Search

Your search keyword '"Viel Q"' showing total 12 results
Start Over Author "Viel Q"
12 results on '"Viel Q"'

1. Recrystallization behaviour of organic compounds from the amorphous state: impact of chirality

Author

Atawa, B., Viel, Q., Couvrat, Nicolas, Dargent, Eric, Petit, Samuel, Coquerel, Gérard, Saiter, Allisson, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Groupe de physique des matériaux (GPM), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Propre, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

National audience

Published
2019

2. Comportement Thermique des Composes Organiques Chiraux Depuis l’Etat Amorphe : Benefice des Analyses DSC et FSC

Author

Atawa, Bienvenu, Viel, Q., Couvrat, Nicolas, Dargent, Eric, Petit, Samuel, Coquerel, Gérard, Allison, Saiter-Fourcin, Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Sciences et Méthodes Séparatives (SMS), Normandie Université (NU)-Normandie Université (NU), and Propre

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

National audience

Published
2019

3. Influence de la pureté sur la cristallisation depuis l’état amorphe d’une molécule chirale

Author

Viel, Q., Brandel, Clément, Cartigny, Y., Coquerel, G., Dargent, E., Petit, S., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2016

4. Influence of Covering Sample on the Polymorphism of a Chiral Molecule: Diprophyline

Author

Viel, Q., Cartigny, Y., Coquerel, G., Gbabode, G., Dargent, E., Petit, S., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2015

5. Influence of sample covering on the polymorphic and solid-solid transitions of a chiral molecule: Diprophylline

Author

Viel, Q., Cartigny, Y., Gbabode, G., Coquerel, G., Canotilho, J., Eusébio, M.E.S., Dargent, E., Petit, S., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

6. Impact of molecular flexibility on the nucleation behaviour of Diprophylline enantiomers

Author

Viel, Q., Brandel, Clément, Cartigny, Y., Coquerel, G., Dargent, E., Petit, S., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

7. Incidence of confinement in the crystallization route from the amorphous state of a chiral molecule

Author

Viel, Q., Cartigny, Y., Coquerel, G., Dargent, E., Petit, S., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

8. Molecular Mobility vs Polymorphism of Chiral Pharmaceutical Compounds: Case of Diprophylline

Author

Viel, Q., Brandel, Clément, Cartigny, Y., Coquerel, G., Dargent, E., Petit, S., Lemercier, Aurélien, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

9. Crystallization Behavior of Diprophylline from the Amorphous State

Author

Viel, Q., Brandel, Clément, Cartigny, Y., Dargent, E., Petit, S., Coquerel, G., Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), and Lemercier, Aurélien

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

10. Exploring different routes of Crystallization from Amorphous Diprophylline at Racemic and Pure Compositions

Author

Viel, Q., Brandel, Clément, Cartigny, Y., Coquerel, G., Dargent, E., Petit, S., Lemercier, Aurélien, Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire d’Etude et de Caractérisation des Amorphes et des Polymères (AMME-LECAP EA 4528 International Laboratory), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CRIS] Chemical Sciences/Cristallography, [CHIM.ORGA] Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

11. Vitrification of two active pharmaceutical ingredients by fast scanning calorimetry: From structural relaxation to nucleation phenomena.

Author

Monnier X, Viel Q, Schammé B, Petit S, Delbreilh L, Dupray V, Coquerel G, and Dargent E

Subjects
Calorimetry, Differential Scanning methods, Crystallization methods, Glass chemistry, Phase Transition, Temperature, Theophylline chemistry, Vitrification, Pharmaceutical Preparations chemistry
Abstract

Cinchonidine and Theophylline vitrification abilities have been investigated by differential and fast scanning calorimetry. These active pharmaceutical compounds are known in the literature to have a very high tendency to crystallize which has been confirmed by classical differential scanning calorimetry. Due to the growing interest in amorphous pharmaceutical compounds, their possible vitrifications have been investigated by fast scanning calorimetry. This work shows the high potential of this advanced thermal analysis technique to investigate the vitrification of active pharmaceutical compounds by melt-quenching protocol. For the first time, glass transitions of Cinchonidine and Theophylline were measured. From Cinchonidine, it has been shown that complete glassy state can be obtained by cooling from the melt at 2000K/s. Crystallization has also been suppressed by cooling down from the melt at 2K/s. However, such rate does not avoid the formation of nuclei. Theophylline crystallization process has been suppressed by a melt-quenching protocol carried out with a cooling rate of 4000K/s. However, the phenomenon of nuclei formation upon cooling seems unavoidable at this cooling rate. For both active pharmaceutical compounds, physical aging has been observed to play a role on the nuclei formation below the glass transition leading to modify the subsequent crystallization., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2018
Full Text
View/download PDF

12. Molecular Mobility of an Amorphous Chiral Pharmaceutical Compound: Impact of Chirality and Chemical Purity.

Author

Viel Q, Delbreilh L, Coquerel G, Petit S, and Dargent E

Subjects
Crystallization, Dielectric Spectroscopy, Phase Transition, Stereoisomerism, Temperature, Theophylline chemistry, Pharmaceutical Preparations chemistry
Abstract

A dielectric relaxation spectroscopy (DRS) study was performed to investigate the molecular mobility of amorphous chiral diprophylline (DPL). For this purpose, both racemic DPL and a single enantiomer of DPL were considered. After fast cooling from the melt at very low temperature (-140 °C), progressive heating below and above the glass transition (T g ≈ 37 °C) induces two secondary relaxations (γ- and δ-) and primary relaxations (α-) for both enantiomeric compositions. After chemical purification of our samples by means of cooling recrystallization, no γ-process could be detected by DRS. Hence, it was highlighted that the molecular mobility in the glassy state is influenced by the presence of theophylline (TPH), the main impurity in DPL samples. We also proved that the dynamic behavior of a single enantiomer and the racemic mixture of the same purified compound are quasi-identical. This study demonstrates that the relative stability and the molecular mobility of chiral amorphous drugs are strongly sensitive to chemical purity.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results