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22 results on '"Viel, Roselyne"'

9. CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice

Author

Poissonnier, Amanda, Sanséau, Doriane, Le Gallo, Matthieu, Malleter, Marine, Levoin, Nicolas, Viel, Roselyne, Morere, Lucie, Penna, Aubin, Blanco, Patrick, Dupuy, Alain, Poizeau, Florence, Fautrel, Alain, Seneschal, Julien, Jouan, Florence, Ritz, Jerome, Forcade, Edouard, Rioux, Nathalie, Contin-Bordes, Cécile, Ducret, Thomas, Vacher, Anne-Marie, Barrow, Paul A., Flynn, Robin J., Vacher, Pierre, and Legembre, Patrick

Published
2016
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10. Hepatocellular carcinomas, exhibiting intratumor fibrosis, express cancer-specific extracellular matrix remodeling and WNT/TGFB signatures, associated with poor outcome

Author

Desert, Romain, primary, Chen, Wei, additional, Ge, Xiaodong, additional, Viel, Roselyne, additional, Han, Hui, additional, Athavale, Dipti, additional, Das, Sukanta, additional, Song, Zhuolun, additional, Lantvit, Daniel, additional, Cano, Luis, additional, Naba, Alexandra, additional, Musso, Orlando, additional, and Nieto, Natalia, additional

Published
2023
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11. An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

Author

Massachusetts Institute of Technology. Department of Biology, Wilson, Molly M, Callens, Céline, Le Gallo, Matthieu, Mironov, Svetlana, Ding, Qiong, Salamagnon, Amandine, Chavarria, Tony E, Viel, Roselyne, Peasah, Abena D, Bhutkar, Arjun, Martin, Sophie, Godey, Florence, Tas, Patrick, Kang, Hong Soon, Juin, Philippe P, Jetten, Anton M, Visvader, Jane E, Weinberg, Robert A, Attanasio, Massimo, Prigent, Claude, Lees, Jacqueline A, Guen, Vincent J, Massachusetts Institute of Technology. Department of Biology, Wilson, Molly M, Callens, Céline, Le Gallo, Matthieu, Mironov, Svetlana, Ding, Qiong, Salamagnon, Amandine, Chavarria, Tony E, Viel, Roselyne, Peasah, Abena D, Bhutkar, Arjun, Martin, Sophie, Godey, Florence, Tas, Patrick, Kang, Hong Soon, Juin, Philippe P, Jetten, Anton M, Visvader, Jane E, Weinberg, Robert A, Attanasio, Massimo, Prigent, Claude, Lees, Jacqueline A, and Guen, Vincent J

Abstract

EMT induces cilium assembly and signaling to promote mammogenesis and tumorigenesis.

Published
2022

12. Pivotal role of PIM2 kinase in plasmablast generation and plasma cell survival, opening new treatment options in myeloma

Author

Haas, Marion, Caron, Gersende, Chatonnet, Fabrice, Manenti, Stephane, Alaterre, Elina, Devin, Julie, Delaloy, Céline, Bertolin, Giulia, Viel, Roselyne, Pignarre, Amandine, Llamas Gutierrez, Francisco, Marchalot, Anne, Decaux, Olivier, Tarte, Karin, Delpy, Laurent, Moreaux, Jerome, Fest, Thierry, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique humaine (IGH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Toulouse (UT), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), H2P2 - Histo Pathologie Hight Precision (H2P2), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), This work was funded by an internal grant from the Hematology Laboratory, CHU deRennes, and Région GO Ligue contre le Cancer. MH has received a doctoral fellowshipfrom FHU CAMIn, Ligue Contre le Cancer/Comité d’Ile et Vilaine. AP received a PhDfellowship from Région Bretagne and Ligue Nationale contre le Cancer.Immunofluorescence studies were performed at the Microscopy Rennes ImagingCenter (MRic-ALMF) and in the H2P2 facility, both of which are members of the UMS6480 Biosit (Rennes, France) and the French national France-BioImaginginfrastructure network funded by the French Research Agency (ANR-10-INBS-04). Cellsorting was performed at the Biosit Flow Cytometry and the CytomeTRI cell sortingfacilities (UMS6480 Biosit). We are indebted to the Centre de Ressources Biologiques(CRB)-Santé (BB-0033-00056, http://www.crbsante-rennes.com) at Rennes UniversityMedical Center for its help with processing biological samples, and we also thankseveral clinicians and patients for providing samples for research purposes. We thankthe MMRF for sharing the RNA sequencing and clinical data for patients enrolled in theCoMMpass study via the MMRF genomics portal., and ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010)

Subjects
[SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Immunotherapy, humanities, Immunobiology
Abstract

International audience; The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a novel morpholino RNA antisense approach), we found that early, sustained upregulation of the proviral integrations of Moloney virus 2 (PIM2) kinase is a pivotal event during human B cell in vitro differentiation and then continues in mature normal and malignant PCs in the bone marrow. In particular, PIM2 sustained the G1/S transition by acting on CDC25A and p27Kip1 and hindering caspase 3-driven apoptosis through BAD phosphorylation and cytoplasmic stabilization of p21Cip1. In PCs, interleukin-6 triggered PIM2 expression, resulting in anti-apoptotic effects on which malignant PCs were particularly dependent. In multiple myeloma, pan-PIM and MCL1 inhibitors displayed synergistic activity. Our results highlight a cell-autonomous function that links kinase activity to the PBs’ newly acquired secretion ability and the adaptability observed in both normal and malignant PCs, and finally should prompt the reconsideration of PIM2 as a therapeutic target in multiple myeloma.

Published
2022
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13. An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

Author

Wilson, Molly M., primary, Callens, Céline, additional, Le Gallo, Matthieu, additional, Mironov, Svetlana, additional, Ding, Qiong, additional, Salamagnon, Amandine, additional, Chavarria, Tony E., additional, Viel, Roselyne, additional, Peasah, Abena D., additional, Bhutkar, Arjun, additional, Martin, Sophie, additional, Godey, Florence, additional, Tas, Patrick, additional, Kang, Hong Soon, additional, Juin, Philippe P., additional, Jetten, Anton M., additional, Visvader, Jane E., additional, Weinberg, Robert A., additional, Attanasio, Massimo, additional, Prigent, Claude, additional, Lees, Jacqueline A., additional, and Guen, Vincent J., additional

Published
2021
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14. The mechanosensitive TRPV2 calcium channel controls human melanoma invasiveness and metastatic potential

Author

Shoji, Kenji F., primary, Bayet, Elsa, additional, Devedec, Dahiana Le, additional, Mallavialle, Aude, additional, Marionneau-Lambot, Séverine, additional, Leverrier-Penna, Sabrina, additional, Rambow, Florian, additional, Perret, Raul, additional, Joussaume, Aurélie, additional, Viel, Roselyne, additional, Fautrel, Alain, additional, Khammari, Amir, additional, Constantin, Bruno, additional, Tartare-Deckert, Sophie, additional, and Penna, Aubin, additional

Published
2021
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15. Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis

Author

Leverrier‐Penna, Sabrina, primary, Michel, Alain, additional, Lecante, Laetitia L., additional, Costet, Nathalie, additional, Suglia, Antonio, additional, Desdoits‐Lethimonier, Christèle, additional, Boulay, Hugoline, additional, Viel, Roselyne, additional, Chemouny, Jonathan M., additional, Becker, Emmanuelle, additional, Lavoué, Vincent, additional, Rolland, Antoine D., additional, Dejucq‐Rainsford, Nathalie, additional, Vigneau, Cécile, additional, and Mazaud‐Guittot, Séverine, additional

Published
2021
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16. TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages

Author

Bellamri, Nessrine, primary, Viel, Roselyne, additional, Morzadec, Claudie, additional, Lecureur, Valérie, additional, Joannes, Audrey, additional, de Latour, Bertrand, additional, Llamas-Gutierrez, Francisco, additional, Wollin, Lutz, additional, Jouneau, Stéphane, additional, and Vernhet, Laurent, additional

Published
2020
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19. CD95 recruits PLCγ1 to trigger a calcium response promoting Th17 accumulation in inflamed organs of lupus mice

Author

Poissonnier, Amanda, Sanseau, Doriane, Le Gallo, Matthieu, Malleter, Marine, Levoin, Nicolas, Viel, Roselyne, Morere, Lucie, Penna, Aubin, Blanco, Patrick, Dupuy, Alain, Poizeau, Florence, Fautrel, Alain, Seneschal, Julien, Jouan, Florence, Ritz, Jerome, Forcade, Edouard, Rioux, Nathalie, Contin, Cecile, Ducret, Thomas, Vacher, Anne-Marie, Barrow, Paul A., Flynn, Robin J., Vacher, Pierre, and Legembre, Patrick

Abstract

CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling. Hence, the pathophysiological role of cl-CD95L remains unclear. We observed that skin-derived endothelial cells from systemic lupus erythematosus (SLE) patients expressed CD95L, and that after cleavage, cl-CD95L promoted T helper 17 (Th17) lymphocyte transmigration across the endothelial barrier at the expense of T regulatory cells. T cell migration relied on a direct interaction between the CD95 domain called calcium-inducing domain (CID) and the Src homology 3 domain of phospholipase Cγ1. Th17 cells stimulated with cl-CD95L produced sphingosine-1-phosphate (S1P), which promoted endothelial transmigration by activating the S1P receptor 3. We generated a cell-penetrating CID peptide that prevented Th17 cell transmigration and alleviated clinical symptoms in lupus mice. Therefore, neutralizing the CD95 non-apoptotic signaling pathway may be attractive therapeutic approach for SLE treatment.

Published
2016

20. PDL-1 and PDL1 expressions in clear cell renal cell carcinoma (ccRCC) of metastatic patients with sunitinib first-line treatment.

Author

Brunot, Angélique, primary, Bernhard, Jean-Christophe, additional, Yacoub, Mokrane, additional, Edeline, Julien, additional, Verhoest, Gregory, additional, Bensalah, Karim, additional, Dupuis, Frantz, additional, Laguerre, Brigitte, additional, Kerbrat, Pierre, additional, Ravaud, Alain, additional, Bellaud, Pascale, additional, Viel, Roselyne, additional, Jouan, Florence, additional, Rioux-Leclercq, Nathalie, additional, and Kammerer-Jacquet, Solene-Florence, additional

Published
2015
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21. Wild type VHL clear cell renal cell carcinomas: A distinct morphological and clinical entity with PD-L1 expression.

Author

Crouzet, Laurence, primary, Brunot, Angelique, additional, Dagher, Julien, additional, Pladys, Adelaide, additional, Edeline, Julien, additional, Laguerre, Brigitte, additional, Kerbrat, Pierre, additional, Verhoest, Gregory, additional, Bensalah, Karim, additional, Bellaud, Pascale, additional, Viel, Roselyne, additional, Jouan, Florence, additional, Rioux-Leclercq, Nathalie, additional, and Kammerer-Jacquet, Solene-Florence, additional

Published
2015
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22. Eye lens organoids going simple: characterization of a new 3-dimensional organoid model for lens development and pathology.

Author

Duot M, Viel R, Viet J, Le Goff-Gaillard C, Paillard L, Lachke SA, Gautier-Courteille C, and Reboutier D

Abstract

The ocular lens, along with the cornea, focuses light on the retina to generate sharp images. Opacification of the lens, or cataract, is the leading cause of blindness worldwide. Presently, the best approach for cataract treatment is to surgically remove the diseased lens and replace it with an artificial implant. Although effective, this is costly and can have post-surgical complications. Toward identifying alternate treatments, it is imperative to develop organoid models relevant for lens studies and anti-cataract drug screening. Here, we demonstrate that by culturing mouse lens epithelial cells under defined 3-dimensional (3D) culture conditions, it is possible to generate organoids that display optical properties and recapitulate many aspects of lens organization at the tissue, cellular and transcriptomic levels. These 3D cultured lens organoids can be rapidly produced in large amounts. High-throughput RNA-sequencing (RNA-seq) on specific organoid regions isolated by laser capture microdissection (LCM) and immunofluorescence assays demonstrate that these lens organoids display spatiotemporal expression of key lens genes, e.g. , Jag1 , Pax6 , Prox1 , Hsf4 and Cryab . Further, these lens organoids are amenable to induction of opacities. Finally, knockdown of a cataract-linked RNA-binding protein encoding gene, Celf1 , induces opacities in these organoids, indicating their use in rapidly screening for genes functionally relevant to lens biology and cataract. In sum, this lens organoid model represents a compelling new tool to advance the understanding of lens biology and pathology, and can find future use in the rapid screening of compounds aimed at preventing and/or treating cataract.

Published
2023
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