Search

Your search keyword '"Vidriales, María Belén"' showing total 232 results
Start Over Author "Vidriales, María Belén"
232 results on '"Vidriales, María Belén"'

3. Enasidenib vs conventional care in older patients with late-stage mutant-IDH2 relapsed/refractory AML: a randomized phase 3 trial

Author

de Botton, Stéphane, Montesinos, Pau, Schuh, Andre C., Papayannidis, Cristina, Vyas, Paresh, Wei, Andrew H., Ommen, Hans, Semochkin, Sergey, Kim, Hee-Je, Larson, Richard A., Koprivnikar, Jaime, Frankfurt, Olga, Thol, Felicitas, Chromik, Jörg, Byrne, Jenny, Pigneux, Arnaud, Thomas, Xavier, Salamero, Olga, Vidriales, Maria Belen, Doronin, Vadim, Döhner, Hartmut, Fathi, Amir T., Laille, Eric, Yu, Xin, Hasan, Maroof, Martin-Regueira, Patricia, and DiNardo, Courtney D.

Published
2023
Full Text
View/download PDF

4. Blast Transformation of Chronic Myeloid Leukemia Driven by Acquisition of t(8;21)(q22;q22)/ RUNX1::RUNX1T1 : Selecting Optimal Treatment Based on Clinical and Molecular Findings.

Author

Fernández-Sánchez, Adolfo, Hernández-Sánchez, Alberto, De Ramón, Cristina, Chillón, María-Carmen, Vidriales, María Belén, Baile-González, Mónica, Fuentes-Morales, Cristina-Teresa, Sierra-Pacho, Magdalena, López-Corral, Lucía, and Sánchez-Guijo, Fermín

Subjects
CHRONIC myeloid leukemia, HEMATOPOIETIC stem cell transplantation, PROTEIN-tyrosine kinase inhibitors, DISEASE management, NATURAL history
Abstract

The advent of tyrosine kinase inhibitors (TKIs) has changed the natural history of chronic myeloid leukemia (CML), and the transformation from the chronic phase to the blast phase (BP) is currently an uncommon situation. However, it is one of the major remaining challenges in the management of this disease, as it is associated with dismal outcomes. We report the case of a 63-year-old woman with a history of CML with poor response to imatinib who progressed to myeloid BP-CML, driven by the acquisition of t(8;21)(q22;q22)/RUNX1::RUNX1T1. The patient received intensive chemotherapy and dasatinib, followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, she suffered an early relapse after allo-HSCT with the acquisition of the T315I mutation in ABL1. Ponatinib and azacitidine were started as salvage treatment, allowing for the achievement of complete remission with deep molecular response after five cycles. Advances in the knowledge of disease biology and clonal evolution are crucial for optimal treatment selection, which ultimately translates into better patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial

Author

Simoes, Catia, Paiva, Bruno, Martínez-Cuadrón, David, Bergua, Juan-Miguel, Vives, Susana, Algarra, Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez, Jose-Luis, Vidriales, Maria-Belen, Labrador, Jorge, Falantes, Jose-Francisco, Sayas, María-José, Ayala, Rosa, Martinez-Lopez, Joaquin, Villar, Sara, Calasanz, Maria-Jose, Prosper, Felipe, San-Miguel, Jesús F., Sanz, Miguel Ángel, and Montesinos, Pau

Published
2021
Full Text
View/download PDF

6. Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Author

Goicoechea, Ibai, Puig, Noemi, Cedena, Maria-Teresa, Burgos, Leire, Cordón, Lourdes, Vidriales, María-Belén, Flores-Montero, Juan, Gutierrez, Norma C., Calasanz, Maria-Jose, Ramos, Maria-Luisa Martin, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Alignani, Diego, Rodriguez, Idoia, Sarvide, Sarai, Alameda, Daniel, Garcés, Juan José, Rodriguez, Sara, Fresquet, Vicente, Celay, Jon, Garcia-Sanz, Ramón, Martinez-Lopez, Joaquin, Oriol, Albert, Rios, Rafael, Martin-Sanchez, Jesus, Martinez-Martinez, Rafael, Sarra, Josep, Hernandez, Miguel-Teodoro, de la Rubia, Javier, Krsnik, Isabel, Moraleda, Jose-Maria, Palomera, Luis, Bargay, Joan, Martinez-Climent, Jose-Angel, Orfao, Alberto, Rosiñol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-José, Blade, Joan, San Miguel, Jesús, and Paiva, Bruno

Published
2021
Full Text
View/download PDF

7. Single-Cell DNA Sequencing and Immunophenotypic Profiling to Track Clonal Evolution in an Acute Myeloid Leukemia Patient

Author

García-Álvarez, María, primary, Yeguas, Ana, additional, Jiménez, Cristina, additional, Medina-Herrera, Alejandro, additional, González-Calle, Verónica, additional, Hernández-Ruano, Montserrat, additional, Maldonado, Rebeca, additional, Aires, Irene, additional, Casquero, Cristina, additional, Sánchez-Villares, Inmaculada, additional, Balanzategui, Ana, additional, Sarasquete, María Eugenia, additional, Alcoceba, Miguel, additional, Vidriales, María Belén, additional, González-Díaz, Marcos, additional, García-Sanz, Ramón, additional, and Chillón, María Carmen, additional

Published
2023
Full Text
View/download PDF

8. Data-driven flow cytometry classification of blast differentiation in older patients with acute myeloid leukemia

Author

Rojas, F., Longoni, H., Milone, G., Fernández, I., Conciencia, Clínica, Ramirez, R., Canepa, C., Saba, S., Balladares, G., Ventiurini, C., Mariano, R., Negri, P., Prates, M.V., Milone, J., Fazio, P., Gelemur, M., Ciarlo, S., Bezares, F., López, L., García, J. J, Giunta, M., Kruss, M., Lafalse, D., Marquesoni, E., Casale, M.F., Gimenez, A., Brulc, E.B., Perusini, M.A., Palmer, L., Correa, M.E., Jaramillo, F.J., Rosales, J., Sossa, C., Herrera, J.C., Arango, M., Holojda, J., Golos, A., Ejduk, A., Ochrem, B., Małgorzata, G., Waszczuk-Gajda, A., Drozd-Sokolowska, J., Czemerska, M., Paluszewska, M., Zarzycka, E., Masternak, A., Hawrylecka, Dr., Podhoreka, M., Giannopoulos, K., Gromek, T., Oleksiuk, J., Armatys, bA., Helbig, G., Sobas, M., Szczepaniak, A., Rzenno, E., Rodzaj, M., Piatkowska-Jakubas, B., Skret, A., Pluta, A., Barańska, E., Vasconcelos, G., Brioso, J., Nunes, A., Bogalho, I., Espadana, A., Coucelo, M., Marini, S., Azevedo, J., Crisostomo, A.I., Ribeiro, L., Pereira, V., Botelho, A., Mariz, J.M., Guimaraes, J.E., Aguiar, E., Coutinho, J., Noriega, V., García, L., Varela, C., Debén, G., González, M.R., Encinas, M., Bendaña, A., González, S., Bello, J.L., Albors, M., Algarra, L., Romero, J.R., Bermon, J.S., Varo, M.J., López, V., López, E., Mora, C., Amorós, C., Romero, A., Jaramillo, A., Valdez, N., Molina, I., Fernández, A., Sánchez, B., García, A., Castaño, V., López, T., Bernabeu, J., Sánchez, M.J., Fernández, C., Gil, C., Botella, C., Fernández, P., Pacheco, M., Tarín, F., Verdú, J.J., García, M.J., Mellado, A., García, M.C., González, J., Castillo, T., Colado, E., Alonso, S., Recio, I., Cabezudo, M., Davila, J., Rodríguez, M.J., Barez, A., Díaz, B., Prieto, J., Arnan, M., Marín, C., Mansilla, M., Balaberdi, A., Amutio, M.E., del Orbe, R.A., Ancin, I., Ruíz, J.C., Olivalres, M., Gómez, C., gonzález, I., Celis, M., Atutxa, K., Carrascosa, T., Artola, T., Lizuain, M., Rodriguez, J .I., Arce, O., Márquez, J.A., Atuch, J., Marco de Lucas, F., Díez, Z., Dávila, B., Cantalejo, R., Díaz, M., Labrador, J., Serra, F., Hermida, G., Díaz, F.J., de Vicente, P., Álvarez, R., Alonso, C., Bergua, J.M., Ugalde, N., Pardal, E., Saldaña, R., Rodríguez, F., Martín, E., Hermosín, L., Garrastazul, M.P., Marchante, I., Raposo, J.A., Capote, F.J., Colorado, M., Batlle, A., Yañez, L., García, S., González, P., Ocio, E.M., Briz, M., Bermúdez, A., Jiménez, C., Beltrán, S., Montagud, M., Castillo, I., García, R., Gascón, A., Clavel, J., Lancharro, A., Lnares, L., Herráez, M.M., Milena, A., Romero, M.J., Hernández, B., Calle, C., Benegas, R., Bolívar, Dr., Serrano, J., Dorado, F.J., Sánchez, J., Martínez, M.C., Cerveró, C.J., Busto, M.J., Bernal, M., Moratalla, L., Mesa, Z., Jurado, M., De Miguel, D., Santos, A.B., Arbeteta, J., Pérez, E., Caminos, N., Uresandi, N., Argoitiaituart, N., Swen, J., Uranga, A., Olazaba, I., Gainza, E., Romero, P., Gil, E., Palma, A.J., Gómez, K.G., Solé, M., Rodríguez, J.N., Murillo, I.M., Marco, J., Serena, J., Marco, V., Perella, M., Costilla, L., López, J.A., Baena, A., Almagro, P., Hermosilla, M., Esteban, A., Campeny, B.A., Nájera, M.J., Herrra, P., Fernández, R., González, J.D., Torres, L., Jiménez, S., Gómez, M.T., Bilbao, C., Rodríguez, C., Hong, A., Ramos de Laón, Y., Afonso, V., Ramos, F., Fuertes, M., de Cabo, E., Aguilera, C., Megido, M., García, T., Lavilla, E., Varela, M., Ferrero, S., Arias, J., Vizcaya, L., Roldán, A., Vilches, A., Penalva, M.J., Vázquez, J., Calderón, M.T., Matilla, A., Serí, C., Otero, M.J., García, N., Sandoval, E., Franco, C., Flores, R., Bravo, P., López, A., López, J.L., Blas, C., Díez, A., Alonso, J.M., Soto, C., Arenas, A., García, J., Martín, Y., Villafuerte, P.S., Magro, E., Bautista, G., De Laiglesia, A., Rodríguez, G., Solán, L., Chicano, M., Balsalobre, P., Monsalvo, S., Font, P., Carbonell, D., Martínez, C., Humala, K., Kerguelen, A.E., Hernández, D., Gasior, M., Gómez, P., Sánchez, I., Redondo, S., Llorente, L., Bengochea, M., Pérez, J., Sebrango, A., M. santero, Morales, A., Figuera, A., Villafuerte, P., Alegre, A., Fernández, E., Alonso, A., Martínez, M.P., Martínez, J., Cedena, M.T., Moreno, L., De la Fuente, A., García, D., Chamorro, C., Pradillo, V., Martí, E., Sánchez, J.M., Delgado, I., Rosado, B., Velasco, A., Miranda, C., Salvatierra, G., Foncillas, M., Hernández, J.A., Escolano, C., Benabente, C., Martínez, R., Polo, M., Anguita, E., Riaza, R., Amores, G., Requena, M.J., Javier, F., Villaloón, L., Aláez, C., Nistal, S., Navas, B., Andreu, M.A., Herrera, P., López, J., García, M., Moreno, M.J., Queipo, M.P., Hernández, A., Barrios, M., Heiniger, A., Jiménez, A., Contento, A., López, F., Alcalá, M., Lorente, S., González, M., Morales, E.M., Gutierrez, J., Serna, M.J., Beltrán, V., Romera, M., Berenguer, M., MArtínez, A., Tejedor, A., Amigo, M.L., Ortuño, F., Jerez, A., López, O., Moraleda, J.M., Rosique, P., Gómez, J., Garay, M.C., Cerezuela, P., MArtínez, A.B., González, A., Ibáñez, J., Alfaro, M.J., Mateos, M., Goñi, M.A., Araiz, M.A., Gorosquieta, A., Zudaire, M., Viguria, M., Zabala, A., Alvarellos, M., Quispe, I., Sánchez, M.P., Hurtado, G., Pérez, M., Burguete, Y., Areizaga, N., Galicia, T., Rifón, J., Alfonso, A., Prósper, F., Marcos, M., Tamariz, L.E., Riego, V., Manubens, A., Larrayoz, M.J., Calasanz, M.J., Mañú, A., Paiva, B., Vázquez, I., Burgos, L., Pereiro, M., Rodríguez, M., Pastoriza, M.C., Mendez, J.A., Sastre, J.L., Iglesias, M., Ulibarrena, C., Campoy, F., Jaimes, D., Albarrán, B., Solano, J., Silvestre, A., Albo, C., Suarez, S., Loureiro, C., Figueroa, I., Fernández, M.A., Martínez, A., Poderós, C., Vazquez, J., Iglesias, L., Nieto, A., Torrado, T., Martínez, A.M., Amador, M.L., Oubiña, P., Feijó, E., Dios, A., Loyola, I., Roreno, R., Simiele, A., Álvarez, L., Turcu, V., Vidriales, B., Avendaño, A., Chillón, C., González, V., Govantes, J.V., Rubio, S., Tapia, M., Olivier, C., Queizán, J.A., Pérez, O., Vera, J.A., Muñoz, C., rodriguez, A., González, N., Pérez, J.A., Soria, E., I.Espigado, Falantes, J., Montero, I., García, P., Rodríguez, E., Carrillo, E., Caballero, T., García, C., Couto, C., Simón, I., Gómez, M., Aguilar, C., González, B.J., Lakhwani, S., Bienert, A., González, B., Cabello, A., Oliva, A.Y., González, H., Sancho, L., Paricio, M., Perdiguer, L., Solano, F., Lerma, A., Martínez, M.D., Gómez, M.I., Yeguas, A., Montesinos, P., Barragán, E., Sargas, C., Amigo, R., Martinez, D., Boluda, B., Rodríguez, R., Acuña, E., Cano, I., Escrivá, A., Pedreño, M., Navalón, A., Orts, M., Sayas, M.J., Fernández, M.J., Juan, M.L., Gómez, E., Gimeno, M., Donato, E., Cejalvo, M., Tormo, M., Calabuig, M., Navarro, B., Martin, I., Villamont, E., Miralles, A., Lluch, R., Moragues, M., Ruiz, M.A., Benet, C., Valero, M., Linares, M., Collado, R., Orero, M., Ibañez, P., Lis, M.J., Pérez, P.L., Roig, M., López, M., Mena, A.V., Picón, I., Cánovas, V., Palacios, A., Cuello, R., Borrego, J., burgois, M., Cantalapiedra, A., Norberto, O., Angomas, E., Cidoncha, B., Cuevas, L., Robles, D., Mendiazabal, A., Oiartzabal, I., Guinea de Castro, J.M., Montes, C., Carrasco, V., Pérez, A., Moneva, J.J., Olave, M., Bonafonte, E., Mayor, L., Azaceta, G., Palomera, L., Malo, M., Escobar, M.J., Grasa, J.M., De Rueda, B., Aulés, A., Salvador, C., Ansó, V., Iborra, A., Delagado, P., Rubio, A., Stevenazzi, M., Alpire, I., Irigoin, V., Díaz, L., Guillermo, C., Guadagna, R., Grille, S., Oliver, C., Boada, M., Vales, V., Prado, A.I., De los Santos, A.P., Simoes, Catia, Gonzalez, Carmen, Vergez, François, Sarry, Audrey, Bertoli, Sarah, Ariceta, Beñat, Martínez-Cuadrón, David, Bergua, Juan-Miguel, Vives, Susana, Algarra, Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez-Lorenzo, Jose-Luis, Vidriales, Maria-Belen, Chillon, Carmen, Labrador, Jorge, Falantes, Jose-Francisco, Sayas, María-José, Ayala, Rosa, Martinez-Lopez, Joaquin, Villar, Sara, Calasanz, Maria-Jose, Prosper, Felipe, San-Miguel, Jesús F., Sanz, Miguel Á., Récher, Christian, Paiva, Bruno, and Montesinos, Pau

Published
2024
Full Text
View/download PDF

9. A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients

Author

Martínez-Cuadrón, David, Gil, Cristina, Serrano, Josefina, Rodríguez, Gabriela, Pérez-Oteyza, Jaime, García-Boyero, Raimundo, Jiménez-Bravo, Santiago, Vives, Susana, Vidriales, María Belén, Lavilla, Esperanza, Pérez-Simón, José A., Tormo, Mar, Colorado, Mercedes, Bergua, Juan, López, Juan A., Herrera, Pilar, Hernández-Campo, Pilar, Gorrochategui, Julián, Primo, Daniel, Rojas, Jose Luis, Villoria, Jesús, Moscardó, Federico, Troconiz, Iñaki, Linares Gómez, María, Martínez-López, Joaquín, Ballesteros, Joan, Sanz, Miguel, and Montesinos, Pau

Published
2019
Full Text
View/download PDF

10. Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy

Author

Matarraz, Sergio, Leoz, Pilar, Fernández, Carlos, Colado, Enrique, Chillón, María Carmen, Vidriales, María Belén, González, Marcos, Rivera, Daniel, Osuna, Carlos Salvador, Caballero-Velázquez, Teresa, Van Der Velden, Vincent, Jongen-Lavrencic, Mojca, Gutiérrez, Oliver, Bermejo, Ana Yeguas, Alonso, Luis García, García, Monique Bourgeois, De Ramón Sánchez, Cristina, García-Donas, Gloria, Mateo, Aránzazu García, Recio, Isabel, Sánchez-Real, Javier, Mayado, Andrea, Gutiérrez, María Laura, Bárcena, Paloma, Barrena, Susana, López, Antonio, Van Dongen, Jacques, and Orfao, Alberto

Published
2018
Full Text
View/download PDF

11. S130: PRELIMINARY RESULTS OF QUIWI: A DOUBLE BLINDED, RANDOMIZED CLINICAL TRIAL COMPARING STANDARD CHEMOTHERAPY PLUS QUIZARTINIB VERSUS PLACEBO IN ADULT PATIENTS WITH NEWLY DIAGNOSED FLT3-ITD WILD-TYPE AML

Author

Montesinos, Pau, primary, Rodríguez-Veiga, Rebeca, additional, Bergua Burgues, Juan Miguel, additional, Algarra, Lorenzo, additional, Botella, Carmen, additional, Josè Antonio, Perez Simon, additional, Bernal, Teresa, additional, Tormo, Mar, additional, Robles, Maria Calbacho, additional, Salamero, Olga, additional, Serrano, Josefina, additional, Noriega, Victor, additional, López-López, Juan Antonio, additional, Polo, Susana Vives, additional, Colorado, Mercedes, additional, Lorenzo, Jose Luis Lopez, additional, Vidriales, María Belén, additional, Boyero, Raimundo Garcia, additional, Olave, Mayte, additional, Herrera-Puente, Pilar, additional, Arce, Olga, additional, Garcia, Manuel Barrios, additional, Jose Sayas Lloris, Maria, additional, Polo, Marta, additional, Isabel Gomez Roncero, Maria, additional, Barragan, Eva, additional, Ayala Diaz, Rosa, additional, Carmen Chillon, Maria, additional, Jose Calasanz, Maria, additional, Boluda, Blanca, additional, Martinez-Cuadrón, David, additional, and Labrador, Jorge, additional

Published
2023
Full Text
View/download PDF

12. Single-Cell DNA Sequencing and Immunophenotypic Profiling to Track Clonal Evolution in an Acute Myeloid Leukemia Patient.

Author

García-Álvarez, María, Yeguas, Ana, Jiménez, Cristina, Medina-Herrera, Alejandro, González-Calle, Verónica, Hernández-Ruano, Montserrat, Maldonado, Rebeca, Aires, Irene, Casquero, Cristina, Sánchez-Villares, Inmaculada, Balanzategui, Ana, Sarasquete, María Eugenia, Alcoceba, Miguel, Vidriales, María Belén, González-Díaz, Marcos, García-Sanz, Ramón, and Chillón, María Carmen

Subjects
ACUTE myeloid leukemia, DNA sequencing, STEM cell transplantation, BLAST injuries, SALVAGE therapy, NUCLEOTIDE sequencing
Abstract

Single-cell DNA sequencing can address the sequence of somatic genetic events during myeloid transformation in relapsed acute myeloid leukemia (AML). We present an NPM1-mutated AML patient with an initial low ratio of FLT3-ITD (low-risk ELN-2017), treated with midostaurin combined with standard chemotherapy as front-line treatment, and with salvage therapy plus gilteritinib following allogenic stem cell transplantation after relapse. Simultaneous single-cell DNA sequencing and cell-surface immunophenotyping was used in diagnostic and relapse samples to understand the clinical scenario of this patient and to reconstruct the clonal composition of both tumors. Four independent clones were present before treatment: DNMT3A/DNMT3A/NPM1 (63.9%), DNMT3A/DNMT3A (13.9%), DNMT3A/DNMT3A/NPM1/FLT3 (13.8%), as well as a wild-type clone (8.3%), but only the minor clone with FLT3-ITD survived and expanded after therapy, being the most represented one (58.6%) at relapse. FLT3-ITD was subclonal and was found only in the myeloid blast population (CD38/CD117/CD123). Our study shows the usefulness of this approach to reveal the clonal architecture of the leukemia and the identification of small subclones at diagnosis and relapse that may explain how the neoplastic cells can escape from the activity of different treatments in a stepwise process that impedes the disease cure despite different stages of complete remission. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Prognostic Value of Measurable Residual Disease in Patients with AML Undergoing HSCT: A Multicenter Study

Author

Caballero-Velázquez, Teresa, primary, Pérez-López, Olga, additional, Yeguas Bermejo, Ana, additional, Rodríguez Arbolí, Eduardo, additional, Colado Varela, Enrique, additional, Sempere Talens, Amparo, additional, Vidriales, María Belén, additional, Solé-Rodríguez, María, additional, Quirós Caso, Covadonga, additional, Pérez López, Estefanía, additional, Reinoso Segura, Marta, additional, Prats-Martín, Concepción, additional, Montesinos, Pau, additional, and Pérez-Simón, Jose A., additional

Published
2023
Full Text
View/download PDF

14. Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients

Author

Paiva, Bruno, Cedena, Maria-Teresa, Puig, Noemi, Arana, Paula, Vidriales, Maria-Belen, Cordon, Lourdes, Flores-Montero, Juan, Gutierrez, Norma C., Martín-Ramos, María-Luisa, Martinez-Lopez, Joaquin, Ocio, Enrique M., Hernandez, Miguel T., Teruel, Ana-Isabel, Rosiñol, Laura, Echeveste, María-Asunción, Martinez, Rafael, Gironella, Mercedes, Oriol, Albert, Cabrera, Carmen, Martin, Jesus, Bargay, Joan, Encinas, Cristina, Gonzalez, Yolanda, Van Dongen, Jacques J.M., Orfao, Alberto, Bladé, Joan, Mateos, Maria-Victoria, Lahuerta, Juan José, and San Miguel, Jesús F.

Published
2016
Full Text
View/download PDF

15. Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Author

Paiva, Bruno, Corchete, Luis A., Vidriales, Maria-Belen, Puig, Noemi, Maiso, Patricia, Rodriguez, Idoia, Alignani, Diego, Burgos, Leire, Sanchez, Maria-Luz, Barcena, Paloma, Echeveste, Maria-Asuncion, Hernandez, Miguel T., García-Sanz, Ramón, Ocio, Enrique M., Oriol, Albert, Gironella, Mercedes, Palomera, Luis, De Arriba, Felipe, Gonzalez, Yolanda, Johnson, Sarah K., Epstein, Joshua, Barlogie, Bart, Lahuerta, Juan José, Blade, Joan, Orfao, Alberto, Mateos, María-Victoria, and San Miguel, Jesús F.

Published
2016
Full Text
View/download PDF

16. Immune status of high-risk smoldering multiple myeloma patients and its therapeutic modulation under LenDex: a longitudinal analysis

Author

Paiva, Bruno, Mateos, María Victoria, Sanchez-Abarca, Luis Ignacio, Puig, Noemi, Vidriales, María-Belén, López-Corral, Lucía, Corchete, Luis A., Hernandez, Miguel T., Bargay, Joan, de Arriba, Felipe, de la Rubia, Javier, Teruel, Ana-Isabel, Giraldo, Pilar, Rosiñol, Laura, Prosper, Felipe, Oriol, Albert, Hernández, José, Esteves, Graça, Lahuerta, Juan José, Bladé, Joan, Perez-Simon, Jose Antonio, and San Miguel, Jesús F.

Published
2016
Full Text
View/download PDF

17. Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia

Author

Vidriales, María-Belén, Pérez-López, Estefanía, Pegenaute, Carlota, Castellanos, Marta, Pérez, José-Juan, Chandía, Mauricio, Díaz-Mediavilla, Joaquín, Rayón, Consuelo, de las Heras, Natalia, Fernández-Abellán, Pascual, Cabezudo, Miguel, de Coca, Alfonso García, Alonso, Jose Mª, Olivier, Carmen, Hernández-Rivas, Jesús Mª, Montesinos, Pau, Fernández, Rosa, García- Suárez, Julio, García, Magdalena, Sayas, María-José, Paiva, Bruno, González, Marcos, Orfao, Alberto, and San Miguel, Jesús F.

Published
2016
Full Text
View/download PDF

18. The cellular origin and malignant transformation of Waldenström macroglobulinemia

Author

Paiva, Bruno, Corchete, Luis A., Vidriales, Maria-Belen, García-Sanz, Ramón, Perez, Jose J., Aires-Mejia, Irene, Sanchez, Maria-Luz, Barcena, Paloma, Alignani, Diego, Jimenez, Cristina, Sarasquete, Maria-Eugenia, Mateos, María-Victoria, Ocio, Enrique M., Puig, Noemi, Escalante, Fernando, Hernández, José, Cuello, Rebeca, García de Coca, Alfonso, Sierra, Magdalena, Montes, Maria-Carmen, González-López, Tomás J., Galende, Josefina, Bárez, Abelardo, Alonso, José, Pardal, Emilia, Orfao, Alberto, Gutierrez, Norma C., and San Miguel, Jesús F.

Published
2015
Full Text
View/download PDF

19. Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile

Author

Paiva, Bruno, Paino, Teresa, Sayagues, Jose-Maria, Garayoa, Mercedes, San-Segundo, Laura, Martín, Montserrat, Mota, Ines, Sanchez, María-Luz, Bárcena, Paloma, Aires-Mejia, Irene, Corchete, Luis, Jimenez, Cristina, Garcia-Sanz, Ramon, Gutierrez, Norma C., Ocio, Enrique M., Mateos, Maria-Victoria, Vidriales, Maria-Belen, Orfao, Alberto, and San Miguel, Jesús F.

Published
2013
Full Text
View/download PDF

20. Multiparameter Flow Cytometry Evaluation of Plasma Cell DNA Content and Proliferation in 595 Transplant-Eligible Patients with Myeloma Included in the Spanish GEM2000 and GEM2005

Author

Paiva, Bruno, Vídriales, María-Belén, Montalbán, María-Ángeles, Pérez, José J., Gutiérrez, Norma C., Rosiñol, Laura, Martínez-López, Joaquín, Mateos, María-Victoria, Cordón, Lourdes, Oriol, Albert, Terol, María-José, Echeveste, María-Asunción, De Paz, Raquel, De Arriba, Felipe, Palomera, Luis, de la Rubia, Javier, Díaz-Mediavilla, Joaquín, Sureda, Anna, Gorosquieta, Ana, Alegre, Adrian, Martin, Alejandro, Lahuerta, Juan-José, Bladé, Joan, Orfao, Alberto, and San Miguel, Jesús F.

Published
2012
Full Text
View/download PDF

21. Use of Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia: The PETHEMA Registry Experience

Author

Labrador, Jorge, primary, Saiz-Rodríguez, Miriam, additional, de Miguel, Dunia, additional, de Laiglesia, Almudena, additional, Rodríguez-Medina, Carlos, additional, Vidriales, María Belén, additional, Pérez-Encinas, Manuel, additional, Sánchez-Sánchez, María José, additional, Cuello, Rebeca, additional, Roldán-Pérez, Alicia, additional, Vives, Susana, additional, Benzo-Callejo, Gonzalo, additional, Colorado, Mercedes, additional, García-Fortes, María, additional, Sayas, María José, additional, Olivier, Carmen, additional, Recio, Isabel, additional, Conde-Royo, Diego, additional, Bienert-García, Álvaro, additional, Vahi, María, additional, Muñoz-García, Carmen, additional, Seri-Merino, Cristina, additional, Tormo, Mar, additional, Vall-llovera, Ferran, additional, Foncillas, María-Ángeles, additional, Martínez-Cuadrón, David, additional, Sanz, Miguel Ángel, additional, and Montesinos, Pau, additional

Published
2022
Full Text
View/download PDF

22. Plasma Cell Disorders

Author

Flores-Montero, Juan, primary, Sanoja, Luzalba, additional, Pérez, José Juan, additional, Pojero, Fanny, additional, Puig, Noemí, additional, Vidriales, María Belén, additional, and Orfao, Alberto, additional

Published
2016
Full Text
View/download PDF

23. Eltrombopag increases the hematopoietic supporting ability of mesenchymal stem/stromal cells

Author

Muntión, Sandra, primary, Preciado, Silvia, additional, Sánchez-Luis, Elena, additional, Corchete, Luis, additional, Díez-Campelo, María, additional, Osugui, Lika, additional, Martí-Chillón, Gerardo-Javier, additional, Vidriales, María-Belén, additional, Navarro-Bailón, Almudena, additional, De Las Rivas, Javier, additional, and Sánchez-Guijo, Fermín, additional

Published
2022
Full Text
View/download PDF

24. Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial

Author

Mateos, María-Victoria, Oriol, Albert, Martínez-López, Joaquín, Gutiérrez, Norma, Teruel, Ana-Isabel, de Paz, Raquel, García-Laraña, José, Bengoechea, Enrique, Martín, Alejandro, Mediavilla, Joaquín Díaz, Palomera, Luis, de Arriba, Felipe, González, Yolanda, Hernández, Jose-Mariano, Sureda, Ana, Bello, José-Luis, Bargay, Joan, Peñalver, Francisco-Javier, Ribera, José-María, Martín-Mateos, María-Luisa, García-Sanz, Ramón, Cibeira, María-Teresa, Ramos, María-Luisa Martín, Vidriales, María-Belén, Paiva, Bruno, Montalbán, María-Angeles, Lahuerta, Juan-José, Bladé, Joan, and Miguel, Jesús-Fernando San

Published
2010
Full Text
View/download PDF

25. Siglec-6 is a novel target for CAR T-cell therapy in acute myeloid leukemia

Author

Jetani, Hardikkumar, primary, Navarro-Bailón, Almudena, additional, Maucher, Marius, additional, Frenz, Silke, additional, Verbruggen, Christina, additional, Yeguas, Ana, additional, Vidriales, María Belén, additional, González, Marcos, additional, Rial Saborido, Judit, additional, Kraus, Sabrina, additional, Mestermann, Katrin, additional, Thomas, Simone, additional, Bonig, Halvard, additional, Luu, Maik, additional, Monjezi, Razieh, additional, Mougiakakos, Dimitrios, additional, Sauer, Markus, additional, Einsele, Hermann, additional, and Hudecek, Michael, additional

Published
2021
Full Text
View/download PDF

26. Integrated Multidimensional Flow Cytometry (MFC) and Next-Generation Sequencing (NGS) to Reconstruct Evolutionary Paterns from Dysplasia to Acute Myeloid Leukemia (AML)

Author

Simoes, Catia Patricia, primary, Chillon, Carmen, additional, Martínez-Cuadrón, David, additional, Calasanz, María José, additional, Vidriales, María-Belén, additional, Vazquez, Iria, additional, Hernández-Ruano, Montserrat, additional, Ariceta, Beñat, additional, Burgos, Leire, additional, Alignani, Diego, additional, Sarai, Sarvide, additional, Villar, Sara, additional, Prósper, Felipe, additional, Ayala, Rosa, additional, Martínez-Lopez, Joaquín, additional, Bergua Burgues, Juan Miguel, additional, Vives, Susana, additional, Perez-Simon, Jose A., additional, García-Fortes, María, additional, González, Marcos, additional, San-Miguel, Jesus, additional, Sanz, Miguel A., additional, Montesinos, Pau, additional, and Paiva, Bruno, additional

Published
2021
Full Text
View/download PDF

27. Bortezomib, thalidomide and dexamethasone, with or without cyclophosphamide, for patients with previously untreated multiple myeloma: 5-year follow-up

Author

Ludwig, Heinz, Greil, Richard, Masszi, Tamas, Spicka, Ivan, Shpilberg, Ofer, Hajek, Roman, Dmoszynska, Anna, Paiva, Bruno, Vidriales, María-Belén, Esteves, Graca, Stoppa, Anne Marie, Robinson, Don, Jr, Chaturvedi, Shalini, Ataman, Ozlem, Enny, Christopher, Feng, Huaibao, van de Velde, Helgi, and Viterbo, Luisa

Published
2015
Full Text
View/download PDF

28. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older

Author

Harousseau, Jean-Luc, Martinelli, Giovanni, Jedrzejczak, Wieslaw W., Brandwein, Joseph M., Bordessoule, Dominique, Masszi, Tamas, Ossenkoppele, Gert J., Alexeeva, Julia A., Beutel, Gernot, Maertens, Johan, Vidriales, Maria-Belen, Dombret, Hervé, Thomas, Xavier, Burnett, Alan K., Robak, Tadeusz, Khuageva, Nuriet K., Golenkov, Anatoly K., Tothova, Elena, Mollgard, Lars, Park, Youn C., Bessems, Annick, De Porre, Peter, and Howes, Angela J.

Published
2009
Full Text
View/download PDF

29. The Mutational Landscape of Acute Myeloid Leukaemia Predicts Responses and Outcomes in Elderly Patients from the PETHEMA-FLUGAZA Phase 3 Clinical Trial

Author

Ayala, Rosa, Rapado, Inmaculada, Onecha, Esther, Martínez-Cuadrón, David, Carreño-Tarragona, Gonzalo, Bergua Burgues, Juan Miguel, Vives Polo, Susana, Algarra, Jesus Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, López Lorenzo, Jose Luis, Vidriales, María Belén, Labrador, Jorge, Falantes, José Francisco, Sayas, María José, Paiva, Bruno, Barragán, Eva, Prosper, Felipe, Sanz, Miguel A.., Martínez-López, Joaquín, Montesinos, Pau, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red Cáncer (España), Instituto de Salud Carlos III, Fundación CRIS contra el Cáncer, Instituto de Investigación Hospital 12 de Octubre, European Commission, Cancer Research UK, Fundación Científica Asociación Española Contra el Cáncer, Associazione Italiana per la Ricerca sul Cancro, Institut Català de la Salut, [Ayala R] Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain. Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain. Departament of Medicine, Complutense University, 28040 Madrid, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain. [Rapado I] Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain. Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto Carlos III, 28029 Madrid, Spain. [Onecha E, Carreño-Tarragona G] Hematology Department, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Imas12, 28041 Madrid, Spain. Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, Spain. [Martínez-Cuadrón D] Hematology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain. [Bergua JM] Hematology Department, Hospital San Pedro Acantara, 10003 Cáceres, Spain. [Salamero O] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Neuroblastoma RAS viral oncogene homolog, Oncology, Cancer Research, genetic risk, Myeloid neoplasia, leukemic cells, 0302 clinical medicine, cytarabine, clinical trials and observations, Other subheadings::/diagnosis [Other subheadings], Medicine, Complete remission, azacytidine, older adults, RC254-282, variants, Leukemia, Azacytidine, Hazard ratio, leukemia, Variants, Cytarabine, acute, Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute [DISEASES], Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Myeloid leukemia, Fludarabine, 030220 oncology & carcinogenesis, NGS, Older adults, Leucèmia mieloide aguda - Tractament, myeloid neoplasia, Myelocytic, medicine.drug, medicine.medical_specialty, myelocytic, complete remission, Otros calificadores::/diagnóstico [Otros calificadores], Subgroup analysis, Leukemic cells, Acute, Prognostic factors, Article, neoplasias::neoplasias por tipo histológico::leucemia::leucemia mieloide::leucemia mieloide aguda [ENFERMEDADES], 03 medical and health sciences, Internal medicine, Genetic risk, business.industry, prognostic factors, diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Odds ratio, Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], medicine.disease, Avaluació de resultats (Assistència sanitària), business, Clinical trials and observations, 030215 immunology
Abstract

This article belongs to the Collection The Biomarkers for the Diagnosis and Prognosis in Cancer., [Simple Summary] Mutational profiling using a custom 43-gene next-generation sequencing panel revealed that patients with mutated DNMT3A or EZH2, or an increase in TET2 VAF and lower TP53 VAF showed a higher overall response. NRAS and TP53 variants were associated with shorter overall survival (OS), whereas only mutated BCOR was associated with a shorter relapse-free survival (RFS). Subgroup analyses of OS according to biological and genomic characteristics showed that patients with low–intermediate cytogenetic risk and mutated NRAS benefited from azacytidine therapy and patients with mutated TP53 showed a better RFS in the azacytidine arm. In conclusion, differential mutational profiling might anticipate the outcomes of first-line treatment choices (AZA or FLUGA) in older patients with AML., [Abstract] We sought to predict treatment responses and outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) from our FLUGAZA phase III clinical trial (PETHEMA group) based on mutational status, comparing azacytidine (AZA) with fludarabine plus low-dose cytarabine (FLUGA). Mutational profiling using a custom 43-gene next-generation sequencing panel revealed differences in profiles between older and younger patients, and several prognostic markers that were useful in young patients were ineffective in older patients. We examined the associations between variables and overall responses at the end of the third cycle. Patients with mutated DNMT3A or EZH2 were shown to benefit from azacytidine in the treatment-adjusted subgroup analysis. An analysis of the associations with tumor burden using variant allele frequency (VAF) quantification showed that a higher overall response was associated with an increase in TET2 VAF (odds ratio (OR), 1.014; p = 0.030) and lower TP53 VAF (OR, 0.981; p = 0.003). In the treatment-adjusted multivariate survival analyses, only the NRAS (hazard ratio (HR), 1.9, p = 0.005) and TP53 (HR, 2.6, p = 9.8 × 10−7) variants were associated with shorter overall survival (OS), whereas only mutated BCOR (HR, 3.6, p = 0.0003) was associated with a shorter relapse-free survival (RFS). Subgroup analyses of OS according to biological and genomic characteristics showed that patients with low–intermediate cytogenetic risk (HR, 1.51, p = 0.045) and mutated NRAS (HR, 3.66, p = 0.047) benefited from azacytidine therapy. In the subgroup analyses, patients with mutated TP53 (HR, 4.71, p = 0.009) showed a better RFS in the azacytidine arm. In conclusion, differential mutational profiling might anticipate the outcomes of first-line treatment choices (AZA or FLUGA) in older patients with AML. The study is registered at ClinicalTrials.gov as NCT02319135., This study was supported by the Centro de Investigación Biomédica en Red—Área de Oncología–del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369) and the Subdirección General de Investigación Sanitaria (Instituto de Salud Carlos III, Spain) grants PI16/01530, PI16/01661, PI19/01518, and PI19/00730, the CRIS against Cancer foundation, grant 2018/001, and by the Instituto de Investigación Hospital 12 de Octubre (IMAS12) (co-financed by FEDER funds). The study was supported internationally by Cancer Research UK, FCAECC and AIRC under the Accelerator Award Program.

Published
2021

30. Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation

Author

Paiva, Bruno, Vidriales, Maria-Belén, Cerveró, Jorge, Mateo, Gema, Pérez, Jose J., Montalbán, Maria A., Sureda, Anna, Montejano, Laura, Gutiérrez, Norma C., de Coca, Alfonso García, de las Heras, Natalia, Mateos, Maria V., López-Berges, Maria C., García-Boyero, Raimundo, Galende, Josefina, Hernández, Jose, Palomera, Luis, Carrera, Dolores, Martínez, Rafael, de la Rubia, Javier, Martín, Alejandro, Bladé, Joan, Lahuerta, Juan J., Orfao, Alberto, and San Miguel, Jesús F.

Published
2008
Full Text
View/download PDF

31. New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells

Author

Pérez-Persona, Ernesto, Vidriales, María-Belén, Mateo, Gema, García-Sanz, Ramón, Mateos, Maria-Victoria, de Coca, Alfonso García, Galende, Josefina, Martín-Nuñez, Guillermo, Alonso, José M., de las Heras, Natalia, Hernández, José M., Martín, Alejandro, López-Berges, Consuelo, Orfao, Alberto, and San Miguel, Jesús F.

Published
2007
Full Text
View/download PDF

33. Impact of Sars-Cov-2 Infection in Acute Myeloid Leukemia Patients: Experience of the Pethema Registry

Author

Martínez, Pilar, primary, Palanques Pastor, Tomás, additional, Lopez Lorenzo, Jose Luiz, additional, Cornago Navascués, Javier, additional, Rodriguez-Macías, Gabriela, additional, Cano, Isabel, additional, Arnan Sangerman, Montserrat, additional, Vidriales, María-Belén, additional, Algarra, Jesús Lorenzo, additional, Foncillas, Maria Angeles, additional, Herrera Puente, Pilar, additional, Botella, Carmen, additional, Vives, Susana, additional, Figuera Alvarez, Angela, additional, Cuevas Palomares, Laida, additional, Sobas, Marta, additional, Contento-Gonzalo, Alejandro, additional, Cuello, Rebeca, additional, Amutio Diez, María Elena, additional, De Miguel, Maria Dunia, additional, Navas, Begoña, additional, Bergua Burgues, Juan Miguel, additional, Bernal del Castillo, Teresa, additional, Mateos Rodríguez, María Carmen, additional, de Cabo López, Erik, additional, Franco Villegas, Ana Carolina, additional, García-Boyero, Raimundo, additional, Escolano Escobar, Cristian, additional, Seri, Cristina, additional, Cervero, Carlos, additional, Roldán Pérez, Alicia, additional, Hermosin, Maria Lourdes, additional, Cervera, Marta, additional, Olave, María Teresa, additional, Villafuerte Gutierrez, Paola Sandra, additional, De Laiglesia, Almudena, additional, Serrano, Josefina, additional, Najera Irazu, María Josefa, additional, Piñana Sanchez, Jose Luis, additional, Sanz, Miguel Ángel, additional, Martinez-Lopez, Joaquin, additional, and Montesinos, Pau, additional

Published
2020
Full Text
View/download PDF

34. AML-013: Venetoclax in Patients with Relapsed or Refractory Acute Myeloid Leukemia – A Retrospective Study of a Real-World Setting

Author

Saiz-Rodríguez, Miriam, primary, Cuevas, Beatriz, additional, Álvarez, Rodolfo, additional, Cuello, Rebeca, additional, Vidriales, María Belén, additional, Olivier, Carmen, additional, Recio, Isabel, additional, Campuzano, Veronica, additional, Yeguas, Ana, additional, Cuevas, Victoria, additional, Díaz-Gálvez, Francisco Javier, additional, Ruano, Teresa, additional, Avendaño, Alejandro, additional, Dueñas, Verónica, additional, García, Covadonga, additional, González-López, Tomás José, additional, Olazábal, Juan, additional, Serra, Fe, additional, De Vicente, Pilar, additional, Hermida, Gerardo, additional, and Labrador, Jorge, additional

Published
2020
Full Text
View/download PDF

35. Measures to Maintain a SARS-CoV-2 Negative Inpatient Hematological Unit in the Midst of the COVID-19 Pandemic

Author

Cabero-Martínez, Almudena, primary, Sánchez-Guijo, Fermín, additional, López-Corral, Lucía, additional, Pérez, Estefanía, additional, Avendaño, Alejandro, additional, Baile, Mónica, additional, Cabrero, Mónica, additional, Martín, Ana-Africa, additional, Rodríguez, Angela, additional, Pérez, Balbina, additional, Peña-Muñoz, Felipe, additional, Román, Luz-Gema, additional, Palomino, Danylo, additional, López-Vázquez, Lourdes, additional, Vidriales, María-Belén, additional, González-Diaz, Marcos, additional, Mateos, María-Victoria, additional, and Caballero, María-Dolores, additional

Published
2020
Full Text
View/download PDF

36. Biological Features and Prognostic Impact of Bone Marrow Infiltration in Patients with Diffuse Large B-cell Lymphoma

Author

Alonso-Álvarez, Sara, primary, Alcoceba, Miguel, additional, García-Álvarez, María, additional, Blanco, Oscar, additional, Rodríguez, Marta, additional, Baile, Mónica, additional, Caballero, Juan Carlos, additional, Dávila, Julio, additional, Vidriales, María Belén, additional, Esteban, Carmen, additional, Arias, Piedad, additional, Díaz, Luis G., additional, Tamayo, Pilar, additional, Caballero, María Dolores, additional, Gutiérrez, Norma C., additional, González, Marcos, additional, and Martín, Alejandro, additional

Published
2020
Full Text
View/download PDF

37. Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells

Author

Pérez-Persona, Ernesto, Mateo, Gema, García-Sanz, Ramón, Mateos, María-Victoria, de las Heras, Natalia, de Coca, Alfonso García, Hernández, José M., Galende, Josefina, Martín-Nuñez, Guillermo, Bárez, Abelardo, Alonso, José M., Martín, Alejandro, López-Berges, Consuelo, Orfao, Alberto, San Miguel, Jesús F., and Vidriales, María-Belén

Published
2010
Full Text
View/download PDF

38. Minimal residual disease in adolescent (older than 14 years) and adult acute lymphoblastic leukemias: early immunophenotypic evaluation has high clinical value

Author

Vidriales, María-Belén, Pérez, José J., López-Berges, Maria Consuelo, Gutiérrez, Norma, Ciudad, Juana, Lucio, Paulo, Vazquez, Lourdes, García-Sanz, Ramón, del Cañizo, Maria Consuelo, Fernández-Calvo, Javier, Ramos, Fernando, Rodríguez, M. Jesús, Calmuntia, M. José, Porwith, Ana, Orfao, Alberto, and San-Miguel, Jesús F.

Published
2003
Full Text
View/download PDF

39. Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma.

Author

Paiva, Bruno, Puig, Noemi, Cedena, Maria-Teresa, Rosiñol, Laura, Cordón, Lourdes, Vidriales, María-Belén, Burgos, Leire, Flores-Montero, Juan, Sanoja-Flores, Luzalba, Lopez-Anglada, Lucia, Maldonado, Roberto, de la Cruz, Javier, Gutierrez, Norma C., Calasanz, Maria-Jose, Martin-Ramos, Maria-Luisa, Garcia-Sanz, Ramón, Martinez-Lopez, Joaquin, Oriol, Albert, Blanchard, María-Jesús, and Rios, Rafael

Published
2020
Full Text
View/download PDF

40. Phenotypic, transcriptomic, and genomic features of clonal plasma cells in light-chain amyloidosis

Author

Paiva, Bruno, Martinez-Lopez, Joaquin, Corchete, Luis A., Sanchez-Vega, Beatriz, Rapado, Inmaculada, Puig, Noemi, Barrio, Santiago, Sanchez, Maria-Luz, Alignani, Diego, Lasa, Marta, García de Coca, Alfonso, Pardal, Emilia, Oriol, Alberto, Garcia, Maria-Esther Gonzalez, Escalante, Fernando, González-López, Tomás J., Palomera, Luis, Alonso, José, Prosper, Felipe, Orfao, Alberto, Vidriales, Maria-Belen, Mateos, María-Victoria, Lahuerta, Juan-Jose, Gutierrez, Norma C., and San Miguel, Jesús F.

Published
2016
Full Text
View/download PDF

41. Measurable Residual Disease (MRD) in Elderly Acute Myeloid Leukemia (AML): Results from the Pethema-Flugaza Phase III Clinical Trial

Author

Simoes, Catia Patricia, Paiva, Bruno, Martínez-Cuadron, David, Bergua, Juan-Miguel, Vives, Susana, Algarra, Jesús Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez Lorenzo, Jose Luiz, Vidriales, Maria-Belen, Labrador, Jorge, Falantes, José F., Sayas, Maria Jose, Ayala, Rosa, Martinez-Lopez, Joaquin, Villar, Sara, Calasanz, María José, Prosper, Felipe, San-Miguel, Jesús F., Sanz, Miguel A., and Montesinos, Pau

Published
2020
Full Text
View/download PDF

42. Critical analysis of the stringent complete response in multiple myeloma: contribution of sFLC and bone marrow clonality

Author

Martínez-López, Joaquín, Paiva, Bruno, López-Anglada, Lucía, Mateos, María-Victoria, Cedena, Teresa, Vidríales, María-Belén, Sáez-Gómez, María Auxiliadora, Contreras, Teresa, Oriol, Albert, Rapado, Inmaculada, Teruel, Ana-Isabel, Cordón, Lourdes, Blanchard, María Jesús, Bengoechea, Enrique, Palomera, Luis, de Arriba, Felipe, Cueto-Felgueroso, Cecilia, Orfao, Alberto, Bladé, Joan, San Miguel, Jesús F., and Lahuerta, Juan José

Published
2015
Full Text
View/download PDF

43. Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma

Author

González-Calle, Verónica, primary, Cerdá, Seila, additional, Labrador, Jorge, additional, Sobejano, Eduardo, additional, González-Mena, Beatriz, additional, Aguilera, Carmen, additional, Ocio, Enrique María, additional, Vidriales, María Belén, additional, Puig, Noemí, additional, Gutiérrez, Norma Carmen, additional, García-Sanz, Ramón, additional, Alonso, José María, additional, López, Rosa, additional, Aguilar, Carlos, additional, de Coca, Alfonso García, additional, Hernández, Roberto, additional, Hernández, José Mariano, additional, Escalante, Fernando, additional, and Mateos, María-Victoria, additional

Published
2017
Full Text
View/download PDF

44. Mutational Profiling Predicts Clinical Outcomes to Azacytidine and Low Dose Cytarabine Plus Fludarabine (FLUGA) in Elderly Acute Myeloid Leukemia Patients Enrolled in the Pethema Phase III Flugaza Trial

Author

Ayala, Rosa M., Rapado, Inmaculada, Martínez-Cuadron, David, Onecha, Esther, Rufian, Laura, Juarez, Alexandra, Bergua Burgues, Juan, Vives, Susana, Algarra, Jesús Lorenzo, Tormo, Mar, Martinez, Pilar, Serrano, Josefina, Herrera, Pilar, Ramos, Fernando, Salamero, Olga, Lavilla, Esperanza, Gil, Cristina, Lopez Lorenzo, Jose Luis, Vidriales, Maria-Belen, Labrador, Jorge, Falantes, José F., Sayas, Maria Jose, Paiva, Bruno, Barragán, Eva, Prosper, Felipe, Sanz, Miguel A., Martinez Lopez, Joaquin, and Fernandez, Pau Montesinos

Published
2019
Full Text
View/download PDF

45. Multidimensional Immunophenotyping Identifies Hallmarks of Systemic Light-Chain Amyloidosis (AL) and Maps the Disease in the Crossroad between MGUS and Multiple Myeloma (MM)

Author

Puig, Noemi, Paiva, Bruno, Lasa, Marta, Burgos, Leire, Pérez, José J, Merino, Juana, Moreno, Cristina, Vidriales, Maria-Belen, Gómez, Dolores, Cedena, María Teresa, Ocio, Enrique M., Lecumberri, Ramon, García de Coca, Alfonso, Labrador, Jorge, Garcia, Esther González, Palomera, Luis, Gironella, Mercedes, Cabañas, Valentin, Casanova, Maria, Oriol, Albert, Krsnik, Isabel, Pérez, Albert, De La Rubia, Javier, de la Puerta, José Enrique, De Arriba, Felipe, Prosper, Felipe, Martinez Lopez, Joaquin, Lecrevisse, Quentin, Verde, Javier, Mateos, Maria-Victoria, Lahuerta, Juan Jose, Orfao, Alberto, and San-Miguel, Jesús F

Published
2018
Full Text
View/download PDF

46. Impact of Next-Generation Flow (NGF) Minimal Residual Disease (MRD) Monitoring in Multiple Myeloma (MM): Results from the Pethema/GEM2012 Trial

Author

Paiva, Bruno, Puig, Noemi, Cedena, Maria Teresa, Cordon, Lourdes, Vidriales, Maria-Belen, Burgos, Leire, Flores-Montero, Juan, Lopez-Anglada, Lucía, Gutierrez, Norma, Calasanz, Maria Jose, Martin-Ramos, Maria Luisa, Garcia-Sanz, Ramon, Martinez-Lopez, Joaquin, Oriol, Albert, Blanchard, M Jesús, Rios, Rafael, Martín, Jesús, Martínez, Rafael, Sarra, Josep, Hernández, Miguel T, de la Rubia, Javier, Krsnik, Isabel, Moraleda, Jose M, Palomera, Luis, Bargay, Juan, Orfao, Alberto, Rosinol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-José, Bladé, Joan, and San Miguel, Jesus F.

Published
2017
Full Text
View/download PDF

47. Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality

Author

Bárcena, Paloma, primary, Jara-Acevedo, María, additional, Tabernero, María Dolores, additional, López, Antonio, additional, Sánchez, María Luz, additional, García-Montero, Andrés C., additional, Muñoz-García, Noemí, additional, Vidriales, María Belén, additional, Paiva, Artur, additional, Lecrevisse, Quentin, additional, Lima, Margarida, additional, Langerak, Anton W., additional, Böttcher, Sebastian, additional, van Dongen, Jacques J.M., additional, Orfao, Alberto, additional, and Almeida, Julia, additional

Published
2015
Full Text
View/download PDF

48. Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma

Author

Flores‐Montero, Juan, primary, de Tute, Ruth, additional, Paiva, Bruno, additional, Perez, José Juan, additional, Böttcher, Sebastian, additional, Wind, Henk, additional, Sanoja, Luzalba, additional, Puig, Noemí, additional, Lecrevisse, Quentin, additional, Vidriales, María Belén, additional, van Dongen, Jacques J. M., additional, and Orfao, Alberto, additional

Published
2015
Full Text
View/download PDF

49. Defining the Differentiation Stage of Multiple Myeloma Plasma Cells: Biological and Clinical Significance

Author

Paiva, Bruno, primary, Puig, Noemi, additional, Vidriales, María-Belén, additional, Gutierrez, Norma Carmen, additional, Hernandez, Miguel T, additional, Rosiñol, Laura, additional, Ocio, Enrique M, additional, Oriol, Albert, additional, Echeveste, María Asunción, additional, Gonzalez, Yolanda, additional, Gironella, Mercedes, additional, Prieto, Julio, additional, Moreno, Maria Jose, additional, Giraldo, Pilar, additional, Palomera, Luis, additional, Aoiz, Intza, additional, Blade, Joan, additional, Lahuerta, Juan José, additional, Mateos, Maria-Victoria, additional, and San Miguel, Jesus F., additional

Published
2014
Full Text
View/download PDF

50. Clinical Significance of Sensitive Flow-MRD Monitoring in Elderly Multiple Myeloma Patients on the Pethema/GEM2010MAS65 Trial

Author

Paiva, Bruno, primary, Montalbán, Maria Angeles, additional, Puig, Noemi, additional, Cordon, Lourdes, additional, Martinez-Lopez, Joaquin, additional, Ocio, Enrique M, additional, Hernandez, Miguel, additional, Teruel, Ana Isabel, additional, Gironella, Mercedes, additional, Echeveste, Maria Asunción, additional, Rosiñol, Laura, additional, Martinez, Rafael, additional, Oriol, Albert, additional, Martin, Jesus, additional, Encinas, Cristina, additional, Gutierrez, Norma Carmen, additional, Vidriales, María-Belén, additional, Blade, Joan, additional, Lahuerta, Juan José, additional, Mateos, Maria-Victoria, additional, and San Miguel, Jesus F., additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results