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3. Insomnia and related factors in patients with pre-existing psychiatric disorders compared to the general population during the COVID-19 lockdown: Findings from the multicentric COMET study

Author

Dell'Osso, Bernardo, Viganò, Caterina, Conti, Dario, Scarpa, Carolina, Casati, Lorenzo, Albert, Umberto, Carmassi, Claudia, Carrà, Giuseppe, Cirulli, Francesca, Nanni, Maria Giulia, Pompili, Maurizio, Sampogna, Gaia, Sani, Gabriele, Tortorella, Alfonso, Volpe, Umberto, and Fiorillo, Andrea

Published
2022
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5. Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis

Author

D’Addario, Claudio, Pucci, Mariangela, Bellia, Fabio, Girella, Antonio, Sabatucci, Annalaura, Fanti, Federico, Vismara, Matteo, Benatti, Beatrice, Ferrara, Luca, Fasciana, Federica, Celebre, Laura, Viganò, Caterina, Elli, Luca, Sergi, Manuel, Maccarrone, Mauro, Buzzelli, Valeria, Trezza, Viviana, and Dell’Osso, Bernardo

Published
2022
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9. Problematic Internet Use and Study Motivation in Higher Education

Author

Truzoli, Roberto, Viganò, Caterina, Galmozzi, Paolo Gabriele, and Reed, Phil

Abstract

The current study explored the relationship between problematic internet use (PIU) and motivation to learn, and examined psychological and social factors mediating this relationship. Two hundred and eighty-five students in an Italian University were recruited for the current study. There was a negative relationship between PIU and motivation to study: a negative impact on learning strategies, meaning that the students found it harder to organize their learning productively; and PIU also positively associated with test anxiety. The current results also demonstrated that there was partial mediation of this effect of PIU on learning strategies in terms of loneliness. This suggest at those with high levels of PIU may be particularly at risk from lower motivations to study, and, hence, lower actual generalized academic performance due to a number of consequences of PIU.

Published
2020
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11. Longitudinal outcomes of a work inclusion program in mental health departments in the city of Milan

Author

Vanzetto, Simone, primary, Quarenghi, Andrea, additional, Varinelli, Alberto, additional, Dragoni, Chiara, additional, Conti, Dario, additional, Boscacci, Maria, additional, Carrà, Giuseppe, additional, Percudani, Mauro, additional, Morganti, Carla, additional, Gambini, Orsola, additional, Barbieri, Valentina, additional, Brambilla, Paolo, additional, Lazzaretti, Matteo, additional, Rubelli, Paola, additional, Mencacci, Claudio, additional, Fusi, Antonio, additional, Viganò, Caterina, additional, and Dell’Osso, Bernardo, additional

Published
2024
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13. The use of antipsychotics in obsessive compulsive disorder.

Author

Conti, Dario, Girone, Nicolaja, Boscacci, Maria, Casati, Lorenzo, Cassina, Niccolò, Cerolini, Lucia, Giacovelli, Luca, Viganò, Caterina, Conde, Marian Mora, Cremaschi, Laura, and Dell'Osso, Bernardo M.

Subjects
ARIPIPRAZOLE, OBSESSIVE-compulsive disorder, ANTIPSYCHOTIC agents, SEROTONIN uptake inhibitors, COGNITIVE therapy, TOURETTE syndrome
Abstract

Obsessive‐compulsive disorder (OCD) is a chronic disease with a prevalence in the general population of around 2%–3%, generally accompanied by a severe impairment of functioning and quality of life. A consistent subgroup of patients may not achieve adequate symptom remission with first‐line treatments (i.e., cognitive behavioral therapy, selective serotonin reuptake inhibitors [SSRIs]). The most validated option for treatment‐resistant cases relies on the augmentative use of antipsychotics to SSRIs, preferably of the 'second generation'. Indeed, dopamine appears to be crucially involved in OCD neuropathology due to its implication in systems relating to goal‐directed behaviour and maladaptive habits. Nevertheless, the mechanism of action of antipsychotics in OCD symptom improvement is still unclear. Risperidone, aripiprazole, and haloperidol seem to be the most useful medications, whereas 'first generation' antipsychotics may be indicated in case of comorbidity with tics and/or Tourette Syndrome. Antipsychotic augmentation may be also related to side‐effects, particularly in the long term (e.g., alteration in metabolic profile, sedation, extrapyramidal symptoms). The present mini‐review sought to provide the most updated evidence on augmentative antipsychotic use in treatment‐resistant patients with OCD, providing a road map for clinicians in daily practice and shedding light on avenues for further research. [ABSTRACT FROM AUTHOR]

Published
2024
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14. The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study

Author

Castellini, Giovanni, primary, Tarchi, Livio, additional, Cassioli, Emanuele, additional, Ricca, Valdo, additional, Abbate Daga, Giovanni, additional, Aguglia, Andrea, additional, Albert, Umberto, additional, Atti, Annarita, additional, Barlati, Stefano, additional, Blasi, Giuseppe, additional, Carmassi, Claudia, additional, Carrà, Giuseppe, additional, De Fazio, Pasquale, additional, De Panfilis, Chiara, additional, Di Lorenzo, Giorgio, additional, Ferrari, Silvia, additional, Goracci, Arianna, additional, Gramaglia, Carla, additional, Luciano, Mario, additional, Martinotti, Giovanni, additional, Menchetti, Marco, additional, Menculini, Giulia, additional, Nanni, Maria Giulia, additional, Nivoli, Alessandra, additional, Pinna, Federica, additional, Pompili, Maurizio, additional, Rosso, Gianluca, additional, Sambataro, Fabio, additional, Sampogna, Gaia, additional, Sani, Gabriele, additional, Serafini, Gianluca, additional, Signorelli, Maria Salvina, additional, Tosato, Sarah, additional, Ventriglio, Antonio, additional, Viganò, Caterina, additional, Volpe, Umberto, additional, and Fiorillo, Andrea, additional

Published
2024
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15. Relevance of pharmacogenetic analyses and therapeutic drug monitoring of antidepressants for an individualized treatment of peripartum psychopathology

Author

Colombo, Anna, primary, Cafaro, Rita, additional, Di Bernardo, Ilaria, additional, Mereghetti, Marta, additional, Cerolini, Lucia, additional, Giacovelli, Luca, additional, Giorgetti, Federica, additional, Vanzetto, Simone, additional, Girone, Nicolaja, additional, Savasi, Valeria, additional, Cetin, Irene, additional, Clementi, Emilio, additional, Bosi, Monica Francesca, additional, Viganò, Caterina Adele, additional, and Dell’Osso, Bernardo, additional

Published
2023
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21. Psychiatric rehabilitation patterns in Italy: Results from the Italian Society of Psychosocial Rehabilitation (SIRP) survey

Author

Viganò, C, Ariu, C, Barbieri, D, Goffredi, A, Ferrara, L, Rea, F, Barlati, S, Vita, A, Viganò, Caterina, Ariu, Cassandra, Barbieri, Deborah, Goffredi, Alessia, Ferrara, Luca, Rea, Federico, Barlati, Stefano, Vita, Antonio, Viganò, C, Ariu, C, Barbieri, D, Goffredi, A, Ferrara, L, Rea, F, Barlati, S, Vita, A, Viganò, Caterina, Ariu, Cassandra, Barbieri, Deborah, Goffredi, Alessia, Ferrara, Luca, Rea, Federico, Barlati, Stefano, and Vita, Antonio

Abstract

Introduction: Psychiatric rehabilitation can be considered a bidirectional technique, designed to allow patients to achieve their personal target, focusing on the individuals’ strengths and challenges related to these targets and also on the community organizations in which they will live them out. Unfortunately, psychiatric rehabilitation is too often not considered a first line treatment. Moreover, rehabilitation has been confused with a generic and rough practice, consisting of extemporary actions and aimless entertainments designed to fill “the time passing”. Methods: The aim of this study was to increase the knowledge and awareness about the state of the art of different systems of management and funding of psychosocial rehabilitation in the Italian “real-world” rehabilitative settings, using a specifically developed questionnaire. Results: The data obtained are positive for some aspects of the rehabilitation interventions, in particular for the use of validated tools for the evaluation and revision of projects and for the trend to work on a team, even though the scarcity of evidence-based rehabilitation interventions applied in Italian psychiatric services is less encouraging. Conclusion: This survey presents, at least partially, the “real-world” of rehabilitation in Italy so that we can lay the foundations for the definition of an updated, validated and shared network of what is implemented in the context of psychiatric rehabilitation.

Published
2023

23. In Search for Biomarkers in Obsessive-Compulsive Disorder: New Evidence on Saliva as a Practical Source of DNA to Assess Epigenetic Regulation

Author

Dell’Osso, Bernardo, primary, D’Addario, Claudio, additional, Macellaro, Monica, additional, Bellia, Fabio, additional, Benatti, Beatrice, additional, Annunzi, Eugenia, additional, Palumbo, Riccardo, additional, Conti, Dario, additional, Fasciana, Federica, additional, Vismara, Matteo, additional, Varinelli, Alberto, additional, Ferrara, Luca, additional, Celebre, Laura, additional, and Viganò, Caterina, additional

Published
2022
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24. Psychiatric rehabilitation patterns in Italy: Results from the Italian Society of Psychosocial Rehabilitation (SIRP) survey

Author

Viganò, Caterina, Ariu, Cassandra, Barbieri, Deborah, Goffredi, Alessia, Ferrara, Luca, Rea, Federico, Barlati, Stefano, Vita, Antonio, Viganò, C, Ariu, C, Barbieri, D, Goffredi, A, Ferrara, L, Rea, F, Barlati, S, and Vita, A

Subjects
community-based intervention, Psychiatry and Mental health, case management (CM), evidence-based, mental health services, psychosocial rehabilitation, recovery, severe mental illness (SMI), mental health service
Abstract

IntroductionPsychiatric rehabilitation can be considered a bidirectional technique, designed to allow patients to achieve their personal target, focusing on the individuals’ strengths and challenges related to these targets and also on the community organizations in which they will live them out. Unfortunately, psychiatric rehabilitation is too often not considered a first line treatment. Moreover, rehabilitation has been confused with a generic and rough practice, consisting of extemporary actions and aimless entertainments designed to fill “the time passing”.MethodsThe aim of this study was to increase the knowledge and awareness about the state of the art of different systems of management and funding of psychosocial rehabilitation in the Italian “real-world” rehabilitative settings, using a specifically developed questionnaire.ResultsThe data obtained are positive for some aspects of the rehabilitation interventions, in particular for the use of validated tools for the evaluation and revision of projects and for the trend to work on a team, even though the scarcity of evidence-based rehabilitation interventions applied in Italian psychiatric services is less encouraging.ConclusionThis survey presents, at least partially, the “real-world” of rehabilitation in Italy so that we can lay the foundations for the definition of an updated, validated and shared network of what is implemented in the context of psychiatric rehabilitation.

Published
2023

28. The impact of Covid-19 on unemployment across Italy: Consequences for those affected by psychiatric conditions

Author

Pompili, M, Innamorati, M, Sampogna, G, Albert, U, Carmassi, C, Carrà, G, Cirulli, F, Erbuto, D, Luciano, M, Nanni, M, Sani, G, Tortorella, A, Viganò, C, Volpe, U, Fiorillo, A, Pompili, Maurizio, Innamorati, Marco, Sampogna, Gaia, Albert, Umberto, Carmassi, Claudia, Carrà, Giuseppe, Cirulli, Francesca, Erbuto, Denise, Luciano, Mario, Nanni, Maria Giulia, Sani, Gabriele, Tortorella, Alfonso, Viganò, Caterina, Volpe, Umberto, Fiorillo, Andrea, Pompili, M, Innamorati, M, Sampogna, G, Albert, U, Carmassi, C, Carrà, G, Cirulli, F, Erbuto, D, Luciano, M, Nanni, M, Sani, G, Tortorella, A, Viganò, C, Volpe, U, Fiorillo, A, Pompili, Maurizio, Innamorati, Marco, Sampogna, Gaia, Albert, Umberto, Carmassi, Claudia, Carrà, Giuseppe, Cirulli, Francesca, Erbuto, Denise, Luciano, Mario, Nanni, Maria Giulia, Sani, Gabriele, Tortorella, Alfonso, Viganò, Caterina, Volpe, Umberto, and Fiorillo, Andrea

Abstract

Background: Severe psychological and psychosocial consequences of the COVID-19 pandemic are expected, especially for people already vulnerable to biological or psychosocial stressors, including those with mental health problems. The study aimed to investigate factors associated with the loss of jobs and unemployment during the COVID-19 pandemic. In particular, we investigated whether mental illness was associated with a higher risk of losing one's job because of the COVID-19 pandemic. Methods: Nineteen thousand four hundred ninety-six adults living in Italy were administered an online protocol including a sociodemographic checklist and questionnaires investigating suicide ideation and risk, mental health status and general distress (stress, anxiety, and depression), resilience, and perceived support. Results: One thousand two hundred seventy-four reported having lost their job because of the COVID-19 pandemic, and 5.4% of the sample reported a mental illness (mostly a depressive disorder). Unemployment was independently associated with mental illness, poor mental health, and depression. Mental illness was associated with the risk of losing one's job because of the COVID-19 pandemic, but not at the multivariate analyses. Those who lost their job because of the COVID-19 pandemic (compared to others) reported worse mental health and depression. Limitations: The presence of mental illness was self-reported by respondents and the administered measures were self-reported questionnaires affected by social desirability and other response bias. Conclusions: The COVID-19 pandemic and social isolation measures and lockdown used to contain its spread among the Italian population were associated with occupational insecurity, especially among the more vulnerable social categories.

Published
2022

29. Additional file 1 of Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis

Author

D’Addario, Claudio, Pucci, Mariangela, Bellia, Fabio, Girella, Antonio, Sabatucci, Annalaura, Fanti, Federico, Vismara, Matteo, Benatti, Beatrice, Ferrara, Luca, Fasciana, Federica, Celebre, Laura, Viganò, Caterina, Elli, Luca, Sergi, Manuel, Maccarrone, Mauro, Buzzelli, Valeria, Trezza, Viviana, and Dell’Osso, Bernardo

Abstract

Additional file 1. Supplementary material: methods, results, tables and figures.

Published
2022
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30. Latency to selective serotonin reuptake inhibitor vs benzodiazepine treatment in patients with panic disorder: a naturalistic study

Author

Piccoli, Eleonora, primary, Bergamaschini, Irma, additional, Molteni, Laura, additional, Vanzetto, Simone, additional, Varinelli, Alberto, additional, Viganò, Caterina, additional, Catania, Gabriele, additional, Baldwin, David S., additional, Domschke, Katharina, additional, and Dell’Osso, Bernardo, additional

Published
2021
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32. A longitudinal analysis of a work inclusion model for psychiatric patients in the Mental Health Departments of the city of Milan.

Author

Ferrara, Luca, Varinelli, Alberto, Caricasole, Valentina, Dragoni, Chiara, Mazzardis, Sonia, Quarenghi, Andrea, Rubelli, Paola, Fusi, Antonio, Percudani, Mauro, Cisima, Michele, Mencacci, Claudio, Maranesi, Teodoro, Gambini, Orsola, Barbieri, Valentina, Brambilla, Paolo, Lazzaretti, Matteo, Carrà, Giuseppe, Latina, Aldo, Viganò, Caterina, and Dell'Osso, Bernardo

Subjects
MENTAL illness treatment, PSYCHOTHERAPY patients, WORK, RETROSPECTIVE studies, PSYCHOSOCIAL factors, DESCRIPTIVE statistics, VOCATIONAL rehabilitation, SOCIAL integration, PSYCHIATRIC hospitals, SUPPORTED employment, MENTAL health services
Abstract

Background: Work functioning impairment is a key diagnostic and transnosographic criterion for psychiatric disorders in both DSM-5 and ICD-11. Occupational inclusion is a fundamental aspect of the care path for patients attending the territorial services provided by the Italian Mental Health and Addiction Departments (DSMDs). Since 2009, the Regional Innovative Programme (PIR) TR106, promoted by the Fatebenefratelli-Sacco hospital of Milan, Italy, in collaboration with six other metropolitan DSMDs, was created to promote integration for people suffering from mental health problems in the city of Milan. Method: Here we present the results of a retrospective epidemiologic analysis on 2,142 interventions on 1,066 patients, conducted between 2012 and 2019. Results: Most of the interventions were conducted with people with psychotic disorders (39%), followed by personality disorders (25.2%) and affective disorders (22.2%). The age range of 25 to 54 years represented 91.5% of the whole sample, mainly in the 35 to 44 years range (36.4%). Significant age group-related changes in interventions were observed in the observation period, with a reduction in the interventions provided to subjects of the 35 to 44 age group, and an increase in the 25 to 34 age group. Conclusions: PIR TR106 provided the most accurate assessment and data collection so far for the city of Milan. Our data characterised psychiatric groups in order to develop specific treatment plans and work inclusion interventions. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Assessing response, remission, and treatment resistance in patients with obsessive–compulsive disorder with and without tic disorders: results from a multicenter study

Author

Benatti, Beatrice, primary, Girone, Nicolaja, additional, Conti, Dario, additional, Cafaro, Rita, additional, Viganò, Caterina, additional, Briguglio, Matteo, additional, Marazziti, Donatella, additional, Mucci, Federico, additional, Gambini, Orsola, additional, Demartini, Benedetta, additional, Tundo, Antonio, additional, Necci, Roberta, additional, De Berardis, Domenico, additional, Galentino, Roberta, additional, De Michele, Sara, additional, Balestrino, Roberta, additional, Albert, Umberto, additional, Rigardetto, Sylvia, additional, Maina, Giuseppe, additional, Grassi, Giacomo, additional, Pallanti, Stefano, additional, Amerio, Andrea, additional, Aguglia, Andrea, additional, Prestia, Davide, additional, Amore, Mario, additional, Priori, Alberto, additional, Servello, Domenico, additional, Porta, Mauro, additional, and Dell’Osso, Bernardo, additional

Published
2021
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36. A longitudinal analysis of a work inclusion model for psychiatric patients in the Mental Health Departments of the city of Milan

Author

Ferrara, Luca, primary, Varinelli, Alberto, additional, Caricasole, Valentina, additional, Dragoni, Chiara, additional, Mazzardis, Sonia, additional, Quarenghi, Andrea, additional, Rubelli, Paola, additional, Fusi, Antonio, additional, Percudani, Mauro, additional, Cisima, Michele, additional, Mencacci, Claudio, additional, Maranesi, Teodoro, additional, Gambini, Orsola, additional, Barbieri, Valentina, additional, Brambilla, Paolo, additional, Lazzaretti, Matteo, additional, Carrà, Giuseppe, additional, Latina, Aldo, additional, Viganò, Caterina, additional, and Dell’Osso, Bernardo, additional

Published
2021
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37. Latency to selective serotonin reuptake inhibitor vs benzodiazepine treatment in patients with panic disorder: a naturalistic study

Author

Piccoli, Eleonora, Bergamaschini, Irma, Molteni, Laura, Vanzetto, Simone, Varinelli, Alberto, Viganò, Caterina, Catania, Gabriele, Baldwin, David S., Domschke, Katharina, and Dell’Osso, Bernardo

Abstract

AbstractBackgroundPanic disorder (PD) is a prevalent and impairing anxiety disorder with previous reports suggesting that the longer the condition remains untreated, the greater the likelihood of nonresponse. However, patients with PD may wait for years before receiving a guideline-recommended pharmacological treatment. The widespread prescription of benzodiazepines (BDZ) for managing anxiety symptoms and disorders might delay the administration of pharmacotherapy according to guidelines (eg, selective serotonin reuptake inhibitors, SSRIs). The present study aimed to determine the mean duration of untreated illness (DUI) in a sample of PD patients, to quantify and compare DUI-SSRI to DUI-BDZ, and to compare findings with those from previous investigations.MethodsThree hundred and fourteen patients with a Diagnostic and Statistical Manual of Mental Disorders, fifth edition diagnosis of PD were recruited from an Italian outpatient psychotherapy unit, and epidemiological and clinical variables were retrieved from medical records. Descriptive statistical analyses were undertaken for sociodemographic and clinical variables, Wilcoxon matched-pair signed rank test was applied to compare the distribution of DUI-SSRI vs DUI-BDZ, and Welch’s ttest was performed to compare findings with those from previous studies.ResultsThe mean DUI-SSRI of the total sample was 64.25 ± 112.74 months, while the mean DUI-BDZ was significantly shorter (35.09 ± 78.62 months; P< 0.0001). A significantly longer DUI-SSRI, compared to findings from previous studies, was also observed.ConclusionsThe present results confirm a substantial delay in implementing adequate pharmacological treatments in patients with PD, and highlight the discrepancy between recommendations from international treatment guidelines and common clinical practice in relation to BDZ prescription.

Published
2023
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38. Managing Problematic Usage of the Internet and Related Disorders in an Era of Diagnostic Transition: An Updated Review

Author

Dell’Osso, Bernardo, primary, Di Bernardo, Ilaria, additional, Vismara, Matteo, additional, Piccoli, Eleonora, additional, Giorgetti, Federica, additional, Molteni, Laura, additional, Fineberg, Naomi A., additional, Virzì, Calogero, additional, Bowden-Jones, Henrietta, additional, Truzoli, Roberto, additional, and Viganò, Caterina, additional

Published
2021
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39. A preliminary investigation of Cyberchondria and its correlates in a clinical sample of patients with obsessive–compulsive disorder, anxiety and depressive disorders attending a tertiary psychiatric clinic

Author

Vismara, Matteo, primary, Benatti, Beatrice, additional, Ferrara, Luca, additional, Colombo, Anna, additional, Bosi, Monica, additional, Varinelli, Alberto, additional, Pellegrini, Luca, additional, Viganò, Caterina, additional, Fineberg, Naomi A., additional, and Dell’Osso, Bernardo, additional

Published
2021
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40. Assessing response, remission, and treatment resistance in patients with obsessive–compulsive disorder with and without tic disorders: results from a multicenter study

Author

Benatti, Beatrice, Girone, Nicolaja, Conti, Dario, Cafaro, Rita, Viganò, Caterina, Briguglio, Matteo, Marazziti, Donatella, Mucci, Federico, Gambini, Orsola, Demartini, Benedetta, Tundo, Antonio, Necci, Roberta, De Berardis, Domenico, Galentino, Roberta, De Michele, Sara, Balestrino, Roberta, Albert, Umberto, Rigardetto, Sylvia, Maina, Giuseppe, Grassi, Giacomo, Pallanti, Stefano, Amerio, Andrea, Aguglia, Andrea, Prestia, Davide, Amore, Mario, Priori, Alberto, Servello, Domenico, Porta, Mauro, and Dell’Osso, Bernardo

Abstract

AbstractBackgroundHighlighting the relationship between obsessive–compulsive disorder (OCD) and tic disorder (TD), two highly disabling, comorbid, and difficult-to-treat conditions, Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) acknowledged a new “tic-related” specifier for OCD, ie, obsessive–compulsive tic-related disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicenter study was to investigate rates and clinical correlates of response, remission, and treatment resistance in a large multicenter sample of OCD patients with versus without tics.MethodsA sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from 10 different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analyzed comparing the rates of response, remission, and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response.ResultsThe remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.ConclusionsAlthough remission was associated with later ages of OCD and TD onset, specific clinical factors, such as early onset and presence of psychiatric comorbidities and concomitant TD, predicted a worse treatment response with a significant impairment in quality of life for both patients and their caregivers, suggesting a worse profile of treatment response for patients with OCTD.

Published
2022
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41. A preliminary investigation of Cyberchondria and its correlates in a clinical sample of patients with obsessive–compulsive disorder, anxiety and depressive disorders attending a tertiary psychiatric clinic.

Author

Vismara, Matteo, Benatti, Beatrice, Ferrara, Luca, Colombo, Anna, Bosi, Monica, Varinelli, Alberto, Pellegrini, Luca, Viganò, Caterina, Fineberg, Naomi A., and Dell'Osso, Bernardo

Subjects
INTERNET searching, CROSS-sectional method, TERTIARY care, COMPARATIVE studies, MENTAL depression, HEALTH, INFORMATION resources, ANXIETY, INTERNET addiction, OBSESSIVE-compulsive disorder, PSYCHIATRIC hospitals
Abstract

Objectives. This cross-sectional study aimed to investigate the frequency and presentation of cyberchondria (CYB) in patients with obsessive–compulsive disorder (OCD), anxiety disorders (ADs), and major depression disorder (MDD). Methods. Seventy-seven patients (OCD:25, ADs:26, MDD:26) referred to a tertiary psychiatry outpatient clinic and 27 healthy controls (HCs) were included. A 'working' definition of CYB was used to measure CYB frequency. CYB severity was measured with the Cyberchondria Severity Scale (CSS). Results. CYB as currently defined was present in just 1.3% of the combined patients' sample. Using a broader definition (omitting the disability criterion), we found a higher distribution (OCD:12%, ADs:19.2%, MDD:15.4%, HCs:3.7%) and greater CYB symptom severity. Patients with OCD (63.3 ± 18.9) and ADs (63.3 ± 25.9) showed a higher CYB severity, compared with HCs (48.4 ± 9.9, p<.05). In the combined patients' sample, a positive correlation was found between the CSS scores and measures of health anxiety or hypochondriasis. Higher CYB symptom severity emerged in patients with a positive family history of psychiatric disorders and in those prescribed benzodiazepines or mood-stabilisers. Conclusion. CYB represents a common transdiagnostic syndrome in patients with OCD, ADs, and MDD with a spectrum of severity and indicates a variable burden of illness, supporting the need for specific clinical considerations and interventions. Cyberchondria (CYB) represents a common transdiagnostic syndrome in patients with obsessive–compulsive disorder, anxiety, and depressive disorders. CYB's frequency as a syndrome of compulsive online health searches associated with an increased anxiety and distress was reported in 10–20% patients. Health anxiety/hypochondriasis showed a strong correlation with CYB. Patients with a positive family history of psychiatric disorders and those prescribed benzodiazepines or mood-stabilisers showed higher CYB symptom severity. Considering the spread of Internet use for health-related information, additional studies investigating CYB in clinical samples are encouraged. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

Author

Vismara, Matteo, Girone, Nicolaja, Cirnigliaro, Giovanna, Fasciana, Federica, Vanzetto, Simone, Ferrara, Luca, Priori, Alberto, D’Addario, Claudio, Viganò, Caterina, and Dell’Osso, Bernardo

Subjects
peripheral biomarkers, anxiety disorders, biomarkers, Review, Anxiety disorders, Biomarkers, Peripheral biomarkers, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571
Abstract

Anxiety disorders are prevalent and highly disabling mental disorders. In recent years, intensive efforts focused on the search for potential neuroimaging, genetic, and peripheral biomarkers in order to better understand the pathophysiology of these disorders, support their diagnosis, and characterize the treatment response. Of note, peripheral blood biomarkers, as surrogates for the central nervous system, represent a promising instrument to characterize psychiatric disorders, although their role has not been extensively applied to clinical practice. In this report, the state of the art on peripheral biomarkers of DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th edition) Anxiety Disorders is presented, in order to examine their role in the pathogenesis of these conditions and their potential application for diagnosis and treatment. Available data on the cerebrospinal fluid and blood-based biomarkers related to neurotransmitters, neuropeptides, the hypothalamic-pituitary-adrenal axis, neurotrophic factors, and the inflammation and immune system are reviewed. Despite the wide scientific literature and the promising results in the field, only a few of the proposed peripheral biomarkers have been defined as a specific diagnostic instrument or have been identified as a guide in the treatment response to DSM-5 Anxiety Disorders. Therefore, further investigations are needed to provide new biological insights into the pathogenesis of anxiety disorders, to help in their diagnosis, and to tailor a treatment.

Published
2020

43. Correlation between pharmacokinetics and pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Selective Serotonin and Noradrenaline Reuptake Inhibitors and maternal and neonatal outcomes: Results from a naturalistic study in patients with affective disorders

Author

Colombo, Anna, primary, Giordano, Francesca, additional, Giorgetti, Federica, additional, Di Bernardo, Ilaria, additional, Bosi, Monica F., additional, Varinelli, Alberto, additional, Cafaro, Rita, additional, Pileri, Paola, additional, Cetin, Irene, additional, Clementi, Emilio, additional, Viganò, Caterina A., additional, and Dell'Osso, Bernardo, additional

Published
2020
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45. Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis.

Author

D'Addario, Claudio, Pucci, Mariangela, Bellia, Fabio, Girella, Antonio, Sabatucci, Annalaura, Fanti, Federico, Vismara, Matteo, Benatti, Beatrice, Ferrara, Luca, Fasciana, Federica, Celebre, Laura, Viganò, Caterina, Elli, Luca, Sergi, Manuel, Maccarrone, Mauro, Buzzelli, Valeria, Trezza, Viviana, and Dell'Osso, Bernardo

Published
2022
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48. A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression

Author

Arici, Chiara, primary, Benatti, Beatrice, additional, Cafaro, Rita, additional, Cremaschi, Laura, additional, Degoni, Luca, additional, Pozzoli, Sara, additional, Oldani, Lucio, additional, Molteni, Laura, additional, Giorgetti, Federica, additional, Priori, Alberto, additional, Viganò, Caterina, additional, and Dell’Osso, Bernardo, additional

Published
2020
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