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8. Synthesis of new N-alkyl-2-mercapto-1-octylamines and respective disulfides.

Author

Vieira Filho SA, Nelson DL, and Piló-Veloso D

Subjects
Amines pharmacology, Animals, Chemical Phenomena, Chemistry, Schistosoma mansoni drug effects, Amines chemical synthesis, Disulfides chemical synthesis
Abstract

Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infection by Schistosoma mansoni, only 2,2'-dithiobis(N-isobutyl-1-octylamine) exhibited activity.

Published
1986

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