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1. Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis

Author

Vidal-González, Judit, Martínez, Javier, Mulay, Akhilesh, López, Marta, Baiges, Anna, Elmahdy, Ahmed, Lampichler, Katharina, Maleux, Geert, Chang, Johannes, Poncela, Marta, Low, Gavin, Ghigliazza, Gabriele, Zipprich, Alexander, Picón, Carmen, Shah, Rushabh, Llop, Elba, Darnell, Anna, Maurer, Martin H., Bonne, Lawrence, Ramón, Enrique, Quiroga, Sergi, Abraldes, Juan G., Krag, Aleksander, Trebicka, Jonel, Ripoll, Cristina, La Mura, Vincenzo, Tandon, Puneeta, García-Martínez, Rita, Praktiknjo, Michael, Laleman, Wim, Reiberger, Thomas, Berzigotti, Annalisa, Hernández-Gea, Virginia, Calleja, José Luis, Tsochatzis, Emmanuel A., Albillos, Agustín, Simón-Talero, Macarena, and Genescà, Joan

Published
2024
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2. mTOR inhibitors a potential predisposing factor for chronic hepatitis E: Results from the prospective collaborative CHES study (Chronic Hepatitis EScreening in patients with immune impairment and increased transaminases levels)

Author

Riveiro-Barciela, Mar, Roade, Luisa, Martínez-Camprecios, Joan, Vidal-González, Judit, Rodríguez-Diez, Basilio, Perelló, Manel, Ortí, Guillermo, Robles-Alonso, Virginia, Berastegui, Cristina, Navarro, Jordi, Martínez-Valle, Fernando, Bilbao, Itxarone, Castells, Lluis, Ventura-Cots, Meritxell, Llaneras, Jordi, Rando-Segura, Ariadna, Forns, Xavier, Lens, Sabela, Prieto, Martín, García-Eliz, María, Imaz, Arkaitz, Rodríguez-Frías, Francisco, Buti, Maria, and Esteban, Rafael

Published
2023
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3. Performance of spleen stiffness measurement by vibration-controlled transient elastography to rule out high-risk varices in patients with porto-sinusoidal vascular disorder

Author

Moga, Lucile, primary, Paradis, Valérie, additional, Gudavalli, Koushik, additional, Silva, Joel, additional, Colecchia, Antonio, additional, Ravaioli, Federico, additional, Nicoara-Farcau, Oana, additional, Tosetti, Giulia, additional, Berzigotti, Annalisa, additional, Procopet, Bogdan, additional, Simón-Talero, Macarena, additional, Turco, Laura, additional, Capinha, Francisco, additional, Elkrief, Laure, additional, Ferrusquia Acosta, Jose Alberto, additional, Goria, Odile, additional, Balcar, Lorenz, additional, Adrien, Lannes, additional, Mallet, Vincent, additional, Poujol-Robert, Armelle, additional, Thabut, Dominique, additional, Houssel-Debry, Pauline, additional, Wong, Yu Jun, additional, Reiberger, Thomas, additional, Monllor-Nunell, Teresa, additional, Vitale, Giovanni, additional, Ferreira, Carlos Noronha, additional, Vidal-González, Judit, additional, Fodor, Andreea, additional, Antonenko, Antonina, additional, Caccia, Riccardo, additional, Turon, Fanny, additional, Dajti, Elton, additional, Schepis, Filippo, additional, Indulti, Federica, additional, Macedo, Guilherme, additional, Rampally, Sai Prasanth, additional, Payancé, Audrey, additional, Laurent, Castera, additional, Valsan, Arun, additional, Plessier, Aurélie, additional, and Rautou, Pierre-Emmanuel, additional

Published
2023
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4. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, and Rull, Anna

Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.

Published
2022

5. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Yeregui, Elena, primary, Masip, Jenifer, additional, Viladés, Consuelo, additional, Domingo, Pere, additional, Pacheco, Yolanda M., additional, Blanco, Julià, additional, Mallolas, Josep, additional, Alba, Verónica, additional, Vargas, Montserrat, additional, García-Pardo, Graciano, additional, Negredo, Eugènia, additional, Olona, Montserrat, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Martí, Anna, additional, Reverté, Laia, additional, Gómez-Bertomeu, Fréderic, additional, Leal, Manuel, additional, Vidal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2022
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6. Hepatocellular carcinoma with tumor thrombus extends to the right atrium and portal vein: a case report

Author

Gomez-Puerto, Diego, Mirallas, Oriol, Vidal-González, Judit, Vargas Blasco, Víctor, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Gomez-Puerto D, Mirallas O] Servei d’Oncologia Mèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Vidal-González J] Servei d’Hepatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERehd, Barcelona, Spain. [Vargas V] Servei d’Hepatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERehd, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
medicine.medical_specialty, Hepatocellular carcinoma, neoplasias::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias hepáticas::carcinoma hepatocelular [ENFERMEDADES], Inferior vena cava, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Cardiac magnetic resonance imaging, Case report, Fetge - Càncer - Prognosi, medicine, Hepatopulmonary syndrome, Vein, Diagnosis::Prognosis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Portopulmonary hypertension, Right atrium, Hepatology, medicine.diagnostic_test, business.industry, Sorafenib, medicine.disease, digestive system diseases, Pulmonary embolism, Tumor thrombus, medicine.anatomical_structure, Neoplasms::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms::Carcinoma, Hepatocellular [DISEASES], medicine.vein, 030220 oncology & carcinogenesis, Alpha-fetoprotein, cardiovascular system, 030211 gastroenterology & hepatology, Radiology, business
Abstract

Alfa-fetoproteïna; Carcinoma hepatocel·lular; Trombe tumoral Alfafetoproteína; Carcinoma hepatocelular; Trombo tumoral Alpha-fetoprotein; Hepatocellular carcinoma; Tumor thrombus BACKGROUND Hepatocellular carcinoma (HCC) is the most important primary malignant liver disease. A large proportion of patients with advanced HCC have macrovascular invasion. HCC tends to infiltrate vascular structures, particularly the portal vein and its branches, and more rarely, the hepatic veins. The intravascular tumor thrombus can affect the inferior vena cava (IVC) or even the right atrium (RA), the latter having a poor prognosis. CASE SUMMARY HCC is one of the most aggressive malignant tumors. Tumor thrombus (TT) formation in advanced HCC stages is common and usually involves the hepatic or portal veins. Herein, we report a 69-year-old woman who presented with dyspnea to the emergency department. A ventilation/perfusion lung scan was performed, ruling out pulmonary embolism. Hepatopulmonary syndrome and portopulmonary hypertension were discarded with contrasted echocardiography, but a mass in the RA was detected and confirmed by cardiac magnetic resonance imaging. Abdominal computed tomography showed a liver mass with a dynamic enhancement pattern compatible with HCC and an intraluminal IVC mass extending from the hepatic vein into the RA. HCC with TT expansion to IVC and RA is rare and indicates poor prognosis. CONCLUSION HCC with TT expansion to IVC and RA is rare and indicates poor prognosis. There is no consensus about anticoagulation or other interventions in these patients. Gomez-Puerto D, Mirallas O, Vidal-González J, Vargas V. Hepatocellular carcinoma with tumor thrombus extends to the right atrium and portal vein: A case report. World J Hepatol 2020; 12(11): 1128-1135 [PMID: 33312435 DOI: 10.4254/wjh.v12.i11.1128]

Published
2020

7. Spontaneous portosystemic shunts in liver cirrhosis : new approaches to an old problem

Author

Vidal-González, Judit, Quiroga, Sergi, Simon-Talero, Macarena, Genescà, J., and Universitat Autònoma de Barcelona

Subjects
medicine.medical_specialty, Cirrhosis, medicine.medical_treatment, hepatic encephalopathy, Portal venous system, embolization, Review, Liver transplantation, Gastroenterology, Embolization, Internal medicine, Ascites, medicine, lcsh:RC799-869, Portal hypertension, Hepatic encephalopathy, Liver transplant, collaterals, business.industry, portal hypertension, Collaterals, medicine.disease, liver transplant, TIPS, lcsh:Diseases of the digestive system. Gastroenterology, Liver function, medicine.symptom, business, Transjugular intrahepatic portosystemic shunt
Abstract

Portal hypertension is the main consequence of liver cirrhosis, leading to severe complications such as variceal hemorrhage, ascites or hepatic encephalopathy. As an attempt to decompress the portal venous system, portal flow is derived into the systemic venous system through spontaneous portosystemic shunts (SPSSs), bypassing the liver. In this review, we aim to provide an overview of the published reports in relation to the prevalence and physiopathology behind the appearance of SPSS in liver cirrhosis, as well as the complications derived from its formation and its management. The role of SPSS embolization is specifically discussed, as SPSSs have been assessed as a therapeutic target, mainly for patients with recurrent/persistent hepatic encephalopathy and preserved liver function. Furthermore, different aspects of the role of SPSS in liver transplantation, as well as in candidates for transjugular intrahepatic portosystemic shunt are reviewed. In these settings, SPSS occlusion has been proposed to minimize possible deleterious effects, but results are so far inconclusive.

Published
2020

8. OS-121-YI - Performance of spleen stiffness measurement by vibration-controlled transient elastography to rule out high-risk varices in patients with porto-sinusoidal vascular disorder

Author

Moga, Lucile, Paradis, Valérie, Gudavalli, Koushik, Silva, Joel, Colecchia, Antonio, Ravaioli, Federico, Nicoara-Farcau, Oana, Tosetti, Giulia, Berzigotti, Annalisa, Procopet, Bogdan, Simón-Talero, Macarena, Turco, Laura, Capinha, Francisco, Elkrief, Laure, Ferrusquia Acosta, Jose Alberto, Goria, Odile, Balcar, Lorenz, Adrien, Lannes, Mallet, Vincent, Poujol-Robert, Armelle, Thabut, Dominique, Houssel-Debry, Pauline, Wong, Yu Jun, Reiberger, Thomas, Monllor-Nunell, Teresa, Vitale, Giovanni, Ferreira, Carlos Noronha, Vidal-González, Judit, Fodor, Andreea, Antonenko, Antonina, Caccia, Riccardo, Turon, Fanny, Dajti, Elton, Schepis, Filippo, Indulti, Federica, Macedo, Guilherme, Rampally, Sai Prasanth, Payancé, Audrey, Laurent, Castera, Valsan, Arun, Plessier, Aurélie, and Rautou, Pierre-Emmanuel

Published
2023
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9. Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author

Samuel, Didier, Baveno VI-SPSS group of the Baveno Cooperation, Praktiknjo, Michael, Simón-Talero, Macarena, Römer, Julia, Roccarina, Davide, Martínez, Javier, Lampichler, Katharina, Baiges, Anna, Low, Gavin, Llop, Elba, Maurer, Martin H., Zipprich, Alexander, Triolo, Michela, Maleux, Geert, Fialla, Annette Dam, Dam, Claus, Vidal-González, Judit, Majumdar, Avik, Picón, Carmen, Toth, Daniel, Darnell, Anna, Abraldes, Juan G., López, Marta, Jansen, Christian, Chang, Johannes, Schierwagen, Robert, Uschner, Frank Erhard, Kukuk, Guido, Meyer, Carsten, Thomas, Daniel, Wolter, Karsten, Straßburg, Christian P., Laleman, Wim, La Mura, Vincenzo, Ripoll, Cristina, Berzigotti, Annalisa, Calleja, José Luis, Tandon, Puneeta, Hernández-Gea, Virginia, Reiberger, Thomas, Albillos, Agustin, Tsochatzis, Emmanuel A., Krag, Aleksander, Genescà, Joan, Trebicka, Jonel, Samuel, Didier, Baveno VI-SPSS group of the Baveno Cooperation, Praktiknjo, Michael, Simón-Talero, Macarena, Römer, Julia, Roccarina, Davide, Martínez, Javier, Lampichler, Katharina, Baiges, Anna, Low, Gavin, Llop, Elba, Maurer, Martin H., Zipprich, Alexander, Triolo, Michela, Maleux, Geert, Fialla, Annette Dam, Dam, Claus, Vidal-González, Judit, Majumdar, Avik, Picón, Carmen, Toth, Daniel, Darnell, Anna, Abraldes, Juan G., López, Marta, Jansen, Christian, Chang, Johannes, Schierwagen, Robert, Uschner, Frank Erhard, Kukuk, Guido, Meyer, Carsten, Thomas, Daniel, Wolter, Karsten, Straßburg, Christian P., Laleman, Wim, La Mura, Vincenzo, Ripoll, Cristina, Berzigotti, Annalisa, Calleja, José Luis, Tandon, Puneeta, Hernández-Gea, Virginia, Reiberger, Thomas, Albillos, Agustin, Tsochatzis, Emmanuel A., Krag, Aleksander, Genescà, Joan, and Trebicka, Jonel

Abstract

Background & Aims: Spontaneous portosystemic shunts (SPSS) frequently develop in liver cirrhosis. Recent data suggested that the presence of a single large SPSS is associated with complications, especially overt hepatic encephalopathy (oHE). However, the presence of >1 SPSS is common. This study evaluates the impact of total cross-sectional SPSS area (TSA) on outcomes in patients with liver cirrhosis. Methods: In this retrospective international multicentric study, CT scans of 908 cirrhotic patients with SPSS were evaluated for TSA. Clinical and laboratory data were recorded. Each detected SPSS radius was measured and TSA calculated. One-year survival was the primary endpoint and acute decompensation (oHE, variceal bleeding, ascites) was the secondary endpoint. Results: A total of 301 patients (169 male) were included in the training cohort. Thirty percent of all patients presented with >1 SPSS. A TSA cut-off of 83 mm2 was used to classify patients with small or large TSA (S-/L-TSA). Patients with L-TSA presented with higher model for end-stage liver disease score (11 vs. 14) and more commonly had a history of oHE (12% vs. 21%, p <0.05). During follow-up, patients with L-TSA experienced more oHE episodes (33% vs. 47%, p <0.05) and had lower 1-year survival than those with S-TSA (84% vs. 69%, p <0.001). Multivariate analysis identified L-TSA (hazard ratio 1.66; 95% CI 1.02–2.70, p <0.05) as an independent predictor of mortality. An independent multicentric validation cohort of 607 patients confirmed that patients with L-TSA had lower 1-year survival (77% vs. 64%, p <0.001) and more oHE development (35% vs. 49%, p <0.001) than those with S-TSA. Conclusion: This study suggests that TSA >83 mm2 increases the risk for oHE and mortality in patients with cirrhosis. Our results support the clinical use of TSA/SPSS for risk stratification and decision-making in the management of patients with cirrhosis. Lay summary: The prevalence of spontaneous portosystemic shunts (SPSS) i

Published
2020

10. High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

Author

Yeregui, Elena, primary, Viladés, Consuelo, additional, Domingo, Pere, additional, Ceausu, Andra, additional, Pacheco, Yolanda María, additional, Veloso, Sergi, additional, Inciarte, Alexy, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Perpiñán, Carles, additional, Falcó, Vicenç, additional, Masip, Jenifer, additional, Alba, Verónica, additional, Vargas, Montserrat, additional, Martí, Anna, additional, Reverté, Laia, additional, Mallolas, Josep, additional, Vidal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2020
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12. Immune‐related hepatitis related to checkpoint inhibitors: Clinical and prognostic factors

Author

Riveiro‐Barciela, Mar, primary, Barreira‐Díaz, Ana, additional, Vidal‐González, Judit, additional, Muñoz‐Couselo, Eva, additional, Martínez‐Valle, Fernando, additional, Viladomiu, Lluís, additional, Mínguez, Beatriz, additional, Ortiz‐Velez, Carolina, additional, Castells, Lluís, additional, Esteban, Rafael, additional, and Buti, María, additional

Published
2020
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13. Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author

Praktiknjo, Michael, primary, Simón-Talero, Macarena, additional, Römer, Julia, additional, Roccarina, Davide, additional, Martínez, Javier, additional, Lampichler, Katharina, additional, Baiges, Anna, additional, Low, Gavin, additional, Llop, Elba, additional, Maurer, Martin H., additional, Zipprich, Alexander, additional, Triolo, Michela, additional, Maleux, Geert, additional, Fialla, Annette Dam, additional, Dam, Claus, additional, Vidal-González, Judit, additional, Majumdar, Avik, additional, Picón, Carmen, additional, Toth, Daniel, additional, Darnell, Anna, additional, Abraldes, Juan G., additional, López, Marta, additional, Jansen, Christian, additional, Chang, Johannes, additional, Schierwagen, Robert, additional, Uschner, Frank, additional, Kukuk, Guido, additional, Meyer, Carsten, additional, Thomas, Daniel, additional, Wolter, Karsten, additional, Strassburg, Christian P., additional, Laleman, Wim, additional, La Mura, Vincenzo, additional, Ripoll, Cristina, additional, Berzigotti, Annalisa, additional, Calleja, José Luis, additional, Tandon, Puneeta, additional, Hernandez-Gea, Virginia, additional, Reiberger, Thomas, additional, Albillos, Agustín, additional, Tsochatzis, Emmanuel A., additional, Krag, Aleksander, additional, Genescà, Joan, additional, Trebicka, Jonel, additional, Quiroga, Sergi, additional, Yu, Dominic, additional, Téllez, Luis, additional, Mandorfer, Mattias, additional, Garcia-Pagan, Juan Carlos, additional, Berbel, Claudia, additional, Ferrusquia, José, additional, Ble, Michel, additional, Garcia-Criado, Mari Angeles, additional, Belmonte, Ernest, additional, Ney, Michael, additional, Margini, Cristina, additional, Casu, Stefania, additional, Murgia, Giuseppe, additional, Ludwig, Christiane, additional, and Stangl, Franz, additional

Published
2020
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14. Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial

Author

Curran, Adrian, primary, Rull, Anna, additional, Navarro, Jordi, additional, Vidal-González, Judit, additional, Martin-Castillo, Mario, additional, Burgos, Joaquin, additional, Falcó, Vicenç, additional, Ribera, Esteban, additional, Torrella, Ariadna, additional, Planas, Bibiana, additional, Peraire, Joaquim, additional, and Crespo, Manuel, additional

Published
2020
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15. High Circulating SDF-1 and MCP-1 Levels and Genetic Variations in CXCL12, CCL2 and CCR5: Prognostic Signature of Immune Recovery Status in Treated HIV-Infected Patients

Author

Yeregui, Elena, primary, Viladés, Consuelo, additional, Domingo, Pere, additional, Ceausu, Andra, additional, Pacheco, Yolanda María, additional, Veloso, Sergi, additional, Inciarte, Alexy, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Perpiñán, Carles, additional, Falcó, Vicenç, additional, Masip, Jenifer, additional, Alba, Veronica, additional, Vargas, Montserrat, additional, Martí, Anna, additional, Reverté, Laia, additional, Vidal Marsal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2020
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18. IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Gilead Sciences, Red Española de Investigación en SIDA, Junta de Andalucía, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Ceausu, Andra, Rodríguez-Gallego, Esther, Peraire, Joaquim, López-Dupla, Miguel, Domingo, Pere, Viladés, Consuelo, Vidal-González, Judit, Peraire, Maria, Perpiñán, Carles, Pacheco, Yolanda M., Veloso, Sergi, Alba, Verónica, Vargas, Montserrat, Castellano, Alfonso J., Ruiz-Mateos, Ezequiel, Mallolas, Josep, Vidal, Francesc, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Gilead Sciences, Red Española de Investigación en SIDA, Junta de Andalucía, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Ceausu, Andra, Rodríguez-Gallego, Esther, Peraire, Joaquim, López-Dupla, Miguel, Domingo, Pere, Viladés, Consuelo, Vidal-González, Judit, Peraire, Maria, Perpiñán, Carles, Pacheco, Yolanda M., Veloso, Sergi, Alba, Verónica, Vargas, Montserrat, Castellano, Alfonso J., Ruiz-Mateos, Ezequiel, Mallolas, Josep, Vidal, Francesc, and Rull, Anna

Abstract

A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.

Published
2019

19. FRI-054-Immune-related hepatitis as an independent entity from autoimmune hepatitis: clinical, prognostic and therapeutic differences

Author

Riveiro-Barciela, Mar, primary, Vidal-González, Judit, additional, Barreira-Díaz, Ana, additional, Muñoz-Couselo, Eva, additional, Viladomiu, Lluís, additional, Velez, Carolina Ortiz, additional, Martínez-Valle, Fernando, additional, Castells, Lluís, additional, Esteban, Rafael, additional, and Buti, Maria, additional

Published
2019
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20. FRI-201-Hepatitis B virus vaccine immunogenicity in anti-HBC+ immunocompromised patients with low anti-HBS levels: Preliminary results of the Hepbare study

Author

Vidal-González, Judit, primary, Riveiro-Barciela, Mar, additional, Martínez, Xavier, additional, Rodríguez, Basilio, additional, Robles, Virginia, additional, Aparicio, Gloria, additional, Castells, Lluís, additional, Perelló, Manel, additional, Berastegui, Cristina, additional, Bilbao, Itxarone, additional, Esteban, Rafael, additional, Campins, Magda, additional, and Buti, Maria, additional

Published
2019
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21. SAT-212-Treatment with mTOR inhibitors is an independent risk factor for chronic hepatitis E in transplant patients with increased transaminases levels

Author

Riveiro-Barciela, Mar, primary, Vidal-González, Judit, additional, Roade, Luisa, additional, Camprecios, Joan Martínez, additional, Rodríguez, Basilio, additional, Perelló, Manel, additional, Ortí, Guillem, additional, Robles, Virginia, additional, Berastegui, Cristina, additional, Navarro, Jordi, additional, Martínez-Valle, Fernando, additional, Bilbao, Itxarone, additional, Castells, Lluís, additional, Nieto, Leonardo, additional, Rodríguez-Frías, Francisco, additional, Buti, Maria, additional, and Esteban, Rafael, additional

Published
2019
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27. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4 + T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy.

Author

Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugènia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Fréderic, Leal, Manuel, Vidal, Francesc, and Peraire, Joaquim

Subjects
ADIPOKINES, ANTIRETROVIRAL agents, APELIN, RETINOL-binding proteins, ENZYME-linked immunosorbent assay, CD4 antigen
Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author

Praktiknjo, Michael, Simón-Talero, Macarena, Römer, Julia, Roccarina, Davide, Martínez, Javier, Lampichler, Katharina, Baiges, Anna, Low, Gavin, Llop, Elba, Maurer, Martin H., Zipprich, Alexander, Triolo, Michela, Maleux, Geert, Fialla, Annette Dam, Dam, Claus, Vidal-González, Judit, Majumdar, Avik, Picón, Carmen, Toth, Daniel, Darnell, Anna, Abraldes, Juan G, López, Marta, Jansen, Christian, Chang, Johannes, Schierwagen, Robert, Uschner, Frank, Kukuk, Guido, Meyer, Carsten, Thomas, Daniel, Wolter, Karsten, Strassburg, Christian P, Laleman, Wim, La Mura, Vincenzo, Ripoll, Cristina, Berzigotti, Annalisa, Calleja, José Luis, Tandon, Puneeta, Hernandez-Gea, Virginia, Reiberger, Thomas, Albillos, Agustín, Tsochatzis, Emmanuel A, Krag, Aleksander, Genescà, Joan, and Trebicka, Jonel

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND & AIMS Spontaneous portosystemic shunts (SPSS) frequently develop in liver cirrhosis. Recent data suggested that the presence of a single large SPSS is associated with complications, especially overt hepatic encephalopathy (oHE). However, the presence of >1 SPSS is common. This study evaluates the impact of total cross-sectional SPSS area (TSA) on outcomes in patients with liver cirrhosis. METHODS In this retrospective international multicentric study, CT scans of 908 cirrhotic patients with SPSS were evaluated for TSA. Clinical and laboratory data were recorded. Each detected SPSS radius was measured and TSA calculated. One-year survival was the primary endpoint and acute decompensation (oHE, variceal bleeding, ascites) was the secondary endpoint. RESULTS A total of 301 patients (169 male) were included in the training cohort. Thirty percent of all patients presented with >1 SPSS. A TSA cut-off of 83 mm2 was used to classify patients with small or large TSA (S-/L-TSA). Patients with L-TSA presented with higher model for end-stage liver disease score (11 vs. 14) and more commonly had a history of oHE (12% vs. 21%, p 83 mm2 increases the risk for oHE and mortality in patients with cirrhosis. Our results support the clinical use of TSA/SPSS for risk stratification and decision-making in the management of patients with cirrhosis. LAY SUMMARY The prevalence of spontaneous portosystemic shunts (SPSS) is higher in patients with more advanced chronic liver disease. The presence of more than 1 SPSS is common in advanced chronic liver disease and is associated with the development of hepatic encephalopathy. This study shows that total cross-sectional SPSS area (rather than diameter of the single largest SPSS) predicts survival in patients with advanced chronic liver disease. Our results support the clinical use of total cross-sectional SPSS area for risk stratification and decision-making in the management of SPSS.

29. Performance of spleen stiffness measurement to rule out high-risk varices in patients with porto-sinusoidal vascular disorder.

Author

Moga L, Paradis V, Ferreira-Silva J, Gudavalli K, Indulti F, Dajti E, Nicoara-Farcau O, Tosetti G, Antonenko A, Fodor A, Vidal-González J, Turco L, Capinha F, Elkrief L, Monllor-Nunell T, Goria O, Balcar L, Lannes A, Mallet V, Poujol-Robert A, Thabut D, Houssel-Debry P, Wong YJ, Ronot M, Vilgrain V, Rampally SP, Payancé A, Castera L, Reiberger T, Ferrusquía-Acosta J, Noronha Ferreira C, Vitale G, Simon-Talero M, Procopet B, Berzigotti A, Caccia R, Turon F, Schepis F, Ravaioli F, Colecchia A, Valsan A, Macedo G, Plessier A, and Rautou PE

Abstract

Background and Aims: Baveno VII consensus suggests that screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is ≤40 kPa as they have a low probability of high-risk varices (HRV). Conversely, screening endoscopy is required in all patients with porto-sinusoidal vascular disorder (PSVD). This study aimed to evaluate the performance of SSM-VCTE to rule out HRV in patients with PSVD and signs of portal hypertension., Approach and Results: We retrospectively included patients with PSVD, ≥1 sign of portal hypertension, without a history of variceal bleeding, who underwent an SSM-VCTE within 2 years before or after an upper endoscopy in 21 VALDIG centers, divided into a derivation and a validation cohort. One hundred fifty-four patients were included in the derivation cohort; 43% had HRV. By multivariable logistic regression analysis, SSM-VCTE >40 kPa and serum bilirubin ≥1 mg/dL were associated with HRV. SSM-VCTE ≤40 kPa combined with bilirubin <1 mg/dL had a sensitivity of 96% to rule out HRV and could spare 38% of screening endoscopies, with 4% of HRV missed, and a 95% negative predictive value. In the validation cohort, including 155 patients, SSM combined with bilirubin could spare 21% of screening endoscopies, with 4% of HRV missed and a 94% negative predictive value., Conclusions: This study gathering a total of 309 patients with PSVD showed that SSM-VCTE ≤40 kPa combined with bilirubin <1 mg/dL identifies patients with PSVD and portal hypertension with a probability of HRV <5%, in whom screening endoscopy can be spared., (Copyright © 2024 American Association for the Study of Liver Diseases.)

Published
2024
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30. Evolution of spontaneous portosystemic shunts over time and following aetiological intervention in patients with cirrhosis.

Author

Vidal-González J, Martínez J, Mulay A, López M, Baiges A, Elmahdy A, Lampichler K, Maleux G, Chang J, Poncela M, Low G, Ghigliazza G, Zipprich A, Picón C, Shah R, Llop E, Darnell A, Maurer MH, Bonne L, Ramón E, Quiroga S, Abraldes JG, Krag A, Trebicka J, Ripoll C, La Mura V, Tandon P, García-Martínez R, Praktiknjo M, Laleman W, Reiberger T, Berzigotti A, Hernández-Gea V, Calleja JL, Tsochatzis EA, Albillos A, Simón-Talero M, and Genescà J

Abstract

Background & Aims: Spontaneous portosystemic shunts (SPSS) develop frequently in cirrhosis. Changes over time and the effect of aetiological interventions on SPSS are unknown, so we aimed to explore the effect of these variables on SPSS evolution., Methods: Patients with cirrhosis from the Baveno VI-SPSS cohort were selected provided a follow-up abdominal CT or MRI scan was available. Clinical and laboratory data were collected at baseline and follow-up. Imaging tests were reviewed to evaluate changes in the presence and size of SPSS (large (L)-SPSS was ≥8 mm) over time. Regarding alcohol- or HCV-related cirrhosis, two populations were defined: cured patients (abstinent from alcohol or successful HCV therapy), and non-cured patients., Results: A total of 617 patients were included. At baseline SPSS distribution was 22% L-SPSS, 30% small (S)-SPSS, and 48% without (W)-SPSS. During follow-up (median follow-up of 63 months), SPSS distribution worsened: L-SPSS 26%, S-SPSS 32%, and W-SPSS 42% ( p <0.001). Patients with worse liver function during follow-up showed a simultaneous aggravation in SPSS distribution. Non-cured patients (n = 191) experienced a significant worsening in liver function, more episodes of liver decompensation and lower transplant-free survival compared to cured patients (n = 191). However, no differences were observed regarding SPSS distribution at inclusion and at follow-up, with both groups showing a trend to worsening. Total shunt diameter increased more in non-cured (52%) than in cured patients (28%). However, total shunt area (TSA) significantly increased only in non-cured patients (74 to 122 mm 2 , p <0.001)., Conclusions: The presence of SPSS in cirrhosis increases over time and parallels liver function deterioration. Aetiological intervention in these patients reduces liver-related complications, but SPSS persist although progression is decreased., Impact and Implications: There is no information regarding the evolution of spontaneous portosystemic shunts (SPSS) during the course of cirrhosis, and especially after disease regression with aetiological interventions, such as HCV treatment with direct-acting antivirals or alcohol abstinence. These results are relevant for clinicians dealing with patients with cirrhosis and portal hypertension because they have important implications for the management of cirrhosis with SPSS after disease regression. From a practical point of view, physicians should be aware that in advanced cirrhosis with portal hypertension, after aetiological intervention, SPSS mostly persist despite liver function improvement, and complications related to SPSS may still develop., Competing Interests: JG has received consulting fees from Boehringer Ingelheim and speaking fees from Echosens. MS-T has received consulting fees from Grifols. AK has served as speaker for Novo Nordisk, Norgine, Siemens and Nordic Bioscience and participated in advisory boards for Norgine, Siemens, Resalis Therapeutics, Boehringer Ingelheim and Novo Nordisk, all outside the submitted work. Research support Norgine, Siemens, Nordic Bioscience, Astra, Echosense. Consulting Takeda, Resalis Therapeutics, Zealand Pharma, Novo Nordisk, Boehringer Ingelheim. Board member and co-founder Evido. Please refer to the accompanying ICMJE disclosure forms for further details., (© 2023 The Authors.)

Published
2023
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