancy of a Breast Lesion Detected on Breast Ultrasound: Radiomics Applied to Clinical Practice

Author

Nicosia, Luca, primary, Pesapane, Filippo, additional, Bozzini, Anna Carla, additional, Latronico, Antuono, additional, Rotili, Anna, additional, Ferrari, Federica, additional, Signorelli, Giulia, additional, Raimondi, Sara, additional, Vignati, Silvano, additional, Gaeta, Aurora, additional, Bellerba, Federica, additional, Origgi, Daniela, additional, De Marco, Paolo, additional, Castiglione Minischetti, Giuseppe, additional, Sangalli, Claudia, additional, Montesano, Marta, additional, Palma, Simone, additional, and Cassano, Enrico, additional

Published
2023
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7. Prediction of the Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer Patients With MRI-Radiomics: A Systematic Review and Meta-analysis

Author

Pesapane, Filippo, primary, Agazzi, Giorgio Maria, additional, Rotili, Anna, additional, Ferrari, Federica, additional, Cardillo, Andrea, additional, Penco, Silvia, additional, Dominelli, Valeria, additional, D'Ecclesiis, Oriana, additional, Vignati, Silvano, additional, Raimondi, Sara, additional, Bozzini, Anna, additional, Pizzamiglio, Maria, additional, Petralia, Giuseppe, additional, Nicosia, Luca, additional, and Cassano, Enrico, additional

Published
2022
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8. The Prognostic Impact of Quitting Smoking at or around Diagnosis on the Survival of Patients with Gastrointestinal Cancers: A Systematic Literature Review

Author

Caini, Saverio, primary, Del Riccio, Marco, additional, Vettori, Virginia, additional, Raimondi, Sara, additional, Assedi, Melania, additional, Vignati, Silvano, additional, Bonaccorsi, Guglielmo, additional, Cattaruzza, Maria Sofia, additional, Bellerba, Federica, additional, Vagnoni, Giulia, additional, Duroni, Giacomo, additional, and Gandini, Sara, additional

Published
2022
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10. Association of MC1R variants with melanoma risk and interaction with sun exposure: An M‐SKIP project.

Author

Stefanaki, Irene, D'Ecclesiis, Oriana, Vignati, Silvano, Gaeta, Aurora, Kypreou, Katerina, Caini, Saverio, Gandini, Sara, Nagore, Eduardo, Sera, Francesco, Botta, Francesca, Newton‐Bishop, Julia, Polsky, David, Lazovich, DeAnn, Kanetsky, Peter A., Puig, Susana, Gruis, Nelleke A., Landi, Maria Teresa, Fargnoli, Maria Concetta, Stratigos, Alexander, and Guida, Gabriella

Subjects
*SUNSHINE, *CUTANEOUS malignant melanoma, *SUNBURN, *CANCER genetics, *ACADEMIC medical centers, *HAIR dyeing & bleaching
Abstract

The article discusses the association of MC1R variants with melanoma risk and their interaction with sun exposure. The study analyzed data from nine melanoma case-control studies to evaluate how sun exposure modifies the effect of MC1R variants on melanoma risk. The findings suggest that there is a significant additive interaction between MC1R R variants and high sunburn frequency, indicating potential at-risk subgroups for melanoma prevention and early diagnosis interventions. The study was supported by various research grants and ethical approval was obtained for all original studies. [Extracted from the article]

Published
2024
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