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A new species of Uscanoidea Girault (Hymenoptera: Trichogrammatidae), Uscanoidea ricoi Viggiani, Gamboa & Pérez-Benavides, sp. nov., is described and illustrated. The species is a solitary egg parasitoid of Monalonion dissimulatum Distant (Hemiptera: Miridae), the main insect pest on cocoa crops. An identification key for the described Uscanoidea species of the world is provided. The new species has a high potential for the biological control of the true bug M. dissimulatum in cocoa plantations in the Neotropical region.

The neutral organosilicon(IV) complex, (C6F5)2Si(OPO)2 (OPO = 1-oxopyridin-2-one, C5H4NO2), was synthesized from (C6F5)2Si(OCH3)2 and 2 equiv. of 1-hydroxypyridin-2-one in tetrahydrofuran (THF). Single crystals grown from the diffusion of n-pentane into a THF solution were identified as a THF hemisolvate and an n-pentane hemisolvate, (C6F5)2Si(OPO)2·0.5THF·0.5C5H12 (1). p-Tolyl2Si(OPO)2 (2) and mesityl2Si(OPO)2 (3) crystallized directly from reaction mixtures of 2 equiv. of Me3Si(OPO) with p-tolyl2SiCl2 and mesityl2SiCl2, respectively, in acetonitrile. The oxygen-bonded carbon and nitrogen atoms of the OPO ligands in 1, 2, and 3 were modeled as disordered indicating co-crystallization of up to three possible diastereomers in each. Solution NMR studies support the presence of exclusively the all-cis isomer in 1 and multiple isomers in 2. Poor solubility of 3 limited its characterization in solution.

Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characterization of platelet expression using single-cell mass cytometry in six ET patients and six age- and sex-matched healthy individuals. A large panel of 18 transmembrane regulators of platelet function and activation were analyzed, at baseline and after ex-vivo stimulation with thrombin receptor-activating peptide (TRAP). We detected a significant overexpression of the activation marker CD62P (p-Selectin) (p = .049) and the collagen receptor GPVI (p = .044) in non-stimulated ET platelets. In contrast, ET platelets had a lower expression of the integrin subunits of the fibrinogen receptor GPIIb/IIIa CD41 (p = .036) and CD61 (p = .044) and of the von Willebrand factor receptor CD42b (p = .044). Using the FlowSOM algorithm, we identified 2 subclusters of ET platelets with a prothrombotic expression profile, one of them (cluster 3) significantly overrepresented in ET (22.13% of the total platelets in ET, 2.94% in controls, p = .035). Platelet counts were significantly increased in ET compared to controls (p = .0123). In ET, MPV inversely correlated with platelet count (r=-0.96). These data highlight the prothrombotic phenotype of ET and postulate GPVI as a potential target to prevent thrombosis in these patients.

This paper discusses the utilization of a cultural humility model to educate social work students in understanding the importance of diversity, power, privilege, oppression, marginalization and social and economic justice in an increasingly diverse society. Social work programs are required to teach students to effectively engage a diversity of clients in practice as well as to take action to resolve issues of oppression and discrimination. While the cultural humility model is gaining acceptance in social work and in social work education, there are few models of how to effectively teach it within the social work curriculum. One model that includes a two-course sequence is presented. The paper discusses components in creating a culturally humble classroom environment as well as specific materials and classroom assignments aimed at providing students with the knowledge, tools and skills essential to practicing with cultural humility. The power of utilizing materials that are representative of a diversity of voices is emphasized with appendices providing written and audio resources.

The authors question how hermetic texts in mathematics, history, and philosophy of mathematics, specifically those referring to abstract algebra, can be open to the understanding of researchers, teachers and students who are intentionally willing to understand them. This discussion suggests that the openness may happen through hermeneutic procedures. These procedures, in the wake of Gadamerian thinking, take the dialectic of the process of formulating the question and pursuing possible ways of answering it, going into the intricacies of the historicity of knowledge constitution based on the Husserlian perspective and the production of algebra itself, in order to explain a methodology of research. They advance by bringing a hermeneutic study on algebraic structures, explaining the research methodology that aims at the formation of the ideality of algebraic structures and their maturation in the living present as notions of algebraic structures, as objects of study and as subjects of algebra.

In this paper, we present our perspective about the importance of teaching Gödel's incompleteness theorem in formation courses to mathematics teacher. The phenomenon of incompleteness evidenced by the incompleteness theorem is manifested by the existence of true propositions about natural numbers that cannot be proved by any metamathematical argument that can be represented according to arithmetic formalism. Knowing Gödel's incompleteness theorem and its conclusions is essential in terms of the mathematical culture of a teacher in preparation to teach mathematics in schools, so that he/she can avoid nurturing the notion of complete mathematics and the notion of axiomatic method totalitarianism. This proposal seeks to evidence that Gödel's incompleteness theorem can be explored in formation courses of mathematics teachers in exercises in Philosophy of Mathematical Education.

Key Clinical Message Situs inversus totalis is a rare diagnosis, but the likelihood of experiencing myocardial infarction is presumed to be comparable to the general population average. In individuals exhibiting situs inversus with suspected myocardial infarction, ECG recording, including right precordial leads, is crucial for diagnostic assessment. Coronary angiography and intervention should be performed with standard equipment using inverted maneuvers and radiographic projections.

Aganaspis daci, a larval-pupal parasitoid of several tephritid species, was unexpectedly recovered in the Campania region (Southern Italy), where it had not been intentionally released. An integrative approach was used to conduct a comprehensive characterization of this parasitoid, confirming its identification through a comparison with specimens obtained from laboratory rearing. While A. daci emerged from puparia of Ceratitis capitata during this study, its original association was recorded with Bactrocera dorsalis. The presence of A. daci in Italy highlights its successful establishment, possibly facilitated by the recent invasive process of its host, B. dorsalis, offering promising prospects for future tephritids control strategies. It is intriguing to note that the mt-haplotypes found in Italy were only partially shared with those observed in specimens originating from a Spanish rearing, suggesting likely distinct origins for at least part of the Italian population.

Purpose – Marksmanship data is a staple of military and law enforcement evaluations. This ubiquitous nature creates a critical need to use all relevant information and to convey outcomes in a meaningful way for the end users. The purpose of this study is to demonstrate how simple simulation techniques can improve interpretations of marksmanship data. Design/methodology/approach – This study uses three simulations to demonstrate the advantages of small arms combat modeling, including (1) the benefits of incorporating a Markov Chain into Monte Carlo shooting simulations; (2) how small arms combat modeling is superior to point-based evaluations; and (3) why continuous-time chains better capture performance than discrete-time chains. Findings – The proposed method reduces ambiguity in low-accuracy scenarios while also incorporating a more holistic view of performance as outcomes simultaneously incorporate speed and accuracy rather than holding one constant. Practical implications – This process determines the probability of winning an engagement against a given opponent while circumventing arbitrary discussions of speed and accuracy trade-offs. Someone wins 70% of combat engagements against a given opponent rather than scoring 15 more points. Moreover, risk exposure is quantified by determining the likely casualties suffered to achieve victory. This combination makes the practical consequences of human performance differences tangible to the end users. Taken together, this approach advances the operations research analyses of squad-level combat engagements. Originality/value – For more than a century, marksmanship evaluations have used point-based systems to classify shooters. However, these scoring methods were developed for competitive integrity rather than lethality as points do not adequately capture combat capabilities. The proposed method thus represents a major shift in the marksmanship scoring paradigm.

To date, not many studies have presented evidence of SARS-CoV-2 infecting the female reproductive system. Furthermore, so far, no effect of the administration of anti-COVID 19 vaccines has been reported to affect the quality of oocytes retrieved from women who resorted to assisted reproduction technology (ART). The FF metabolic profiles of women who had been infected by SARS-CoV-2 before IVF treatments or after COVID-19 vaccination were examined by 1H NMR. Immunochemical characterization of proteins and cytokines involved in the redox and inflammatory pathways was performed. The increased expression of SOD2 and NQO1, the lack of alteration of IL-6 and CXCL10 levels, as well as the increased expression of CD39, suggested that, both sharing similar molecular mechanisms or proceeding along different routes, the redox balance is controlled in the FF of both vaccinated and recovered women compared to controls. The lower amount of metabolites known to have proinflammatory activity, i.e., TMAO and lipids, further supported the biochemical results, suggesting that the FF microenvironment is controlled so as to guarantee oocyte quality and does not compromise the outcome of ART. In terms of the number of blastocysts obtained after ICSI and the pregnancy rate, the results are also comforting.

RESUMO O presente artigo aborda o uso de fontes alternativas de abastecimento no município de São Paulo, com objetivo de analisar como a desregulamentação do setor poderá oferecer riscos à saúde da população, avaliar custos incorridos no saneamento nessas áreas e estimar custos que possam ocorrer no Sistema Único de Saúde (SUS). Foi feita revisão bibliográfica e projeção econométrica do impacto das doenças de veiculação hídrica no orçamento do SUS. Resultados demonstraram que, para cada 1.000 m3 de outorga concedida, serão 3.320 usuários em situação de vulnerabilidade, cujos subsídios foram sonegados, gerando custo social, déficit na universalização do saneamento e necessidade de criação de 180 leitos no SUS.

A Orientação Educacional, como o próprio nome indica, significa uma orientação que se pretende imprimir na trajetória do acontecer do projeto educacional da vida da pessoa.

A concepção kantiana sobre educação moral está intimamente conectada à forma que Kant vê a própria educação, dado o vínculo que estabelece de modo implícito, entre a tarefa da educação e o pleno desenvolvimento das possibilidades do homem visto como um ser moral, por excelência.

ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into the membrane of poxvirus. The protein of interest is correctly folded and expressed in the cell-derived viral membrane and does not require any detergents or refolding before downstream use. The poxvirus is selective in which proteins are incorporated into the viral membrane, making the antigen poxvirus an antigenically cleaner target for in vitro panning. Antigen-expressing virus can be readily purified at scale and used for antibody selection using any in vitro display platform.

Abstract Background: Idursulfase and laronidase are drugs used to treat Hunter syndrome (mucopolysaccharidosis type 2) and Scheie syndrome (mucopolysaccharidosis type 1 S), respectively. These are rare lysosomal storage disorders, leading to accumulation of glycosaminoglycans within lysosomes. Failure of early recognition of the disease and/or delay in starting the appropriate treatment result in severe clinical impairment and death. For almost 20 years, enzyme replacement therapy with recombinant proteins has represented the first line therapeutic option. However, administration of idursulfase and laronidase is associated with infusion-related hypersensitivity reactions, in approx. 20% of patients. In these patients, rapid desensitization by intravenous administration protocols has been used in order to avoid treatment discontinuation. This approach proved effective and safe. However, long-term tolerance could not be achieved. Thus, we decided to combine rapid desensitization with allergen immunotherapy-like desensitization. Results: Two patients with Hunter syndrome and one patient with Scheie syndrome developed severe allergy to idursulfase and laronidase, respectively, preventing them from continuing the otherwise indispensable therapy. In all three patients, the possible IgE-mediated nature of the reactions suffered was suggested by positive skin tests with the two enzymes, respectively. By devising 12-step, 3-dilution rapid desensitization protocols, we resumed the enzyme replacement therapy. However, the prolonged time required for administration (a not negligible pitfall, since therapy should be given weekly for life) and the persistent occurrence of reactions (mild but still requiring anti-allergic medication at full dosage) led us to combine rapid desensitization with a compact 11-step, 24-day allergen immunotherapy-like desensitization protocol. Thus, idursulfase and laronidase were injected subcutaneously, with a 500-fold increase from step 1 to step 11 for idursulfase and a 222-fold increase for laronidase. This strategy led to restoration of long-term tolerance, allowing weekly intravenous therapy administration under standard conditions, according to the manufacturer instructions, in the absence of side effects and with only precautionary low-dose premedication. Conclusion: Rapid desensitization is a suitable and safe option in the case of idursulfase and laronidase allergy. Combination with subcutaneous allergen immunotherapy-like desensitization afforded restoration of enzyme replacement therapy given by the normal administration schedule, by inducing sustained tolerance.

Summary: Antibody–drug conjugates (ADCs) represent a novel and evolving class of antineoplastic agents, constituted by monoclonal antibody linked to biologically active drugs, delivering cytotoxic compounds at the tumor site, reducing the likelihood of systemic exposure and toxicity. They are generally well tolerated, nevertheless some predictable adverse reactions need careful monitoring and timely approach. These include neutropenia, nausea and vomiting, alopecia, diarrhea, left ventricular dysfunction, ILD/pneumonitis. The mechanisms leading to drug-associated toxicities are summarized, and prophylaxis protocols and appropriate management strategies are proposed, based on current literature. This review aims to collect the most updated evidence on toxicities potentially occurring during breast cancer treatment with approved or under clinical investigation (advanced stage) ADCs. A focus is dedicated to monitoring protocols and clinical management, aimed at preventing and/or promptly address relevant problems, in order to avoid premature discontinuation or improper dose reduction.

O artigo em epígrafe tem como objetivo pesquisar a dimensão social da sustentabilidade, com foco no princípio da valorização e inclusão de comunidades locais em projetos de moda, por meio das coleções de Ronaldo Fraga. A metodologia para obtenção dos dados iniciou-se por pesquisa bibliográfica para definição dos objetivos e construção do estado da arte, posteriormente, realizou-se um estudo de caso a partir de duas coleções de Ronaldo Fraga, para investigar como o designer valoriza e inclui comunidades em seus projetos de moda, por fim, para análise qualitativa dos dados pautou-se na técnica de análise de conteúdo. Conclui-se que as coleções escolhidas para análise neste trabalho demonstram como o estilista consegue colocar em suas criações discussões relevante para a sociedade, remetendo debates sobre o modo de produção da indústria da moda, assim como, o consumo consciente e a integração com recursos do próprio país, sendo estes aspectos ideológicos da sustentabilidade.

The mechanical behaviour of fibre-reinforced sands (FRS) has been thoroughly explored with a laboratory study, firstly investigating the influence of relevant parameters such as grading index, soil density, amount, diameter, and length of fibres then focusing on their orientation with respect to the principal stress directions. This aspect has been deeply investigated performing parallel tests on samples of pure sand and on samples with randomly and uniformly oriented fibres compacted at a similarly high relative density (Dr≈1). Direct and triaxial shear tests have been performed, the former enforcing deformation on a predetermined shear plane. The results show that reinforcement with oriented fibres provides a higher strength and ductility to the sand. The grain scale investigation of the materials’ response to direct shearing has been carried out performing X-ray tomography post-mortem (i.e., after the test). The evolution of porosity in several samples prepared with the same procedure and sheared under the same conditions has been studied freezing the material fabric with nanosilica grout injected at different displacement levels. On the contrary, X-ray tomography performed along with miniature triaxial tests (operando method) enabled the analysis of the spatial distribution of deviatoric strain too. In both cases, maps show the relevant role of fibres orientation with reference to the shear band. If adequately activated, fibres tension modifies the strain field in the samples, preventing the fragile rupture along a shear plane and transferring the stresses to the outer soil portions, in this way providing a more dilatant and ductile overall response of the reinforced material.

The importance of physico-chemical processes at the particle scale for the engineering scale behaviour of fine-grained geomaterials is undisputed. Yet, despite great advances in the discipline, experimental evidence that fully resolves the clay micromechanics i.e. linking the evolving microstructure and interparticle actions under loading, is lacking. This paper will discuss the challenges ahead in quantifying the evolving kinematics and interparticle interactions of fine-grained geomaterials. As such, the current limitations, and the potential opportunities of experimental methodologies for manipulating, monitoring and (post-mortem) analysing fine-grained materials at the particle scale will be discussed. In addition to the need of integrating multiple experimental techniques that span several length scales and modalities, the critical role of advanced data reduction and analysis is highlighted, as required for a measurement as opposed to qualitative observation. Throughout the paper, the link between experimental clay micromechanics and modelling will be discussed.

Mass cytometry (CyTOF) is a new technology that allows the investigation of protein expression at single cell level with high resolution. While several protocols are available to investigate leukocyte expression, platelet staining and analysis with CyTOF have been described only from whole blood. Moreover, available protocols do not allow sample storage but require fresh samples to be obtained, processed, and measured immediately. We provide a structured and reproducible method to stain platelets from platelet-rich plasma to study thrombocyte protein expression and reactivity using mass cytometry. With our method, it is possible to acquire a large number of events allowing deep bioinformatic investigation of platelet expression heterogeneity. Integrated in our protocol is also a previously established freezing protocol that allows the storage of stained samples and to delay their measurement. Finally, we provide a structured workflow using different platelet stimulators and a freely available bioinformatic pipeline to analyze platelet expression. Our protocol unlocks the potential of CyTOF analysis for studying platelet biology in health and disease.

Abstract Breast cancer is one of leading causes of death worldwide in the female population. Deaths from breast cancer could be reduced significantly through earlier and more efficient detection of the disease. Saliva, an oral fluid that contains an abundance of protein biomarkers, has been recognized as a promising diagnostic biofluid that is easy to isolate through non-invasive techniques. Assays on saliva can be performed rapidly and are cost-effective. Therefore, our work aimed to identify salivary biomarkers present in the initial stages of breast cancer, where cell alterations are not yet detectable by histopathological analysis. Using state-of-the-art techniques, we employed a transgenic mouse model of mammary cancer to identify molecular changes in precancerous stage breast cancer through protein analysis in saliva. Through corroborative molecular approaches, we established that proteins related to metabolic changes, inflammatory process and cell matrix degradation are detected in saliva at the onset of tumor development. Our work demonstrated that salivary protein profiles can be used to identify cellular changes associated with precancerous stage breast cancer through non-invasive means even prior to biopsy-evident disease.

O objetivo deste artigo é expor compreensões e possibilidades de trabalhar com professores em forma/ação durante o curso de graduação em licenciatura em Matemática, enlaçando-os em discussões que foquem temas importantes da Matemática, da Educação Escolar, da complexidade da Educação e da Educação Matemática. Assumimos que a abordagem de questões filosóficas pertinentes à Matemática e à conduta dos professores de Matemática são vitais para a forma/ação dos estudantes de cursos de licenciatura em Matemática. Afirmamos que é preciso que os estudantes se deem conta do que falam, quando falam de Matemática e de produtos matemáticos, bem como possam compreender o que significa transpor o conhecimento matemático, com seus valores de certeza e de exatidão, implícitos à produção desse conhecimento, para outras realidades não matemáticas, como as econômicas, políticas e sociais. Para explicitar nossas argumentações tomamos como material a ser entendido e questionado o teorema da incompletude de Gödel, focando-o como um exemplo de realizar a possibilidade de uma educação metamatemática, em cursos de forma/ação de professores de Matemática, focando as perguntas acima mencionadas.

Abstract Maize seedlings are grown in Hostun sand with two different gradings and two different densities. The root-soil system is imaged daily for the first 8 days of plant growth with X-ray computed tomography. Segmentation, skeletonisation and digital image correlation techniques are used to analyse the evolution of the root system architecture, the displacement fields and the local strain fields due to plant growth in the soil. It is found that root thickness and root length density do not depend on the initial soil configuration. However, the depth of the root tip is strongly influenced by the initial soil density, and the number of laterals is impacted by grain size, which controls pore size, capillary rise and thus root access to water. Consequently, shorter root axes are observed in denser sand and fewer second order roots are observed in coarser sands. In all soil configurations tested, root growth induces shear strain in the soil around the root system, and locally, in the vicinity of the first order roots axis. Root-induced shear is accompanied by dilative volumetric strain close to the root body. Further away, the soil experiences dilation in denser sand and compaction in looser sand. These results suggest that the increase of porosity close to the roots can be caused by a mix of shear strain and steric exclusion.

The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis.The aim of the study is to prospectively evaluate the effectiveness of bedaquiline (and/or delamanid)- containing regimens in a large cohort of consecutive TB patients treated globally.This observational, prospective study is based on data collected and provided by Global Tuberculosis Network (GTN) centres and analysed twice a year.All consecutive patients (including children/adolescents) treated with bedaquiline and/or delamanid were enrolled, and managed according to WHO and national guidelines.Overall, 52 centres from 29 countries/regions in all continents reported 883 patients as of January 31st 2021, 24/29 countries/regions providing data on 100% of their consecutive patients (10–80% in the remaining 5 countries).The drug-resistance pattern of the patients was severe (>30% with extensively drug-resistant -TB; median number of resistant drugs 5 (3−7) in the overall cohort and 6 (4−8) among patients with a final outcome).For the patients with a final outcome (477/883, 54.0%) the median (IQR) number of months of anti-TB treatment was 18 (13−23) (in days 553 (385–678)). The proportion of patients achieving sputum smear and culture conversion ranged from 93.4% and 92.8% respectively (whole cohort) to 89.3% and 88.8% respectively (patients with a final outcome), a median (IQR) time to sputum smear and culture conversion of 58 (30−90) days for the whole cohort and 60 (30−100) for patients with a final outcome and, respectively, of 55 (30−90) and 60 (30−90) days for culture conversion.Of 383 patients treated with bedaquiline but not delamanid, 284 (74.2%) achieved treatment success, while 25 (6.5%) died, 11 (2.9%) failed and 63 (16.5%) were lost to follow-up.

Abstract Background Many primary care patients receive both medical and chiropractic care; however, interprofessional relations between physicians and chiropractors are often suboptimal which may adversely affect care of shared patients. We surveyed Canadian family physicians in 2010 to explore their attitudes towards chiropractic and re-administered the same survey a decade later to explore for changes in attitudes. Methods A 50-item survey administered to a random sample of Canadian family physicians in 2010, and again in 2019, that inquired about demographic variables, knowledge and use of chiropractic. Imbedded in our survey was a 20-item chiropractic attitude questionnaire (CAQ); scores could range from 0 to 80 with higher scores indicating more positive attitudes toward chiropractic. We constructed a multivariable regression model to explore factors associated with CAQ scores. Results Among eligible physicians, 251 of 685 in 2010 (37% response rate) and 162 of 2429 in 2019 (7% response rate) provided a completed survey. Approximately half of respondents (48%) endorsed a positive impression of chiropractic, 27% were uncertain, and 25% held negative views. Most respondents (72%) referred at least some patients for chiropractic care, mainly due to patient request or lack of response to medical care. Most physicians believed that chiropractors provide effective therapy for some musculoskeletal complaints (84%) and disagreed that chiropractic care was beneficial for non-musculoskeletal conditions (77%). The majority agreed that chiropractic care was a useful supplement to conventional care (65%) but most respondents (59%) also indicated that practice diversity among chiropractors presented a barrier to interprofessional collaboration. In our adjusted regression model, attitudes towards chiropractic showed trivial improvement from 2010 to 2019 (0.31 points on the 80-point CAQ; 95%CI 0.001 to 0.62). More negative attitudes were associated with older age (− 1.55 points for each 10-year increment from age 28; 95%CI − 2.67 to − 0.44), belief that adverse events are common with chiropractic care (− 1.41 points; 95% CI − 2.59 to − 0.23) and reported use of the research literature (− 6.04 points; 95% CI − 8.47 to − 3.61) or medical school (− 5.03 points; 95% CI − 7.89 to − 2.18) as sources of knowledge on chiropractic. More positive attitudes were associated with endorsing a relationship with a specific chiropractor (5.24 points; 95% CI 2.85 to 7.64), family and friends (4.06 points; 95% CI 1.53 to 6.60), or personal treatment experience (4.63 points; 95% CI 2.14 to 7.11) as sources of information regarding chiropractic. Conclusions Although generally positive, Canadian family physicians’ attitudes towards chiropractic are diverse, and most physicians felt that practice diversity among chiropractors was a barrier to interprofessional collaboration.

The water retention curve (WRC) represents a key function in unsaturated soil mechanics as it can be applied for the modeling of the hydro-mechanical behaviour of unsaturated soils. The macroscopic WRC is characterised by different phenomena, such as hysteresis upon cyclic drainage and imbibition as well as a multitude of hydraulic scanning paths upon a reversal of water flow direction. With the help of modern X-ray computed tomography and hydraulic experiments that can be performed in a CT scanning environment, so-called in situ CT experiments, we image cyclic drainage and imbibition in a sand on the pore scale in order to quantitatively measure and study the change of microstructure and capillary state variables, characterising capillary effects in unsaturated granular soils. The measured pore scale data can then be related to the macroscopic WRC. To our knowledge, for the first time very different capillary state variables, such as interfacial areas, contact lines and contact angles, could be extensively measured in high detail for various hydraulic cycles in our experiment. Besides the experimental procedure, the wealth of measured data will be comprehensively presented and discussed and finally shared with the research community for further investigations as it is believed to yield deep insights into the microstructural origins of water retention behaviour with its hydraulic hysteresis and clues for effective stress in unsaturated granular soils.

Nesse artigo nos dedicamos à formação de professores que ensinam Matemática, nos atentando a possíveis sentidos e significados que foram se revelando num estudo teórico-filosófico, no âmbito da Educação Matemática, numa perspectiva fenomenológica. Mais especificamente, damos atenção às palavras formação, ensinar e aprender, trazendo uma revisão bibliográfica, num exercício hermenêutico que busca compreensões. Primeiramente explicitamos nosso entendimento de “Ensino de Matemática” e de “Educação Matemática”. No percurso investigativo teórico, no diálogo com a literatura explicitamos compreensões, incialmente sobre formação de professores que ensinam matemática, na esteira destas nos dirigimos a expor um modo articulador de compreender as dimensões do aprender e do ensinar entrelaçados. Concluímos com a compreensão de aprender-ensinar como compromisso assumido consigo e com o outro; compromisso pautado no cuidado ao formar e formar-se, numa perspectiva crítica e reflexiva, tendo em vista a Matemática enquanto possibilidade formativa de pessoas.

Neste artigo discutimos desafios que vimos enfrentando na pesquisa qualitativa de abordagem fenomenológica, conduzida à distância, com o uso de recursos tecnologicos digitais. Para isto, trazemos a descrição e a discussão de trabalhos em desenvolvimento no âmbito dos grupos Fenomenologia em Educação Matemática (FEM) e no de Estudos e Pesquisa em Formação de Professores (GEForProf). Nestes, lançamos luz às possibilidades de estar com o outro à distância; ao modo pelo qual os encontros foram promovidos entre pessoas, bem como ao estilo como produzimos pesquisa qualitativa de abordagem fenomenológica, estando à distância. Concluímos que os modos de estar junto à distância solicitou produzir recursos formativos e criar vínculos que sustentassem encontros capazes de manterem-se na continuidade programada das pesquisas.

Breast cancer (BC) is the most common type of cancer among women in almost all countries worldwide and is one of the oncological pathologies for which is indicated fertility preservation, a type of procedure used to help keep a person’s ability to have children. Follicular fluid (FF) is a major component of oocyte microenvironment, which is involved in oocyte growth, follicular maturation, and in communication between germ and somatic cells; furthermore, it accumulates all metabolites during oocytes growth. To obtain information about changes on fertility due to cancer, we aimed at investigating potential biomarkers to discriminate between FF samples obtained from 16 BC patients and 10 healthy women undergoing in vitro fertilization treatments. An NMR-based metabolomics approach was performed to investigate the FF metabolic profiles; ELISA and western blotting assays were used to investigate protein markers of oxidative and inflammatory stress, which are processes closely related to cancer. Our results seem to suggest that FFs of BC women display some significant metabolic alterations in comparison to healthy controls, and these variations are also related with tumor staging.

Functional tricuspid regurgitation (TR) can develop either because of right ventricular (RV) remodeling (ventricular functional TR) and/or right atrial dilation (atrial functional TR). This meta-analysis aimed to investigate the association between right heart remodeling and long-term (>1 year) all-cause mortality in patients with significant TR (at least moderate, ≥2+). MEDLINE, ISI Web of Science, and SCOPUS databases were searched. Studies reporting data on at least 1 RV functional parameter and long-term all-cause mortality in patients with significant TR were included. This study was designed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) requirements. Out of 8,902 studies, a total of 14 were included, enrolling 4,394 subjects. The duration of follow-up across the studies varied, ranging from a minimum of 15.5 months to a maximum of 73.2 months. Overall, long-term all-cause mortality was 31% (95% CI: 20%-41%; P ≤ 0.001). By means of meta-regression analyses, an inverse relation was found between tricuspid annular plane systolic excursion (11 studies enrolling 3,551 subjects, −6.3% [95% CI: −11.1% to −1.4%]; P = 0.011), RV fractional area change (9 studies, 2,975 subjects, −4.4% [95% CI: −5.9% to −2.9%]; P < 0.001), tricuspid annular dimension (7 studies, 2,986 subjects, −4.1% [95% CI: −7.6% to −0.5%]; P = 0.026), right atrial area (6 studies, 1,920 subjects, −1.9% [95% CI: −2.5% to −1.3%]; P < 0.001) and mortality. RV dysfunction parameters are associated to worse clinical outcomes in patients with TR, whereas right atrial dilatation is linked to a better prognostic outcome. Further studies are needed to unravel the pathophysiological differences within the functional TR spectrum. (Right heart remodeling and outcomes in patients with tricuspid regurgitation; CRD42023418667) [Display omitted] [ABSTRACT FROM AUTHOR]

Introduction A combination of punitive sentencing practices within ageing populations, compounded by the health challenges faced by people in prison, means that dedicated palliative care provision within prisons is a pressing requirement. However, evidence about exactly how quality palliative and end-of-life care is delivered in this environment remains sparse.This review aims to develop a typology of models of palliative and end-of-life care delivery within prisons in high-income countries to inform service development and policy.Methods and analysis We will conduct a scoping review of published studies and grey literature, following the Arksey and O’Malley framework. We will report data on models of palliative and end-of-life care delivery in prisons in high-income countries. Searches will be undertaken in Medline, EMBASE, CINAHL, Social Sciences Citation Index and PsyINFO for all study types, published from 1 January 2000 to December 2021, and reference lists from key reviews and studies will be screened for additional references. We will also screen grey literature from within other high-income countries using a targeted search strategy. For published reports of original research, study quality and risk of bias will be assessed independently by two reviewers using the Mixed Methods Appraisal Tool. A narrative synthesis of the data will be undertaken, integrating the results of the quality assessment.Ethics and dissemination Approval by research ethics committee is not required since the review only includes published and publicly accessible data. We will publish our findings in a peer-reviewed journal as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidance.Protocol registration The final protocol was registered with the Research Registry on 26 November 2021 (www.researchregistry.com).Unique ID number: reviewregistry1260.

This paper presents the development of a laboratory scale apparatus and first experimental results on the characterization of fingering patterns of immiscible fluids in a porous rock (Fontainebleau sandstone), using three dimensional full-field measurements from x-ray tomography. The few existing studies that have extended experimental investigation of immiscible fluid flow from 2D to 3D have been primarily interested in the pore scale or performed on idealized porous media. While the heterogeneities inherent to natural rocks are known to play an important role on subsurface fluid flow regimes, a limited number of studies have approached the problem of characterizing the time resolved 3D multiphase flow in these material, at the mesoscale. The series of experiments reported in this paper has been performed at a low viscosity ratio, water invasion into oil as the defending fluid, and different capillary numbers (1.8 orders of magnitude). The results illustrate the qualitative transition in the flow regime, from capillary fingering to viscous fingering. While a full quantitative characterization of geometrical features of fluid fingers will require further technical refinements, a qualitative understanding can be already gathered from the results presented herein.